Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YML126C
Length:
491
Number of sequences:
5887
Description:
YML126C ERG13 SGDID:S000004595, Chr XIII from 20535-19060, Genome Release 64-1-1, reverse complement, Verified ORF, "3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P54839    491   HMCS_YEAST Hydroxymethylglutaryl-CoA synthase...4910     1020     100     100
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IMP:SGD.
GO:0006696; P:ergosterol biosynthetic process; IMP:SGD.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
2P54874    447   HMCS_SCHPO Hydroxymethylglutaryl-CoA synthase...4480     550     61     74GO:0005829; C:cytosol; IDA:PomBase.::GO:0005783; C:endoplasmic reticulum; IC:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IMP:PomBase.
GO:0006084; P:acetyl-CoA metabolic process; IMP:PomBase.::GO:0006696; P:ergosterol biosynthetic process; IMP:PomBase.::GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; IMP:PomBase.::GO:0070317; P:negative regulation of G0 to G1 transition; IMP:PomBase.
3P54872    482   HMCSA_DICDI Hydroxymethylglutaryl-CoA synthas...4578e-150     444     49     67
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC.
GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
4Q8JZK9    520   HMCS1_MOUSE Hydroxymethylglutaryl-CoA synthas...4573e-147     438     49     66GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
5P17425    520   HMCS1_RAT Hydroxymethylglutaryl-CoA synthase,...4571e-146     437     49     66GO:0005829; C:cytosol; IDA:RGD.
GO:0008144; F:drug binding; IDA:RGD.::GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IDA:RGD.::GO:0016853; F:isomerase activity; IDA:RGD.::GO:0043177; F:organic acid binding; IDA:RGD.::GO:0042803; F:protein homodimerization activity; IDA:RGD.
GO:0007420; P:brain development; IEP:RGD.::GO:0071397; P:cellular response to cholesterol; IEP:RGD.::GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEP:RGD.::GO:0071407; P:cellular response to organic cyclic compound; IEP:RGD.::GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0001889; P:liver development; IEP:RGD.::GO:0008584; P:male gonad development; IEP:RGD.::GO:0001101; P:response to acid; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0055094; P:response to lipoprotein stimulus; IEP:RGD.::GO:0009645; P:response to low light intensity stimulus; IEP:RGD.::GO:0010243; P:response to organic nitrogen; IDA:RGD.::GO:0014074; P:response to purine-containing compound; IEP:RGD.::GO:0046690; P:response to tellurium ion; IEP:RGD.::GO:0033197; P:response to vitamin E; IEP:RGD.
6Q5R7Z9    520   HMCS1_PONAB Hydroxymethylglutaryl-CoA synthas...4572e-146     436     49     66GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
7Q01581    520   HMCS1_HUMAN Hydroxymethylglutaryl-CoA synthas...4574e-146     436     49     66GO:0005829; C:cytosol; TAS:Reactome.::GO:0005625; C:soluble fraction; TAS:ProtInc.
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; TAS:ProtInc.
GO:0006695; P:cholesterol biosynthetic process; TAS:Reactome.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
8P54961    453   HMCS1_BLAGE Hydroxymethylglutaryl-CoA synthas...4614e-145     431     48     68
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC.
GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
9P13704    520   HMCS1_CRIGR Hydroxymethylglutaryl-CoA synthas...4574e-144     431     49     65GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
10P23228    522   HMCS1_CHICK Hydroxymethylglutaryl-CoA synthas...4572e-143     429     49     66GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
11P54869    508   HMCS2_MOUSE Hydroxymethylglutaryl-CoA synthas...4632e-139     418     45     66GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
12P54868    508   HMCS2_HUMAN Hydroxymethylglutaryl-CoA synthas...4633e-139     417     45     65GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0046951; P:ketone body biosynthetic process; TAS:Reactome.
13P54873    461   HMCS_ARATH Hydroxymethylglutaryl-CoA synthase...4582e-138     414     48     64GO:0005829; C:cytosol; IDA:TAIR.::GO:0009506; C:plasmodesma; IDA:TAIR.
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IGI:TAIR.
GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; TAS:TAIR.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
14Q2KIE6    508   HMCS2_BOVIN Hydroxymethylglutaryl-CoA synthas...4633e-138     415     46     65
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
15P22791    508   HMCS2_RAT Hydroxymethylglutaryl-CoA synthase,...4897e-138     414     43     64GO:0005759; C:mitochondrial matrix; IDA:RGD.
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IDA:RGD.
