Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YMR224C
Length:
692
Number of sequences:
5887
Description:
YMR224C MRE11 SGDID:S000004837, Chr XIII from 720653-718575, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of a complex with Rad50p and Xrs2p (MRX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for MRX function; widely conserved"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P32829    692   MRE11_YEAST Double-strand break repair protei...6920     1433     100     100GO:0005739; C:mitochondrion; IDA:SGD.::GO:0030870; C:Mre11 complex; IPI:SGD.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0008296; F:3'-5'-exodeoxyribonuclease activity; EXP:Reactome.::GO:0003691; F:double-stranded telomeric DNA binding; IDA:SGD.::GO:0004520; F:endodeoxyribonuclease activity; IDA:SGD.::GO:0051880; F:G-quadruplex DNA binding; IDA:SGD.::GO:0030145; F:manganese ion binding; IEA:InterPro.::GO:0032947; F:protein complex scaffold; IMP:SGD.::GO:0043047; F:single-stranded telomeric DNA binding; IDA:SGD.
GO:0030437; P:ascospore formation; IMP:SGD.::GO:0006284; P:base-excision repair; IMP:SGD.::GO:0000727; P:double-strand break repair via break-induced replication; IMP:SGD.::GO:0006303; P:double-strand break repair via nonhomologous end joining; IMP:SGD.::GO:0042138; P:meiotic DNA double-strand break formation; TAS:SGD.::GO:0000706; P:meiotic DNA double-strand break processing; TAS:SGD.::GO:0051037; P:regulation of transcription during meiosis; IMP:SGD.
2Q9C291    739   MRE11_NEUCR Double-strand break repair protei...5137e-157     478     48     65GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0030145; F:manganese ion binding; IEA:InterPro.
GO:0006302; P:double-strand break repair; IEA:InterPro.::GO:0007126; P:meiosis; IEA:UniProtKB-KW.
3Q09683    649   RAD32_SCHPO DNA repair protein rad32 OS=Schiz...4972e-154     468     48     66GO:0030870; C:Mre11 complex; TAS:PomBase.
GO:0008311; F:double-stranded DNA specific 3'-5' exodeoxyribonuclease activity; TAS:PomBase.::GO:0030145; F:manganese ion binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008310; F:single-stranded DNA specific 3'-5' exodeoxyribonuclease activity; TAS:PomBase.::GO:0000014; F:single-stranded DNA specific endodeoxyribonuclease activity; TAS:PomBase.
GO:0034613; P:cellular protein localization; IGI:PomBase.::GO:0000724; P:double-strand break repair via homologous recombination; IGI:PomBase.::GO:0006303; P:double-strand break repair via nonhomologous end joining; IMP:PomBase.::GO:0031573; P:intra-S DNA damage checkpoint; IMP:PomBase.::GO:0042138; P:meiotic DNA double-strand break formation; TAS:PomBase.::GO:0006311; P:meiotic gene conversion; IDA:PomBase.::GO:0007131; P:reciprocal meiotic recombination; IMP:PomBase.::GO:0000723; P:telomere maintenance; IMP:PomBase.
4Q61216    706   MRE11_MOUSE Double-strand break repair protei...4957e-130     407     43     60
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0030145; F:manganese ion binding; IEA:InterPro.
GO:0000075; P:cell cycle checkpoint; IMP:MGI.::GO:0008283; P:cell proliferation; IMP:MGI.::GO:0006302; P:double-strand break repair; IMP:MGI.::GO:0007129; P:synapsis; IMP:MGI.
5Q9W6K1    711   MRE11_XENLA Double-strand break repair protei...5844e-129     405     40     57GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0030145; F:manganese ion binding; IEA:InterPro.
GO:0006302; P:double-strand break repair; IEA:InterPro.::GO:0007126; P:meiosis; IEA:UniProtKB-KW.
6Q60HE6    707   MRE11_MACFA Double-strand break repair protei...5437e-128     402     41     59GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0030145; F:manganese ion binding; IEA:InterPro.
GO:0006302; P:double-strand break repair; IEA:InterPro.::GO:0007126; P:meiosis; IEA:UniProtKB-KW.
7P49959    708   MRE11_HUMAN Double-strand break repair protei...5437e-128     402     41     59GO:0030870; C:Mre11 complex; NAS:BHF-UCL.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0008408; F:3'-5' exonuclease activity; TAS:ProtInc.::GO:0003690; F:double-stranded DNA binding; TAS:ProtInc.::GO:0030145; F:manganese ion binding; IEA:InterPro.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.::GO:0000014; F:single-stranded DNA specific endodeoxyribonuclease activity; TAS:ProtInc.
GO:0032508; P:DNA duplex unwinding; IMP:BHF-UCL.::GO:0000724; P:double-strand break repair via homologous recombination; TAS:Reactome.::GO:0006303; P:double-strand break repair via nonhomologous end joining; TAS:ProtInc.::GO:0032876; P:negative regulation of DNA endoreduplication; IMP:BHF-UCL.::GO:0033674; P:positive regulation of kinase activity; IDA:BHF-UCL.::GO:0031954; P:positive regulation of protein autophosphorylation; IDA:BHF-UCL.::GO:0007131; P:reciprocal meiotic recombination; TAS:ProtInc.::GO:0000019; P:regulation of mitotic recombination; TAS:ProtInc.::GO:0007062; P:sister chromatid cohesion; IMP:BHF-UCL.::GO:0007004; P:telomere maintenance via telomerase; TAS:ProtInc.
