UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YMR223W

Length:

471

Number of sequences:

5887

Description:

YMR223W UBP8 SGDID:S000004836, Chr XIII from 716715-718130, Genome Release 64-1-1, Verified ORF, "Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
61	P40818	1118	UBP8_HUMAN Ubiquitin carboxyl-terminal hydrol...	358	8e-32	133	31	50	GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005769; C:early endosome; IDA:UniProtKB.::GO:0019897; C:extrinsic to plasma membrane; IDA:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0004197; F:cysteine-type endopeptidase activity; TAS:ProtInc.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.::GO:0004843; F:ubiquitin-specific protease activity; IDA:UniProtKB.
									GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0008283; P:cell proliferation; TAS:ProtInc.::GO:0007032; P:endosome organization; IMP:UniProtKB.::GO:0071108; P:protein K48-linked deubiquitination; IDA:UniProtKB.::GO:0070536; P:protein K63-linked deubiquitination; IDA:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
62	Q70CQ1	688	UBP49_HUMAN Ubiquitin carboxyl-terminal hydro...	96	0.003	43.9	25	48	GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005634; C:nucleus; IDA:HPA.
									GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
63	Q9SJA1	672	UBP19_ARATH Ubiquitin carboxyl-terminal hydro...	337	1e-31	132	30	47	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
64	Q67XW5	631	UBP18_ARATH Ubiquitin carboxyl-terminal hydro...	339	2e-31	130	30	48	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
65	Q80U87	1080	UBP8_MOUSE Ubiquitin carboxyl-terminal hydrol...	358	2e-31	132	31	50	GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0031313; C:extrinsic to endosome membrane; IDA:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.::GO:0004843; F:ubiquitin-specific protease activity; IDA:UniProtKB.
									GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0007032; P:endosome organization; IMP:UniProtKB.::GO:0007265; P:Ras protein signal transduction; IPI:MGI.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
66	Q6P9L4	685	UBP49_MOUSE Ubiquitin carboxyl-terminal hydro...	96	0.003	43.9	25	49
									GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
67	Q5RBQ4	366	UBP46_PONAB Ubiquitin carboxyl-terminal hydro...	358	6e-31	126	30	46
									GO:0004221; F:ubiquitin thiolesterase activity; ISS:UniProtKB.::GO:0004843; F:ubiquitin-specific protease activity; ISS:UniProtKB.
									GO:0007610; P:behavior; ISS:UniProtKB.::GO:0016579; P:protein deubiquitination; ISS:UniProtKB.::GO:0032228; P:regulation of synaptic transmission, GABAergic; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
68	P62069	366	UBP46_MOUSE Ubiquitin carboxyl-terminal hydro...	358	6e-31	126	30	46
									GO:0004221; F:ubiquitin thiolesterase activity; ISS:UniProtKB.::GO:0004843; F:ubiquitin-specific protease activity; ISS:UniProtKB.
									GO:0007610; P:behavior; IMP:UniProtKB.::GO:0016579; P:protein deubiquitination; ISS:UniProtKB.::GO:0032228; P:regulation of synaptic transmission, GABAergic; IMP:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
69	P62068	366	UBP46_HUMAN Ubiquitin carboxyl-terminal hydro...	358	6e-31	126	30	46
									GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.::GO:0004843; F:ubiquitin-specific protease activity; IDA:UniProtKB.
									GO:0007610; P:behavior; ISS:UniProtKB.::GO:0016579; P:protein deubiquitination; IDA:UniProtKB.::GO:0032228; P:regulation of synaptic transmission, GABAergic; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
70	Q6NTR6	690	UP44A_XENLA Ubiquitin carboxyl-terminal hydro...	91	0.13	38.5	25	43	GO:0005634; C:nucleus; ISS:UniProtKB.
									GO:0004221; F:ubiquitin thiolesterase activity; ISS:UniProtKB.::GO:0004843; F:ubiquitin-specific protease activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
