Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YOL013C
Length:
551
Number of sequences:
5887
Description:
YOL013C HRD1 SGDID:S000005373, Chr XV from 303035-301380, Genome Release 64-1-1, reverse complement, Verified ORF, "Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1Q08109    551   HRD1_YEAST ERAD-associated E3 ubiquitin-prote...5510     1133     100     100GO:0000839; C:Hrd1p ubiquitin ligase ERAD-L complex; IDA:SGD.::GO:0000838; C:Hrd1p ubiquitin ligase ERAD-M complex; IDA:SGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030433; P:ER-associated protein catabolic process; IPI:SGD.::GO:0031505; P:fungal-type cell wall organization; IGI:SGD.
2Q75CC8    575   HRD1_ASHGO ERAD-associated E3 ubiquitin-prote...4137e-56     202     32     53GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
3O74757    677   HRD1_SCHPO ERAD-associated E3 ubiquitin-prote...4864e-28     122     25     41GO:0005938; C:cell cortex; IDA:PomBase.::GO:0005789; C:endoplasmic reticulum membrane; ISS:PomBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005515; F:protein binding; IPI:PomBase.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:PomBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030433; P:ER-associated protein catabolic process; IMP:PomBase.::GO:0010620; P:negative regulation of transcription by transcription factor catabolism; IMP:PomBase.
4Q803I8    625   SYVN1_DANRE E3 ubiquitin-protein ligase synov...3691e-25     115     26     44GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
5Q86TM6    617   SYVN1_HUMAN E3 ubiquitin-protein ligase synov...3692e-25     114     26     44GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; IDA:HPA.
GO:0016881; F:acid-amino acid ligase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.::GO:0030433; P:ER-associated protein catabolic process; IDA:UniProtKB.
6Q9DBY1    612   SYVN1_MOUSE E3 ubiquitin-protein ligase synov...3672e-25     114     26     44GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006916; P:anti-apoptosis; IMP:MGI.::GO:0001701; P:in utero embryonic development; IMP:MGI.
7Q5XHH7    595   SYVNB_XENLA E3 ubiquitin-protein ligase synov...3695e-23     106     26     44GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
8Q6NRL6    605   SYVNA_XENLA E3 ubiquitin-protein ligase synov...3691e-22     105     26     44GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
9Q95SP2    626   HRD1_DROME E3 ubiquitin-protein ligase HRD1 O...3681e-20     99.8     23     43GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016881; F:acid-amino acid ligase activity; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030433; P:ER-associated protein catabolic process; ISS:UniProtKB.
10Q20798    610   HRD1_CAEEL E3 ubiquitin-protein ligase hrd-1 ...3431e-19     95.9     24     43GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
11A8Y4B2    622   HRD1_CAEBR E3 ubiquitin-protein ligase hrd-1 ...3432e-18     92.8     24     42GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
12Q9UKV5    643   AMFR2_HUMAN E3 ubiquitin-protein ligase AMFR ...750.000001     55.1     32     55GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:UniProtKB.::GO:0000299; C:integral to membrane of membrane fraction; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030968; P:endoplasmic reticulum unfolded protein response; IMP:UniProtKB.::GO:0030433; P:ER-associated protein catabolic process; IDA:UniProtKB.::GO:0051259; P:protein oligomerization; IDA:UniProtKB.::GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.
13Q9R049    643   AMFR_MOUSE E3 ubiquitin-protein ligase AMFR O...750.000001     54.7     32     55GO:0030176; C:integral to endoplasmic reticulum membrane; ISS:UniProtKB.
GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030433; P:ER-associated protein catabolic process; ISS:UniProtKB.::GO:0000209; P:protein polyubiquitination; ISS:UniProtKB.
14Q9Y3C5    154   RNF11_HUMAN RING finger protein 11 OS=Homo sa...560.000005     50.4     41     54GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0003677; F:DNA binding; TAS:ProtInc.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; TAS:ProtInc.
GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
15Q08DI6    154   RNF11_BOVIN RING finger protein 11 OS=Bos tau...560.000005     50.4     41     54GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
16Q9QYK7    154   RNF11_MOUSE RING finger protein 11 OS=Mus mus...560.000005     50.1     41     54GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0000151; C:ubiquitin ligase complex; IPI:MGI.
GO:0008270; F:zinc ion binding; IEA:InterPro.
