Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLR398C
Length:
1287
Number of sequences:
5887
Description:
YLR398C SKI2 SGDID:S000004390, Chr XII from 919019-915156, Genome Release 64-1-1, reverse complement, Verified ORF, "Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31P53327    1967   SLH1_YEAST Antiviral helicase SLH1 OS=Sacchar...1260.00009     50.8     32     48GO:0005737; C:cytoplasm; IDA:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0006417; P:regulation of translation; IMP:SGD.::GO:0009615; P:response to virus; IEA:UniProtKB-KW.
32Q8TL39    730   HELS_METAC Putative ski2-type helicase OS=C2A...1640.0000000000004     77.8     31     54
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:InterPro.
33Q8IY21    1712   DDX60_HUMAN Probable ATP-dependent RNA helica...1860.00000000005     71.6     28     49GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003690; F:double-stranded DNA binding; IDA:UniProtKB.::GO:0003725; F:double-stranded RNA binding; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0003727; F:single-stranded RNA binding; IDA:UniProtKB.
GO:1900245; P:positive regulation of MDA-5 signaling pathway; IMP:UniProtKB.::GO:1900246; P:positive regulation of RIG-I signaling pathway; IMP:UniProtKB.::GO:0009615; P:response to virus; IDA:UniProtKB.
34Q8PZR7    730   HELS_METMA Putative ski2-type helicase OS=JCM...1520.00000000000006     80.5     34     54
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
35A8MB76    756   HELS_CALMQ Putative ski2-type helicase OS=/ I...1930.0000000000002     79     31     53
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:InterPro.
36Q465R3    729   HELS_METBF Putative ski2-type helicase OS=Met...930.000000000003     74.7     42     61
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:InterPro.
37A3MSA1    708   HELS_PYRCJ Putative ski2-type helicase OS=Pyr...940.000000000004     74.3     44     62
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:InterPro.
38A2RUV5    1336   HFM1_XENTR Probable ATP-dependent DNA helicas...1520.000000000002     75.9     33     49
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
39Q9HMV6    783   HELS_HALSA Putative ski2-type helicase OS=(Ha...1570.0000000003     68.6     31     48
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
40B0R7Q2    783   HELS_HALS3 Putative ski2-type helicase OS=Hal...1570.0000000003     68.6     31     48
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
41Q5UYM9    799   HELS_HALMA Putative ski2-type helicase OS=B-1...1550.0000000007     67.4     33     50
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:InterPro.
42Q3IU46    747   HELS_NATPD Putative ski2-type helicase OS=Nat...1560.00000009     60.5     31     50
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:InterPro.
43O60072    1935   MUG81_SCHPO Putative helicase mug81 OS=Schizo...1030.0000008     57.4     30     50GO:0005829; C:cytosol; IDA:PomBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004004; F:ATP-dependent RNA helicase activity; ISS:PomBase.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0007126; P:meiosis; IEA:UniProtKB-KW.::GO:2000765; P:regulation of cytoplasmic translation; ISS:PomBase.
44A2PYH4    1435   HFM1_HUMAN Probable ATP-dependent DNA helicas...970.0000000000005     77.8     38     56
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
45O75417    2590   DPOLQ_HUMAN DNA polymerase theta OS=Homo sapi...1940.0006     48.1     26     43GO:0005654; C:nucleoplasm; TAS:ProtInc.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003684; F:damaged DNA binding; TAS:ProtInc.::GO:0003887; F:DNA-directed DNA polymerase activity; IDA:UniProtKB.::GO:0043142; F:single-stranded DNA-dependent ATPase activity; IDA:UniProtKB.
GO:0006281; P:DNA repair; TAS:ProtInc.::GO:0006260; P:DNA replication; IEA:InterPro.
46Q0W6L1    740   HELS_UNCMA Putative ski2-type helicase OS=Unc...920.0000000003     68.2     41     57
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:InterPro.
47Q58796    808   Y1401_METJA Probable ATP-dependent helicase M...980.0000006     57.8     33     51
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
48Q55CI8    2237   HELCL_DICDI Activating signal cointegrator 1 ...830.0003     49.3     34     55GO:0005681; C:spliceosomal complex; ISS:dictyBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004004; F:ATP-dependent RNA helicase activity; ISS:dictyBase.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0008380; P:RNA splicing; ISS:dictyBase.
