Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YNL238W
Length:
814
Number of sequences:
5887
Description:
YNL238W KEX2 SGDID:S000005182, Chr XIV from 202428-204872, Genome Release 64-1-1, Verified ORF, "Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P13134    814   KEX2_YEAST Kexin OS=Saccharomyces cerevisiae ...8140     1682     100     100GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005802; C:trans-Golgi network; IDA:SGD.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; IDA:SGD.
GO:0007323; P:peptide pheromone maturation; IMP:SGD.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
2P09231    756   KEX1A_KLULA Protease KEX1 OS=1267 / NRRL Y-11...7600     877     58     73GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
3O13359    938   KEX2_CANAW Kexin OS=Candida albicans (strain ...6550     642     49     65GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
4P42781    976   XPR6_YARLI Dibasic-processing endoprotease OS...1556     34.3     28     43GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
5Q09175    709   KRP1_SCHPO Dibasic-processing endoprotease OS...5772e-155     478     44     62GO:0009986; C:cell surface; NAS:PomBase.::GO:0005794; C:Golgi apparatus; IDA:PomBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004252; F:serine-type endopeptidase activity; IDA:PomBase.
GO:0071432; P:peptide mating pheromone maturation involved in conjugation with cellular fusion; TAS:PomBase.::GO:0016485; P:protein processing; ISS:RefGenome.::GO:0006508; P:proteolysis; IGI:PomBase.
6P28840    752   NEC1_RAT Neuroendocrine convertase 1 OS=Rattu...5494e-115     373     39     59GO:0043679; C:axon terminus; IDA:RGD.::GO:0030425; C:dendrite; IDA:RGD.::GO:0005615; C:extracellular space; IDA:RGD.::GO:0043025; C:neuronal cell body; IDA:RGD.::GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.::GO:0005791; C:rough endoplasmic reticulum; IDA:RGD.::GO:0030141; C:secretory granule; IDA:RGD.::GO:0005802; C:trans-Golgi network; IDA:RGD.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
GO:0051087; F:chaperone binding; IPI:RGD.::GO:0043559; F:insulin binding; IPI:RGD.::GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome.
GO:0009790; P:embryo development; IEP:RGD.::GO:0022008; P:neurogenesis; IEP:RGD.::GO:0031016; P:pancreas development; IEP:RGD.::GO:0016486; P:peptide hormone processing; IDA:RGD.::GO:0021983; P:pituitary gland development; IEP:RGD.::GO:0050714; P:positive regulation of protein secretion; IDA:RGD.::GO:0016540; P:protein autoprocessing; IMP:RGD.::GO:0006508; P:proteolysis; IMP:RGD.::GO:0048678; P:response to axon injury; IEP:RGD.::GO:0051592; P:response to calcium ion; IEP:RGD.::GO:0010157; P:response to chlorate; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0070542; P:response to fatty acid; IEP:RGD.::GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.::GO:0009749; P:response to glucose stimulus; IEP:RGD.::GO:0070555; P:response to interleukin-1; IEP:RGD.::GO:0032496; P:response to lipopolysaccharide; IEP:RGD.::GO:0043278; P:response to morphine; IEP:RGD.::GO:0031667; P:response to nutrient levels; IEP:RGD.::GO:0043434; P:response to peptide hormone stimulus; IEP:RGD.
7P63239    753   NEC1_MOUSE Neuroendocrine convertase 1 OS=Mus...4832e-114     371     42     61GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.::GO:0005615; C:extracellular space; IDA:BHF-UCL.::GO:0005794; C:Golgi apparatus; IBA:RefGenome.::GO:0030141; C:secretory granule; TAS:Reactome.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; IDA:BHF-UCL.
GO:0043043; P:peptide biosynthetic process; IDA:BHF-UCL.::GO:0016486; P:peptide hormone processing; IDA:BHF-UCL.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
8P63240    753   NEC1_MUSCO Neuroendocrine convertase 1 OS=Mus...4832e-114     371     42     61GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
9P29120    753   NEC1_HUMAN Neuroendocrine convertase 1 OS=Hom...4787e-113     367     41     62GO:0005615; C:extracellular space; IDA:BHF-UCL.::GO:0005794; C:Golgi apparatus; IBA:RefGenome.::GO:0030141; C:secretory granule; TAS:Reactome.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; ISS:BHF-UCL.
