Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YNL068C
Length:
862
Number of sequences:
5887
Description:
YNL068C FKH2 SGDID:S000005012, Chr XIV from 498289-495701, Genome Release 64-1-1, reverse complement, Verified ORF, "Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
121Q28BS5    373   FOXF1_XENTR Forkhead box protein F1 OS=Xenopu...892e-17     88.6     44     66GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0030509; P:BMP signaling pathway; ISS:UniProtKB.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0008283; P:cell proliferation; ISS:UniProtKB.::GO:0048566; P:embryonic digestive tract development; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0048745; P:smooth muscle tissue development; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
122Q9W706    373   FXF1A_XENLA Forkhead box protein F1-A OS=Xeno...892e-17     88.6     44     66GO:0005634; C:nucleus; NAS:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.
GO:0030509; P:BMP signaling pathway; ISS:UniProtKB.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0008283; P:cell proliferation; ISS:UniProtKB.::GO:0048566; P:embryonic digestive tract development; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0048745; P:smooth muscle tissue development; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
123P33206    400   FXA4B_XENLA Forkhead box protein A4-B OS=Xeno...792e-17     88.6     48     68GO:0005634; C:nucleus; NAS:UniProtKB.
GO:0019904; F:protein domain specific binding; IEA:InterPro.::GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.::GO:0008134; F:transcription factor binding; IEA:InterPro.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
124P33205    399   FXA4A_XENLA Forkhead box protein A4-A OS=Xeno...793e-17     88.6     48     68GO:0005634; C:nucleus; NAS:UniProtKB.
GO:0019904; F:protein domain specific binding; IEA:InterPro.::GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.::GO:0008134; F:transcription factor binding; IEA:InterPro.
GO:0009948; P:anterior/posterior axis specification; IMP:UniProtKB.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0030900; P:forebrain development; IMP:UniProtKB.::GO:0001707; P:mesoderm formation; IMP:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0001840; P:neural plate development; IMP:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
125Q17241    349   SGF1_BOMMO Silk gland factor 1 OS=Bombyx mori...793e-17     87.8     47     72GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0019904; F:protein domain specific binding; IEA:InterPro.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.::GO:0008134; F:transcription factor binding; IEA:InterPro.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
126P35583    459   FOXA2_MOUSE Hepatocyte nuclear factor 3-beta ...793e-17     89.4     48     71GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0019904; F:protein domain specific binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IDA:MGI.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0008344; P:adult locomotory behavior; IMP:MGI.::GO:0007596; P:blood coagulation; IBA:RefGenome.::GO:0021533; P:cell differentiation in hindbrain; IMP:MGI.::GO:0032289; P:central nervous system myelin formation; IBA:RefGenome.::GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0071542; P:dopaminergic neuron differentiation; IMP:MGI.::GO:0021904; P:dorsal/ventral neural tube patterning; IDA:MGI.::GO:0001705; P:ectoderm formation; IGI:MGI.::GO:0031018; P:endocrine pancreas development; IMP:MGI.::GO:0007492; P:endoderm development; IBA:RefGenome.::GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IGI:MGI.::GO:0001701; P:in utero embryonic development; IMP:MGI.::GO:0060487; P:lung epithelial cell differentiation; IGI:MGI.::GO:2000971; P:negative regulation of detection of glucose; IDA:BHF-UCL.::GO:0033132; P:negative regulation of glucokinase activity; IDA:BHF-UCL.::GO:0045665; P:negative regulation of neuron differentiation; IGI:MGI.::GO:0000433; P:negative regulation of transcription from RNA polymerase II promoter by glucose; IDA:BHF-UCL.::GO:0048665; P:neuron fate specification; IMP:MGI.::GO:0021779; P:oligodendrocyte cell fate commitment; IBA:RefGenome.::GO:0040019; P:positive regulation of embryonic development; IMP:UniProtKB.::GO:2000543; P:positive regulation of gastrulation; IMP:UniProtKB.::GO:0045666; P:positive regulation of neuron differentiation; IMP:MGI.::GO:0000432; P:positive regulation of transcription from RNA polymerase II promoter by glucose; IDA:BHF-UCL.::GO:0045945; P:positive regulation of transcription from RNA polymerase III promoter; IMP:UniProtKB.::GO:0090009; P:primitive streak formation; IMP:UniProtKB.::GO:0061178; P:regulation of insulin secretion involved in cellular response to glucose stimulus; IDA:BHF-UCL.::GO:2000976; P:regulation of transcription from RNA polymerase II promoter involved in detection of glucose; IDA:BHF-UCL.::GO:0070741; P:response to interleukin-6; TAS:UniProtKB.::GO:0023019; P:signal transduction involved in regulation of gene expression; IDA:MGI.::GO:0032525; P:somite rostral/caudal axis specification; IMP:MGI.
