Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
Home About FGC Use Cases Species List

UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YOL006C
Length:
769
Number of sequences:
5887
Description:
YOL006C TOP1 SGDID:S000005366, Chr XV from 315387-313078, Genome Release 64-1-1, reverse complement, Verified ORF, "Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P04786    769   TOP1_YEAST DNA topoisomerase 1 OS=Saccharomyc...7690     1569     100     100GO:0005730; C:nucleolus; IPI:SGD.::GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.::GO:0031298; C:replication fork protection complex; IDA:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0031490; F:chromatin DNA binding; IBA:RefGenome.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; IDA:SGD.
GO:0006333; P:chromatin assembly or disassembly; IMP:SGD.::GO:0000183; P:chromatin silencing at rDNA; IMP:SGD.::GO:0006271; P:DNA strand elongation involved in DNA replication; IMP:SGD.::GO:0006265; P:DNA topological change; IDA:SGD.::GO:0007076; P:mitotic chromosome condensation; IMP:SGD.::GO:0007097; P:nuclear migration; IMP:SGD.::GO:0000019; P:regulation of mitotic recombination; IMP:SGD.::GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:SGD.::GO:0006368; P:transcription elongation from RNA polymerase II promoter; IMP:SGD.
2Q00313    778   TOP1_CANAX DNA topoisomerase 1 OS=Candida alb...7890     905     59     75GO:0005694; C:chromosome; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; IEA:EC.
GO:0006265; P:DNA topological change; IEA:InterPro.
3P07799    814   TOP1_SCHPO DNA topoisomerase 1 OS=Schizosacch...6330     736     58     76GO:0000790; C:nuclear chromatin; NAS:PomBase.::GO:0005730; C:nucleolus; IDA:PomBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0031490; F:chromatin DNA binding; ISS:RefGenome.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; ISS:PomBase.
GO:0006333; P:chromatin assembly or disassembly; ISS:PomBase.::GO:0006265; P:DNA topological change; IMP:PomBase.::GO:0007076; P:mitotic chromosome condensation; ISS:PomBase.::GO:0042790; P:transcription of nuclear large rRNA transcript from RNA polymerase I promoter; IGI:PomBase.
4Q54RC3    893   TOP1_DICDI DNA topoisomerase 1 OS=Dictyosteli...6282e-153     477     43     60GO:0005694; C:chromosome; IEA:InterPro.::GO:0005634; C:nucleus; ISS:dictyBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0031490; F:chromatin DNA binding; IBA:RefGenome.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; ISS:dictyBase.
GO:0006260; P:DNA replication; ISS:dictyBase.::GO:0006265; P:DNA topological change; ISS:dictyBase.
5Q969P6    601   TOP1M_HUMAN DNA topoisomerase I, mitochondria...862e-19     96.3     49     77GO:0005694; C:chromosome; IEA:InterPro.::GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0031490; F:chromatin DNA binding; IBA:RefGenome.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; IBA:RefGenome.
GO:0006265; P:DNA topological change; IBA:RefGenome.
6A9Q1D5    601   TOP1M_PANTR DNA topoisomerase I, mitochondria...862e-19     96.7     49     77GO:0005694; C:chromosome; IEA:InterPro.::GO:0042645; C:mitochondrial nucleoid; ISS:RefGenome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0031490; F:chromatin DNA binding; ISS:RefGenome.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; ISS:RefGenome.
GO:0006265; P:DNA topological change; ISS:RefGenome.
7P30189    972   TOP1_DROME DNA topoisomerase 1 OS=Drosophila ...1183e-20     99.8     43     66GO:0005737; C:cytoplasm; IDA:FlyBase.::GO:0005875; C:microtubule associated complex; IDA:FlyBase.::GO:0005719; C:nuclear euchromatin; IDA:FlyBase.::GO:0005730; C:nucleolus; IDA:FlyBase.::GO:0005703; C:polytene chromosome puff; IDA:FlyBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0031490; F:chromatin DNA binding; IBA:RefGenome.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; IDA:FlyBase.::GO:0004672; F:protein kinase activity; IDA:FlyBase.
GO:0008283; P:cell proliferation; IMP:FlyBase.::GO:0030261; P:chromosome condensation; IMP:FlyBase.::GO:0007059; P:chromosome segregation; IMP:FlyBase.::GO:0006265; P:DNA topological change; IDA:FlyBase.::GO:0009790; P:embryo development; IMP:FlyBase.::GO:0002168; P:instar larval development; IMP:FlyBase.::GO:0048477; P:oogenesis; IMP:FlyBase.
8P41512    829   TOP1_XENLA DNA topoisomerase 1 OS=Xenopus lae...1000.000000000000006     82.8     43     65GO:0005694; C:chromosome; IEA:InterPro.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; IEA:EC.
GO:0006265; P:DNA topological change; IEA:InterPro.
