Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLR418C
Length:
393
Number of sequences:
5887
Description:
YLR418C CDC73 SGDID:S000004410, Chr XII from 958095-956914, Genome Release 64-1-1, reverse complement, Verified ORF, "Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1Q06697    393   CDC73_YEAST Cell division control protein 73 ...3930     816     100     100GO:0016593; C:Cdc73/Paf1 complex; IPI:SGD.::GO:0035327; C:transcriptionally active chromatin; IDA:SGD.
GO:0003682; F:chromatin binding; IDA:SGD.::GO:0000993; F:RNA polymerase II core binding; IPI:SGD.::GO:0001089; F:TFIIF-class binding transcription factor activity; IMP:SGD.
GO:0045910; P:negative regulation of DNA recombination; IMP:SGD.::GO:2001255; P:positive regulation of histone H3-K36 trimethylation; IMP:SGD.::GO:2001165; P:positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues; IMP:SGD.::GO:2001209; P:positive regulation of transcription elongation from RNA polymerase I promoter; IDA:SGD.::GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IMP:SGD.::GO:0034402; P:recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex; IMP:SGD.::GO:2001173; P:regulation of histone H2B conserved C-terminal lysine ubiquitination; IDA:SGD.::GO:0006362; P:transcription elongation from RNA polymerase I promoter; IMP:SGD.
2Q9UUE7    371   CDC73_SCHPO Cell division control protein 73 ...3362e-42     157     33     49GO:0016593; C:Cdc73/Paf1 complex; ISS:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006368; P:transcription elongation from RNA polymerase II promoter; ISS:PomBase.
3Q8JZM7    531   CDC73_MOUSE Parafibromin OS=Mus musculus (Mou...2123e-17     87     27     46GO:0016593; C:Cdc73/Paf1 complex; ISS:UniProtKB.
GO:0000993; F:RNA polymerase II core binding; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0001711; P:endodermal cell fate commitment; IMP:UniProtKB.::GO:0006378; P:mRNA polyadenylation; ISS:UniProtKB.::GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; ISS:UniProtKB.::GO:0045638; P:negative regulation of myeloid cell differentiation; ISS:UniProtKB.::GO:0045749; P:negative regulation of S phase of mitotic cell cycle; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.::GO:0031442; P:positive regulation of mRNA 3'-end processing; ISS:UniProtKB.::GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0030177; P:positive regulation of Wnt receptor signaling pathway; ISS:UniProtKB.::GO:0019827; P:stem cell maintenance; IMP:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
4Q6P1J9    531   CDC73_HUMAN Parafibromin OS=Homo sapiens (Hum...2123e-17     87     27     46GO:0016593; C:Cdc73/Paf1 complex; IDA:UniProtKB.
GO:0000993; F:RNA polymerase II core binding; IDA:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0001711; P:endodermal cell fate commitment; ISS:UniProtKB.::GO:0033523; P:histone H2B ubiquitination; IDA:UniProtKB.::GO:0010390; P:histone monoubiquitination; IDA:UniProtKB.::GO:0006378; P:mRNA polyadenylation; IMP:UniProtKB.::GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:UniProtKB.::GO:0048147; P:negative regulation of fibroblast proliferation; IMP:UniProtKB.::GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IDA:UniProtKB.::GO:0045638; P:negative regulation of myeloid cell differentiation; IDA:UniProtKB.::GO:0045749; P:negative regulation of S phase of mitotic cell cycle; IMP:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.::GO:0031442; P:positive regulation of mRNA 3'-end processing; IMP:UniProtKB.::GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IDA:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0030177; P:positive regulation of Wnt receptor signaling pathway; IDA:UniProtKB.::GO:0031648; P:protein destabilization; IMP:UniProtKB.::GO:0019827; P:stem cell maintenance; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
5Q4V8C8    531   CDC73_RAT Parafibromin OS=Rattus norvegicus (...2123e-17     87     27     46GO:0016593; C:Cdc73/Paf1 complex; ISS:UniProtKB.
GO:0000993; F:RNA polymerase II core binding; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0001711; P:endodermal cell fate commitment; ISS:UniProtKB.::GO:0006378; P:mRNA polyadenylation; ISS:UniProtKB.::GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; ISS:UniProtKB.::GO:0045638; P:negative regulation of myeloid cell differentiation; ISS:UniProtKB.::GO:0045749; P:negative regulation of S phase of mitotic cell cycle; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0031442; P:positive regulation of mRNA 3'-end processing; ISS:UniProtKB.::GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0030177; P:positive regulation of Wnt receptor signaling pathway; ISS:UniProtKB.::GO:0019827; P:stem cell maintenance; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
6Q5ZLM0    531   CDC73_CHICK Parafibromin OS=Gallus gallus (Ch...2213e-17     86.7     26     45GO:0016593; C:Cdc73/Paf1 complex; ISS:UniProtKB.
GO:0000993; F:RNA polymerase II core binding; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0001711; P:endodermal cell fate commitment; ISS:UniProtKB.::GO:0006378; P:mRNA polyadenylation; ISS:UniProtKB.::GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; ISS:UniProtKB.::GO:0045638; P:negative regulation of myeloid cell differentiation; ISS:UniProtKB.::GO:0045749; P:negative regulation of S phase of mitotic cell cycle; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0031442; P:positive regulation of mRNA 3'-end processing; ISS:UniProtKB.::GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0030177; P:positive regulation of Wnt receptor signaling pathway; ISS:UniProtKB.::GO:0019827; P:stem cell maintenance; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
7Q9HI21    213   GVPF1_HALSA Protein gvpF 1 OS=(Halobacterium ...800.47     35.4     29     50GO:0031411; C:gas vesicle; IEA:UniProtKB-SubCell.::GO:0005773; C:vacuole; IEA:UniProtKB-KW.
GO:0031412; P:gas vesicle organization; IEA:InterPro.
8Q8X034    203   RL15_NEUCR 60S ribosomal protein L15 OS=1257 ...1380.84     34.7     24     39GO:0005840; C:ribosome; IEA:UniProtKB-KW.
GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
GO:0006412; P:translation; IEA:InterPro.
9Q6KAQ7    910   ZZZ3_MOUSE ZZ-type zinc finger-containing pro...680.95     35.4     32     49GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
10Q2QDE6    304   DNSL1_CRIGR Deoxyribonuclease-1-like 1 OS=Cri...1041.3     34.7     28     48GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
GO:0016888; F:endodeoxyribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.
GO:0006308; P:DNA catabolic process; IEA:InterPro.
11A1C928    1178   TOF1_ASPCL Topoisomerase 1-associated factor ...893.5     33.5     30     47GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0007126; P:meiosis; IEA:UniProtKB-KW.::GO:0008156; P:negative regulation of DNA replication; IEA:UniProtKB-KW.
12P46835    911   DPO1_MYCLE DNA polymerase I OS=Mycobacterium ...1368.4     32.3     27     43GO:0005622; C:intracellular; IEA:InterPro.
GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0008409; F:5'-3' exonuclease activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
records
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