17Q9Y7K6    741   YGI4_SCHPO Uncharacterized RING finger protei...590.000005     53.1     37     54GO:0005634; C:nucleus; IDA:PomBase.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:PomBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006325; P:chromatin organization; ISS:PomBase.::GO:0006342; P:chromatin silencing; ISS:PomBase.::GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:PomBase.
18Q7T037    757   RF12B_XENLA E3 ubiquitin-protein ligase RNF12...1080.00001     52     32     46GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0042802; F:identical protein binding; ISS:UniProtKB.::GO:0008134; F:transcription factor binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000578; P:embryonic axis specification; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
19Q9H6Y7    350   RN167_HUMAN E3 ubiquitin-protein ligase RNF16...1600.00001     51.2     26     40GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045786; P:negative regulation of cell cycle; IMP:UniProtKB.::GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.
20Q9NVW2    624   RNF12_HUMAN E3 ubiquitin-protein ligase RLIM ...880.00001     51.6     35     47GO:0005737; C:cytoplasm; IDA:HPA.::GO:0017053; C:transcriptional repressor complex; NAS:UniProtKB.
GO:0003714; F:transcription corepressor activity; NAS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0060816; P:random inactivation of X chromosome; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
21Q641J8    622   RF12A_XENLA E3 ubiquitin-protein ligase RNF12...880.00001     51.6     34     45GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0042802; F:identical protein binding; IPI:UniProtKB.::GO:0008134; F:transcription factor binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000578; P:embryonic axis specification; IMP:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
22Q9DBU5    667   RNF6_MOUSE E3 ubiquitin-protein ligase RNF6 O...810.00001     51.6     28     48GO:0030424; C:axon; IDA:MGI.::GO:0005737; C:cytoplasm; IDA:MGI.::GO:0016605; C:PML body; IDA:MGI.
GO:0050681; F:androgen receptor binding; ISS:UniProtKB.::GO:0003677; F:DNA binding; IDA:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030517; P:negative regulation of axon extension; IMP:MGI.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:MGI.::GO:0044314; P:protein K27-linked ubiquitination; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; IMP:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; ISS:UniProtKB.::GO:0060765; P:regulation of androgen receptor signaling pathway; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:MGI.
23Q07G42    639   RNF12_XENTR E3 ubiquitin-protein ligase RNF12...880.00002     51.2     34     45GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0042802; F:identical protein binding; ISS:UniProtKB.::GO:0008134; F:transcription factor binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000578; P:embryonic axis specification; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
24Q8VYC8    578   RIN2_ARATH E3 ubiquitin protein ligase RIN2 O...820.00003     50.4     34     49GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:TAIR.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:TAIR.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.::GO:0034052; P:positive regulation of plant-type hypersensitive response; IGI:TAIR.
25Q8LPN7    328   RNG1L_ARATH E3 ubiquitin-protein ligase RING1...970.00004     49.3     29     44
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
26Q9Y252    685   RNF6_HUMAN E3 ubiquitin-protein ligase RNF6 O...880.00004     50.1     28     44GO:0030424; C:axon; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
GO:0050681; F:androgen receptor binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IMP:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030517; P:negative regulation of axon extension; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:UniProtKB.::GO:0044314; P:protein K27-linked ubiquitination; IDA:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; IDA:UniProtKB.::GO:0060765; P:regulation of androgen receptor signaling pathway; IMP:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
27Q8RXD3    310   AIP2_ARATH E3 ubiquitin-protein ligase AIP2 O...780.00004     49.3     33     45GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0009738; P:abscisic acid mediated signaling pathway; IEA:UniProtKB-KW.::GO:0009788; P:negative regulation of abscisic acid mediated signaling pathway; IMP:UniProtKB.
28Q9WTV7    600   RNF12_MOUSE E3 ubiquitin-protein ligase RLIM ...880.00005     50.1     34     47GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IGI:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IGI:MGI.::GO:0060816; P:random inactivation of X chromosome; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
29Q86XS8    419   GOLI_HUMAN E3 ubiquitin-protein ligase RNF130...1440.00005     49.7     26     42GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; IDA:HPA.
GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
30Q9M0R7    132   ATL39_ARATH RING-H2 finger protein ATL39 OS=A...570.00005     47     35     51GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
31Q8W4Q5    577   RIN3_ARATH E3 ubiquitin protein ligase RIN3 O...740.00007     49.3     32     51GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; TAS:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:TAIR.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.::GO:0034052; P:positive regulation of plant-type hypersensitive response; IGI:TAIR.
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