9P11387    765   TOP1_HUMAN DNA topoisomerase 1 OS=Homo sapien...1164e-21     102     44     69GO:0005694; C:chromosome; IEA:InterPro.::GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.::GO:0005730; C:nucleolus; IDA:UniProtKB.::GO:0005654; C:nucleoplasm; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0031490; F:chromatin DNA binding; IBA:RefGenome.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; IMP:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0006265; P:DNA topological change; IBA:RefGenome.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0016310; P:phosphorylation; NAS:UniProtKB.::GO:0012501; P:programmed cell death; NAS:UniProtKB.::GO:0042493; P:response to drug; IEP:UniProtKB.
10Q7YR26    767   TOP1_CHLAE DNA topoisomerase 1 OS=Chlorocebus...1164e-21     102     44     69GO:0005694; C:chromosome; IEA:InterPro.::GO:0005730; C:nucleolus; ISS:UniProtKB.::GO:0005654; C:nucleoplasm; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003682; F:chromatin binding; ISS:UniProtKB.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; ISS:UniProtKB.
GO:0006265; P:DNA topological change; IEA:InterPro.
11Q04750    767   TOP1_MOUSE DNA topoisomerase 1 OS=Mus musculu...1165e-21     102     44     68GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005730; C:nucleolus; IBA:RefGenome.::GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.::GO:0043204; C:perikaryon; IDA:MGI.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0031490; F:chromatin DNA binding; IBA:RefGenome.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; IDA:MGI.
GO:0006260; P:DNA replication; IMP:MGI.::GO:0006265; P:DNA topological change; IDA:MGI.::GO:0040016; P:embryonic cleavage; IMP:MGI.
12Q9WUL0    767   TOP1_RAT DNA topoisomerase 1 OS=Rattus norveg...1163e-21     102     45     68GO:0005694; C:chromosome; IEA:InterPro.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.::GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0031490; F:chromatin DNA binding; IDA:RGD.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; IDA:RGD.::GO:0032403; F:protein complex binding; IDA:RGD.
GO:0071373; P:cellular response to luteinizing hormone stimulus; IEP:RGD.::GO:0033554; P:cellular response to stress; IEP:RGD.::GO:0006265; P:DNA topological change; IDA:RGD.::GO:0031100; P:organ regeneration; IEP:RGD.::GO:0051591; P:response to cAMP; IEP:RGD.::GO:0009266; P:response to temperature stimulus; IEP:RGD.::GO:0009303; P:rRNA transcription; IMP:RGD.
13Q07050    767   TOP1_CRIGR DNA topoisomerase 1 OS=Cricetulus ...1166e-21     101     44     68GO:0005694; C:chromosome; IEA:InterPro.::GO:0005730; C:nucleolus; ISS:UniProtKB.::GO:0005654; C:nucleoplasm; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003682; F:chromatin binding; ISS:UniProtKB.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; ISS:UniProtKB.
GO:0006265; P:DNA topological change; IEA:InterPro.
14Q6IM78    593   TOP1M_RAT DNA topoisomerase I, mitochondrial ...4493e-139     430     48     65GO:0005694; C:chromosome; IEA:InterPro.::GO:0042645; C:mitochondrial nucleoid; IBA:RefGenome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0031490; F:chromatin DNA binding; IBA:RefGenome.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; IBA:RefGenome.
GO:0006265; P:DNA topological change; IBA:RefGenome.
15Q8R4U6    593   TOP1M_MOUSE DNA topoisomerase I, mitochondria...4712e-138     428     48     64GO:0005694; C:chromosome; IEA:InterPro.::GO:0042645; C:mitochondrial nucleoid; IBA:RefGenome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0031490; F:chromatin DNA binding; IBA:RefGenome.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; IBA:RefGenome.
GO:0006265; P:DNA topological change; IBA:RefGenome.
16P30181    916   TOP1_ARATH DNA topoisomerase 1 OS=Arabidopsis...770.000000000000005     83.2     52     77GO:0005694; C:chromosome; IEA:InterPro.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; IGI:TAIR.::GO:0005515; F:protein binding; IPI:TAIR.
GO:0006338; P:chromatin remodeling; IGI:TAIR.::GO:0006265; P:DNA topological change; ISS:TAIR.::GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.::GO:0048439; P:flower morphogenesis; IMP:TAIR.::GO:0009965; P:leaf morphogenesis; IMP:TAIR.::GO:0009933; P:meristem structural organization; IMP:TAIR.::GO:0048645; P:organ formation; IMP:TAIR.::GO:0010075; P:regulation of meristem growth; IMP:TAIR.::GO:0019827; P:stem cell maintenance; IGI:TAIR.
17P41511    1019   TOP1_USTMA DNA topoisomerase 1 OS=Ustilago ma...6784e-135     432     39     56GO:0005694; C:chromosome; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; IEA:EC.
GO:0006265; P:DNA topological change; IEA:InterPro.
