UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YMR015C

Length:

538

Number of sequences:

5887

Description:

YMR015C ERG5 SGDID:S000004617, Chr XIII from 302485-300869, Genome Release 64-1-1, reverse complement, Verified ORF, "C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	P54781	538	ERG5_YEAST Cytochrome P450 61 OS=Saccharomyce...	538	0	1121	100	100	GO:0005783; C:endoplasmic reticulum; IDA:SGD.
									GO:0000249; F:C-22 sterol desaturase activity; IDA:SGD.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:InterPro.
									GO:0006696; P:ergosterol biosynthetic process; IDA:SGD.
2	O13820	543	ERG5_SCHPO Cytochrome P450 61 OS=Schizosaccha...	488	3e-178	520	51	69	GO:0005783; C:endoplasmic reticulum; ISS:PomBase.
									GO:0000249; F:C-22 sterol desaturase activity; ISS:PomBase.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:PomBase.
									GO:0006696; P:ergosterol biosynthetic process; IMP:PomBase.::GO:0090002; P:establishment of protein localization in plasma membrane; IMP:PomBase.::GO:0071210; P:protein insertion into membrane raft; IMP:PomBase.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.
3	Q55EK2	532	C524A_DICDI Probable cytochrome P450 524A1 OS...	487	5e-66	229	31	51	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
4	O64697	495	C7101_ARATH Cytochrome P450 710A1 OS=Arabidop...	500	9e-54	195	28	49	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0000249; F:C-22 sterol desaturase activity; IDA:TAIR.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
									GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
5	Q9ZV28	493	C7104_ARATH Cytochrome P450 710A1 OS=Arabidop...	476	4e-52	190	29	49	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0000249; F:C-22 sterol desaturase activity; IDA:UniProtKB.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
									GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
6	O64698	499	C7102_ARATH Cytochrome P450 710A2 OS=Arabidop...	498	2e-50	186	27	47	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0000249; F:C-22 sterol desaturase activity; IDA:TAIR.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
									GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
7	Q9VS79	463	CP4D8_DROME Cytochrome P450 4d8 OS=Drosophila...	467	6e-25	111	25	43	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
									GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
8	P79739	492	CP26A_DANRE Cytochrome P450 26A1 OS=Danio rer...	379	2e-24	110	25	49	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
									GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
9	Q9FMA5	465	C85A1_ARATH Cytochrome P450 85A1 OS=Arabidops...	463	5e-23	105	25	42	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IDA:TAIR.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
									GO:0016132; P:brassinosteroid biosynthetic process; IDA:TAIR.::GO:0010268; P:brassinosteroid homeostasis; IEP:TAIR.
10	O09158	503	CP3AP_MOUSE Cytochrome P450 3A25 OS=Mus muscu...	516	2e-21	101	23	41	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
									GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.
11	Q964T2	533	CP9E2_BLAGE Cytochrome P450 9e2 OS=Blattella ...	181	2e-21	101	33	55	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
									GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
12	Q940V4	465	C85A2_ARATH Cytochrome P450 85A2 OS=Arabidops...	469	3e-21	100	26	42	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IDA:TAIR.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
									GO:0016132; P:brassinosteroid biosynthetic process; IDA:TAIR.
13	Q29496	503	CP3AO_SHEEP Cytochrome P450 3A24 OS=Ovis arie...	390	4e-21	100	26	45	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
									GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.
14	P11707	501	CP3A6_RABIT Cytochrome P450 3A6 OS=Oryctolagu...	388	7e-21	99.4	25	44	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
									GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.
15	Q0J185	500	ABAH3_ORYSJ Abscisic acid 8'-hydroxylase 3 OS...	476	1e-20	98.6	23	40	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0010295; F:(+)-abscisic acid 8'-hydroxylase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.
16	A2Z212	500	ABAH3_ORYSI Abscisic acid 8'-hydroxylase 3 OS...	487	2e-20	98.2	23	40	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0010295; F:(+)-abscisic acid 8'-hydroxylase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.
17	Q9PUB4	492	CP26A_CHICK Cytochrome P450 26A1 OS=Gallus ga...	385	2e-20	98.2	24	46	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
									GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
									GO:0034653; P:retinoic acid catabolic process; IDA:MGI.
18	Q64459	504	CP3AB_MOUSE Cytochrome P450 3A11 OS=Mus muscu...	394	4e-20	97.4	26	44	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IDA:MGI.
									GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.
19	O48786	520	C734A_ARATH Cytochrome P450 734A1 OS=Arabidop...	528	5e-20	97.1	24	41	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.::GO:0008395; F:steroid hydroxylase activity; IMP:TAIR.
									GO:0010268; P:brassinosteroid homeostasis; IEP:TAIR.::GO:0016131; P:brassinosteroid metabolic process; IDA:TAIR.::GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.::GO:0009741; P:response to brassinosteroid stimulus; IEP:TAIR.::GO:0009416; P:response to light stimulus; IGI:TAIR.
