Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YNL045W
Length:
671
Number of sequences:
5887
Description:
YNL045W LAP2 SGDID:S000004990, Chr XIV from 542963-544978, Genome Release 64-1-1, Verified ORF, "Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31Q3SZH7    611   LKHA4_BOVIN Leukotriene A-4 hydrolase OS=Bos ...6137e-144     439     41     60GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; ISS:UniProtKB.::GO:0004301; F:epoxide hydrolase activity; ISS:UniProtKB.::GO:0004463; F:leukotriene-A4 hydrolase activity; ISS:UniProtKB.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0019370; P:leukotriene biosynthetic process; ISS:UniProtKB.::GO:0043171; P:peptide catabolic process; ISS:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
32P09960    611   LKHA4_HUMAN Leukotriene A-4 hydrolase OS=Homo...6155e-142     435     40     59GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IDA:HPA.
GO:0004177; F:aminopeptidase activity; IDA:UniProtKB.::GO:0004301; F:epoxide hydrolase activity; IDA:UniProtKB.::GO:0004463; F:leukotriene-A4 hydrolase activity; IDA:UniProtKB.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0006954; P:inflammatory response; NAS:ProtInc.::GO:0019370; P:leukotriene biosynthetic process; IDA:UniProtKB.::GO:0043171; P:peptide catabolic process; IDA:UniProtKB.::GO:0006692; P:prostanoid metabolic process; TAS:Reactome.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
33Q6S9C8    611   LKHA4_CHILA Leukotriene A-4 hydrolase OS=Chin...6153e-141     433     40     59GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; ISS:UniProtKB.::GO:0004301; F:epoxide hydrolase activity; ISS:UniProtKB.::GO:0004463; F:leukotriene-A4 hydrolase activity; ISS:UniProtKB.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0019370; P:leukotriene biosynthetic process; ISS:UniProtKB.::GO:0043171; P:peptide catabolic process; ISS:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
34P24527    611   LKHA4_MOUSE Leukotriene A-4 hydrolase OS=Mus ...6152e-139     428     40     58GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; ISS:UniProtKB.::GO:0004301; F:epoxide hydrolase activity; ISS:UniProtKB.::GO:0004463; F:leukotriene-A4 hydrolase activity; ISS:UniProtKB.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0019370; P:leukotriene biosynthetic process; ISS:UniProtKB.::GO:0043171; P:peptide catabolic process; ISS:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
35P19602    611   LKHA4_CAVPO Leukotriene A-4 hydrolase OS=Cavi...6134e-138     424     39     59GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; ISS:UniProtKB.::GO:0004301; F:epoxide hydrolase activity; ISS:UniProtKB.::GO:0004463; F:leukotriene-A4 hydrolase activity; ISS:UniProtKB.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0019370; P:leukotriene biosynthetic process; ISS:UniProtKB.::GO:0043171; P:peptide catabolic process; ISS:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
36P52922    606   LKHA4_DICDI Leukotriene A-4 hydrolase homolog...6302e-136     420     40     59GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; ISS:UniProtKB.::GO:0004301; F:epoxide hydrolase activity; ISS:UniProtKB.::GO:0004463; F:leukotriene-A4 hydrolase activity; IEA:EC.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0019370; P:leukotriene biosynthetic process; IEA:UniProtKB-KW.::GO:0043171; P:peptide catabolic process; ISS:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
37P30349    610   LKHA4_RAT Leukotriene A-4 hydrolase OS=Rattus...6159e-136     418     40     58GO:0005737; C:cytoplasm; IDA:RGD.::GO:0005634; C:nucleus; IDA:RGD.
GO:0004177; F:aminopeptidase activity; ISS:UniProtKB.::GO:0004301; F:epoxide hydrolase activity; ISS:UniProtKB.::GO:0004463; F:leukotriene-A4 hydrolase activity; IDA:RGD.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0019370; P:leukotriene biosynthetic process; ISS:UniProtKB.::GO:0043171; P:peptide catabolic process; ISS:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0043434; P:response to peptide hormone stimulus; IEP:RGD.::GO:0010043; P:response to zinc ion; IEP:RGD.::GO:0060509; P:Type I pneumocyte differentiation; IEP:RGD.