									GO:0051322; P:anaphase; ISS:UniProtKB.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0060564; P:negative regulation of mitotic anaphase-promoting complex activity; ISS:UniProtKB.::GO:0016579; P:protein deubiquitination; ISS:UniProtKB.::GO:0090231; P:regulation of spindle checkpoint; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
71	Q4R6D3	373	UBP50_MACFA Putative ubiquitin carboxyl-termi...	381	1e-30	125	28	45
									GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
72	Q9FPS9	924	UBP15_ARATH Ubiquitin carboxyl-terminal hydro...	333	2e-30	129	29	48	GO:0005737; C:cytoplasm; IDA:TAIR.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; IDA:TAIR.
									GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.::GO:0004843; F:ubiquitin-specific protease activity; IDA:TAIR.::GO:0008270; F:zinc ion binding; IEA:InterPro.
									GO:0008283; P:cell proliferation; IMP:TAIR.::GO:0009908; P:flower development; IMP:TAIR.::GO:0010154; P:fruit development; IMP:TAIR.::GO:0048366; P:leaf development; IMP:TAIR.::GO:0016579; P:protein deubiquitination; IDA:TAIR.::GO:0048364; P:root development; IMP:TAIR.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
73	A5WWB0	370	UBP46_DANRE Ubiquitin carboxyl-terminal hydro...	361	2e-30	124	29	45
									GO:0004221; F:ubiquitin thiolesterase activity; ISS:UniProtKB.::GO:0004843; F:ubiquitin-specific protease activity; ISS:UniProtKB.
									GO:0007610; P:behavior; ISS:UniProtKB.::GO:0016579; P:protein deubiquitination; ISS:UniProtKB.::GO:0032228; P:regulation of synaptic transmission, GABAergic; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
74	Q5XGZ2	690	UP44B_XENLA Ubiquitin carboxyl-terminal hydro...	91	0.13	38.5	25	43	GO:0005634; C:nucleus; ISS:UniProtKB.
									GO:0004221; F:ubiquitin thiolesterase activity; ISS:UniProtKB.::GO:0004843; F:ubiquitin-specific protease activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
									GO:0051322; P:anaphase; ISS:UniProtKB.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0060564; P:negative regulation of mitotic anaphase-promoting complex activity; ISS:UniProtKB.::GO:0016579; P:protein deubiquitination; ISS:UniProtKB.::GO:0090231; P:regulation of spindle checkpoint; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
75	Q2KHV7	606	UBP2_BOVIN Ubiquitin carboxyl-terminal hydrol...	360	6e-30	126	30	48	GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
									GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; ISS:UniProtKB.
									GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0045931; P:positive regulation of mitotic cell cycle; ISS:UniProtKB.::GO:0016579; P:protein deubiquitination; ISS:UniProtKB.::GO:0050821; P:protein stabilization; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
76	Q9FIQ1	732	UBP21_ARATH Ubiquitin carboxyl-terminal hydro...	342	7e-29	124	31	47
									GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
77	Q9UK80	565	UBP21_HUMAN Ubiquitin carboxyl-terminal hydro...	380	7e-29	122	28	44	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0019784; F:NEDD8-specific protease activity; IDA:UniProtKB.::GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.::GO:0004221; F:ubiquitin thiolesterase activity; IDA:UniProtKB.::GO:0004843; F:ubiquitin-specific protease activity; IDA:UniProtKB.
									GO:0016578; P:histone deubiquitination; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
78	Q2KJ72	565	UBP21_BOVIN Ubiquitin carboxyl-terminal hydro...	380	1e-28	122	28	44	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0019784; F:NEDD8-specific protease activity; ISS:UniProtKB.::GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.::GO:0004221; F:ubiquitin thiolesterase activity; ISS:UniProtKB.::GO:0004843; F:ubiquitin-specific protease activity; ISS:UniProtKB.
									GO:0016578; P:histone deubiquitination; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
79	Q6P8X6	390	UBP50_MOUSE Putative ubiquitin carboxyl-termi...	362	2e-28	119	28	43
									GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
