Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YNL123W
Length:
997
Number of sequences:
5887
Description:
YNL123W NMA111 SGDID:S000005067, Chr XIV from 394685-397678, Genome Release 64-1-1, Verified ORF, "Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
61D3ZKF5    488   HTRA4_RAT Serine protease HTR4 OS=Rattus norv...3070.000000003     63.9     24     44GO:0005576; C:extracellular region; IEA:InterPro.
GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:InterPro.::GO:0001558; P:regulation of cell growth; IEA:InterPro.
62P45129    466   HTOA_HAEIN Probable periplasmic serine protea...2880.000000008     62.8     24     44GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
63P54925    503   DEGPL_BARHE Probable periplasmic serine endop...2910.000000008     62.8     27     45GO:0030288; C:outer membrane-bounded periplasmic space; ISS:UniProtKB.
GO:0004252; F:serine-type endopeptidase activity; ISS:UniProtKB.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.
64Q9PL97    497   DEGPL_CHLMU Probable periplasmic serine endop...3820.046     41.2     22     39GO:0030288; C:outer membrane-bounded periplasmic space; ISS:UniProtKB.
GO:0004252; F:serine-type endopeptidase activity; ISS:UniProtKB.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.
65Q2SL36    469   DEGPL_HAHCH Probable periplasmic serine endop...1770.08     40.4     27     41GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.
66P26982    475   DEGP_SALTY Periplasmic serine endoprotease De...3780.56     37.7     22     40GO:0030288; C:outer membrane-bounded periplasmic space; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; ISS:UniProtKB.::GO:0004252; F:serine-type endopeptidase activity; ISS:UniProtKB.
GO:0006515; P:misfolded or incompletely synthesized protein catabolic process; ISS:UniProtKB.::GO:0006457; P:protein folding; ISS:UniProtKB.::GO:0006979; P:response to oxidative stress; ISS:UniProtKB.::GO:0009266; P:response to temperature stimulus; ISS:UniProtKB.
67Q297U2    427   HTRA2_DROPS Serine protease HTRA2, mitochondr...3190.00000001     62     27     44GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
68B4G316    427   HTRA2_DROPE Serine protease HTRA2, mitochondr...3180.00000001     62     27     43GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
69P83105    476   HTRA4_HUMAN Serine protease HTRA4 OS=Homo sap...3450.00000003     61.2     24     43GO:0005576; C:extracellular region; IEA:InterPro.
GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0001558; P:regulation of cell growth; IEA:InterPro.
70A2RT60    483   HTRA4_MOUSE Serine protease HTRA4 OS=Mus musc...3080.00000003     61.2     24     44GO:0005576; C:extracellular region; IEA:InterPro.
GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:InterPro.::GO:0001558; P:regulation of cell growth; IEA:InterPro.
71P0C0V0    474   DEGP_ECOLI Periplasmic serine endoprotease De...3760.003     45.1     23     41GO:0030288; C:outer membrane-bounded periplasmic space; IDA:EcoliWiki.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0004252; F:serine-type endopeptidase activity; IDA:EcoliWiki.
GO:0006515; P:misfolded or incompletely synthesized protein catabolic process; IMP:EcoliWiki.::GO:0006457; P:protein folding; IMP:EcoliWiki.::GO:0006979; P:response to oxidative stress; IEP:EcoliWiki.::GO:0009266; P:response to temperature stimulus; IEP:EcoliWiki.
72P0C0V1    474   DEGP_ECO57 Periplasmic serine endoprotease De...3760.003     45.1     23     41GO:0030288; C:outer membrane-bounded periplasmic space; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0042802; F:identical protein binding; ISS:UniProtKB.::GO:0004252; F:serine-type endopeptidase activity; ISS:UniProtKB.
GO:0006515; P:misfolded or incompletely synthesized protein catabolic process; ISS:UniProtKB.::GO:0006457; P:protein folding; ISS:UniProtKB.::GO:0006979; P:response to oxidative stress; ISS:UniProtKB.::GO:0009266; P:response to temperature stimulus; ISS:UniProtKB.
73Q9Z6T0    488   DEGPL_CHLPN Probable periplasmic serine endop...3870.48     37.7     22     39GO:0030288; C:outer membrane-bounded periplasmic space; ISS:UniProtKB.
GO:0004252; F:serine-type endopeptidase activity; ISS:UniProtKB.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.
74A6VUA4    469   DEGPL_MARMS Probable periplasmic serine endop...4201.3     36.6     23     37GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.
75Q52894    504   DEGPL_RHIME Probable periplasmic serine endop...2960.0000002     58.2     25     42GO:0030288; C:outer membrane-bounded periplasmic space; ISS:UniProtKB.
GO:0004252; F:serine-type endopeptidase activity; ISS:UniProtKB.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.
