UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YML075C

Length:

1054

Number of sequences:

5887

Description:

YML075C HMG1 SGDID:S000004540, Chr XIII from 118898-115734, Genome Release 64-1-1, reverse complement, Verified ORF, "One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
31	P48020	596	HMDH1_SOLTU 3-hydroxy-3-methylglutaryl-coenzy...	410	2e-156	483	58	75	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
32	Q00583	586	HMDH3_HEVBR 3-hydroxy-3-methylglutaryl-coenzy...	416	3e-156	483	57	75	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0042170; C:plastid membrane; IEA:UniProtKB-SubCell.
									GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
33	P48022	602	HMDH2_SOLLC 3-hydroxy-3-methylglutaryl-coenzy...	434	9e-156	482	55	74	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
34	Q03163	601	HMDH_CATRO 3-hydroxy-3-methylglutaryl-coenzym...	427	9e-156	482	55	74	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
35	P14891	592	HMDH1_ARATH 3-hydroxy-3-methylglutaryl-coenzy...	411	3e-155	480	57	76	GO:0005789; C:endoplasmic reticulum membrane; IDA:TAIR.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0042282; F:hydroxymethylglutaryl-CoA reductase activity; IDA:TAIR.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:TAIR.
									GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IDA:TAIR.::GO:0060964; P:regulation of gene silencing by miRNA; IMP:TAIR.::GO:0016126; P:sterol biosynthetic process; IMP:TAIR.
36	P34135	552	HMDH1_DICDI 3-hydroxy-3-methylglutaryl-coenzy...	414	3e-152	471	56	74	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:InterPro.
									GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
37	P43256	562	HMDH2_ARATH 3-hydroxy-3-methylglutaryl-coenzy...	410	6e-152	471	57	73	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:TAIR.
									GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IMP:TAIR.::GO:0016104; P:triterpenoid biosynthetic process; IMP:TAIR.
38	Q41437	595	HMDH2_SOLTU 3-hydroxy-3-methylglutaryl-coenzy...	411	1e-151	471	56	75	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
39	A2X8W3	539	HMDH1_ORYSI 3-hydroxy-3-methylglutaryl-coenzy...	425	4e-151	468	57	72	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
40	Q0DY59	532	HMDH1_ORYSJ 3-hydroxy-3-methylglutaryl-coenzy...	425	9e-151	466	57	72	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
41	O76819	833	HMDH_AGRIP 3-hydroxy-3-methylglutaryl-coenzym...	527	6e-144	459	48	64	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
42	P14773	920	HMDH_DROME 3-hydroxy-3-methylglutaryl-coenzym...	869	9e-141	452	36	55	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0018990; P:ecdysis, chitin-based cuticle; IMP:FlyBase.::GO:0035050; P:embryonic heart tube development; IMP:FlyBase.::GO:0035232; P:germ cell attraction; TAS:FlyBase.::GO:0008406; P:gonad development; TAS:FlyBase.::GO:0008299; P:isoprenoid biosynthetic process; TAS:FlyBase.::GO:0007626; P:locomotory behavior; IMP:FlyBase.::GO:0007280; P:pole cell migration; IMP:UniProtKB.
43	P16237	948	HMDH_SCHMA 3-hydroxy-3-methylglutaryl-coenzym...	590	4e-120	398	42	58	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
									GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
44	O59469	413	HMDH_PYRHO 3-hydroxy-3-methylglutaryl-coenzym...	425	7e-98	322	44	63	GO:0016021; C:integral to membrane; IEA:InterPro.
									GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
45	Q9V1R3	408	HMDH_PYRAB 3-hydroxy-3-methylglutaryl-coenzym...	408	1e-95	315	44	63	GO:0016021; C:integral to membrane; IEA:InterPro.
									GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
46	O26662	397	HMDH_METTH 3-hydroxy-3-methylglutaryl-coenzym...	401	2e-91	304	43	62	GO:0016021; C:integral to membrane; IEA:InterPro.
									GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
47	Q9YAS4	421	HMDH_AERPE 3-hydroxy-3-methylglutaryl-coenzym...	418	3e-87	293	45	62	GO:0016021; C:integral to membrane; IEA:InterPro.
									GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
48	O08424	409	HMDH_SULSO 3-hydroxy-3-methylglutaryl-coenzym...	416	8e-84	283	40	61	GO:0016021; C:integral to membrane; IEA:InterPro.
									GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
49	Q59468	403	HMDH_HALVD 3-hydroxy-3-methylglutaryl-coenzym...	407	9e-84	283	44	59	GO:0016021; C:integral to membrane; IEA:InterPro.
									GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
50	P29058	210	HMDH2_HEVBR 3-hydroxy-3-methylglutaryl-coenzy...	206	3e-80	266	64	82	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0042170; C:plastid membrane; IEA:UniProtKB-SubCell.
