Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLR396C
Length:
691
Number of sequences:
5887
Description:
YLR396C VPS33 SGDID:S000004388, Chr XII from 912310-910235, Genome Release 64-1-1, reverse complement, Verified ORF, "ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essential for protein sorting, vesicle docking and fusion at the vacuole"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P20795    691   VPS33_YEAST Vacuolar protein sorting-associat...6910     1420     100     100GO:0033263; C:CORVET complex; IDA:SGD.::GO:0005829; C:cytosol; IDA:SGD.::GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.
GO:0005524; F:ATP binding; IMP:SGD.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0006897; P:endocytosis; IMP:SGD.::GO:0006896; P:Golgi to vacuole transport; IMP:SGD.::GO:0034727; P:piecemeal microautophagy of nucleus; IMP:SGD.::GO:0006623; P:protein targeting to vacuole; IMP:SGD.::GO:0035542; P:regulation of SNARE complex assembly; IDA:SGD.::GO:0032889; P:regulation of vacuole fusion, non-autophagic; IDA:SGD.::GO:0042144; P:vacuole fusion, non-autophagic; IMP:SGD.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.::GO:0051469; P:vesicle fusion with vacuole; IGI:SGD.
2Q63615    597   VP33A_RAT Vacuolar protein sorting-associated...4401e-35     145     28     48GO:0031410; C:cytoplasmic vesicle; IDA:RGD.::GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.::GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
3Q96AX1    596   VP33A_HUMAN Vacuolar protein sorting-associat...4333e-35     144     28     48GO:0005769; C:early endosome; IDA:UniProtKB.::GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.::GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0032418; P:lysosome localization; IDA:UniProtKB.::GO:0032400; P:melanosome localization; IDA:UniProtKB.::GO:0030220; P:platelet formation; ISS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0048070; P:regulation of developmental pigmentation; ISS:UniProtKB.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
4Q9D2N9    598   VP33A_MOUSE Vacuolar protein sorting-associat...4343e-34     141     28     48GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.::GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
GO:0043473; P:pigmentation; IMP:MGI.::GO:0030220; P:platelet formation; IMP:MGI.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0048070; P:regulation of developmental pigmentation; IMP:MGI.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
5Q9P7V6    592   VPS33_SCHPO Vacuolar protein sorting-associat...6024e-27     120     24     43GO:0005829; C:cytosol; IDA:PomBase.::GO:0030897; C:HOPS complex; ISS:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0005524; F:ATP binding; ISS:PomBase.
GO:0006895; P:Golgi to endosome transport; ISS:PomBase.::GO:0045324; P:late endosome to vacuole transport; ISS:PomBase.::GO:0006623; P:protein targeting to vacuole; IMP:PomBase.::GO:0042144; P:vacuole fusion, non-autophagic; ISS:PomBase.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
6Q58EN8    617   VP33B_DANRE Vacuolar protein sorting-associat...4434e-25     114     25     44GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.::GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
GO:0035622; P:intrahepatic bile duct development; IMP:ZFIN.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
7Q2HJ18    617   VP33B_BOVIN Vacuolar protein sorting-associat...4915e-24     110     25     42GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.::GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.::GO:0031091; C:platelet alpha granule; ISS:UniProtKB.
GO:0006944; P:cellular membrane fusion; ISS:UniProtKB.::GO:0032418; P:lysosome localization; ISS:UniProtKB.::GO:0032400; P:melanosome localization; ISS:UniProtKB.::GO:0070889; P:platelet alpha granule organization; ISS:UniProtKB.::GO:0015031; P:protein transport; ISS:UniProtKB.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
8Q63616    617   VP33B_RAT Vacuolar protein sorting-associated...4911e-23     109     24     42GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.::GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
9Q94KJ7    592   VPS33_ARATH Vacuolar protein sorting-associat...4822e-23     108     25     45GO:0005829; C:cytosol; IDA:TAIR.::GO:0009705; C:plant-type vacuole membrane; IDA:TAIR.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0007033; P:vacuole organization; TAS:TAIR.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
10Q9H267    617   VP33B_HUMAN Vacuolar protein sorting-associat...4913e-23     108     24     42GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.::GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.::GO:0031091; C:platelet alpha granule; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0006944; P:cellular membrane fusion; IMP:UniProtKB.::GO:0032418; P:lysosome localization; IDA:UniProtKB.::GO:0032400; P:melanosome localization; IDA:UniProtKB.::GO:0070889; P:platelet alpha granule organization; IMP:UniProtKB.::GO:0015031; P:protein transport; IMP:UniProtKB.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
11P59016    617   VP33B_MOUSE Vacuolar protein sorting-associat...4913e-23     108     24     42GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.::GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
12Q9Y1I2    617   VP33A_DROME Vacuolar protein sorting-associat...4550.000000000002     73.9     23     40GO:0005829; C:cytosol; TAS:FlyBase.::GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.::GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0000046; P:autophagic vacuole fusion; IMP:FlyBase.::GO:0048072; P:compound eye pigmentation; IMP:FlyBase.::GO:0008340; P:determination of adult lifespan; IMP:FlyBase.::GO:0007032; P:endosome organization; IMP:FlyBase.::GO:0008333; P:endosome to lysosome transport; IMP:FlyBase.::GO:0008057; P:eye pigment granule organization; IMP:UniProtKB.::GO:0006727; P:ommochrome biosynthetic process; IMP:FlyBase.::GO:0006622; P:protein targeting to lysosome; IMP:UniProtKB.::GO:0031396; P:regulation of protein ubiquitination; IMP:FlyBase.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
13P34260    603   VP33A_CAEEL Vacuolar protein sorting-associat...3010.0000000005     66.2     20     45
GO:0005515; F:protein binding; IPI:IntAct.
GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
14Q09805    558   YAB3_SCHPO Putative vacuolar protein sorting-...1610.000000001     65.1     26     52GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0006895; P:Golgi to endosome transport; IMP:PomBase.::GO:0006896; P:Golgi to vacuole transport; IMP:PomBase.::GO:0006900; P:membrane budding; NAS:PomBase.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
15Q54GE3    563   VPS45_DICDI Vacuolar protein sorting-associat...1840.00000001     62     24     52GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; ISS:dictyBase.::GO:0045335; C:phagocytic vesicle; IDA:dictyBase.
GO:0051082; F:unfolded protein binding; ISS:dictyBase.
GO:0006896; P:Golgi to vacuole transport; ISS:dictyBase.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
16P38932    577   VPS45_YEAST Vacuolar protein sorting-associat...1840.00000001     62     26     48GO:0005829; C:cytosol; IDA:SGD.::GO:0019898; C:extrinsic to membrane; IDA:SGD.::GO:0000139; C:Golgi membrane; IDA:SGD.::GO:0031201; C:SNARE complex; IPI:SGD.::GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
GO:0051082; F:unfolded protein binding; IMP:SGD.
GO:0032258; P:CVT pathway; IMP:SGD.::GO:0006895; P:Golgi to endosome transport; IGI:SGD.::GO:0006896; P:Golgi to vacuole transport; IMP:SGD.::GO:0048210; P:Golgi vesicle fusion to target membrane; IMP:SGD.::GO:0035543; P:positive regulation of SNARE complex assembly; IMP:SGD.::GO:0007035; P:vacuolar acidification; IMP:SGD.::GO:0000011; P:vacuole inheritance; IMP:SGD.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
17O49048    569   VPS45_ARATH Vacuolar protein sorting-associat...2650.00000003     60.8     23     46GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0009705; C:plant-type vacuole membrane; IDA:TAIR.::GO:0005802; C:trans-Golgi network; IDA:TAIR.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0006886; P:intracellular protein transport; IGI:TAIR.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
18O08700    570   VPS45_RAT Vacuolar protein sorting-associated...1850.0000004     57     24     51GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0000299; C:integral to membrane of membrane fraction; IDA:BHF-UCL.
GO:0005515; F:protein binding; IPI:BHF-UCL.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
19P97390    570   VPS45_MOUSE Vacuolar protein sorting-associat...1850.0000004     57     24     51GO:0010008; C:endosome membrane; IDA:MGI.::GO:0000139; C:Golgi membrane; IDA:MGI.
GO:0005515; F:protein binding; IPI:MGI.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
20Q28288    593   STXB2_CANFA Syntaxin-binding protein 2 OS=Can...2590.000006     53.1     23     46GO:0042582; C:azurophil granule; ISS:UniProtKB.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0042581; C:specific granule; ISS:UniProtKB.::GO:0070820; C:tertiary granule; ISS:UniProtKB.
GO:0030348; F:syntaxin-3 binding; ISS:UniProtKB.
GO:0043312; P:neutrophil degranulation; ISS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
21Q15833    593   STXB2_HUMAN Syntaxin-binding protein 2 OS=Hom...2590.00002     51.6     22     46GO:0042582; C:azurophil granule; IDA:UniProtKB.::GO:0044194; C:cytolytic granule; IDA:UniProtKB.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0042581; C:specific granule; IDA:UniProtKB.::GO:0070820; C:tertiary granule; IDA:UniProtKB.
GO:0030348; F:syntaxin-3 binding; IPI:UniProtKB.
GO:0001909; P:leukocyte mediated cytotoxicity; IMP:UniProtKB.::GO:0043312; P:neutrophil degranulation; IEP:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0043304; P:regulation of mast cell degranulation; ISS:UniProtKB.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
22Q9NRW7    570   VPS45_HUMAN Vacuolar protein sorting-associat...1850.00003     50.8     24     50GO:0010008; C:endosome membrane; TAS:Reactome.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0000299; C:integral to membrane of membrane fraction; ISS:BHF-UCL.
GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0006886; P:intracellular protein transport; NAS:UniProtKB.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
23Q64324    593   STXB2_MOUSE Syntaxin-binding protein 2 OS=Mus...2590.00004     50.4     22     46GO:0016324; C:apical plasma membrane; IDA:MGI.