76Q9JIY5    458   HTRA2_MOUSE Serine protease HTRA2, mitochondr...3220.0000004     57.4     28     44GO:0035631; C:CD40 receptor complex; IDA:BHF-UCL.::GO:0009898; C:internal side of plasma membrane; IDA:BHF-UCL.::GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0007628; P:adult walking behavior; IMP:MGI.::GO:0030900; P:forebrain development; IMP:MGI.::GO:0008629; P:induction of apoptosis by intracellular signals; IMP:MGI.::GO:0007005; P:mitochondrion organization; IMP:MGI.::GO:0048666; P:neuron development; IMP:MGI.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0040014; P:regulation of multicellular organism growth; IMP:MGI.
77Q9D236    459   HTRA3_MOUSE Serine protease HTRA3 OS=Mus musc...2900.0000006     56.6     25     42GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IDA:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0001558; P:regulation of cell growth; IEA:InterPro.
78A9JRB3    476   HTR1B_DANRE Serine protease HTRA1B OS=Danio r...3090.0000007     56.6     26     43GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0001558; P:regulation of cell growth; IEA:InterPro.
79Q3E6S8    429   DGP14_ARATH Putative protease Do-like 14 OS=A...3320.0000009     56.2     25     43
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
80O43464    458   HTRA2_HUMAN Serine protease HTRA2, mitochondr...3110.000001     55.8     27     43GO:0035631; C:CD40 receptor complex; ISS:BHF-UCL.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005789; C:endoplasmic reticulum membrane; TAS:UniProtKB.::GO:0009898; C:internal side of plasma membrane; ISS:BHF-UCL.::GO:0005758; C:mitochondrial intermembrane space; IDA:MGI.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; TAS:UniProtKB.
GO:0004252; F:serine-type endopeptidase activity; TAS:UniProtKB.::GO:0051082; F:unfolded protein binding; NAS:UniProtKB.
GO:0007050; P:cell cycle arrest; TAS:UniProtKB.::GO:0071363; P:cellular response to growth factor stimulus; IMP:UniProtKB.::GO:0006923; P:cleavage of cytoskeletal proteins involved in apoptosis; TAS:UniProtKB.::GO:0097194; P:execution phase of apoptosis; TAS:UniProtKB.::GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.::GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IMP:UniProtKB.::GO:0006950; P:response to stress; TAS:UniProtKB.
81P39099    455   DEGQ_ECOLI Periplasmic pH-dependent serine en...2930.000002     55.1     24     42GO:0042597; C:periplasmic space; IDA:UniProtKB.
GO:0004252; F:serine-type endopeptidase activity; IDA:UniProtKB.
GO:0051603; P:proteolysis involved in cellular protein catabolic process; IDA:UniProtKB.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.
82A0JNK3    458   HTRA2_BOVIN Serine protease HTRA2, mitochondr...3310.000004     53.9     27     43GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
83P73940    416   HHOB_SYNY3 Putative serine protease HhoB OS=S...2990.000008     53.1     22     42
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
84P18584    497   DEGPL_CHLTR Probable periplasmic serine endop...3820.016     42.7     23     40GO:0030288; C:outer membrane-bounded periplasmic space; ISS:UniProtKB.
GO:0004252; F:serine-type endopeptidase activity; ISS:UniProtKB.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.
85O05942    513   DEGPL_RICPR Probable periplasmic serine endop...2970.000008     53.1     26     45GO:0030288; C:outer membrane-bounded periplasmic space; ISS:UniProtKB.
GO:0004252; F:serine-type endopeptidase activity; ISS:UniProtKB.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.
86Q4L530    639   HTRAL_STAHJ Serine protease htrA-like OS=Stap...2110.00001     53.1     30     43GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
87D3ZA76    459   HTRA3_RAT Serine protease HTRA3 OS=Rattus nor...2890.00001     52.4     24     40GO:0005576; C:extracellular region; IEA:InterPro.
GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.::GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.::GO:0006508; P:proteolysis; IEA:InterPro.::GO:0001558; P:regulation of cell growth; IEA:InterPro.
88O22609    439   DEGP1_ARATH Protease Do-like 1, chloroplastic...2920.00002     51.6     24     45GO:0009535; C:chloroplast thylakoid membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:TAIR.::GO:0031977; C:thylakoid lumen; IDA:TAIR.
GO:0004252; F:serine-type endopeptidase activity; IDA:TAIR.
GO:0010206; P:photosystem II repair; IMP:TAIR.::GO:0030163; P:protein catabolic process; TAS:TAIR.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.
89Q89AP5    465   DEGPL_BUCBP Probable periplasmic serine endop...2620.00003     51.2     24     45GO:0030288; C:outer membrane-bounded periplasmic space; ISS:UniProtKB.
GO:0004252; F:serine-type endopeptidase activity; ISS:UniProtKB.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.
90Q9R9I1    458   HTRB_BACSU Serine protease Do-like HtrB OS=Ba...2980.00004     51.2     22     42GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.
91Q2FI55    769   HTRAL_STAA3 Serine protease htrA-like OS=Stap...2380.00009     50.1     27     45GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
records
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