Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YNL238W
Length:
814
Number of sequences:
5887
Description:
YNL238W KEX2 SGDID:S000005182, Chr XIV from 202428-204872, Genome Release 64-1-1, Verified ORF, "Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31Q63415    937   PCSK6_RAT Proprotein convertase subtilisin/ke...5162e-100     338     38     54GO:0005615; C:extracellular space; IBA:RefGenome.::GO:0005794; C:Golgi apparatus; IBA:RefGenome.
GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome.
GO:0016486; P:peptide hormone processing; IEP:RGD.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
32P29122    969   PCSK6_HUMAN Proprotein convertase subtilisin/...5973e-100     338     35     52GO:0009986; C:cell surface; IDA:BHF-UCL.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0031012; C:extracellular matrix; IDA:BHF-UCL.::GO:0005615; C:extracellular space; IDA:BHF-UCL.::GO:0005796; C:Golgi lumen; TAS:Reactome.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0005625; C:soluble fraction; IDA:BHF-UCL.
GO:0043499; F:eukaryotic cell surface binding; IDA:BHF-UCL.::GO:0008201; F:heparin binding; IDA:BHF-UCL.::GO:0048406; F:nerve growth factor binding; IDA:BHF-UCL.::GO:0004252; F:serine-type endopeptidase activity; IDA:BHF-UCL.
GO:0009100; P:glycoprotein metabolic process; IDA:BHF-UCL.::GO:0032455; P:nerve growth factor processing; TAS:Reactome.::GO:0032902; P:nerve growth factor production; IDA:BHF-UCL.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0030510; P:regulation of BMP signaling pathway; TAS:BHF-UCL.::GO:0032940; P:secretion by cell; IDA:BHF-UCL.
33P51559    943   BLI4_CAEEL Endoprotease bli-4 OS=Caenorhabdit...5141e-99     337     37     55GO:0016021; C:integral to membrane; NAS:UniProtKB.::GO:0005634; C:nucleus; IDA:WormBase.
GO:0004252; F:serine-type endopeptidase activity; NAS:UniProtKB.
GO:0010171; P:body morphogenesis; IMP:WormBase.::GO:0040002; P:collagen and cuticulin-based cuticle development; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0018996; P:molting cycle, collagen and cuticulin-based cuticle; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
34Q9NJ15    1696   PCSK5_BRACL Proprotein convertase subtilisin/...4928e-96     333     39     56GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
35Q92824    1860   PCSK5_HUMAN Proprotein convertase subtilisin/...4843e-95     332     40     57GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0005615; C:extracellular space; ISS:BHF-UCL.::GO:0005796; C:Golgi lumen; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0030141; C:secretory granule; ISS:BHF-UCL.
GO:0042277; F:peptide binding; ISS:BHF-UCL.::GO:0004252; F:serine-type endopeptidase activity; IDA:BHF-UCL.
GO:0009952; P:anterior/posterior pattern specification; IMP:BHF-UCL.::GO:0007267; P:cell-cell signaling; TAS:ProtInc.::GO:0042089; P:cytokine biosynthetic process; ISS:BHF-UCL.::GO:0007566; P:embryo implantation; ISS:BHF-UCL.::GO:0048566; P:embryonic digestive tract development; IMP:BHF-UCL.::GO:0048706; P:embryonic skeletal system development; IMP:BHF-UCL.::GO:0007507; P:heart development; ISS:BHF-UCL.::GO:0001822; P:kidney development; IMP:BHF-UCL.::GO:0035108; P:limb morphogenesis; ISS:BHF-UCL.::GO:0032455; P:nerve growth factor processing; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0043043; P:peptide biosynthetic process; IDA:BHF-UCL.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0002001; P:renin secretion into blood stream; IEP:BHF-UCL.::GO:0030323; P:respiratory tube development; ISS:BHF-UCL.::GO:0006465; P:signal peptide processing; IDA:HGNC.::GO:0019067; P:viral assembly, maturation, egress, and release; IEP:BHF-UCL.
36P41413    1809   PCSK5_RAT Proprotein convertase subtilisin/ke...4844e-95     332     40     57GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0005615; C:extracellular space; IBA:RefGenome.::GO:0005794; C:Golgi apparatus; IBA:RefGenome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004252; F:serine-type endopeptidase activity; IBA:RefGenome.
GO:0007565; P:female pregnancy; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
37Q04592    1877   PCSK5_MOUSE Proprotein convertase subtilisin/...4845e-95     332     40     57GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.::GO:0005615; C:extracellular space; IDA:BHF-UCL.::GO:0005794; C:Golgi apparatus; IDA:MGI.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0030141; C:secretory granule; IDA:MGI.