GO:0017075; F:syntaxin-1 binding; IPI:MGI.::GO:0030348; F:syntaxin-3 binding; IPI:MGI.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
24Q62753    594   STXB2_RAT Syntaxin-binding protein 2 OS=Rattu...2590.00008     49.3     22     46GO:0005737; C:cytoplasm; IDA:RGD.::GO:0030027; C:lamellipodium; IDA:RGD.::GO:0043234; C:protein complex; IDA:RGD.
GO:0017075; F:syntaxin-1 binding; IPI:RGD.::GO:0030348; F:syntaxin-3 binding; IPI:RGD.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0043304; P:regulation of mast cell degranulation; IMP:RGD.::GO:0010447; P:response to acidity; IEP:RGD.::GO:0016079; P:synaptic vesicle exocytosis; TAS:RGD.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
25O18637    656   SLY1_DROVI Protein sly1 homolog OS=Drosophila...2920.002     45.4     21     42GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
26Q6R748    594   STXB1_CHICK Syntaxin-binding protein 1 OS=Gal...2010.002     44.7     22     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
27Q07327    597   ROP_DROME Protein ROP OS=Drosophila melanogas...2030.007     43.5     22     46GO:0005829; C:cytosol; IDA:FlyBase.::GO:0016020; C:membrane; TAS:FlyBase.::GO:0000300; C:peripheral to membrane of membrane fraction; IDA:FlyBase.::GO:0043195; C:terminal button; IDA:FlyBase.
GO:0000910; P:cytokinesis; IMP:FlyBase.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0007317; P:regulation of pole plasm oskar mRNA localization; IMP:FlyBase.::GO:0009416; P:response to light stimulus; IMP:FlyBase.::GO:0016082; P:synaptic vesicle priming; NAS:FlyBase.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
28P61765    594   STXB1_RAT Syntaxin-binding protein 1 OS=Rattu...2010.009     42.7     22     49GO:0005829; C:cytosol; TAS:RGD.::GO:0005886; C:plasma membrane; IDA:RGD.::GO:0043234; C:protein complex; IDA:RGD.
GO:0042802; F:identical protein binding; IPI:BHF-UCL.::GO:0019904; F:protein domain specific binding; IDA:RGD.::GO:0019901; F:protein kinase binding; IPI:RGD.::GO:0047485; F:protein N-terminus binding; IDA:RGD.::GO:0017075; F:syntaxin-1 binding; IDA:MGI.
GO:0050821; P:protein stabilization; IDA:MGI.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0010807; P:regulation of synaptic vesicle priming; IMP:RGD.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
29Q5R6D2    594   STXB1_PONAB Syntaxin-binding protein 1 OS=Pon...2010.009     42.7     22     49GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0015031; P:protein transport; IEA:UniProtKB-KW.
30O08599    594   STXB1_MOUSE Syntaxin-binding protein 1 OS=Mus...2010.009     42.7     22     49GO:0005739; C:mitochondrion; IDA:MGI.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0017075; F:syntaxin-1 binding; IPI:MGI.
GO:0007412; P:axon target recognition; IMP:MGI.::GO:0060292; P:long term synaptic depression; IMP:MGI.::GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.::GO:0032229; P:negative regulation of synaptic transmission, GABAergic; IDA:MGI.::GO:0007274; P:neuromuscular synaptic transmission; IMP:MGI.::GO:0007269; P:neurotransmitter secretion; IMP:MGI.::GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IDA:MGI.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0016188; P:synaptic vesicle maturation; IMP:MGI.::GO:0006904; P:vesicle docking involved in exocytosis; IMP:MGI.
31P61764    594   STXB1_HUMAN Syntaxin-binding protein 1 OS=Hom...2010.009     42.7     22     49GO:0005829; C:cytosol; TAS:Reactome.::GO:0005739; C:mitochondrion; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0031091; C:platelet alpha granule; IDA:UniProtKB.::GO:0043234; C:protein complex; ISS:UniProtKB.
GO:0042802; F:identical protein binding; ISS:UniProtKB.::GO:0017075; F:syntaxin-1 binding; ISS:UniProtKB.
GO:0007412; P:axon target recognition; ISS:UniProtKB.::GO:0006112; P:energy reserve metabolic process; TAS:Reactome.::GO:0014047; P:glutamate secretion; TAS:Reactome.::GO:0032229; P:negative regulation of synaptic transmission, GABAergic; ISS:UniProtKB.::GO:0007269; P:neurotransmitter secretion; TAS:Reactome.::GO:0070527; P:platelet aggregation; IMP:UniProtKB.::GO:0002576; P:platelet degranulation; IMP:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0050796; P:regulation of insulin secretion; TAS:Reactome.::GO:0010807; P:regulation of synaptic vesicle priming; ISS:UniProtKB.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0016188; P:synaptic vesicle maturation; ISS:UniProtKB.::GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
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