127Q6P839    399   FOXA4_XENTR Forkhead box protein A4 OS=Xenopu...793e-17     88.6     48     68GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0010843; F:promoter binding; IBA:RefGenome.::GO:0019904; F:protein domain specific binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0016563; F:transcription activator activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0009790; P:embryo development; IBA:RefGenome.::GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IBA:RefGenome.::GO:0042593; P:glucose homeostasis; IBA:RefGenome.::GO:0060487; P:lung epithelial cell differentiation; IBA:RefGenome.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0048665; P:neuron fate specification; IBA:RefGenome.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0045666; P:positive regulation of neuron differentiation; IBA:RefGenome.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.::GO:0010817; P:regulation of hormone levels; IBA:RefGenome.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
128O54743    446   FOXF2_MOUSE Forkhead box protein F2 OS=Mus mu...903e-17     89     43     66GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0048566; P:embryonic digestive tract development; IGI:MGI.::GO:0042249; P:establishment of planar polarity of embryonic epithelium; IMP:MGI.::GO:0030198; P:extracellular matrix organization; IMP:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
129Q9Y261    457   FOXA2_HUMAN Hepatocyte nuclear factor 3-beta ...793e-17     89     48     71GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0019904; F:protein domain specific binding; IBA:RefGenome.::GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:BHF-UCL.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0016563; F:transcription activator activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0021533; P:cell differentiation in hindbrain; IBA:RefGenome.::GO:0032289; P:central nervous system myelin formation; IBA:RefGenome.::GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0021904; P:dorsal/ventral neural tube patterning; IBA:RefGenome.::GO:0001705; P:ectoderm formation; IBA:RefGenome.::GO:0031018; P:endocrine pancreas development; IDA:BHF-UCL.::GO:0007492; P:endoderm development; IBA:RefGenome.::GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IBA:RefGenome.::GO:0001701; P:in utero embryonic development; IBA:RefGenome.::GO:0060487; P:lung epithelial cell differentiation; IBA:RefGenome.::GO:2000971; P:negative regulation of detection of glucose; ISS:BHF-UCL.::GO:0010719; P:negative regulation of epithelial to mesenchymal transition; IMP:BHF-UCL.::GO:0033132; P:negative regulation of glucokinase activity; ISS:BHF-UCL.::GO:0045665; P:negative regulation of neuron differentiation; IBA:RefGenome.::GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IMP:BHF-UCL.::GO:0000433; P:negative regulation of transcription from RNA polymerase II promoter by glucose; ISS:BHF-UCL.::GO:0048665; P:neuron fate specification; IBA:RefGenome.::GO:0021779; P:oligodendrocyte cell fate commitment; IBA:RefGenome.::GO:2000049; P:positive regulation of cell-cell adhesion mediated by cadherin; IC:BHF-UCL.::GO:0040019; P:positive regulation of embryonic development; ISS:UniProtKB.::GO:2000543; P:positive regulation of gastrulation; ISS:UniProtKB.::GO:0045666; P:positive regulation of neuron differentiation; IBA:RefGenome.::GO:0000432; P:positive regulation of transcription from RNA polymerase II promoter by glucose; ISS:BHF-UCL.::GO:0090009; P:primitive streak formation; ISS:UniProtKB.::GO:0030193; P:regulation of blood coagulation; IDA:UniProtKB.::GO:0061178; P:regulation of insulin secretion involved in cellular response to glucose stimulus; ISS:BHF-UCL.::GO:2000976; P:regulation of transcription from RNA polymerase II promoter involved in detection of glucose; ISS:BHF-UCL.::GO:0070741; P:response to interleukin-6; TAS:UniProtKB.
130Q12947    444   FOXF2_HUMAN Forkhead box protein F2 OS=Homo s...903e-17     89     43     66GO:0005667; C:transcription factor complex; IDA:UniProtKB.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0010843; F:promoter binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO:0001837; P:epithelial to mesenchymal transition; NAS:UniProtKB.::GO:0048806; P:genitalia development; IMP:UniProtKB.::GO:0060021; P:palate development; IMP:UniProtKB.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
131Q8AWH1    428   FOXA1_XENTR Forkhead box protein A1 OS=Xenopu...794e-17     88.6     47     70GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0010843; F:promoter binding; IBA:RefGenome.::GO:0019904; F:protein domain specific binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0016563; F:transcription activator activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0009790; P:embryo development; IBA:RefGenome.::GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IBA:RefGenome.::GO:0042593; P:glucose homeostasis; IBA:RefGenome.::GO:0060487; P:lung epithelial cell differentiation; IBA:RefGenome.::GO:0048665; P:neuron fate specification; IBA:RefGenome.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0045666; P:positive regulation of neuron differentiation; IBA:RefGenome.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.::GO:0010817; P:regulation of hormone levels; IBA:RefGenome.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
132Q6LD29    429   FXA1A_XENLA Forkhead box protein A1-A OS=Xeno...794e-17     88.2     47     70GO:0005634; C:nucleus; NAS:UniProtKB.