GO:0042277; F:peptide binding; IDA:BHF-UCL.::GO:0004252; F:serine-type endopeptidase activity; IDA:BHF-UCL.
GO:0009952; P:anterior/posterior pattern specification; IMP:BHF-UCL.::GO:0042089; P:cytokine biosynthetic process; IDA:BHF-UCL.::GO:0007566; P:embryo implantation; IMP:BHF-UCL.::GO:0048566; P:embryonic digestive tract development; IMP:BHF-UCL.::GO:0048706; P:embryonic skeletal system development; IMP:BHF-UCL.::GO:0007507; P:heart development; IMP:BHF-UCL.::GO:0001822; P:kidney development; IMP:BHF-UCL.::GO:0035108; P:limb morphogenesis; IMP:BHF-UCL.::GO:0043043; P:peptide biosynthetic process; IDA:BHF-UCL.::GO:0016486; P:peptide hormone processing; IDA:BHF-UCL.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0030323; P:respiratory tube development; IMP:BHF-UCL.::GO:0019067; P:viral assembly, maturation, egress, and release; IDA:BHF-UCL.
38P26016    1269   FUR11_DROME Furin-like protease 1, isoforms 1...4722e-93     324     39     60GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:FlyBase.
GO:0004252; F:serine-type endopeptidase activity; IDA:FlyBase.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
39P30430    1101   FUR1C_DROME Furin-like protease 1, isoform 1-...4952e-93     322     38     59GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:FlyBase.
GO:0004252; F:serine-type endopeptidase activity; IDA:FlyBase.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
40P23916    662   PRCA_ANAVT Calcium-dependent protease OS=Anab...4352e-36     149     32     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
41Q59149    662   PRCA_NOSS1 Calcium-dependent protease OS=Nost...4363e-35     146     32     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
42Q00139    370   VG47_ICHVA Subtilisin-like protease OS=herpes...3076e-16     84     25     43
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
43P42779    603   BPRV_DICNO Extracellular basic protease OS=Di...5220.000000000007     72.4     25     39GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
44P31339    621   ASPA_AERSA Microbial serine proteinase OS=Aer...5280.000000007     63.2     22     37
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
45P29141    806   SUBV_BACSU Minor extracellular protease vpr O...1940.0000001     59.3     32     44GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; ISS:RefGenome.
GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
46P42780    595   BPRX_DICNO Extracellular subtilisin-like prot...3150.0000001     58.9     26     38GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
47P29139    326   ISP_PAEPO Intracellular serine protease OS=Pa...2670.0000001     57.8     29     44
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
48O31788    442   APRX_BACSU Serine protease AprX OS=Bacillus s...3190.0000002     58.2     26     40GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; ISS:RefGenome.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
49P00782    382   SUBT_BACAM Subtilisin BPN' OS=Bacillus amylol...2740.0000002     57.8     30     44
50P16396    645   SUBE_BACSU Minor extracellular protease epr O...2850.0000002     58.5     29     43GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; ISS:RefGenome.
GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
51P04189    381   SUBT_BACSU Subtilisin E OS=Bacillus subtilis ...2670.0000002     57.4     28     42GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; ISS:RefGenome.
GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
52P29143    530   HLY_HAL17 Halolysin OS=Halophilic archaebacte...2870.0000005     57     28     45GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
53P35835    381   SUBN_BACNA Subtilisin NAT OS=Bacillus subtili...2670.0000006     56.2     28     42GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.::GO:0042730; P:fibrinolysis; IEA:UniProtKB-KW.::GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
54P07518    275   SUBT_BACPU Subtilisin OS=Bacillus pumilus (Ba...2670.000005     52.8     27     42GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
55P23314    580   EXPR_XANCP Extracellular protease OS=LMG 568)...3350.000005     53.5     26     37GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
56P20724    378   ELYA_BACYA Alkaline elastase YaB OS=Bacillus ...2530.000006     53.1     28     43GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
57P11018    319   ISP1_BACSU Major intracellular serine proteas...2560.00002     51.6     27     43GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; ISS:RefGenome.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
58P29142    381   SUBT_GEOSE Subtilisin J OS=Geobacillus stearo...2730.00002     51.2     28     41GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
59P54423    894   WPRA_BACSU Cell wall-associated protease OS=B...3180.00002     51.6     28     39GO:0005618; C:cell wall; IEA:UniProtKB-SubCell.::GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
GO:0004252; F:serine-type endopeptidase activity; ISS:RefGenome.
GO:0007047; P:cellular cell wall organization; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
60P00783    381   SUBT_BACSA Subtilisin amylosacchariticus OS=B...2730.00003     50.8     28     41GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0043086; P:negative regulation of catalytic activity; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
61Q45670    401   THES_BACSJ Thermophilic serine proteinase OS=...2330.00003     50.8     31     45GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
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