Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLR450W
Length:
1045
Number of sequences:
5887
Description:
YLR450W HMG2 SGDID:S000004442, Chr XII from 1032627-1035764, Genome Release 64-1-1, Verified ORF, "One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P12684    1045   HMDH2_YEAST 3-hydroxy-3-methylglutaryl-coenzy...10450     2156     100     100GO:0005789; C:endoplasmic reticulum membrane; IDA:SGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005635; C:nuclear envelope; IDA:SGD.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
2P12683    1054   HMDH1_YEAST 3-hydroxy-3-methylglutaryl-coenzy...10480     1323     62     76GO:0005789; C:endoplasmic reticulum membrane; IDA:SGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005635; C:nuclear envelope; IDA:SGD.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IDA:SGD.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0006696; P:ergosterol biosynthetic process; IMP:SGD.::GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IC:SGD.
3O74164    934   HMDH_CYBJA 3-hydroxy-3-methylglutaryl-coenzym...9120     931     53     68GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
4Q12649    1176   HMDH_PHYBL 3-hydroxy-3-methylglutaryl-coenzym...9370     682     43     59GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
5Q10283    1053   HMDH_SCHPO 3-hydroxy-3-methylglutaryl-coenzym...9070     678     44     61GO:0005789; C:endoplasmic reticulum membrane; IDA:PomBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031965; C:nuclear membrane; ISS:PomBase.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IDA:PomBase.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:PomBase.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0006696; P:ergosterol biosynthetic process; IMP:PomBase.::GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; ISS:PomBase.::GO:0031505; P:fungal-type cell wall organization; IMP:PomBase.
6Q0C8L9    1048   HMDH_ASPTN 3-hydroxy-3-methylglutaryl-coenzym...10900     658     38     53GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
7Q9Y7D2    1048   HMDH_ASPTE 3-hydroxy-3-methylglutaryl-coenzym...10900     654     38     53GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
8Q12577    976   HMDH_GIBFU 3-hydroxy-3-methylglutaryl-coenzym...2192e-18     94.7     36     47GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
9P20715    883   HMDH_XENLA 3-hydroxy-3-methylglutaryl-coenzym...8582e-167     522     39     54GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
10P34136    526   HMDH2_DICDI 3-hydroxy-3-methylglutaryl-coenzy...4668e-165     503     55     71GO:0016021; C:integral to membrane; IEA:InterPro.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
11Q01237    887   HMDH_MOUSE 3-hydroxy-3-methylglutaryl-coenzym...4363e-164     513     59     74GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
12P00347    887   HMDH_CRIGR 3-hydroxy-3-methylglutaryl-coenzym...4887e-164     512     55     70GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
13A7Z064    888   HMDH_BOVIN 3-hydroxy-3-methylglutaryl-coenzym...4355e-163     510     58     74GO:0005789; C:endoplasmic reticulum membrane; IEA:InterPro.::GO:0016021; C:integral to membrane; IEA:InterPro.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
14P09610    887   HMDH_MESAU 3-hydroxy-3-methylglutaryl-coenzym...4475e-162     508     57     72GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
15Q5R6N3    888   HMDH_PONAB 3-hydroxy-3-methylglutaryl-coenzym...4352e-161     506     58     74GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
16P16393    932   HMDH_STRPU 3-hydroxy-3-methylglutaryl-coenzym...4509e-161     506     57     73GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
17P51639    887   HMDH_RAT 3-hydroxy-3-methylglutaryl-coenzyme ...4361e-160     504     58     74GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:RGD.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0042282; F:hydroxymethylglutaryl-CoA reductase activity; IDA:RGD.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; IDA:RGD.
GO:0007568; P:aging; IEP:RGD.::GO:0006695; P:cholesterol biosynthetic process; IDA:RGD.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; TAS:RGD.::GO:0045445; P:myoblast differentiation; IEP:RGD.::GO:0061179; P:negative regulation of insulin secretion involved in cellular response to glucose stimulus; IMP:RGD.::GO:0010664; P:negative regulation of striated muscle cell apoptotic process; IMP:RGD.::GO:0045908; P:negative regulation of vasodilation; IMP:RGD.::GO:0061045; P:negative regulation of wound healing; IMP:RGD.::GO:0010666; P:positive regulation of cardiac muscle cell apoptotic process; IMP:RGD.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:RGD.::GO:0048643; P:positive regulation of skeletal muscle tissue development; IMP:RGD.::GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:RGD.::GO:0032874; P:positive regulation of stress-activated MAPK cascade; IMP:RGD.::GO:0045471; P:response to ethanol; IEP:RGD.::GO:0007584; P:response to nutrient; IEP:RGD.::GO:0006743; P:ubiquinone metabolic process; IMP:RGD.
18P04035    888   HMDH_HUMAN 3-hydroxy-3-methylglutaryl-coenzym...4351e-160     504     58     74GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0006695; P:cholesterol biosynthetic process; TAS:Reactome.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
19Q29512    888   HMDH_RABIT 3-hydroxy-3-methylglutaryl-coenzym...4366e-160     502     58     74GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
20Q1W675    885   HMDH_PIG 3-hydroxy-3-methylglutaryl-coenzyme ...5112e-159     501     52     67GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
21P54960    856   HMDH_BLAGE 3-hydroxy-3-methylglutaryl-coenzym...5012e-158     497     53     68GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
22Q01559    604   HMDH_NICSY 3-hydroxy-3-methylglutaryl-coenzym...4122e-157     486     58     75GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
23P29057    575   HMDH1_HEVBR 3-hydroxy-3-methylglutaryl-coenzy...4095e-157     484     58     76GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0042170; C:plastid membrane; IEA:UniProtKB-SubCell.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
24Q9XHL5    561   HMDH3_ORYSJ 3-hydroxy-3-methylglutaryl-coenzy...4189e-157     483     57     74GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
25Q00583    586   HMDH3_HEVBR 3-hydroxy-3-methylglutaryl-coenzy...4112e-156     483     58     75GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0042170; C:plastid membrane; IEA:UniProtKB-SubCell.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
26O64967    628   HMDH2_GOSHI 3-hydroxy-3-methylglutaryl-coenzy...4191e-155     482     58     73GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0042170; C:plastid membrane; IEA:UniProtKB-SubCell.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
27O24594    579   HMDH_MAIZE 3-hydroxy-3-methylglutaryl-coenzym...4142e-155     480     57     74GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
28Q41438    574   HMDH3_SOLTU 3-hydroxy-3-methylglutaryl-coenzy...4034e-155     479     59     75GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
29Q03163    601   HMDH_CATRO 3-hydroxy-3-methylglutaryl-coenzym...4127e-155     479     57     75GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
30O64966    585   HMDH1_GOSHI 3-hydroxy-3-methylglutaryl-coenzy...4679e-155     478     54     69GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0042170; C:plastid membrane; IEA:UniProtKB-SubCell.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
31P48021    593   HMDH_CAMAC 3-hydroxy-3-methylglutaryl-coenzym...4552e-154     478     54     72GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
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