8Q9JIM0    706   MRE11_RAT Double-strand break repair protein ...4951e-127     401     43     60GO:0000794; C:condensed nuclear chromosome; IDA:RGD.::GO:0030870; C:Mre11 complex; TAS:RGD.::GO:0000790; C:nuclear chromatin; IDA:RGD.::GO:0005654; C:nucleoplasm; IDA:RGD.::GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0030145; F:manganese ion binding; IEA:InterPro.
GO:0000075; P:cell cycle checkpoint; TAS:RGD.::GO:0006302; P:double-strand break repair; TAS:RGD.::GO:0007507; P:heart development; IEP:RGD.::GO:0007131; P:reciprocal meiotic recombination; TAS:RGD.::GO:0000723; P:telomere maintenance; TAS:RGD.
9Q9IAM7    700   MRE11_CHICK Double-strand break repair protei...5247e-121     383     41     58GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0030145; F:manganese ion binding; IEA:InterPro.
GO:0000724; P:double-strand break repair via homologous recombination; TAS:Reactome.::GO:0007126; P:meiosis; IEA:UniProtKB-KW.
10Q9UVN9    731   MRE11_COPC7 Double-strand break repair protei...5205e-113     363     40     59GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0030145; F:manganese ion binding; IEA:InterPro.
GO:0006302; P:double-strand break repair; IEA:InterPro.::GO:0007126; P:meiosis; IEA:UniProtKB-KW.
11Q9XGM2    720   MRE11_ARATH Double-strand break repair protei...5357e-104     339     36     59GO:0000791; C:euchromatin; IDA:TAIR.::GO:0000795; C:synaptonemal complex; IDA:TAIR.
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0030145; F:manganese ion binding; IEA:InterPro.
GO:0006302; P:double-strand break repair; IEA:InterPro.::GO:0007126; P:meiosis; IEA:UniProtKB-KW.
12Q23255    728   MRE11_CAEEL Double-strand break repair protei...4942e-82     282     36     52GO:0005634; C:nucleus; IDA:WormBase.
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0030145; F:manganese ion binding; IEA:InterPro.
GO:0006302; P:double-strand break repair; IEA:InterPro.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0051729; P:germline cell cycle switching, mitotic to meiotic cell cycle; IMP:WormBase.::GO:0019915; P:lipid storage; IMP:WormBase.::GO:0045132; P:meiotic chromosome segregation; IMP:WormBase.
13Q8SRV0    567   MRE11_ENCCU Double-strand break repair protei...4961e-66     235     30     50GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0030145; F:manganese ion binding; IEA:InterPro.
GO:0006302; P:double-strand break repair; IEA:InterPro.::GO:0007126; P:meiosis; IEA:UniProtKB-KW.
14O29231    443   MRE11_ARCFU DNA double-strand break repair pr...1380.0000003     57.4     29     43
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
15Q8PUY5    617   MRE11_METMA DNA double-strand break repair pr...2070.0000004     57     25     37
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
16Q8TRL2    614   MRE11_METAC DNA double-strand break repair pr...2080.000003     53.9     26     38
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
17D4GUK0    441   MRE11_HALVD DNA double-strand break repair pr...1430.0002     47.8     25     36
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
18Q8U1N9    426   MRE11_PYRFU DNA double-strand break repair pr...1380.0008     46.2     28     44
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
19Q97WG9    381   MRE11_SULSO DNA double-strand break repair pr...1250.001     45.4     27     47
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
20Q9HRW4    387   MRE11_HALSA DNA double-strand break repair pr...760.003     44.3     32     49
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
21O58686    413   MRE11_PYRHO DNA double-strand break repair pr...1130.027     41.2     26     43
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
22Q8NKQ0    382   MRE11_SULAC DNA double-strand break repair pr...1450.035     40.8     25     41
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
23Q96YR6    387   MRE11_SULTO DNA double-strand break repair pr...1440.048     40.4     24     39
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
24Q9HLR7    376   MRE11_THEAC DNA double-strand break repair pr...580.12     38.9     34     55
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
25Q9UZC9    415   MRE11_PYRAB DNA double-strand break repair pr...1190.12     38.9     25     42
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0016787; F:hydrolase activity; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
26Q97C75    374   MRE11_THEVO DNA double-strand break repair pr...640.89     36.2     31     52
GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
27O52655    275   APAH_AGGAC Bis(5'-nucleosyl)-tetraphosphatase...701.6     35     30     47
GO:0008803; F:bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity; IEA:EC.
28P0AEW4    275   CPDA_ECOLI 3',5'-cyclic adenosine monophospha...511.7     35     27     61
GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:EcoCyc.::GO:0008198; F:ferrous iron binding; IDA:EcoCyc.::GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
29P0AEW5    275   CPDA_ECO57 3',5'-cyclic adenosine monophospha...511.7     35     27     61
GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
30Q9F771    427   XERCL_PSEAI Tyrosine recombinase XerC-like OS...1826.5     33.5     23     38
GO:0003677; F:DNA binding; IEA:InterPro.
GO:0015074; P:DNA integration; IEA:InterPro.::GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
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