GO:0019904; F:protein domain specific binding; IEA:InterPro.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.::GO:0008134; F:transcription factor binding; IEA:InterPro.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
133P32027    508   CROC_DROME Fork head domain-containing protei...844e-17     89     49     63GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0010843; F:promoter binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0016563; F:transcription activator activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0009653; P:anatomical structure morphogenesis; IBA:RefGenome.::GO:0048513; P:organ development; IBA:RefGenome.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0007380; P:specification of segmental identity, head; IMP:FlyBase.::GO:0009888; P:tissue development; IBA:RefGenome.
134Q64731    337   FOXL1_MOUSE Forkhead box protein L1 OS=Mus mu...875e-17     87     46     60GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
135Q33BP8    485   FOXN3_PIG Forkhead box protein N3 OS=Sus scro...1005e-17     88.6     43     63GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
136Q28G71    464   FOXN3_XENTR Forkhead box protein N3 OS=Xenopu...1005e-17     88.2     43     63GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
137O00409    490   FOXN3_HUMAN Forkhead box protein N3 OS=Homo s...1006e-17     88.6     43     63GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0010843; F:promoter binding; IBA:RefGenome.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0016563; F:transcription activator activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0000077; P:DNA damage checkpoint; TAS:ProtInc.::GO:0009790; P:embryo development; IBA:RefGenome.::GO:0000085; P:G2 phase of mitotic cell cycle; TAS:ProtInc.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0009888; P:tissue development; IBA:RefGenome.
138P32183    354   FOXA3_RAT Hepatocyte nuclear factor 3-gamma O...897e-17     86.7     45     65GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0010843; F:promoter binding; IBA:RefGenome.::GO:0019904; F:protein domain specific binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0016563; F:transcription activator activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0007420; P:brain development; IBA:RefGenome.::GO:0001678; P:cellular glucose homeostasis; TAS:UniProtKB.::GO:0009267; P:cellular response to starvation; IBA:RefGenome.::GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0009790; P:embryo development; IBA:RefGenome.::GO:0008285; P:negative regulation of cell proliferation; IMP:RGD.::GO:0021999; P:neural plate anterior/posterior regionalization; IBA:RefGenome.::GO:0048665; P:neuron fate specification; IBA:RefGenome.::GO:0070368; P:positive regulation of hepatocyte differentiation; IMP:RGD.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
139Q499D0    457   FOXN3_MOUSE Forkhead box protein N3 OS=Mus mu...1007e-17     87.8     43     63GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0009790; P:embryo development; IBA:RefGenome.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0009888; P:tissue development; IBA:RefGenome.
140P35584    353   FOXA3_MOUSE Hepatocyte nuclear factor 3-gamma...827e-17     86.7     46     68GO:0005829; C:cytosol; TAS:Reactome.::GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0019904; F:protein domain specific binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IDA:MGI.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0007420; P:brain development; IBA:RefGenome.::GO:0001678; P:cellular glucose homeostasis; IMP:MGI.::GO:0009267; P:cellular response to starvation; IMP:MGI.::GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0009790; P:embryo development; IBA:RefGenome.::GO:0031018; P:endocrine pancreas development; TAS:Reactome.::GO:0008285; P:negative regulation of cell proliferation; IBA:RefGenome.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.::GO:0021999; P:neural plate anterior/posterior regionalization; IBA:RefGenome.::GO:0048665; P:neuron fate specification; IBA:RefGenome.::GO:0070368; P:positive regulation of hepatocyte differentiation; IBA:RefGenome.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0007283; P:spermatogenesis; IMP:UniProtKB.