80	B2GUX4	565	UBP21_RAT Ubiquitin carboxyl-terminal hydrola...	380	8e-28	119	28	44	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0019784; F:NEDD8-specific protease activity; ISS:UniProtKB.::GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.::GO:0004221; F:ubiquitin thiolesterase activity; ISS:UniProtKB.::GO:0004843; F:ubiquitin-specific protease activity; ISS:UniProtKB.
									GO:0016578; P:histone deubiquitination; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
81	Q9QZL6	566	UBP21_MOUSE Ubiquitin carboxyl-terminal hydro...	381	1e-27	119	28	44	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IC:UniProtKB.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0019784; F:NEDD8-specific protease activity; ISS:UniProtKB.::GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.::GO:0004221; F:ubiquitin thiolesterase activity; IDA:UniProtKB.::GO:0004843; F:ubiquitin-specific protease activity; ISS:UniProtKB.
									GO:0016578; P:histone deubiquitination; IDA:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
82	Q9HFS7	796	UBP4_KLULA Ubiquitin carboxyl-terminal hydrol...	377	3e-27	119	28	46	GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
									GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
83	Q754R5	848	UBP4_ASHGO Ubiquitin carboxyl-terminal hydrol...	376	3e-27	119	27	46	GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
									GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
84	O24454	371	UBP3_ARATH Ubiquitin carboxyl-terminal hydrol...	375	9e-27	114	27	43	GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
85	Q8LAM0	365	UBP4_ARATH Ubiquitin carboxyl-terminal hydrol...	367	9e-27	114	28	45	GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
86	A6ZY34	926	UBP4_YEAS7 Ubiquitin carboxyl-terminal hydrol...	385	1e-26	117	28	45	GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
									GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
87	P32571	926	UBP4_YEAST Ubiquitin carboxyl-terminal hydrol...	385	1e-26	117	28	45	GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.::GO:0000502; C:proteasome complex; IPI:SGD.
									GO:0004175; F:endopeptidase activity; IPI:SGD.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004221; F:ubiquitin thiolesterase activity; IMP:SGD.::GO:0004843; F:ubiquitin-specific protease activity; IDA:SGD.
									GO:0006897; P:endocytosis; IMP:SGD.::GO:0010995; P:free ubiquitin chain depolymerization; IDA:SGD.::GO:0016579; P:protein deubiquitination; TAS:SGD.::GO:0006275; P:regulation of DNA replication; IMP:SGD.::GO:0010992; P:ubiquitin homeostasis; IMP:SGD.::GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IMP:SGD.
88	B4HUI5	1059	UBP36_DROSE Ubiquitin carboxyl-terminal hydro...	335	1e-26	117	27	45	GO:0005730; C:nucleolus; ISS:UniProtKB.
									GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; ISS:UniProtKB.
									GO:0030718; P:germ-line stem cell maintenance; ISS:UniProtKB.::GO:0016579; P:protein deubiquitination; ISS:UniProtKB.::GO:0035019; P:somatic stem cell maintenance; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
89	P0C7H9	530	U17L7_HUMAN Inactive ubiquitin carboxyl-termi...	366	2e-26	115	27	46	GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
90	B3LGK1	926	UBP4_YEAS1 Ubiquitin carboxyl-terminal hydrol...	385	2e-26	116	28	45	GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
									GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
									GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
91	P34547	426	UBPX_CAEEL Probable ubiquitin carboxyl-termin...	402	3e-26	113	27	41	GO:0044297; C:cell body; IDA:WormBase.::GO:0005768; C:endosome; IDA:WormBase.
									GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.::GO:0035255; F:ionotropic glutamate receptor binding; IPI:WormBase.::GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
									GO:0040027; P:negative regulation of vulval development; IMP:WormBase.::GO:0071947; P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:WormBase.::GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; IMP:WormBase.

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