GO:0060612; P:adipose tissue development; IEP:RGD.::GO:0007420; P:brain development; IEP:RGD.::GO:0071230; P:cellular response to amino acid stimulus; IEP:RGD.::GO:0071398; P:cellular response to fatty acid; IEP:RGD.::GO:0071385; P:cellular response to glucocorticoid stimulus; IEP:RGD.::GO:0032869; P:cellular response to insulin stimulus; IEP:RGD.::GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.::GO:0071407; P:cellular response to organic cyclic compound; IEP:RGD.::GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0046951; P:ketone body biosynthetic process; IEP:RGD.::GO:0001822; P:kidney development; IEP:RGD.::GO:0001889; P:liver development; IEP:RGD.::GO:0030324; P:lung development; IEP:RGD.::GO:0007494; P:midgut development; IEP:RGD.::GO:0033555; P:multicellular organismal response to stress; IEP:RGD.::GO:0051591; P:response to cAMP; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0045471; P:response to ethanol; IEP:RGD.::GO:0033762; P:response to glucagon stimulus; IEP:RGD.::GO:0060416; P:response to growth hormone stimulus; IEP:RGD.::GO:0070543; P:response to linoleic acid; IEP:RGD.::GO:0010038; P:response to metal ion; IEP:RGD.::GO:0034284; P:response to monosaccharide stimulus; IEP:RGD.::GO:0007584; P:response to nutrient; IEP:RGD.::GO:0034696; P:response to prostaglandin F stimulus; IEP:RGD.::GO:0042594; P:response to starvation; IEP:RGD.::GO:0009266; P:response to temperature stimulus; IEP:RGD.::GO:0033574; P:response to testosterone stimulus; IEP:RGD.::GO:0034014; P:response to triglyceride; IEP:RGD.
16O02734    508   HMCS2_PIG Hydroxymethylglutaryl-CoA synthase,...4631e-137     413     45     65
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
17Q86HL5    468   HMCSB_DICDI Hydroxymethylglutaryl-CoA synthas...4699e-136     407     47     64
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC.
GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
18P54870    455   HMCS2_BLAGE Hydroxymethylglutaryl-CoA synthas...4521e-132     399     48     64
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC.
GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
19P54871    462   HMCS_CAEEL Hydroxymethylglutaryl-CoA synthase...4532e-89     288     40     57
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC.
GO:0010171; P:body morphogenesis; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0018996; P:molting cycle, collagen and cuticulin-based cuticle; IMP:WormBase.::GO:0002009; P:morphogenesis of an epithelium; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0006898; P:receptor-mediated endocytosis; IMP:WormBase.::GO:0000003; P:reproduction; IMP:WormBase.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
20P40830    420   PKSG_BACSU Polyketide biosynthesis 3-hydroxy-...4130.000000000000009     79.7     22     38GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.
GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
21A5UNI8    345   Y1561_METS3 UPF0219 protein Msm_1561 OS=Metha...3700.000000005     61.6     22     37
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro.
GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
22O30256    343   Y2415_ARCFU UPF0219 protein AF_2415 OS=9628 /...3890.00000002     59.7     21     37
GO:0004315; F:3-oxoacyl-[acyl-carrier-protein synthase activity; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.]
23Q4J933    348   Y1362_SULAC UPF0219 protein Saci_1362 OS=NBRC...2670.0000002     56.6     26     42
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro.
GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
24A1RSQ5    350   Y811_PYRIL UPF0219 protein Pisl_0811 OS=Pyrob...3740.0000003     55.8     23     38
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro.
GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
25Q46F10    349   Y551_METBF UPF0219 protein Mbar_A0551 OS=Meth...3990.0000003     55.8     22     35
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro.
GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
26C5A401    350   Y461_THEGJ UPF0219 protein TGAM_0461 OS=Therm...2740.0000005     55.5     26     38
GO:0004315; F:3-oxoacyl-[acyl-carrier-protein synthase activity; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.]
27O26883    346   Y792_METTH UPF0219 protein MTH_792 OS=thermoa...2780.0000006     55.1     24     38
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro.
GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
28Q8TVL0    350   Y1379_METKA UPF0219 protein MK1379 OS=100938)...3820.000001     54.3     22     36
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro.
GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
29Q2NHU7    346   Y117_METST UPF0219 protein Msp_0117 OS=Methan...3920.000002     53.1     21     36
GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro.
GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
30Q51798    350   Y972_PYRFU UPF0219 protein PF0972 OS=Pyrococc...2730.000003     53.1     25     38
GO:0004315; F:3-oxoacyl-[acyl-carrier-protein synthase activity; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.]
31O58410    350   Y677_PYRHO UPF0219 protein PH0677 OS=NBRC 100...2720.000005     52.4     25     36
GO:0004315; F:3-oxoacyl-[acyl-carrier-protein synthase activity; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.]
records
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