| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
61 | Q9WVR3 | 1257 | SHIP2_RAT Phosphatidylinositol 3,4,5-trisphos... | 343 | 1e-25 | 118 | 28 | 45 | GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:RGD. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IDA:RGD.::GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:RGD.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007420; P:brain development; IEP:RGD.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0032957; P:inositol trisphosphate metabolic process; IDA:RGD.::GO:0008156; P:negative regulation of DNA replication; IMP:RGD.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:RGD.::GO:0043569; P:negative regulation of insulin-like growth factor receptor signaling pathway; IMP:RGD.::GO:0043407; P:negative regulation of MAP kinase activity; IMP:RGD.::GO:0010977; P:negative regulation of neuron projection development; IMP:RGD.::GO:0010642; P:negative regulation of platelet-derived growth factor receptor signaling pathway; IMP:RGD.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0042493; P:response to drug; IEP:RGD. | 62 | Q6P549 | 1257 | SHIP2_MOUSE Phosphatidylinositol 3,4,5-trisph... | 343 | 1e-25 | 118 | 28 | 45 | GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:MGI. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0006006; P:glucose metabolic process; IMP:MGI.::GO:0008285; P:negative regulation of cell proliferation; IDA:MGI.::GO:0010629; P:negative regulation of gene expression; IMP:MGI.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0009791; P:post-embryonic development; IMP:MGI.::GO:0032868; P:response to insulin stimulus; IMP:MGI. | 63 | O15357 | 1258 | SHIP2_HUMAN Phosphatidylinositol 3,4,5-trisph... | 338 | 2e-25 | 118 | 27 | 46 | GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; IDA:HPA. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0042169; F:SH2 domain binding; IPI:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007015; P:actin filament organization; IMP:UniProtKB.::GO:0007155; P:cell adhesion; TAS:UniProtKB.::GO:0006897; P:endocytosis; IMP:UniProtKB.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 64 | Q08227 | 384 | INP54_YEAST Phosphatidylinositol 4,5-bisphosp... | 328 | 5e-18 | 91.3 | 28 | 43 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:SGD. | | | | | | | | | | GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:SGD.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0015031; P:protein transport; IEA:UniProtKB-KW. | 65 | Q6PDK2 | 5588 | MLL2_MOUSE Histone-lysine N-methyltransferase... | 242 | 0.083 | 41.2 | 26 | 40 | | | | | | | | | | | GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006342; P:chromatin silencing; IMP:UniProtKB.::GO:0051568; P:histone H3-K4 methylation; IMP:UniProtKB.::GO:0001701; P:in utero embryonic development; IMP:MGI.::GO:0001555; P:oocyte growth; IMP:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 66 | Q14642 | 412 | I5P1_HUMAN Type I inositol 1,4,5-trisphosphat... | 230 | 0.11 | 40 | 22 | 35 | GO:0016020; C:membrane; NAS:UniProtKB. | | | | | | | | | | GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; NAS:UniProtKB.::GO:0042731; F:PH domain binding; IPI:BHF-UCL. | | | | | | | | | | GO:0007154; P:cell communication; NAS:UniProtKB.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 67 | Q17848 | 409 | I5P1_CAEEL Probable type I inositol 1,4,5-tri... | 76 | 0.29 | 38.9 | 32 | 45 | | | | | | | | | | | GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC. | | | | | | | | | | GO:0007173; P:epidermal growth factor receptor signaling pathway; IGI:WormBase.::GO:0048016; P:inositol phosphate-mediated signaling; IGI:WormBase.::GO:0030728; P:ovulation; IMP:WormBase.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:WormBase.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 68 | Q29467 | 412 | I5P1_CANFA Type I inositol 1,4,5-trisphosphat... | 230 | 0.65 | 37.7 | 23 | 36 | GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC. | | | | | | | | | | GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 69 | P17627 | 556 | PHL_LEPIR Sphingomyelinase C OS=Leptospira in... | 81 | 5.2 | 34.7 | 33 | 47 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:EC. | | | | | | | | | | |
