rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | P32829 | 692 | MRE11_YEAST Double-strand break repair protei... | 692 | 0 | 1433 | 100 | 100 | GO:0005739; C:mitochondrion; IDA:SGD.::GO:0030870; C:Mre11 complex; IPI:SGD.::GO:0005654; C:nucleoplasm; TAS:Reactome. | | | | | | | | | | GO:0008296; F:3'-5'-exodeoxyribonuclease activity; EXP:Reactome.::GO:0003691; F:double-stranded telomeric DNA binding; IDA:SGD.::GO:0004520; F:endodeoxyribonuclease activity; IDA:SGD.::GO:0051880; F:G-quadruplex DNA binding; IDA:SGD.::GO:0030145; F:manganese ion binding; IEA:InterPro.::GO:0032947; F:protein complex scaffold; IMP:SGD.::GO:0043047; F:single-stranded telomeric DNA binding; IDA:SGD. | | | | | | | | | | GO:0030437; P:ascospore formation; IMP:SGD.::GO:0006284; P:base-excision repair; IMP:SGD.::GO:0000727; P:double-strand break repair via break-induced replication; IMP:SGD.::GO:0006303; P:double-strand break repair via nonhomologous end joining; IMP:SGD.::GO:0042138; P:meiotic DNA double-strand break formation; TAS:SGD.::GO:0000706; P:meiotic DNA double-strand break processing; TAS:SGD.::GO:0051037; P:regulation of transcription during meiosis; IMP:SGD. | 2 | Q9C291 | 739 | MRE11_NEUCR Double-strand break repair protei... | 513 | 7e-157 | 478 | 48 | 65 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0030145; F:manganese ion binding; IEA:InterPro. | | | | | | | | | | GO:0006302; P:double-strand break repair; IEA:InterPro.::GO:0007126; P:meiosis; IEA:UniProtKB-KW. | 3 | Q09683 | 649 | RAD32_SCHPO DNA repair protein rad32 OS=Schiz... | 497 | 2e-154 | 468 | 48 | 66 | GO:0030870; C:Mre11 complex; TAS:PomBase. | | | | | | | | | | GO:0008311; F:double-stranded DNA specific 3'-5' exodeoxyribonuclease activity; TAS:PomBase.::GO:0030145; F:manganese ion binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008310; F:single-stranded DNA specific 3'-5' exodeoxyribonuclease activity; TAS:PomBase.::GO:0000014; F:single-stranded DNA specific endodeoxyribonuclease activity; TAS:PomBase. | | | | | | | | | | GO:0034613; P:cellular protein localization; IGI:PomBase.::GO:0000724; P:double-strand break repair via homologous recombination; IGI:PomBase.::GO:0006303; P:double-strand break repair via nonhomologous end joining; IMP:PomBase.::GO:0031573; P:intra-S DNA damage checkpoint; IMP:PomBase.::GO:0042138; P:meiotic DNA double-strand break formation; TAS:PomBase.::GO:0006311; P:meiotic gene conversion; IDA:PomBase.::GO:0007131; P:reciprocal meiotic recombination; IMP:PomBase.::GO:0000723; P:telomere maintenance; IMP:PomBase. | 4 | Q61216 | 706 | MRE11_MOUSE Double-strand break repair protei... | 495 | 7e-130 | 407 | 43 | 60 | | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0030145; F:manganese ion binding; IEA:InterPro. | | | | | | | | | | GO:0000075; P:cell cycle checkpoint; IMP:MGI.::GO:0008283; P:cell proliferation; IMP:MGI.::GO:0006302; P:double-strand break repair; IMP:MGI.::GO:0007129; P:synapsis; IMP:MGI. | 5 | Q9W6K1 | 711 | MRE11_XENLA Double-strand break repair protei... | 584 | 4e-129 | 405 | 40 | 57 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0030145; F:manganese ion binding; IEA:InterPro. | | | | | | | | | | GO:0006302; P:double-strand break repair; IEA:InterPro.::GO:0007126; P:meiosis; IEA:UniProtKB-KW. | 6 | Q60HE6 | 707 | MRE11_MACFA Double-strand break repair protei... | 543 | 7e-128 | 402 | 41 | 59 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0030145; F:manganese ion binding; IEA:InterPro. | | | | | | | | | | GO:0006302; P:double-strand break repair; IEA:InterPro.::GO:0007126; P:meiosis; IEA:UniProtKB-KW. | 7 | P49959 | 708 | MRE11_HUMAN Double-strand break repair protei... | 543 | 7e-128 | 402 | 41 | 59 | GO:0030870; C:Mre11 complex; NAS:BHF-UCL.::GO:0005654; C:nucleoplasm; TAS:Reactome. | | | | | | | | | | GO:0008408; F:3'-5' exonuclease activity; TAS:ProtInc.::GO:0003690; F:double-stranded DNA binding; TAS:ProtInc.::GO:0030145; F:manganese ion binding; IEA:InterPro.