38Q8VCT3    650   AMPB_MOUSE Aminopeptidase B OS=Mus musculus (...6628e-101     328     33     51
GO:0019370; P:leukotriene biosynthetic process; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
39O09175    650   AMPB_RAT Aminopeptidase B OS=Rattus norvegicu...6577e-98     320     33     52GO:0009897; C:external side of plasma membrane; IDA:RGD.::GO:0005615; C:extracellular space; IDA:RGD.::GO:0005794; C:Golgi apparatus; NAS:UniProtKB.::GO:0030141; C:secretory granule; IDA:RGD.::GO:0005625; C:soluble fraction; IDA:RGD.::GO:0019717; C:synaptosome; IDA:RGD.
GO:0050897; F:cobalt ion binding; IDA:RGD.::GO:0005507; F:copper ion binding; IDA:RGD.::GO:0070006; F:metalloaminopeptidase activity; IDA:RGD.::GO:0042277; F:peptide binding; IDA:RGD.::GO:0008270; F:zinc ion binding; NAS:UniProtKB.
GO:0007568; P:aging; IEP:RGD.::GO:0019370; P:leukotriene biosynthetic process; IEA:InterPro.::GO:0045776; P:negative regulation of blood pressure; IMP:RGD.::GO:0016485; P:protein processing; NAS:UniProtKB.::GO:0006508; P:proteolysis; IC:UniProtKB.::GO:0060041; P:retina development in camera-type eye; IEP:RGD.
40Q9H4A4    650   AMPB_HUMAN Aminopeptidase B OS=Homo sapiens (...6513e-92     305     32     51
GO:0004301; F:epoxide hydrolase activity; NAS:UniProtKB.::GO:0008270; F:zinc ion binding; NAS:UniProtKB.
GO:0019370; P:leukotriene biosynthetic process; IEA:InterPro.::GO:0006508; P:proteolysis; IC:UniProtKB.
41Q9HAU8    494   RNPL1_HUMAN Arginyl aminopeptidase-like 1 OS=...4504e-47     178     27     44
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0019370; P:leukotriene biosynthetic process; IEA:InterPro.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
42Q97VF1    784   APE1_SULSO Probable aminopeptidase 1 OS=P2). ...4453e-23     108     26     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
43Q96ZT9    786   APE1_SULTO Probable aminopeptidase 1 OS=Sulfo...4314e-22     105     24     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
44P95928    785   APE2_SULSO Leucyl aminopeptidase OS=P2). GN=a...4248e-22     104     25     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
45Q10730    844   AMPN_LACHE Aminopeptidase N OS=Lactobacillus ...4721e-20     100     22     41GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
46P69527    816   AMPO_RAT Aminopeptidase O OS=Rattus norvegicu...6082e-20     99.8     22     38GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; ISS:UniProtKB.::GO:0008237; F:metallopeptidase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0019370; P:leukotriene biosynthetic process; IEA:InterPro.::GO:0006508; P:proteolysis; ISS:UniProtKB.
47Q8N6M6    819   AMPO_HUMAN Aminopeptidase O OS=Homo sapiens (...4521e-19     97.4     22     39GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; IDA:UniProtKB.::GO:0008237; F:metallopeptidase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0019370; P:leukotriene biosynthetic process; IEA:InterPro.::GO:0006508; P:proteolysis; IDA:UniProtKB.
48Q8BXQ6    817   AMPO_MOUSE Aminopeptidase O OS=Mus musculus (...4262e-19     97.1     24     40GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; ISS:UniProtKB.::GO:0008237; F:metallopeptidase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0019370; P:leukotriene biosynthetic process; IEA:InterPro.::GO:0006508; P:proteolysis; ISS:UniProtKB.
