Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YNL045W
Length:
671
Number of sequences:
5887
Description:
YNL045W LAP2 SGDID:S000004990, Chr XIV from 542963-544978, Genome Release 64-1-1, Verified ORF, "Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
61Q95334    942   AMPE_PIG Glutamyl aminopeptidase OS=Sus scrof...3354e-17     89.4     27     42GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0070006; F:metalloaminopeptidase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0008283; P:cell proliferation; ISS:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0003081; P:regulation of systemic arterial blood pressure by renin-angiotensin; ISS:UniProtKB.
62P15144    967   AMPN_HUMAN Aminopeptidase N OS=Homo sapiens (...3251e-16     88.2     26     42GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:UniProtKB.::GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
GO:0004177; F:aminopeptidase activity; TAS:ProtInc.::GO:0008237; F:metallopeptidase activity; TAS:ProtInc.::GO:0004872; F:receptor activity; TAS:ProtInc.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
63P15145    963   AMPN_PIG Aminopeptidase N OS=Sus scrofa (Pig)...3202e-16     87.4     26     43GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
64Q9JJ22    930   ERAP1_RAT Endoplasmic reticulum aminopeptidas...3252e-16     87     25     41GO:0005788; C:endoplasmic reticulum lumen; IDA:RGD.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005576; C:extracellular region; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:RGD.
GO:0004177; F:aminopeptidase activity; ISS:UniProtKB.::GO:0005138; F:interleukin-6 receptor binding; ISS:UniProtKB.::GO:0008235; F:metalloexopeptidase activity; ISS:UniProtKB.::GO:0005164; F:tumor necrosis factor receptor binding; IPI:RGD.::GO:0008270; F:zinc ion binding; IMP:RGD.
GO:0019882; P:antigen processing and presentation; TAS:RGD.::GO:0006509; P:membrane protein ectodomain proteolysis; ISS:UniProtKB.
65P37896    843   AMPN_LACDL Aminopeptidase N OS=Lactobacillus ...4733e-16     86.7     23     41GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
66P15541    966   AMPN_RABIT Aminopeptidase N OS=Oryctolagus cu...3193e-16     86.7     25     44GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
67Q9NZ08    941   ERAP1_HUMAN Endoplasmic reticulum aminopeptid...3305e-16     85.9     26     40GO:0005829; C:cytosol; NAS:UniProtKB.::GO:0005788; C:endoplasmic reticulum lumen; TAS:HGNC.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005576; C:extracellular region; IDA:UniProtKB.::GO:0016021; C:integral to membrane; NAS:UniProtKB.
GO:0004177; F:aminopeptidase activity; IDA:UniProtKB.::GO:0005151; F:interleukin-1, Type II receptor binding; TAS:HGNC.::GO:0005138; F:interleukin-6 receptor binding; IPI:UniProtKB.::GO:0008235; F:metalloexopeptidase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; NAS:UniProtKB.
GO:0001525; P:angiogenesis; TAS:HGNC.::GO:0019885; P:antigen processing and presentation of endogenous peptide antigen via MHC class I; NAS:UniProtKB.::GO:0045444; P:fat cell differentiation; NAS:UniProtKB.::GO:0006509; P:membrane protein ectodomain proteolysis; IDA:UniProtKB.::GO:0008217; P:regulation of blood pressure; NAS:UniProtKB.::GO:0045088; P:regulation of innate immune response; NAS:UniProtKB.::GO:0009617; P:response to bacterium; IEP:BHF-UCL.
68Q9EQH2    930   ERAP1_MOUSE Endoplasmic reticulum aminopeptid...3256e-16     85.9     25     41GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005576; C:extracellular region; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004177; F:aminopeptidase activity; ISS:UniProtKB.::GO:0005138; F:interleukin-6 receptor binding; ISS:UniProtKB.::GO:0008235; F:metalloexopeptidase activity; ISS:UniProtKB.
GO:0006509; P:membrane protein ectodomain proteolysis; ISS:UniProtKB.::GO:0045766; P:positive regulation of angiogenesis; IMP:MGI.
69Q5RFP3    960   ERAP2_PONAB Endoplasmic reticulum aminopeptid...3346e-16     85.5     28     40GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
70Q2KHK3    559   AMPQ_MOUSE Aminopeptidase Q OS=Mus musculus (...3177e-16     84.7     25     42GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
71O57579    967   AMPN_CHICK Aminopeptidase N OS=Gallus gallus ...3347e-16     85.5     26     44GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
72Q59KZ1    924   APE2_CANAL Aminopeptidase 2 OS=Candida albica...4570.000000000000001     84.3     25     42GO:0005576; C:extracellular region; IDA:CGD.::GO:0009277; C:fungal-type cell wall; IDA:CGD.::GO:0005622; C:intracellular; IDA:CGD.
GO:0070006; F:metalloaminopeptidase activity; IDA:CGD.::GO:0008236; F:serine-type peptidase activity; IDA:CGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
73Q6P179    960   ERAP2_HUMAN Endoplasmic reticulum aminopeptid...3270.000000000000002     84.3     28     40GO:0005788; C:endoplasmic reticulum lumen; TAS:HGNC.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004177; F:aminopeptidase activity; IDA:HGNC.::GO:0008237; F:metallopeptidase activity; IDA:HGNC.::GO:0008270; F:zinc ion binding; TAS:HGNC.
GO:0019885; P:antigen processing and presentation of endogenous peptide antigen via MHC class I; TAS:HGNC.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0008217; P:regulation of blood pressure; TAS:HGNC.
