Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLR450W
Length:
1045
Number of sequences:
5887
Description:
YLR450W HMG2 SGDID:S000004442, Chr XII from 1032627-1035764, Genome Release 64-1-1, Verified ORF, "One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31P48021    593   HMDH_CAMAC 3-hydroxy-3-methylglutaryl-coenzym...4552e-154     478     54     72GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
32P48020    596   HMDH1_SOLTU 3-hydroxy-3-methylglutaryl-coenzy...4733e-154     478     53     69GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
33Q9XEL8    604   HMDH2_CAPAN 3-hydroxy-3-methylglutaryl-coenzy...4384e-154     477     55     71GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
34P14891    592   HMDH1_ARATH 3-hydroxy-3-methylglutaryl-coenzy...4378e-154     476     54     73GO:0005789; C:endoplasmic reticulum membrane; IDA:TAIR.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0042282; F:hydroxymethylglutaryl-CoA reductase activity; IDA:TAIR.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:TAIR.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IDA:TAIR.::GO:0060964; P:regulation of gene silencing by miRNA; IMP:TAIR.::GO:0016126; P:sterol biosynthetic process; IMP:TAIR.
35P48022    602   HMDH2_SOLLC 3-hydroxy-3-methylglutaryl-coenzy...4414e-153     474     54     71GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
36P43256    562   HMDH2_ARATH 3-hydroxy-3-methylglutaryl-coenzy...4318e-152     470     55     71GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:TAIR.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IMP:TAIR.::GO:0016104; P:triterpenoid biosynthetic process; IMP:TAIR.
37P34135    552   HMDH1_DICDI 3-hydroxy-3-methylglutaryl-coenzy...4231e-151     469     56     74GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:InterPro.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
38Q41437    595   HMDH2_SOLTU 3-hydroxy-3-methylglutaryl-coenzy...4471e-150     468     53     70GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
39A2X8W3    539   HMDH1_ORYSI 3-hydroxy-3-methylglutaryl-coenzy...4132e-149     463     58     73GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
40Q0DY59    532   HMDH1_ORYSJ 3-hydroxy-3-methylglutaryl-coenzy...4136e-149     461     58     73GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
41O76819    833   HMDH_AGRIP 3-hydroxy-3-methylglutaryl-coenzym...4335e-138     442     52     70GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
42P14773    920   HMDH_DROME 3-hydroxy-3-methylglutaryl-coenzym...4524e-134     435     50     69GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0018990; P:ecdysis, chitin-based cuticle; IMP:FlyBase.::GO:0035050; P:embryonic heart tube development; IMP:FlyBase.::GO:0035232; P:germ cell attraction; TAS:FlyBase.::GO:0008406; P:gonad development; TAS:FlyBase.::GO:0008299; P:isoprenoid biosynthetic process; TAS:FlyBase.::GO:0007626; P:locomotory behavior; IMP:FlyBase.::GO:0007280; P:pole cell migration; IMP:UniProtKB.
43P16237    948   HMDH_SCHMA 3-hydroxy-3-methylglutaryl-coenzym...4443e-123     406     50     66GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
44O59469    413   HMDH_PYRHO 3-hydroxy-3-methylglutaryl-coenzym...4195e-96     317     44     63GO:0016021; C:integral to membrane; IEA:InterPro.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
45Q9V1R3    408   HMDH_PYRAB 3-hydroxy-3-methylglutaryl-coenzym...4181e-94     313     44     63GO:0016021; C:integral to membrane; IEA:InterPro.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
46O26662    397   HMDH_METTH 3-hydroxy-3-methylglutaryl-coenzym...4066e-93     308     43     62GO:0016021; C:integral to membrane; IEA:InterPro.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
47Q9YAS4    421   HMDH_AERPE 3-hydroxy-3-methylglutaryl-coenzym...4003e-88     295     46     63GO:0016021; C:integral to membrane; IEA:InterPro.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
48Q59468    403   HMDH_HALVD 3-hydroxy-3-methylglutaryl-coenzym...4117e-84     283     44     59GO:0016021; C:integral to membrane; IEA:InterPro.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
49O08424    409   HMDH_SULSO 3-hydroxy-3-methylglutaryl-coenzym...4171e-82     280     41     60GO:0016021; C:integral to membrane; IEA:InterPro.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
50P29058    210   HMDH2_HEVBR 3-hydroxy-3-methylglutaryl-coenzy...2014e-79     262     65     82GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0042170; C:plastid membrane; IEA:UniProtKB-SubCell.
GO:0050662; F:coenzyme binding; IEA:InterPro.::GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
51Q58116    405   HMDH_METJA 3-hydroxy-3-methylglutaryl-coenzym...4181e-74     257     40     57GO:0016021; C:integral to membrane; IEA:InterPro.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
52O51628    431   HMDH_BORBU Probable 3-hydroxy-3-methylglutary...770.0003     48.5     32     57
GO:0050662; F:coenzyme binding; IEA:InterPro.::GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.::GO:0042282; F:hydroxymethylglutaryl-CoA reductase activity; IEA:EC.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
53O28538    436   HMDH_ARCFU 3-hydroxy-3-methylglutaryl-coenzym...3910.025     42     25     39
GO:0050662; F:coenzyme binding; IEA:InterPro.::GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
54P39586    126   YWBC_BACSU Uncharacterized protein ywbC OS=Ba...1210.76     35.4     31     43
GO:0004462; F:lactoylglutathione lyase activity; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:InterPro.
55Q0CMF3    1022   BGALB_ASPTN Probable beta-galactosidase B OS=...1053.4     35.4     28     49GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0004565; F:beta-galactosidase activity; IEA:EC.::GO:0043169; F:cation binding; IEA:InterPro.
GO:0000272; P:polysaccharide catabolic process; IEA:UniProtKB-KW.
56Q9YX47    1146   VP4_FDVS Uncharacterized protein VP4 OS=Fiji ...669.4     33.9     30     55
57P21852    567   PHNL_DESVM Periplasmic [NiFe] hydrogenase lar...669.8     33.9     33     53GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
GO:0047806; F:cytochrome-c3 hydrogenase activity; IEA:EC.::GO:0008901; F:ferredoxin hydrogenase activity; IEA:InterPro.::GO:0016151; F:nickel cation binding; IEA:InterPro.
records
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