GO:0007267; P:cell-cell signaling; TAS:ProtInc.::GO:0034641; P:cellular nitrogen compound metabolic process; TAS:Reactome.::GO:0006112; P:energy reserve metabolic process; TAS:Reactome.::GO:0043043; P:peptide biosynthetic process; ISS:BHF-UCL.::GO:0016486; P:peptide hormone processing; TAS:Reactome.::GO:0006508; P:proteolysis; TAS:ProtInc.::GO:0050796; P:regulation of insulin secretion; TAS:Reactome.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.
10Q62849    783   PCSK7_RAT Proprotein convertase subtilisin/ke...4821e-112     367     41     60
GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
11Q61139    770   PCSK7_MOUSE Proprotein convertase subtilisin/...5413e-112     366     39     57GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome.
GO:0016485; P:protein processing; IBA:RefGenome.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
12Q9GLR1    753   NEC1_BOVIN Neuroendocrine convertase 1 OS=Bos...4837e-112     365     41     61GO:0005615; C:extracellular space; ISS:RefGenome.::GO:0005794; C:Golgi apparatus; ISS:RefGenome.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; ISS:RefGenome.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
13Q16549    785   PCSK7_HUMAN Proprotein convertase subtilisin/...4801e-111     365     41     60GO:0030173; C:integral to Golgi membrane; IDA:UniProtKB.
GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome.
GO:0016486; P:peptide hormone processing; NAS:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
14P29119    783   FURI1_XENLA Furin-1 OS=Xenopus laevis (Africa...4531e-109     359     42     61GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
15P23188    793   FURIN_MOUSE Furin OS=Mus musculus (Mouse). GN...4492e-109     359     42     61GO:0005769; C:early endosome; TAS:MGI.::GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.::GO:0005615; C:extracellular space; IBA:RefGenome.::GO:0016021; C:integral to membrane; TAS:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0012510; C:trans-Golgi network transport vesicle membrane; TAS:MGI.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
16P23377    793   FURIN_RAT Furin OS=Rattus norvegicus (Rat). G...4488e-109     357     42     61GO:0005789; C:endoplasmic reticulum membrane; IDA:RGD.::GO:0005615; C:extracellular space; IBA:RefGenome.::GO:0031985; C:Golgi cisterna; IDA:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:RGD.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; IMP:RGD.
GO:0007568; P:aging; IEP:RGD.::GO:0030335; P:positive regulation of cell migration; IMP:RGD.::GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IMP:RGD.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
17Q28193    797   FURIN_BOVIN Furin OS=Bos taurus (Bovine). GN=...4483e-107     353     42     61GO:0005615; C:extracellular space; ISS:RefGenome.::GO:0005794; C:Golgi apparatus; ISS:RefGenome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; ISS:RefGenome.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
18P09958    794   FURIN_HUMAN Furin OS=Homo sapiens (Human). GN...4489e-107     352     42     61GO:0009986; C:cell surface; IDA:BHF-UCL.::GO:0005796; C:Golgi lumen; TAS:Reactome.::GO:0000139; C:Golgi membrane; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0045121; C:membrane raft; IDA:BHF-UCL.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0005802; C:trans-Golgi network; IDA:BHF-UCL.::GO:0030140; C:trans-Golgi network transport vesicle; IDA:MGI.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0048406; F:nerve growth factor binding; IDA:BHF-UCL.::GO:0042277; F:peptide binding; IDA:BHF-UCL.::GO:0002020; F:protease binding; IPI:BHF-UCL.::GO:0004252; F:serine-type endopeptidase activity; IDA:BHF-UCL.::GO:0004867; F:serine-type endopeptidase inhibitor activity; IDA:BHF-UCL.
GO:0008283; P:cell proliferation; IMP:BHF-UCL.::GO:0022617; P:extracellular matrix disassembly; TAS:Reactome.::GO:0032804; P:negative regulation of low-density lipoprotein particle receptor catabolic process; IDA:HGNC.::GO:0032911; P:negative regulation of transforming growth factor beta1 production; IMP:BHF-UCL.::GO:0032455; P:nerve growth factor processing; TAS:Reactome.::GO:0032902; P:nerve growth factor production; IDA:BHF-UCL.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007219; P:Notch signaling pathway; TAS:Reactome.::GO:0043043; P:peptide biosynthetic process; IDA:BHF-UCL.::GO:0017187; P:peptidyl-glutamic acid carboxylation; TAS:Reactome.::GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IC:BHF-UCL.::GO:0043687; P:post-translational protein modification; TAS:Reactome.::GO:0006508; P:proteolysis; TAS:Reactome.::GO:0032940; P:secretion by cell; IDA:BHF-UCL.::GO:0006465; P:signal peptide processing; IDA:HGNC.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:Reactome.::GO:0019067; P:viral assembly, maturation, egress, and release; IEP:BHF-UCL.