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.::GO:0000014; F:single-stranded DNA specific endodeoxyribonuclease activity; TAS:ProtInc. | | | | | | | | | | GO:0032508; P:DNA duplex unwinding; IMP:BHF-UCL.::GO:0000724; P:double-strand break repair via homologous recombination; TAS:Reactome.::GO:0006303; P:double-strand break repair via nonhomologous end joining; TAS:ProtInc.::GO:0032876; P:negative regulation of DNA endoreduplication; IMP:BHF-UCL.::GO:0033674; P:positive regulation of kinase activity; IDA:BHF-UCL.::GO:0031954; P:positive regulation of protein autophosphorylation; IDA:BHF-UCL.::GO:0007131; P:reciprocal meiotic recombination; TAS:ProtInc.::GO:0000019; P:regulation of mitotic recombination; TAS:ProtInc.::GO:0007062; P:sister chromatid cohesion; IMP:BHF-UCL.::GO:0007004; P:telomere maintenance via telomerase; TAS:ProtInc. | 8 | Q9JIM0 | 706 | MRE11_RAT Double-strand break repair protein ... | 495 | 1e-127 | 401 | 43 | 60 | GO:0000794; C:condensed nuclear chromosome; IDA:RGD.::GO:0030870; C:Mre11 complex; TAS:RGD.::GO:0000790; C:nuclear chromatin; IDA:RGD.::GO:0005654; C:nucleoplasm; IDA:RGD.::GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD. | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0030145; F:manganese ion binding; IEA:InterPro. | | | | | | | | | | GO:0000075; P:cell cycle checkpoint; TAS:RGD.::GO:0006302; P:double-strand break repair; TAS:RGD.::GO:0007507; P:heart development; IEP:RGD.::GO:0007131; P:reciprocal meiotic recombination; TAS:RGD.::GO:0000723; P:telomere maintenance; TAS:RGD. | 9 | Q9IAM7 | 700 | MRE11_CHICK Double-strand break repair protei... | 524 | 7e-121 | 383 | 41 | 58 | GO:0005654; C:nucleoplasm; TAS:Reactome. | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0030145; F:manganese ion binding; IEA:InterPro. | | | | | | | | | | GO:0000724; P:double-strand break repair via homologous recombination; TAS:Reactome.::GO:0007126; P:meiosis; IEA:UniProtKB-KW. | 10 | Q9UVN9 | 731 | MRE11_COPC7 Double-strand break repair protei... | 520 | 5e-113 | 363 | 40 | 59 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0030145; F:manganese ion binding; IEA:InterPro. | | | | | | | | | | GO:0006302; P:double-strand break repair; IEA:InterPro.::GO:0007126; P:meiosis; IEA:UniProtKB-KW. | 11 | Q9XGM2 | 720 | MRE11_ARATH Double-strand break repair protei... | 535 | 7e-104 | 339 | 36 | 59 | GO:0000791; C:euchromatin; IDA:TAIR.::GO:0000795; C:synaptonemal complex; IDA:TAIR. | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0030145; F:manganese ion binding; IEA:InterPro. | | | | | | | | | | GO:0006302; P:double-strand break repair; IEA:InterPro.::GO:0007126; P:meiosis; IEA:UniProtKB-KW. | 12 | Q23255 | 728 | MRE11_CAEEL Double-strand break repair protei... | 494 | 2e-82 | 282 | 36 | 52 | GO:0005634; C:nucleus; IDA:WormBase. | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0030145; F:manganese ion binding; IEA:InterPro. | | | | | | | | | | GO:0006302; P:double-strand break repair; IEA:InterPro.