Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLR398C
Length:
1287
Number of sequences:
5887
Description:
YLR398C SKI2 SGDID:S000004390, Chr XII from 919019-915156, Genome Release 64-1-1, reverse complement, Verified ORF, "Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P35207    1287   SKI2_YEAST Antiviral helicase SKI2 OS=Sacchar...12870     2658     100     100GO:0055087; C:Ski complex; IDA:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0070478; P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; IMP:SGD.::GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; IMP:SGD.::GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.::GO:0009615; P:response to virus; IEA:UniProtKB-KW.
2O59801    1213   SKI2_SCHPO Putative ATP-dependent RNA helicas...12440     934     43     61GO:0005829; C:cytosol; IDA:PomBase.::GO:0005730; C:nucleolus; ISS:PomBase.::GO:0055087; C:Ski complex; ISS:PomBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0003724; F:RNA helicase activity; ISS:PomBase.
GO:0006402; P:mRNA catabolic process; ISS:PomBase.::GO:2000765; P:regulation of cytoplasmic translation; ISS:PomBase.
3Q15477    1246   SKIV2_HUMAN Helicase SKI2W OS=Homo sapiens (H...12630     736     38     53GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0055087; C:Ski complex; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004004; F:ATP-dependent RNA helicase activity; TAS:ProtInc.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
4Q9CZU3    1040   SK2L2_MOUSE Superkiller viralicidic activity ...9895e-170     540     35     54GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
5P42285    1042   SK2L2_HUMAN Superkiller viralicidic activity ...9892e-169     538     36     54GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0000460; P:maturation of 5.8S rRNA; IMP:UniProtKB.::GO:0000398; P:nuclear mRNA splicing, via spliceosome; IC:UniProtKB.
6P47047    1073   MTR4_YEAST ATP-dependent RNA helicase DOB1 OS...1842e-29     131     40     60GO:0005730; C:nucleolus; IDA:SGD.::GO:0031499; C:TRAMP complex; IDA:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0034459; F:ATP-dependent 3'-5' RNA helicase activity; IDA:SGD.::GO:0016491; F:oxidoreductase activity; IEA:InterPro.::GO:0008143; F:poly(A) RNA binding; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.::GO:0043629; P:ncRNA polyadenylation; IDA:SGD.::GO:0071042; P:nuclear polyadenylation-dependent mRNA catabolic process; IMP:SGD.::GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; IMP:SGD.::GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; IDA:SGD.::GO:0071049; P:nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription; IGI:SGD.::GO:0071051; P:polyadenylation-dependent snoRNA 3'-end processing; IMP:SGD.::GO:0034475; P:U4 snRNA 3'-end processing; IMP:SGD.::GO:0034476; P:U5 snRNA 3'-end processing; IMP:SGD.
7Q23223    1026   MTR4_CAEEL mRNA transport homolog 4 OS=Caenor...1993e-23     110     32     56GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040022; P:feminization of hermaphroditic germ-line; IMP:WormBase.::GO:0007281; P:germ cell development; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0002009; P:morphogenesis of an epithelium; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0042127; P:regulation of cell proliferation; IMP:WormBase.::GO:0040020; P:regulation of meiosis; IMP:WormBase.
8Q9ZBD8    920   HELY_MYCLE Probable helicase helY OS=Mycobact...9191e-87     310     28     46
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
9B9DFG3    1171   ISE2_ARATH DEAD-box ATP-dependent RNA helicas...5261e-85     308     37     54GO:0009570; C:chloroplast stroma; IDA:TAIR.::GO:0010494; C:cytoplasmic stress granule; IDA:TAIR.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.::GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.::GO:0010497; P:plasmodesmata-mediated intercellular transport; IMP:TAIR.::GO:0016441; P:posttranscriptional gene silencing; IMP:TAIR.
10O14232    1117   MTR4_SCHPO ATP-dependent RNA helicase mtr4 OS...7124e-84     303     31     52GO:0005730; C:nucleolus; ISS:PomBase.::GO:0031499; C:TRAMP complex; IDA:PomBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004004; F:ATP-dependent RNA helicase activity; ISS:PomBase.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0043630; P:ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process; ISS:PomBase.::GO:0071049; P:nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription; ISS:PomBase.::GO:0006364; P:rRNA processing; ISS:PomBase.::GO:0016078; P:tRNA catabolic process; ISS:PomBase.