141Q12952    345   FOXL1_HUMAN Forkhead box protein L1 OS=Homo s...877e-17     86.7     46     59GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; NAS:UniProtKB.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0010843; F:promoter binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0016563; F:transcription activator activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0007420; P:brain development; IBA:RefGenome.::GO:0043010; P:camera-type eye development; IBA:RefGenome.::GO:0051216; P:cartilage development; IBA:RefGenome.::GO:0009790; P:embryo development; IBA:RefGenome.::GO:0035136; P:forelimb morphogenesis; IBA:RefGenome.::GO:0007507; P:heart development; IMP:DFLAT.::GO:0009887; P:organ morphogenesis; ISS:UniProtKB.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0030166; P:proteoglycan biosynthetic process; ISS:UniProtKB.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0030111; P:regulation of Wnt receptor signaling pathway; ISS:UniProtKB.::GO:0007495; P:visceral mesoderm-endoderm interaction involved in midgut development; ISS:UniProtKB.
142P14734    510   FKH_DROME Protein fork head OS=Drosophila mel...798e-17     88.2     46     72GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0010843; F:promoter binding; IBA:RefGenome.::GO:0019904; F:protein domain specific binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0016563; F:transcription activator activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0006916; P:anti-apoptosis; IMP:FlyBase.::GO:0042023; P:DNA endoreduplication; IMP:FlyBase.::GO:0035072; P:ecdysone-mediated induction of salivary gland cell autophagic cell death; IDA:FlyBase.::GO:0007439; P:ectodermal digestive tract development; TAS:FlyBase.::GO:0001706; P:endoderm formation; TAS:FlyBase.::GO:0007443; P:Malpighian tubule morphogenesis; IMP:FlyBase.::GO:0030308; P:negative regulation of cell growth; IMP:FlyBase.::GO:0040015; P:negative regulation of multicellular organism growth; IMP:FlyBase.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:FlyBase.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:FlyBase.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
143P32315    427   FXA1B_XENLA Forkhead box protein A1-B OS=Xeno...798e-17     87.4     47     70GO:0005634; C:nucleus; NAS:UniProtKB.
GO:0019904; F:protein domain specific binding; IEA:InterPro.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.::GO:0008134; F:transcription factor binding; IEA:InterPro.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
144P55318    350   FOXA3_HUMAN Hepatocyte nuclear factor 3-gamma...898e-17     86.3     45     65GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0019904; F:protein domain specific binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0016563; F:transcription activator activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IBA:RefGenome.::GO:0044212; F:transcription regulatory region DNA binding; IMP:UniProtKB.
GO:0007420; P:brain development; IBA:RefGenome.::GO:0001678; P:cellular glucose homeostasis; TAS:UniProtKB.::GO:0009267; P:cellular response to starvation; IBA:RefGenome.::GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0009790; P:embryo development; IBA:RefGenome.::GO:0031018; P:endocrine pancreas development; TAS:Reactome.::GO:0008285; P:negative regulation of cell proliferation; IBA:RefGenome.::GO:0021999; P:neural plate anterior/posterior regionalization; IBA:RefGenome.::GO:0048665; P:neuron fate specification; IBA:RefGenome.::GO:0070368; P:positive regulation of hepatocyte differentiation; IBA:RefGenome.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
145P55317    472   FOXA1_HUMAN Hepatocyte nuclear factor 3-alpha...799e-17     87.8     47     70GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0019904; F:protein domain specific binding; IBA:RefGenome.::GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; ISS:BHF-UCL.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0016563; F:transcription activator activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IBA:RefGenome.::GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
GO:0006338; P:chromatin remodeling; ISS:UniProtKB.::GO:0009790; P:embryo development; IBA:RefGenome.::GO:0060743; P:epithelial cell maturation involved in prostate gland development; IBA:RefGenome.::GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IBA:RefGenome.::GO:0060738; P:epithelial-mesenchymal signaling involved in prostate gland development; IBA:RefGenome.::GO:0042593; P:glucose homeostasis; IBA:RefGenome.::GO:0060487; P:lung epithelial cell differentiation; IBA:RefGenome.::GO:0010719; P:negative regulation of epithelial to mesenchymal transition; IMP:BHF-UCL.::GO:0008634; P:negative regulation of survival gene product expression; IDA:UniProtKB.::GO:0048665; P:neuron fate specification; IBA:RefGenome.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:2000049; P:positive regulation of cell-cell adhesion mediated by cadherin; IC:BHF-UCL.::GO:0033148; P:positive regulation of intracellular estrogen receptor signaling pathway; IMP:UniProtKB.::GO:0045931; P:positive regulation of mitotic cell cycle; IMP:UniProtKB.::GO:0045666; P:positive regulation of neuron differentiation; IBA:RefGenome.::GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IMP:UniProtKB.::GO:0060740; P:prostate gland epithelium morphogenesis; IBA:RefGenome.::GO:0060741; P:prostate gland stromal morphogenesis; IBA:RefGenome.::GO:0032355; P:response to estradiol stimulus; IDA:UniProtKB.::GO:0060528; P:secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; IBA:RefGenome.