19Q6UW60    755   PCSK4_HUMAN Proprotein convertase subtilisin/...4874e-106     349     38     59GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome.
GO:0006508; P:proteolysis; IBA:RefGenome.
20P29145    710   NECB_HYDVU PC3-like endoprotease variant B OS...4556e-105     345     41     60
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
21P29121    655   PCSK4_MOUSE Proprotein convertase subtilisin/...4442e-104     342     40     61GO:0002080; C:acrosomal membrane; IDA:MGI.::GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome.
GO:0007340; P:acrosome reaction; IMP:MGI.::GO:0007339; P:binding of sperm to zona pellucida; IMP:MGI.::GO:0006508; P:proteolysis; IBA:RefGenome.::GO:0048240; P:sperm capacitation; IMP:MGI.
22P29146    793   NECA_HYDVU PC3-like endoprotease variant A OS...4552e-104     345     41     60
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
23Q5REC2    638   NEC2_PONAB Neuroendocrine convertase 2 OS=Pon...4856e-104     340     40     60GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
24P16519    638   NEC2_HUMAN Neuroendocrine convertase 2 OS=Hom...4857e-104     340     40     60GO:0005615; C:extracellular space; IDA:BHF-UCL.::GO:0016020; C:membrane; IDA:BHF-UCL.::GO:0030141; C:secretory granule; TAS:Reactome.::GO:0005625; C:soluble fraction; IDA:BHF-UCL.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0034230; P:enkephalin processing; ISS:BHF-UCL.::GO:0030070; P:insulin processing; IDA:BHF-UCL.::GO:0034231; P:islet amyloid polypeptide processing; ISS:BHF-UCL.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
25Q78EH2    678   PCSK4_RAT Proprotein convertase subtilisin/ke...4447e-104     341     39     61
GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome.
GO:0006508; P:proteolysis; IBA:RefGenome.
26Q03333    638   NEC2_PIG Neuroendocrine convertase 2 OS=Sus s...4854e-103     338     39     60GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
27P21661    637   NEC2_MOUSE Neuroendocrine convertase 2 OS=Mus...4649e-103     337     40     62GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.::GO:0005615; C:extracellular space; IDA:BHF-UCL.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; IDA:BHF-UCL.
GO:0034230; P:enkephalin processing; IDA:BHF-UCL.::GO:0007399; P:nervous system development; IEP:HGNC.::GO:0016540; P:protein autoprocessing; IDA:HGNC.::GO:0006508; P:proteolysis; IMP:MGI.
28Q9GLR0    638   NEC2_BOVIN Neuroendocrine convertase 2 OS=Bos...4642e-102     336     40     61GO:0005615; C:extracellular space; ISS:RefGenome.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; ISS:RefGenome.
GO:0007399; P:nervous system development; ISS:AgBase.::GO:0016486; P:peptide hormone processing; ISS:AgBase.::GO:0016540; P:protein autoprocessing; ISS:AgBase.::GO:0006508; P:proteolysis; ISS:AgBase.
29P28841    637   NEC2_RAT Neuroendocrine convertase 2 OS=Rattu...4642e-102     336     40     62GO:0005615; C:extracellular space; IBA:RefGenome.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0004252; F:serine-type endopeptidase activity; IMP:BHF-UCL.
GO:0034231; P:islet amyloid polypeptide processing; IMP:BHF-UCL.::GO:0006508; P:proteolysis; IMP:RGD.
30P30432    1679   FUR2_DROME Furin-like protease 2 OS=Drosophil...5083e-101     348     38     56GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; ISS:FlyBase.
GO:0005524; F:ATP binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IDA:FlyBase.::GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
31Q63415    937   PCSK6_RAT Proprotein convertase subtilisin/ke...5162e-100     338     38     54GO:0005615; C:extracellular space; IBA:RefGenome.::GO:0005794; C:Golgi apparatus; IBA:RefGenome.
GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome.
GO:0016486; P:peptide hormone processing; IEP:RGD.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
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