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0051729; P:germline cell cycle switching, mitotic to meiotic cell cycle; IMP:WormBase.::GO:0019915; P:lipid storage; IMP:WormBase.::GO:0045132; P:meiotic chromosome segregation; IMP:WormBase. | 13 | Q8SRV0 | 567 | MRE11_ENCCU Double-strand break repair protei... | 496 | 1e-66 | 235 | 30 | 50 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0030145; F:manganese ion binding; IEA:InterPro. | | | | | | | | | | GO:0006302; P:double-strand break repair; IEA:InterPro.::GO:0007126; P:meiosis; IEA:UniProtKB-KW. | 14 | O29231 | 443 | MRE11_ARCFU DNA double-strand break repair pr... | 138 | 0.0000003 | 57.4 | 29 | 43 | | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 15 | Q8PUY5 | 617 | MRE11_METMA DNA double-strand break repair pr... | 207 | 0.0000004 | 57 | 25 | 37 | | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 16 | Q8TRL2 | 614 | MRE11_METAC DNA double-strand break repair pr... | 208 | 0.000003 | 53.9 | 26 | 38 | | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 17 | D4GUK0 | 441 | MRE11_HALVD DNA double-strand break repair pr... | 143 | 0.0002 | 47.8 | 25 | 36 | | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 18 | Q8U1N9 | 426 | MRE11_PYRFU DNA double-strand break repair pr... | 138 | 0.0008 | 46.2 | 28 | 44 | | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 19 | Q97WG9 | 381 | MRE11_SULSO DNA double-strand break repair pr... | 125 | 0.001 | 45.4 | 27 | 47 | | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 20 | Q9HRW4 | 387 | MRE11_HALSA DNA double-strand break repair pr... | 76 | 0.003 | 44.3 | 32 | 49 | | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 21 | O58686 | 413 | MRE11_PYRHO DNA double-strand break repair pr... | 113 | 0.027 | 41.2 | 26 | 43 | | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 22 | Q8NKQ0 | 382 | MRE11_SULAC DNA double-strand break repair pr... | 145 | 0.035 | 40.8 | 25 | 41 | | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 23 | Q96YR6 | 387 | MRE11_SULTO DNA double-strand break repair pr... | 144 | 0.048 | 40.4 | 24 | 39 | | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 24 | Q9HLR7 | 376 | MRE11_THEAC DNA double-strand break repair pr... | 58 | 0.12 | 38.9 | 34 | 55 | | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 25 | Q9UZC9 | 415 | MRE11_PYRAB DNA double-strand break repair pr... | 119 | 0.12 | 38.9 | 25 | 42 | | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0016787; F:hydrolase activity; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 26 | Q97C75 | 374 | MRE11_THEVO DNA double-strand break repair pr... | 64 | 0.89 | 36.2 | 31 | 52 | | | | | | | | | | | GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 27 | O52655 | 275 | APAH_AGGAC Bis(5'-nucleosyl)-tetraphosphatase... | 70 | 1.6 | 35 | 30 | 47 | | | | | | | | | | | GO:0008803; F:bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity; IEA:EC. | | | | | | | | | | | 28 | P0AEW4 | 275 | CPDA_ECOLI 3',5'-cyclic adenosine monophospha... | 51 | 1.7 | 35 | 27 | 61 | | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:EcoCyc.::GO:0008198; F:ferrous iron binding; IDA:EcoCyc.::GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW. | | | | | | | | | | | 29 | P0AEW5 | 275 | CPDA_ECO57 3',5'-cyclic adenosine monophospha... | 51 | 1.7 | 35 | 27 | 61 | | | | | | | | | | | GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW. | | | | | | | | | | | 30 | Q9F771 | 427 | XERCL_PSEAI Tyrosine recombinase XerC-like OS... | 182 | 6.5 | 33.5 | 23 | 38 | | | | | | | | | | | GO:0003677; F:DNA binding; IEA:InterPro. | | | | | | | | | | GO:0015074; P:DNA integration; IEA:InterPro.::GO:0006310; P:DNA recombination; IEA:UniProtKB-KW. |