146Q3Y598    351   FOXA3_BOVIN Hepatocyte nuclear factor 3-gamma...829e-17     86.3     46     68GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0010843; F:promoter binding; IBA:RefGenome.::GO:0019904; F:protein domain specific binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0016563; F:transcription activator activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0007420; P:brain development; IBA:RefGenome.::GO:0001678; P:cellular glucose homeostasis; IBA:RefGenome.::GO:0009267; P:cellular response to starvation; IBA:RefGenome.::GO:0009790; P:embryo development; IBA:RefGenome.::GO:0008285; P:negative regulation of cell proliferation; IBA:RefGenome.::GO:0021999; P:neural plate anterior/posterior regionalization; IBA:RefGenome.::GO:0048665; P:neuron fate specification; IBA:RefGenome.::GO:0070368; P:positive regulation of hepatocyte differentiation; IBA:RefGenome.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
147Q3BJS3    485   FOXN3_XENLA Forkhead box protein N3 OS=Xenopu...1009e-17     87.8     42     63GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
148P35582    468   FOXA1_MOUSE Hepatocyte nuclear factor 3-alpha...799e-17     87.8     47     70GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0019904; F:protein domain specific binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IDA:MGI.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0006338; P:chromatin remodeling; IDA:UniProtKB.::GO:0009790; P:embryo development; IBA:RefGenome.::GO:0060743; P:epithelial cell maturation involved in prostate gland development; IMP:MGI.::GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IGI:MGI.::GO:0060738; P:epithelial-mesenchymal signaling involved in prostate gland development; IGI:MGI.::GO:0042593; P:glucose homeostasis; IMP:MGI.::GO:0042445; P:hormone metabolic process; IMP:MGI.::GO:0060487; P:lung epithelial cell differentiation; IGI:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.::GO:0048665; P:neuron fate specification; IGI:MGI.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0045666; P:positive regulation of neuron differentiation; IMP:MGI.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.::GO:0060740; P:prostate gland epithelium morphogenesis; IMP:MGI.::GO:0060741; P:prostate gland stromal morphogenesis; IMP:MGI.::GO:0060528; P:secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; IMP:MGI.
149Q5J3Q5    379   FOXE1_XENLA Forkhead box protein E1 OS=Xenopu...851e-16     86.3     44     62GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
150P23512    466   FOXA1_RAT Hepatocyte nuclear factor 3-alpha O...791e-16     87.4     47     70GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IDA:RGD.::GO:0010843; F:promoter binding; IBA:RefGenome.::GO:0019904; F:protein domain specific binding; IDA:RGD.::GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:BHF-UCL.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IDA:RGD.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IPI:MGI.
GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0009790; P:embryo development; IBA:RefGenome.::GO:0060743; P:epithelial cell maturation involved in prostate gland development; IBA:RefGenome.::GO:0060441; P:epithelial tube branching involved in lung morphogenesis; IBA:RefGenome.::GO:0060738; P:epithelial-mesenchymal signaling involved in prostate gland development; IBA:RefGenome.::GO:0042593; P:glucose homeostasis; IBA:RefGenome.::GO:0060487; P:lung epithelial cell differentiation; IBA:RefGenome.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IGI:MGI.::GO:0048665; P:neuron fate specification; IBA:RefGenome.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0045666; P:positive regulation of neuron differentiation; IBA:RefGenome.::GO:0060740; P:prostate gland epithelium morphogenesis; IBA:RefGenome.::GO:0060741; P:prostate gland stromal morphogenesis; IBA:RefGenome.::GO:0010817; P:regulation of hormone levels; IBA:RefGenome.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0060528; P:secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development; IBA:RefGenome.
151O00358    373   FOXE1_HUMAN Forkhead box protein E1 OS=Homo s...851e-16     86.3     45     61GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0010843; F:promoter binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0016563; F:transcription activator activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0048562; P:embryonic organ morphogenesis; ISS:UniProtKB.::GO:0031069; P:hair follicle morphogenesis; ISS:UniProtKB.::GO:0060022; P:hard palate development; IMP:UniProtKB.::GO:0002089; P:lens morphogenesis in camera-type eye; IBA:RefGenome.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0007422; P:peripheral nervous system development; IBA:RefGenome.::GO:0060465; P:pharynx development; IEP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0060023; P:soft palate development; IMP:UniProtKB.::GO:0048538; P:thymus development; IEP:UniProtKB.::GO:0030878; P:thyroid gland development; IMP:UniProtKB.::GO:0006590; P:thyroid hormone generation; ISS:UniProtKB.
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