74P50123    945   AMPE_RAT Glutamyl aminopeptidase OS=Rattus no...3990.000000000000002     84.3     24     42GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005625; C:soluble fraction; IDA:RGD.::GO:0031983; C:vesicle lumen; IDA:RGD.::GO:0012506; C:vesicle membrane; IDA:RGD.
GO:0070006; F:metalloaminopeptidase activity; ISS:UniProtKB.::GO:0042277; F:peptide binding; IDA:RGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0008283; P:cell proliferation; ISS:UniProtKB.::GO:0006725; P:cellular aromatic compound metabolic process; IDA:RGD.::GO:0006508; P:proteolysis; IDA:RGD.::GO:0003081; P:regulation of systemic arterial blood pressure by renin-angiotensin; ISS:UniProtKB.
75A6QPT7    954   ERAP2_BOVIN Endoplasmic reticulum aminopeptid...3250.000000000000004     82.8     27     39GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
76Q48656    849   AMPN_LACLL Aminopeptidase N OS=Lactococcus la...4450.000000000000005     82.4     25     41GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
77P55786    919   PSA_HUMAN Puromycin-sensitive aminopeptidase ...3140.00000000000001     81.6     25     43GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; TAS:ProtInc.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; TAS:Reactome.::GO:0071456; P:cellular response to hypoxia; IDA:UniProtKB.::GO:0000209; P:protein polyubiquitination; TAS:Reactome.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
78Q11011    920   PSA_MOUSE Puromycin-sensitive aminopeptidase ...3140.00000000000001     81.6     25     43GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
79P16406    945   AMPE_MOUSE Glutamyl aminopeptidase OS=Mus mus...3390.00000000000002     80.5     27     42GO:0016324; C:apical plasma membrane; IDA:MGI.::GO:0005903; C:brush border; IDA:MGI.::GO:0031410; C:cytoplasmic vesicle; IDA:MGI.::GO:0009897; C:external side of plasma membrane; IDA:MGI.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0070006; F:metalloaminopeptidase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0001525; P:angiogenesis; IMP:MGI.::GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0008283; P:cell proliferation; ISS:UniProtKB.::GO:0032835; P:glomerulus development; IEP:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0003081; P:regulation of systemic arterial blood pressure by renin-angiotensin; ISS:UniProtKB.
80Q11010    857   AMPN_STRLI Aminopeptidase N OS=Streptomyces l...3080.00000000000004     79.7     27     41GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
81Q07075    957   AMPE_HUMAN Glutamyl aminopeptidase OS=Homo sa...3520.00000000000004     79.7     27     39GO:0016324; C:apical plasma membrane; ISS:UniProtKB.::GO:0005903; C:brush border; ISS:UniProtKB.::GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.::GO:0009897; C:external side of plasma membrane; ISS:UniProtKB.::GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
GO:0070006; F:metalloaminopeptidase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0001525; P:angiogenesis; ISS:UniProtKB.::GO:0002005; P:angiotensin catabolic process in blood; NAS:UniProtKB.::GO:0016477; P:cell migration; IDA:MGI.::GO:0008283; P:cell proliferation; NAS:UniProtKB.::GO:0007267; P:cell-cell signaling; NAS:UniProtKB.::GO:0032835; P:glomerulus development; ISS:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
82Q10737    972   AMPN_HAECO Aminopeptidase N OS=Haemonchus con...3100.00000000000006     79.3     25     44GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
83P37898    856   AAP1_YEAST Alanine/arginine aminopeptidase OS...4740.0000000000001     77.8     24     38GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0005977; P:glycogen metabolic process; IMP:SGD.::GO:0006508; P:proteolysis; IMP:SGD.
84O93654    783   TRF2_THEAC Tricorn protease-interacting facto...3810.0000000000008     75.5     26     41GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
85Q9UKU6    1024   TRHDE_HUMAN Thyrotropin-releasing hormone-deg...4080.000000000001     74.7     24     39GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
GO:0004177; F:aminopeptidase activity; TAS:ProtInc.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007267; P:cell-cell signaling; TAS:ProtInc.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0007165; P:signal transduction; TAS:ProtInc.
86Q32LQ0    956   AMPE_BOVIN Glutamyl aminopeptidase OS=Bos tau...3350.000000000002     74.7     26     41GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0070006; F:metalloaminopeptidase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0008283; P:cell proliferation; ISS:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0003081; P:regulation of systemic arterial blood pressure by renin-angiotensin; ISS:UniProtKB.
87Q10836    1025   TRHDE_RAT Thyrotropin-releasing hormone-degra...4040.000000000004     73.6     23     40GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004177; F:aminopeptidase activity; TAS:RGD.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; TAS:RGD.
88Q8K093    1025   TRHDE_MOUSE Thyrotropin-releasing hormone-deg...4040.000000000004     73.6     23     40GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
89P32454    952   APE2_YEAST Aminopeptidase 2, mitochondrial OS...4630.000000000004     73.2     24     39GO:0030287; C:cell wall-bounded periplasmic space; IDA:SGD.::GO:0005576; C:extracellular region; IDA:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.
GO:0070006; F:metalloaminopeptidase activity; IDA:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0043171; P:peptide catabolic process; IDA:SGD.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
90Q11001    990   AMPM_MANSE Membrane alanyl aminopeptidase OS=...3160.000000000009     72     23     41GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
91Q11000    1009   AMPM_HELVI Membrane alanyl aminopeptidase OS=...3570.00000000001     71.6     23     41GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
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