49Q9U2G0    2145   U520_CAEEL Putative U5 small nuclear ribonucl...1900.000001     57     24     47GO:0005681; C:spliceosomal complex; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0016477; P:cell migration; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0007281; P:germ cell development; IMP:WormBase.::GO:0008406; P:gonad development; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0018991; P:oviposition; IMP:WormBase.::GO:0042127; P:regulation of cell proliferation; IMP:WormBase.::GO:0040020; P:regulation of meiosis; IMP:WormBase.::GO:0008380; P:RNA splicing; ISS:UniProtKB.
50Q54G57    2195   HELC1_DICDI Activating signal cointegrator 1 ...2080.000001     57.4     25     47
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
51P51979    1187   HFM1_YEAST ATP-dependent DNA helicase MER3 OS...920.000000007     64.3     33     55GO:0005634; C:nucleus; IDA:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003678; F:DNA helicase activity; IDA:SGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006268; P:DNA unwinding involved in replication; IDA:SGD.::GO:0007131; P:reciprocal meiotic recombination; IMP:SGD.::GO:0007129; P:synapsis; IMP:SGD.
52O75643    2136   U520_HUMAN U5 small nuclear ribonucleoprotein...1600.000009     54.3     28     46GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0005682; C:U5 snRNP; IDA:HGNC.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IDA:HGNC.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0000354; P:cis assembly of pre-catalytic spliceosome; IC:HGNC.
53Q2VPA6    1069   HELQ_MOUSE Helicase POLQ-like OS=Mus musculus...1600.00000000001     73.2     33     52
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
54Q54XN7    1816   Y8827_DICDI Uncharacterized helicase DDB_G027...2070.0000000002     69.3     31     43GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
55Q9UT24    2176   BRR2_SCHPO Pre-mRNA-splicing factor brr2 OS=S...1725.1     35.4     24     39GO:0005829; C:cytosol; IDA:PomBase.::GO:0005681; C:spliceosomal complex; IDA:PomBase.::GO:0046540; C:U4/U6 x U5 tri-snRNP complex; ISS:PomBase.::GO:0005682; C:U5 snRNP; ISS:PomBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004004; F:ATP-dependent RNA helicase activity; ISS:PomBase.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0000393; P:spliceosomal conformational changes to generate catalytic conformation; IGI:PomBase.
56Q9VUV9    2142   U520_DROME Putative U5 small nuclear ribonucl...1820.002     46.2     26     42GO:0071013; C:catalytic step 2 spliceosome; IDA:FlyBase.::GO:0071011; C:precatalytic spliceosome; IDA:FlyBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004004; F:ATP-dependent RNA helicase activity; ISS:FlyBase.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0007067; P:mitosis; IMP:FlyBase.::GO:0000398; P:nuclear mRNA splicing, via spliceosome; IC:FlyBase.::GO:0000381; P:regulation of alternative nuclear mRNA splicing, via spliceosome; IMP:FlyBase.
57O26901    690   HELS_METTH Putative ski2-type helicase OS=the...980.00000000009     70.1     39     54
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:InterPro.
58E1BNG3    2201   ASCC3_BOVIN Activating signal cointegrator 1 ...1900.000006     54.7     25     47GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043140; F:ATP-dependent 3'-5' DNA helicase activity; ISS:UniProtKB.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0008283; P:cell proliferation; ISS:UniProtKB.::GO:0006307; P:DNA dealkylation involved in DNA repair; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
59F1LPQ2    2197   ASCC3_RAT Activating signal cointegrator 1 co...1900.000006     54.7     25     47GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043140; F:ATP-dependent 3'-5' DNA helicase activity; ISS:UniProtKB.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0008283; P:cell proliferation; ISS:UniProtKB.::GO:0006307; P:DNA dealkylation involved in DNA repair; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
60E7F8F4    1534   ASCC3_DANRE Activating signal cointegrator 1 ...1910.00001     53.9     25     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043140; F:ATP-dependent 3'-5' DNA helicase activity; ISS:UniProtKB.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0008283; P:cell proliferation; ISS:UniProtKB.::GO:0006307; P:DNA dealkylation involved in DNA repair; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
61Q8N3C0    2202   ASCC3_HUMAN Activating signal cointegrator 1 ...1900.00001     53.5     25     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; TAS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043140; F:ATP-dependent 3'-5' DNA helicase activity; IDA:UniProtKB.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0008283; P:cell proliferation; IMP:UniProtKB.::GO:0006307; P:DNA dealkylation involved in DNA repair; IDA:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
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