Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLR422W
Length:
1932
Number of sequences:
5887
Description:
YLR422W YLR422W SGDID:S000004414, Chr XII from 965897-971695, Genome Release 64-1-1, Uncharacterized ORF, "Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1Q06409    1932   YL422_YEAST DOCK-like protein YLR422W OS=Sacc...19320     3995     100     100GO:0005737; C:cytoplasm; IDA:SGD.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
2Q8CIQ7    2027   DOCK3_MOUSE Dedicator of cytokinesis protein ...6361e-34     149     24     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
3Q8IZD9    2030   DOCK3_HUMAN Dedicator of cytokinesis protein ...6361e-34     149     24     44GO:0005737; C:cytoplasm; IDA:HPA.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
4Q8N1I0    1966   DOCK4_HUMAN Dedicator of cytokinesis protein ...4111e-30     136     27     47GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IDA:UniProtKB.::GO:0032420; C:stereocilium; ISS:HGNC.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0030165; F:PDZ domain binding; IPI:HGNC.::GO:0030675; F:Rac GTPase activator activity; IDA:HGNC.::GO:0048365; F:Rac GTPase binding; IDA:HGNC.::GO:0030971; F:receptor tyrosine kinase binding; IPI:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0060326; P:cell chemotaxis; IMP:UniProtKB.
5P59764    1978   DOCK4_MOUSE Dedicator of cytokinesis protein ...4112e-30     135     26     47GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; ISS:UniProtKB.::GO:0032420; C:stereocilium; IDA:HGNC.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0060326; P:cell chemotaxis; ISS:UniProtKB.
6Q9H7D0    1870   DOCK5_HUMAN Dedicator of cytokinesis protein ...4709e-29     130     26     46GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
7B2RY04    1868   DOCK5_MOUSE Dedicator of cytokinesis protein ...4468e-27     124     26     46GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:UniProtKB.
8Q8C3J5    1828   DOCK2_MOUSE Dedicator of cytokinesis protein ...4375e-25     118     24     46GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0030675; F:Rac GTPase activator activity; IMP:MGI.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; ISS:UniProtKB.::GO:0042608; F:T cell receptor binding; ISS:UniProtKB.
GO:0046633; P:alpha-beta T cell proliferation; IMP:MGI.::GO:0006935; P:chemotaxis; IMP:MGI.::GO:0007010; P:cytoskeleton organization; IDA:MGI.::GO:0001768; P:establishment of T cell polarity; IMP:MGI.::GO:0001771; P:immunological synapse formation; IMP:MGI.::GO:0001766; P:membrane raft polarization; IMP:MGI.::GO:0045060; P:negative thymic T cell selection; IMP:MGI.::GO:0035022; P:positive regulation of Rac protein signal transduction; IC:MGI.::GO:0045059; P:positive thymic T cell selection; IMP:MGI.
9Q92608    1830   DOCK2_HUMAN Dedicator of cytokinesis protein ...4382e-23     113     24     46GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA.::GO:0005886; C:plasma membrane; IDA:HPA.
GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0005525; F:GTP binding; IEA:InterPro.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IDA:UniProtKB.::GO:0042608; F:T cell receptor binding; IDA:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; TAS:UniProtKB.::GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.::GO:0016032; P:viral reproduction; TAS:Reactome.
10Q14185    1865   DOCK1_HUMAN Dedicator of cytokinesis protein ...4492e-22     109     23     45GO:0005829; C:cytosol; TAS:Reactome.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0005096; F:GTPase activator activity; TAS:ProtInc.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; TAS:ProtInc.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0007229; P:integrin-mediated signaling pathway; TAS:ProtInc.::GO:0006911; P:phagocytosis, engulfment; TAS:ProtInc.::GO:0007264; P:small GTPase mediated signal transduction; TAS:ProtInc.
11Q8BUR4    1865   DOCK1_MOUSE Dedicator of cytokinesis protein ...4493e-22     109     23     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0016477; P:cell migration; IDA:MGI.::GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
12Q8BIK4    2055   DOCK9_MOUSE Dedicator of cytokinesis protein ...3480.000000004     65.9     22     41GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
13Q9BZ29    2069   DOCK9_HUMAN Dedicator of cytokinesis protein ...3480.00000001     63.9     22     41GO:0005829; C:cytosol; TAS:Reactome.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0007596; P:blood coagulation; TAS:Reactome.