11Q10701    906   HELY_MYCTU Probable helicase helY OS=Mycobact...2530.17     40     21     40GO:0005618; C:cell wall; IDA:MTBBASE.::GO:0005829; C:cytosol; IDA:MTBBASE.::GO:0005886; C:plasma membrane; IDA:MTBBASE.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
12O13799    1030   YE02_SCHPO Uncharacterized helicase C17H9.02 ...1932e-24     115     38     56GO:0005730; C:nucleolus; ISS:PomBase.::GO:0031499; C:TRAMP complex; ISS:PomBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004004; F:ATP-dependent RNA helicase activity; ISS:PomBase.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0043630; P:ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process; ISS:PomBase.::GO:0071049; P:nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription; ISS:PomBase.::GO:0006364; P:rRNA processing; ISS:PomBase.::GO:0016078; P:tRNA catabolic process; ISS:PomBase.
13Q9V0A9    715   HELS_PYRAB Putative ski2-type helicase OS=Pyr...2050.0000000002     68.9     30     46
GO:0005524; F:ATP binding; IEA:HAMAP.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:HAMAP.
GO:0006281; P:DNA repair; IEA:InterPro.
14Q9HJX7    674   HELS_THEAC Putative ski2-type helicase OS=NBR...2260.00000000000006     80.5     30     46
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:InterPro.
15O59025    715   HELS_PYRHO Putative ski2-type helicase OS=NBR...2050.00000000003     71.6     31     45
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:InterPro.
16Q09475    1714   YP93_CAEEL Uncharacterized helicase C28H8.3 O...2050.000000000003     75.5     27     49GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
17Q97AI2    674   HELS_THEVO Putative ski2-type helicase OS=154...2320.000000000005     73.9     28     46
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
18O73946    720   HELS_PYRFU Putative ski2-type helicase OS=Pyr...3120.0000000001     69.7     27     44
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:InterPro.
19A7IB61    723   HELS_METB6 Putative ski2-type helicase OS=Met...1520.00000000003     72     32     50
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
20A6UN73    751   HELS_METVS Putative ski2-type helicase OS=Met...1470.000000002     66.2     35     52
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:InterPro.
21Q974S1    704   HELS_SULTO Putative ski2-type helicase OS=Sul...1640.00000000000006     80.5     32     55
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:InterPro.
22Q4JC00    705   HELS_SULAC Putative ski2-type helicase OS=NBR...970.000000000004     74.3     40     61
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:InterPro.
23Q97VY9    708   HELS_SULSO Putative ski2-type helicase OS=P2)...2330.000000000000002     85.1     31     51
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:InterPro.
24Q5H9U9    1706   DDX6L_HUMAN Probable ATP-dependent RNA helica...1760.0000002     60.1     27     47
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
25P32639    2163   BRR2_YEAST Pre-mRNA-splicing helicase BRR2 OS...2700.00000001     63.5     26     46GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.::GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IDA:SGD.::GO:0005682; C:U5 snRNP; IDA:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004004; F:ATP-dependent RNA helicase activity; IMP:SGD.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0000388; P:spliceosome conformational change to release U4 (or U4atac) and U1 (or U11); IMP:SGD.
26Q5JGV6    1125   HELS_PYRKO Putative ski2-type helicase OS=(Th...540.24     39.7     35     52
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
GO:0006281; P:DNA repair; IEA:InterPro.::GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.::GO:0006314; P:intron homing; IEA:UniProtKB-KW.
27Q9YFQ8    735   HELS_AERPE Putative ski2-type helicase OS=100...1740.000000000000002     85.1     32     53
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:InterPro.
28Q9P7T8    1717   YIW2_SCHPO Uncharacterized helicase C694.02 O...1300.00000000000008     80.5     38     58GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
29Q12WZ6    760   HELS_METBU Putative ski2-type helicase OS=Met...930.0000000000006     77.4     44     62
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:InterPro.
30Q58524    1195   HELS_METJA Putative ski2-type helicase OS=JCM...680.0004     48.9     35     51
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
GO:0006281; P:DNA repair; IEA:InterPro.::GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.::GO:0006314; P:intron homing; IEA:UniProtKB-KW.
31P53327    1967   SLH1_YEAST Antiviral helicase SLH1 OS=Sacchar...1260.00009     50.8     32     48GO:0005737; C:cytoplasm; IDA:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.
GO:0006417; P:regulation of translation; IMP:SGD.::GO:0009615; P:response to virus; IEA:UniProtKB-KW.
records
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