rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | Q06412 | 1307 | TUS1_YEAST Rho1 guanine nucleotide exchange f... | 1307 | 0 | 2704 | 100 | 100 | GO:0005935; C:cellular bud neck; IDA:SGD.::GO:0000131; C:incipient cellular bud site; IDA:SGD. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:SGD. | | | | | | | | | | GO:0031505; P:fungal-type cell wall organization; IGI:SGD.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007165; P:signal transduction; IGI:SGD. | 2 | Q9Y7U5 | 1275 | RGF3_SCHPO Rho1 guanine nucleotide exchange f... | 1067 | 4e-36 | 153 | 22 | 39 | GO:0032153; C:cell division site; IDA:PomBase.::GO:0030428; C:cell septum; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:PomBase.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IGI:PomBase. | | | | | | | | | | GO:0051666; P:actin cortical patch localization; IMP:PomBase.::GO:0000917; P:barrier septum assembly; IEA:UniProtKB-KW.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0030994; P:primary cell septum disassembly; IMP:PomBase.::GO:0060624; P:regulation of ascospore wall (1->3)-beta-D-glucan biosynthetic process; IC:PomBase.::GO:0010590; P:regulation of cytokinetic cell separation; IMP:PomBase.::GO:0032319; P:regulation of Rho GTPase activity; IC:PomBase. | 3 | Q9UTR5 | 1158 | RGF2_SCHPO Rho1 guanine nucleotide exchange f... | 399 | 0.0000001 | 60.1 | 21 | 40 | GO:0000935; C:barrier septum; IDA:PomBase.::GO:0051285; C:cell cortex of cell tip; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:PomBase.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IGI:PomBase. | | | | | | | | | | GO:0051666; P:actin cortical patch localization; IMP:PomBase.::GO:0030476; P:ascospore wall assembly; IMP:BHF-UCL.::GO:0000917; P:barrier septum assembly; IEA:UniProtKB-KW.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0060622; P:regulation of ascospore wall beta-glucan biosynthetic process; IMP:BHF-UCL.::GO:0032319; P:regulation of Rho GTPase activity; IC:PomBase. | 4 | P51862 | 1356 | ROM2_YEAST RHO1 GDP-GTP exchange protein 2 OS... | 426 | 0.000004 | 55.5 | 23 | 40 | GO:0005934; C:cellular bud tip; IDA:SGD.::GO:0000131; C:incipient cellular bud site; IDA:SGD.::GO:0043332; C:mating projection tip; IDA:SGD. | | | | | | | | | | GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:SGD.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:SGD.::GO:0004871; F:signal transducer activity; IGI:SGD. | | | | | | | | | | GO:0032862; P:activation of Rho GTPase activity; IDA:SGD.::GO:0030010; P:establishment of cell polarity; IMP:SGD.::GO:0043951; P:negative regulation of cAMP-mediated signaling; IMP:SGD.::GO:0045807; P:positive regulation of endocytosis; IMP:SGD.::GO:0007264; P:small GTPase mediated signal transduction; IPI:SGD. | 5 | Q9NZM3 | 1697 | ITSN2_HUMAN Intersectin-2 OS=Homo sapiens (Hu... | 211 | 0.000004 | 55.5 | 26 | 46 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 6 | Q9Z0R6 | 1659 | ITSN2_MOUSE Intersectin-2 OS=Mus musculus (Mo... | 212 | 0.0005 | 48.5 | 25 | 46 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 7 | O15085 | 1522 | ARHGB_HUMAN Rho guanine nucleotide exchange f... | 225 | 0.005 | 45.1 | 22 | 46 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0001664; F:G-protein coupled receptor binding; IDA:MGI.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; TAS:UniProtKB. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; NAS:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0006928; P:cellular component movement; NAS:UniProtKB.::GO:0000910; P:cytokinesis; NAS:UniProtKB.::GO:0030010; P:establishment of cell polarity; NAS:UniProtKB.::GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0001558; P:regulation of cell growth; NAS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007266; P:Rho protein signal transduction; IDA:UniProtKB.::GO:0006941; P:striated muscle contraction; NAS:UniProtKB.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. | 8 | Q9ES67 | 1527 | ARHGB_RAT Rho guanine nucleotide exchange fac... | 262 | 0.011 | 43.9 | 21 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:RGD.