49Q978U3    783   TRF2_THEVO Tricorn protease-interacting facto...4682e-19     96.7     24     42GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
50Q9UIQ6    1025   LCAP_HUMAN Leucyl-cystinyl aminopeptidase OS=...3822e-19     96.7     26     43GO:0005829; C:cytosol; TAS:Reactome.::GO:0031905; C:early endosome lumen; TAS:Reactome.::GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
GO:0004177; F:aminopeptidase activity; TAS:HGNC.::GO:0008237; F:metallopeptidase activity; TAS:ProtInc.::GO:0008270; F:zinc ion binding; TAS:ProtInc.
GO:0002480; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; TAS:Reactome.::GO:0007267; P:cell-cell signaling; TAS:ProtInc.::GO:0007565; P:female pregnancy; TAS:ProtInc.::GO:0000209; P:protein polyubiquitination; TAS:Reactome.::GO:0006508; P:proteolysis; TAS:ProtInc.
51Q97AJ6    779   TRF3_THEVO Tricorn protease-interacting facto...4644e-19     95.5     24     42GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
52P15684    965   AMPN_RAT Aminopeptidase N OS=Rattus norvegicu...3431e-18     94     26     45GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005625; C:soluble fraction; IDA:RGD.::GO:0031983; C:vesicle lumen; IDA:RGD.::GO:0012506; C:vesicle membrane; IDA:RGD.
GO:0004177; F:aminopeptidase activity; IDA:RGD.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0042277; F:peptide binding; IDA:RGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0006725; P:cellular aromatic compound metabolic process; IDA:RGD.::GO:0035814; P:negative regulation of renal sodium excretion; IMP:RGD.::GO:0006508; P:proteolysis; IDA:RGD.
53Q8SRG3    864   AMP12_ENCCU Probable M1 family aminopeptidase...3513e-18     93.2     26     44
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
54P97629    1025   LCAP_RAT Leucyl-cystinyl aminopeptidase OS=Ra...4644e-18     92.8     25     42GO:0009986; C:cell surface; IDA:RGD.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0032593; C:insulin-responsive compartment; IDA:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:RGD.::GO:0043025; C:neuronal cell body; IDA:RGD.::GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.::GO:0005886; C:plasma membrane; IDA:RGD.
GO:0004177; F:aminopeptidase activity; IDA:RGD.::GO:0001595; F:angiotensin receptor activity; IMP:RGD.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0017046; F:peptide hormone binding; IMP:RGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0010813; P:neuropeptide catabolic process; IMP:RGD.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:RGD.::GO:0009725; P:response to hormone stimulus; IDA:RGD.
55Q8C129    1025   LCAP_MOUSE Leucyl-cystinyl aminopeptidase OS=...4644e-18     92.8     24     42GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:MGI.::GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.::GO:0005886; C:plasma membrane; IDA:MGI.
GO:0004177; F:aminopeptidase activity; IMP:MGI.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030163; P:protein catabolic process; IMP:MGI.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
56Q8SQI6    864   AMP11_ENCCU Probable M1 family aminopeptidase...3515e-18     92.4     26     44
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
57P79171    967   AMPN_FELCA Aminopeptidase N OS=Felis catus (C...3669e-18     91.3     25     42GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
58P97449    966   AMPN_MOUSE Aminopeptidase N OS=Mus musculus (...3162e-17     90.5     25     44GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
59Q974N6    781   APE2_SULTO Probable aminopeptidase 2 OS=Sulfo...3782e-17     90.1     27     43GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
60P79098    965   AMPN_BOVIN Aminopeptidase N OS=Bos taurus (Bo...3213e-17     90.1     26     43GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.::GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
61Q95334    942   AMPE_PIG Glutamyl aminopeptidase OS=Sus scrof...3354e-17     89.4     27     42GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0070006; F:metalloaminopeptidase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0008283; P:cell proliferation; ISS:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0003081; P:regulation of systemic arterial blood pressure by renin-angiotensin; ISS:UniProtKB.
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