20	Q64148	503	CP3AA_MESAU Lithocholate 6-beta-hydroxylase O...	396	6e-20	96.7	25	45	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
									GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0033777; F:lithocholate 6beta-hydroxylase activity; IEA:EC.::GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
21	Q43147	464	C85A1_SOLLC Cytochrome P450 85A1 OS=Solanum l...	472	1e-19	95.5	24	42	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
									GO:0016132; P:brassinosteroid biosynthetic process; IEA:UniProtKB-KW.
22	Q9V675	519	CP6G2_DROME Probable cytochrome P450 6g2 OS=D...	420	1e-19	95.5	24	45	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
									GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
23	Q64581	497	CP3AI_RAT Cytochrome P450 3A18 OS=Rattus norv...	384	2e-19	95.1	24	43	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
									GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0008390; F:testosterone 16-alpha-hydroxylase activity; IDA:RGD.::GO:0050649; F:testosterone 6-beta-hydroxylase activity; IDA:RGD.
24	O43174	497	CP26A_HUMAN Cytochrome P450 26A1 OS=Homo sapi...	382	2e-19	95.1	23	44	GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0005792; C:microsome; IDA:BHF-UCL.
									GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; NAS:BHF-UCL.::GO:0019825; F:oxygen binding; TAS:ProtInc.::GO:0008401; F:retinoic acid 4-hydroxylase activity; IDA:BHF-UCL.::GO:0001972; F:retinoic acid binding; IDA:BHF-UCL.
									GO:0048387; P:negative regulation of retinoic acid receptor signaling pathway; TAS:BHF-UCL.::GO:0034653; P:retinoic acid catabolic process; IDA:BHF-UCL.::GO:0006805; P:xenobiotic metabolic process; TAS:Reactome.
25	Q9FH76	463	ABAH3_ARATH Abscisic acid 8'-hydroxylase 3 OS...	428	7e-19	93.2	23	42	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0010295; F:(+)-abscisic acid 8'-hydroxylase activity; IDA:TAIR.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.
									GO:0046345; P:abscisic acid catabolic process; TAS:TAIR.::GO:0009639; P:response to red or far red light; IEP:TAIR.::GO:0009414; P:response to water deprivation; IMP:TAIR.
26	O46051	507	C4D14_DROME Probable cytochrome P450 4d14 OS=...	254	7e-19	93.2	26	46	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
									GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
27	P20815	502	CP3A5_HUMAN Cytochrome P450 3A5 OS=Homo sapie...	405	9e-19	93.2	25	43	GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0005792; C:microsome; TAS:ProtInc.
									GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0019825; F:oxygen binding; TAS:ProtInc.
									GO:0009822; P:alkaloid catabolic process; IDA:BHF-UCL.::GO:0042737; P:drug catabolic process; IDA:BHF-UCL.::GO:0070989; P:oxidative demethylation; IDA:BHF-UCL.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0008202; P:steroid metabolic process; TAS:ProtInc.::GO:0006805; P:xenobiotic metabolic process; TAS:Reactome.
28	Q9HB55	503	CP343_HUMAN Cytochrome P450 3A43 OS=Homo sapi...	236	9e-19	93.2	30	50	GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
									GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.
									GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0006805; P:xenobiotic metabolic process; TAS:Reactome.
29	P08684	503	CP3A4_HUMAN Cytochrome P450 3A4 OS=Homo sapie...	235	1e-18	92.8	27	51	GO:0009986; C:cell surface; IDA:UniProtKB.::GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:BHF-UCL.
									GO:0047638; F:albendazole monooxygenase activity; IEA:EC.::GO:0034875; F:caffeine oxidase activity; IDA:BHF-UCL.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0019899; F:enzyme binding; IPI:BHF-UCL.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro.::GO:0019825; F:oxygen binding; TAS:ProtInc.::GO:0050591; F:quinine 3-monooxygenase activity; IEA:EC.::GO:0005496; F:steroid binding; IDA:BHF-UCL.::GO:0033780; F:taurochenodeoxycholate 6alpha-hydroxylase activity; IEA:EC.::GO:0050649; F:testosterone 6-beta-hydroxylase activity; IMP:BHF-UCL.::GO:0070576; F:vitamin D 24-hydroxylase activity; IDA:BHF-UCL.::GO:0030343; F:vitamin D3 25-hydroxylase activity; IDA:BHF-UCL.
									GO:0009822; P:alkaloid catabolic process; IDA:BHF-UCL.::GO:0008209; P:androgen metabolic process; TAS:BHF-UCL.::GO:0042738; P:exogenous drug catabolic process; IDA:BHF-UCL.::GO:0046483; P:heterocycle metabolic process; IDA:BHF-UCL.::GO:0016098; P:monoterpenoid metabolic process; IDA:BHF-UCL.::GO:0070989; P:oxidative demethylation; IDA:BHF-UCL.::GO:0006706; P:steroid catabolic process; IMP:BHF-UCL.::GO:0042359; P:vitamin D metabolic process; IC:BHF-UCL.::GO:0006805; P:xenobiotic metabolic process; TAS:Reactome.
30	Q64481	504	CP3AG_MOUSE Cytochrome P450 3A16 OS=Mus muscu...	350	1e-18	92.4	27	45	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell.
									GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.
31	P49602	561	CP51_USTMA Lanosterol 14-alpha demethylase OS...	368	2e-18	92.4	22	40	GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
									GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0008398; F:sterol 14-demethylase activity; IEA:EC.
									GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.

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