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0001505; P:regulation of neurotransmitter levels; TAS:RGD.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. | 9 | P53046 | 1155 | ROM1_YEAST RHO1 GDP-GTP exchange protein 1 OS... | 422 | 0.011 | 43.9 | 21 | 40 | GO:0005622; C:intracellular; TAS:SGD. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0004871; F:signal transducer activity; TAS:SGD. | | | | | | | | | | GO:0007015; P:actin filament organization; TAS:SGD.::GO:0007117; P:budding cell bud growth; TAS:SGD.::GO:0030010; P:establishment of cell polarity; TAS:SGD.::GO:0031505; P:fungal-type cell wall organization; TAS:SGD.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:SGD. | 10 | Q5ZLX4 | 524 | ARHG3_CHICK Rho guanine nucleotide exchange f... | 328 | 0.019 | 42.7 | 21 | 38 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 11 | Q9Z0R4 | 1714 | ITSN1_MOUSE Intersectin-1 OS=Mus musculus (Mo... | 216 | 0.028 | 42.7 | 24 | 42 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0030139; C:endocytic vesicle; IDA:MGI.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0019209; F:kinase activator activity; IDA:MGI.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IDA:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IDA:MGI. | 12 | Q7Z628 | 596 | ARHG8_HUMAN Neuroepithelial cell-transforming... | 333 | 0.064 | 41.2 | 21 | 39 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0070301; P:cellular response to hydrogen peroxide; IDA:UniProtKB.::GO:0071479; P:cellular response to ionizing radiation; IDA:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0032321; P:positive regulation of Rho GTPase activity; IMP:UniProtKB.::GO:0001558; P:regulation of cell growth; NAS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 13 | Q15811 | 1721 | ITSN1_HUMAN Intersectin-1 OS=Homo sapiens (Hu... | 216 | 0.066 | 41.6 | 24 | 42 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005905; C:coated pit; IDA:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0070064; F:proline-rich region binding; IPI:UniProtKB.::GO:0032947; F:protein complex scaffold; IDA:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0048488; P:synaptic vesicle endocytosis; TAS:ProtInc. | 14 | Q54EH3 | 1031 | Y1510_DICDI GTPase-activating protein DDB_G02... | 87 | 2.4 | 36.2 | 31 | 52 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 15 | Q9Y7U6 | 1334 | RGF1_SCHPO Rho1 guanine nucleotide exchange f... | 433 | 2.6 | 36.2 | 21 | 36 | GO:0000935; C:barrier septum; IDA:PomBase.::GO:0051285; C:cell cortex of cell tip; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:PomBase.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IGI:PomBase. | | | | | | | | | | GO:0051666; P:actin cortical patch localization; IMP:PomBase.::GO:0000917; P:barrier septum assembly; IEA:UniProtKB-KW.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0009272; P:fungal-type cell wall biogenesis; IGI:PomBase.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0051518; P:positive regulation of bipolar cell growth; IMP:PomBase.::GO:0035025; P:positive regulation of Rho protein signal transduction; IGI:PomBase.::GO:0008360; P:regulation of cell shape; IGI:PomBase.::GO:0090334; P:regulation of cell wall (1->3)-beta-D-glucan biosynthetic process; IGI:PomBase.::GO:0032319; P:regulation of Rho GTPase activity; IGI:PomBase. | 16 | Q92888 | 912 | ARHG1_HUMAN Rho guanine nucleotide exchange f... | 236 | 3.8 | 35.4 | 20 | 45 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; TAS:ProtInc. | | | | | | | | | | GO:0008283; P:cell proliferation; TAS:ProtInc.::GO:0050771; P:negative regulation of axonogenesis; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007266; P:Rho protein signal transduction; TAS:ProtInc.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. | 17 | Q8R4H2 | 1543 | ARHGC_MOUSE Rho guanine nucleotide exchange f... | 237 | 3.9 | 35.8 | 22 | 42 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:BHF-UCL.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. | 18 | Q6P9R4 | 1021 | ARHGI_MOUSE Rho guanine nucleotide exchange f... | 282 | 7.7 | 34.7 | 22 | 42 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. |