Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YMR217W
Length:
525
Number of sequences:
5887
Description:
YMR217W GUA1 SGDID:S000004830, Chr XIII from 701790-703367, Genome Release 64-1-1, Verified ORF, "GMP synthase; highly conserved enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation; reduction-of-function mutation gua1-G388D causes changes in cellular guanine nucleotide pools, defects in general protein synthesis, and impaired translation of GCN4 mRNA"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
961B5Y8Q4    296   NADE_COPPD NH(3)-dependent NAD(+) synthetase ...391.4     35     44     56
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003952; F:NAD+ synthase (glutamine-hydrolyzing) activity; IEA:InterPro.::GO:0008795; F:NAD+ synthase activity; IEA:EC.
GO:0009435; P:NAD biosynthetic process; IEA:InterPro.
962Q9PMG8    372   CARA_CAMJE Carbamoyl-phosphate synthase small...1941.4     35     24     42
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC.
GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0070409; P:carbamoyl phosphate biosynthetic process; IEA:InterPro.::GO:0006543; P:glutamine catabolic process; IEA:InterPro.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
963P07333    972   CSF1R_HUMAN Macrophage colony-stimulating fac...1551.4     35.4     23     39GO:0009986; C:cell surface; ISS:UniProtKB.::GO:0005887; C:integral to plasma membrane; TAS:ProtInc.::GO:0043235; C:receptor complex; ISS:BHF-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0019955; F:cytokine binding; IDA:UniProtKB.::GO:0005011; F:macrophage colony-stimulating factor receptor activity; IMP:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:BHF-UCL.
GO:0008283; P:cell proliferation; IMP:UniProtKB.::GO:0045217; P:cell-cell junction maintenance; IMP:UniProtKB.::GO:0036006; P:cellular response to macrophage colony-stimulating factor stimulus; IMP:UniProtKB.::GO:0019221; P:cytokine-mediated signaling pathway; IMP:UniProtKB.::GO:0006954; P:inflammatory response; TAS:UniProtKB.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0030225; P:macrophage differentiation; TAS:UniProtKB.::GO:0060603; P:mammary gland duct morphogenesis; TAS:UniProtKB.::GO:0030224; P:monocyte differentiation; TAS:UniProtKB.::GO:0030316; P:osteoclast differentiation; ISS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0046488; P:phosphatidylinositol metabolic process; ISS:UniProtKB.::GO:0048015; P:phosphatidylinositol-mediated signaling; ISS:UniProtKB.::GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.::GO:0090197; P:positive regulation of chemokine secretion; IMP:UniProtKB.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0071902; P:positive regulation of protein serine/threonine kinase activity; ISS:UniProtKB.::GO:0061098; P:positive regulation of protein tyrosine kinase activity; IMP:UniProtKB.::GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:2000249; P:regulation of actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0045124; P:regulation of bone resorption; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; IMP:UniProtKB.::GO:0031529; P:ruffle organization; ISS:UniProtKB.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; ISS:UniProtKB.
964Q57929    196   HIS5_METJA Imidazole glycerol phosphate synth...1351.7     34.3     26     43GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016763; F:transferase activity, transferring pentosyl groups; IEA:InterPro.
GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.
965Q820D2    212   HIS5_NITEU Imidazole glycerol phosphate synth...2161.8     34.3     23     41GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016763; F:transferase activity, transferring pentosyl groups; IEA:InterPro.
GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.
966Q8KGA2    366   CARA_CHLTE Carbamoyl-phosphate synthase small...1411.8     34.7     26     43
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC.
GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0070409; P:carbamoyl phosphate biosynthetic process; IEA:InterPro.::GO:0006543; P:glutamine catabolic process; IEA:InterPro.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
967Q96YL5    279   NADE_SULTO NH(3)-dependent NAD(+) synthetase ...311.9     34.7     42     68
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003952; F:NAD+ synthase (glutamine-hydrolyzing) activity; IEA:InterPro.::GO:0008795; F:NAD+ synthase activity; IEA:EC.
GO:0009435; P:NAD biosynthetic process; IEA:InterPro.
968Q5WDI0    207   HIS5_BACSK Imidazole glycerol phosphate synth...1542     34.3     27     38GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016763; F:transferase activity, transferring pentosyl groups; IEA:InterPro.
GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.
969A8FWC9    218   HIS5_SHESH Imidazole glycerol phosphate synth...1322.2     33.9     24     39GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016763; F:transferase activity, transferring pentosyl groups; IEA:InterPro.
GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.
970Q31G65    420   TILS_THICR tRNA(Ile)-lysidine synthase OS=Thi...792.5     34.3     27     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0016879; F:ligase activity, forming carbon-nitrogen bonds; IEA:InterPro.
GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
971B4SEZ8    277   NADE_PELPB NH(3)-dependent NAD(+) synthetase ...1922.6     33.9     23     40
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003952; F:NAD+ synthase (glutamine-hydrolyzing) activity; IEA:InterPro.::GO:0008795; F:NAD+ synthase activity; IEA:EC.
GO:0009435; P:NAD biosynthetic process; IEA:InterPro.
972P14952    91   TRPG_CLOTM Anthranilate synthase component 2 ...932.6     32     28     49
GO:0004049; F:anthranilate synthase activity; IEA:EC.
GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.::GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-KW.
973Q18E36    397   ASSY_HALWD Argininosuccinate synthase OS=Halo...662.8     34.3     38     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004055; F:argininosuccinate synthase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.
974A7Z964    212   HIS5_BACA2 Imidazole glycerol phosphate synth...1393     33.5     25     39GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016763; F:transferase activity, transferring pentosyl groups; IEA:InterPro.
GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.
975A5FHA9    395   MNMA_FLAJ1 tRNA-specific 2-thiouridylase MnmA...783.1     34.3     37     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0016783; F:sulfurtransferase activity; IEA:InterPro.::GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
976Q5UNX1    205   YL716_MIMIV Putative glutamine amidotransfera...983.2     33.5     27     43
GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
977P73846    268   Y1717_SYNY3 Uncharacterized protein slr1717 O...2413.2     33.9     23     42
978Q8KEX2    277   NADE_CHLTE NH(3)-dependent NAD(+) synthetase ...1893.5     33.5     24     41
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003952; F:NAD+ synthase (glutamine-hydrolyzing) activity; IEA:InterPro.::GO:0008795; F:NAD+ synthase activity; IEA:EC.
GO:0009435; P:NAD biosynthetic process; IEA:InterPro.
979Q9X0Y0    576   NADE2_THEMA Probable glutamine-dependent NAD(...764     33.9     29     53
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0016810; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; IEA:InterPro.::GO:0003952; F:NAD+ synthase (glutamine-hydrolyzing) activity; IEA:EC.
GO:0009435; P:NAD biosynthetic process; IEA:InterPro.
980P57204    196   HIS5_BUCAI Imidazole glycerol phosphate synth...1284     33.1     29     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016763; F:transferase activity, transferring pentosyl groups; IEA:InterPro.
GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.
981B3E4K8    273   NADE_GEOLS NH(3)-dependent NAD(+) synthetase ...1904.1     33.5     21     39
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003952; F:NAD+ synthase (glutamine-hydrolyzing) activity; IEA:InterPro.::GO:0008795; F:NAD+ synthase activity; IEA:EC.
GO:0009435; P:NAD biosynthetic process; IEA:InterPro.
982Q1MPN3    376   CARA_LAWIP Carbamoyl-phosphate synthase small...1805     33.5     26     42
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC.
GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0070409; P:carbamoyl phosphate biosynthetic process; IEA:InterPro.::GO:0006543; P:glutamine catabolic process; IEA:InterPro.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
983B3QM51    277   NADE_CHLP8 NH(3)-dependent NAD(+) synthetase ...1965.3     33.1     26     41
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003952; F:NAD+ synthase (glutamine-hydrolyzing) activity; IEA:InterPro.::GO:0008795; F:NAD+ synthase activity; IEA:EC.
GO:0009435; P:NAD biosynthetic process; IEA:InterPro.
984Q5NMD4    213   HIS5_ZYMMO Imidazole glycerol phosphate synth...2065.6     32.7     24     38GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016763; F:transferase activity, transferring pentosyl groups; IEA:InterPro.
GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.
985B2IUR7    224   QUEC_NOSP7 7-cyano-7-deazaguanine synthase OS...345.8     32.7     41     59
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008616; P:queuosine biosynthetic process; IEA:UniProtKB-KW.
986B3ELE3    277   NADE_CHLPB NH(3)-dependent NAD(+) synthetase ...1906.6     32.7     25     41
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003952; F:NAD+ synthase (glutamine-hydrolyzing) activity; IEA:InterPro.::GO:0008795; F:NAD+ synthase activity; IEA:EC.
GO:0009435; P:NAD biosynthetic process; IEA:InterPro.
987Q58742    232   QUEC_METJA 7-cyano-7-deazaguanine synthase OS...597.9     32.3     37     53
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
988E4TJ18    517   SECD_CALNY Protein translocase subunit SecD O...507.9     32.7     36     56GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0015450; F:P-P-bond-hydrolysis-driven protein transmembrane transporter activity; IEA:InterPro.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
989Q8R883    203   HIS5_THETN Imidazole glycerol phosphate synth...1268.6     32     27     43GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016763; F:transferase activity, transferring pentosyl groups; IEA:InterPro.
GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.
records
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