18O17966    806   TOP1_CAEEL DNA topoisomerase 1 OS=Caenorhabdi...942e-18     94     52     76GO:0005694; C:chromosome; IEA:InterPro.::GO:0005730; C:nucleolus; IDA:WormBase.::GO:0031616; C:spindle pole centrosome; IDA:WormBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0031490; F:chromatin DNA binding; IBA:RefGenome.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; IDA:WormBase.
GO:0010171; P:body morphogenesis; IMP:WormBase.::GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0006265; P:DNA topological change; IBA:RefGenome.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0008406; P:gonad development; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0045132; P:meiotic chromosome segregation; IMP:WormBase.::GO:0018996; P:molting cycle, collagen and cuticulin-based cuticle; IMP:WormBase.::GO:0002009; P:morphogenesis of an epithelium; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0048477; P:oogenesis; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0006898; P:receptor-mediated endocytosis; IMP:WormBase.
19P93119    790   TOP1_DAUCA DNA topoisomerase 1 OS=Daucus caro...6277e-133     420     42     60GO:0005694; C:chromosome; IEA:InterPro.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; IEA:EC.
GO:0006265; P:DNA topological change; IEA:InterPro.
20Q7T6X9    336   TOP1E_MIMIV DNA topoisomerase 1B OS=Acanthamo...1790.16     38.9     25     44GO:0005694; C:chromosome; IEA:InterPro.::GO:0019012; C:virion; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; IEA:EC.
GO:0006265; P:DNA topological change; IEA:InterPro.
21P68698    314   TOP1_VACCW DNA topoisomerase 1B OS=WR)). GN=T...1200.16     38.5     28     48GO:0005694; C:chromosome; IEA:InterPro.::GO:0019012; C:virion; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; IEA:EC.
GO:0006265; P:DNA topological change; IEA:InterPro.
22P68697    314   TOP1_VACCC DNA topoisomerase 1B OS=Vaccinia v...1200.16     38.5     28     48GO:0005694; C:chromosome; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; IEA:EC.
GO:0006265; P:DNA topological change; IEA:InterPro.
23Q76ZS7    314   TOP1_VACCA DNA topoisomerase 1B OS=Vaccinia v...1200.16     38.5     28     48GO:0005694; C:chromosome; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; IEA:EC.
GO:0006265; P:DNA topological change; IEA:InterPro.
24P32989    314   TOP1_VAR67 DNA topoisomerase 1 OS=Variola vir...1200.18     38.5     28     48GO:0005694; C:chromosome; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.::GO:0003917; F:DNA topoisomerase type I activity; IEA:EC.
GO:0006265; P:DNA topological change; IEA:InterPro.
25Q74FF1    865   CLPB_GEOSL Chaperone protein ClpB OS=Geobacte...1160.39     38.1     33     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
GO:0016485; P:protein processing; IEA:InterPro.::GO:0009408; P:response to heat; IEA:InterPro.
26A4W8A9    331   6PGL_ENT38 6-phosphogluconolactonase OS=Enter...820.71     36.6     28     43
GO:0017057; F:6-phosphogluconolactonase activity; IEA:EC.
GO:0006098; P:pentose-phosphate shunt; IEA:InterPro.
27Q65QC6    86   Y2227_MANSM UPF0350 protein MS2227 OS=Mannhei...780.99     33.9     31     54
28Q9UZ09    332   ILVC_PYRAB Ketol-acid reductoisomerase OS=Pyr...2034     34.3     20     38
GO:0050662; F:coenzyme binding; IEA:InterPro.::GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.::GO:0004455; F:ketol-acid reductoisomerase activity; IEA:HAMAP.
GO:0009082; P:branched chain family amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0009097; P:isoleucine biosynthetic process; IEA:HAMAP.::GO:0009099; P:valine biosynthetic process; IEA:HAMAP.
29A9BGP6    330   ILVC_PETMO Ketol-acid reductoisomerase OS=Pet...1854.6     33.9     23     43
GO:0050662; F:coenzyme binding; IEA:InterPro.::GO:0004455; F:ketol-acid reductoisomerase activity; IEA:EC.
GO:0009082; P:branched chain family amino acid biosynthetic process; IEA:UniProtKB-KW.
30Q63HN8    5207   RN213_HUMAN E3 ubiquitin-protein ligase RNF21...1306.7     34.3     28     45GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0016887; F:ATPase activity; IDA:UniProtKB.::GO:0000166; F:nucleotide binding; IEA:InterPro.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
31C4L0I9    412   PEPT_EXISA Peptidase T OS=Exiguobacterium sp....627     33.5     31     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0045148; F:tripeptide aminopeptidase activity; IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006518; P:peptide metabolic process; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
records
Previous ‹‹ ›› Next Total records: 31 1 - 30
Elimate unknown annotation:
Filter for keyword on hit description:
Select upper E value:
Select lower bit score:
Select lower %idenity value:
Select lower %positive value:
Taxonomic division:
Lower limit on hit length:
Lower limit on alignment length::