14Q96BY6    2186   DOC10_HUMAN Dedicator of cytokinesis protein ...3320.00000008     61.6     23     40
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.
15Q96N67    2140   DOCK7_HUMAN Dedicator of cytokinesis protein ...3670.0000003     60.1     25     41GO:0030424; C:axon; TAS:BHF-UCL.::GO:0045178; C:basal part of cell; TAS:BHF-UCL.::GO:0030426; C:growth cone; TAS:BHF-UCL.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0048365; F:Rac GTPase binding; IDA:BHF-UCL.
GO:0032863; P:activation of Rac GTPase activity; IDA:BHF-UCL.::GO:0007409; P:axonogenesis; IMP:BHF-UCL.::GO:0045200; P:establishment of neuroblast polarity; IMP:BHF-UCL.::GO:0000226; P:microtubule cytoskeleton organization; IMP:BHF-UCL.::GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IMP:BHF-UCL.
16Q8R1A4    2130   DOCK7_MOUSE Dedicator of cytokinesis protein ...3670.0000006     58.5     25     41GO:0030424; C:axon; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0048365; F:Rac GTPase binding; IDA:BHF-UCL.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0043473; P:pigmentation; IMP:MGI.
17Q8VDR9    2080   DOCK6_MOUSE Dedicator of cytokinesis protein ...2450.0000009     58.2     27     44GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
18Q96HP0    2047   DOCK6_HUMAN Dedicator of cytokinesis protein ...2840.000005     55.5     26     42GO:0005829; C:cytosol; TAS:Reactome.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
GO:0007596; P:blood coagulation; TAS:Reactome.
19Q8BZN6    2150   DOC10_MOUSE Dedicator of cytokinesis protein ...2990.000005     55.5     22     40
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
20Q8NF50    2099   DOCK8_HUMAN Dedicator of cytokinesis protein ...3660.00001     54.7     24     42GO:0005829; C:cytosol; TAS:Reactome.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
GO:0007596; P:blood coagulation; TAS:Reactome.
21Q5JSL3    2073   DOC11_HUMAN Dedicator of cytokinesis protein ...2960.00001     54.7     22     43GO:0005829; C:cytosol; TAS:Reactome.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0007596; P:blood coagulation; TAS:Reactome.
22A2AF47    2073   DOC11_MOUSE Dedicator of cytokinesis protein ...3370.00001     54.3     21     42
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0017048; F:Rho GTPase binding; IPI:MGI.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:MGI.
23Q8C147    2100   DOCK8_MOUSE Dedicator of cytokinesis protein ...3420.00002     53.5     24     42
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
24Q63603    720   DOCK9_RAT Dedicator of cytokinesis protein 9 ...2880.0007     48.1     21     40GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
25Q9LKX9    867   RBR1_MAIZE Retinoblastoma-related protein 1 O...1070.028     43.1     33     45GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0051726; P:regulation of cell cycle; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
26Q8H0J6    866   RBR2_MAIZE Retinoblastoma-related protein 2 O...1070.27     40     32     45GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051726; P:regulation of cell cycle; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
27Q296J6    279   RRP15_DROPS RRP15-like protein OS=Drosophila ...400.73     37.7     45     58
28Q64EW6    222   SPC25_DROMA Kinetochore protein Spc25 OS=Dros...1152.3     35.8     27     45GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.::GO:0031262; C:Ndc80 complex; ISS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0051311; P:meiotic metaphase plate congression; ISS:UniProtKB.::GO:0000212; P:meiotic spindle organization; ISS:UniProtKB.::GO:0007080; P:mitotic metaphase plate congression; ISS:UniProtKB.::GO:0007052; P:mitotic spindle organization; ISS:UniProtKB.
29A5UNK6    655   UVRB_METS3 UvrABC system protein B OS=Methano...882.6     36.6     30     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0009381; F:excinuclease ABC activity; IEA:InterPro.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
GO:0006289; P:nucleotide-excision repair; IEA:InterPro.::GO:0009432; P:SOS response; IEA:UniProtKB-KW.
30C0QUE7    238   PUR7_PERMH Phosphoribosylaminoimidazole-succi...705.7     34.7     29     57
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity; IEA:EC.
GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.
records
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