									GO:0050662; F:coenzyme binding; IEA:InterPro.::GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.
									GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
51	Q58116	405	HMDH_METJA 3-hydroxy-3-methylglutaryl-coenzym...	408	9e-75	258	40	57	GO:0016021; C:integral to membrane; IEA:InterPro.
									GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
									GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
52	O51628	431	HMDH_BORBU Probable 3-hydroxy-3-methylglutary...	77	0.0004	47.8	32	55
									GO:0050662; F:coenzyme binding; IEA:InterPro.::GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.::GO:0042282; F:hydroxymethylglutaryl-CoA reductase activity; IEA:EC.
									GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
53	B1WB17	200	WIBG_XENTR Partner of Y14 and mago OS=Xenopus...	58	0.27	37.7	31	60	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0035145; C:exon-exon junction complex; ISS:UniProtKB.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.::GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
									GO:0043022; F:ribosome binding; ISS:UniProtKB.
									GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.::GO:0045727; P:positive regulation of translation; ISS:UniProtKB.
54	O28538	436	HMDH_ARCFU 3-hydroxy-3-methylglutaryl-coenzym...	32	0.49	37.7	53	63
									GO:0050662; F:coenzyme binding; IEA:InterPro.::GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.
									GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
55	O35305	625	TNR11_MOUSE Tumor necrosis factor receptor su...	139	0.55	37.7	22	41	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005031; F:tumor necrosis factor-activated receptor activity; IMP:BHF-UCL.
									GO:0060086; P:circadian temperature homeostasis; IMP:BHF-UCL.::GO:0048535; P:lymph node development; IMP:MGI.::GO:0060749; P:mammary gland alveolus development; IMP:MGI.::GO:0001503; P:ossification; IMP:MGI.::GO:0071812; P:positive regulation of fever generation by positive regulation of prostaglandin secretion; IMP:BHF-UCL.::GO:0070555; P:response to interleukin-1; IMP:BHF-UCL.::GO:0032496; P:response to lipopolysaccharide; IMP:BHF-UCL.
56	Q5MNU5	1279	SCAP_PIG Sterol regulatory element-binding pr...	239	0.81	37.4	21	44	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
57	A6QM06	1278	SCAP_BOVIN Sterol regulatory element-binding ...	188	1	37.4	21	46	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
58	Q12770	1279	SCAP_HUMAN Sterol regulatory element-binding ...	188	1.1	37	21	46	GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; NAS:UniProtKB.
									GO:0051082; F:unfolded protein binding; NAS:UniProtKB.
									GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0045541; P:negative regulation of cholesterol biosynthetic process; NAS:UniProtKB.::GO:0045716; P:positive regulation of low-density lipoprotein particle receptor biosynthetic process; NAS:UniProtKB.::GO:0006994; P:positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway; IMP:UniProtKB.
59	Q6GQT6	1276	SCAP_MOUSE Sterol regulatory element-binding ...	243	1.2	37	21	43	GO:0005789; C:endoplasmic reticulum membrane; IDA:MGI.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0015485; F:cholesterol binding; TAS:MGI.::GO:0005515; F:protein binding; IPI:MGI.
									GO:0008203; P:cholesterol metabolic process; IDA:MGI.::GO:0045540; P:regulation of cholesterol biosynthetic process; IMP:MGI.::GO:0042304; P:regulation of fatty acid biosynthetic process; IMP:MGI.::GO:0001666; P:response to hypoxia; IMP:MGI.::GO:0032868; P:response to insulin stimulus; IMP:MGI.
60	Q640E9	199	WIBG_XENLA Partner of Y14 and mago OS=Xenopus...	58	1.7	35.4	29	59	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0035145; C:exon-exon junction complex; ISS:UniProtKB.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.::GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
									GO:0043022; F:ribosome binding; ISS:UniProtKB.
									GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; ISS:UniProtKB.::GO:0045727; P:positive regulation of translation; ISS:UniProtKB.
61	P21852	567	PHNL_DESVM Periplasmic [NiFe] hydrogenase lar...	66	1.9	36.2	33	55	GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
									GO:0047806; F:cytochrome-c3 hydrogenase activity; IEA:EC.::GO:0008901; F:ferredoxin hydrogenase activity; IEA:InterPro.::GO:0016151; F:nickel cation binding; IEA:InterPro.

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