rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | Q06010 | 1027 | STE23_YEAST A-factor-processing enzyme OS=Sac... | 1027 | 0 | 2123 | 100 | 100 | GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0000300; C:peripheral to membrane of membrane fraction; IDA:SGD. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IDA:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007323; P:peptide pheromone maturation; IGI:SGD.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0019236; P:response to pheromone; IEA:UniProtKB-KW. | 2 | P35559 | 1019 | IDE_RAT Insulin-degrading enzyme OS=Rattus no... | 960 | 0 | 715 | 39 | 60 | GO:0009986; C:cell surface; IDA:RGD.::GO:0031597; C:cytosolic proteasome complex; IDA:RGD.::GO:0005615; C:extracellular space; IDA:RGD.::GO:0005634; C:nucleus; IDA:RGD.::GO:0005782; C:peroxisomal matrix; IDA:RGD.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0016887; F:ATPase activity; IDA:RGD.::GO:0001540; F:beta-amyloid binding; IPI:RGD.::GO:0031626; F:beta-endorphin binding; IMP:RGD.::GO:0043559; F:insulin binding; IMP:RGD.::GO:0004222; F:metalloendopeptidase activity; ISS:UniProtKB.::GO:0042803; F:protein homodimerization activity; IDA:RGD.::GO:0008270; F:zinc ion binding; ISS:UniProtKB. | | | | | | | | | | GO:0050435; P:beta-amyloid metabolic process; ISS:UniProtKB.::GO:0010815; P:bradykinin catabolic process; ISS:UniProtKB.::GO:0042447; P:hormone catabolic process; IDA:RGD.::GO:0045861; P:negative regulation of proteolysis; IDA:RGD.::GO:0051291; P:protein heterooligomerization; IDA:RGD.::GO:0051289; P:protein homotetramerization; IDA:RGD.::GO:0051603; P:proteolysis involved in cellular protein catabolic process; IMP:RGD. | 3 | P14735 | 1019 | IDE_HUMAN Insulin-degrading enzyme OS=Homo sa... | 965 | 0 | 714 | 39 | 60 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0004222; F:metalloendopeptidase activity; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:UniProtKB. | | | | | | | | | | GO:0050435; P:beta-amyloid metabolic process; IDA:UniProtKB.::GO:0010815; P:bradykinin catabolic process; IDA:UniProtKB.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW. | 4 | Q24K02 | 1019 | IDE_BOVIN Insulin-degrading enzyme OS=Bos tau... | 965 | 0 | 714 | 38 | 60 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0004222; F:metalloendopeptidase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB. | | | | | | | | | | GO:0050435; P:beta-amyloid metabolic process; ISS:UniProtKB.::GO:0010815; P:bradykinin catabolic process; ISS:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 5 | Q9JHR7 | 1019 | IDE_MOUSE Insulin-degrading enzyme OS=Mus mus... | 960 | 0 | 710 | 39 | 60 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0004222; F:metalloendopeptidase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB. | | | | | | | | | | GO:0050435; P:beta-amyloid metabolic process; ISS:UniProtKB.::GO:0010815; P:bradykinin catabolic process; ISS:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 6 | O14077 | 969 | MU138_SCHPO Putative zinc protease mug138 OS=... | 956 | 0 | 659 | 39 | 59 | GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007126; P:meiosis; IEA:UniProtKB-KW.::GO:0071432; P:peptide mating pheromone maturation involved in conjugation with cellular fusion; ISS:PomBase.::GO:0006508; P:proteolysis; ISS:PomBase. | 7 | P22817 | 990 | IDE_DROME Insulin-degrading enzyme OS=Drosoph... | 955 | 0 | 659 | 36 | 57 | | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 8 | O22941 | 970 | PXM16_ARATH Zinc-metallopeptidase, peroxisoma... | 976 | 0 | 595 | 35 | 54 | GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 9 | Q5R4H6 | 1152 | NRDC_PONAB Nardilysin OS=Pongo abelii (Sumatr... | 879 | 3e-120 | 403 | 31 | 50 | | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 10 | O43847 | 1150 | NRDC_HUMAN Nardilysin OS=Homo sapiens (Human)... | 879 | 4e-120 | 402 | 30 | 50 | GO:0009986; C:cell surface; TAS:UniProtKB.::GO:0005829; C:cytosol; TAS:UniProtKB. | | | | | | | | | | GO:0048408; F:epidermal growth factor binding; TAS:UniProtKB.::GO:0004222; F:metalloendopeptidase activity; NAS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0016477; P:cell migration; TAS:UniProtKB.::GO:0008283; P:cell proliferation; TAS:UniProtKB.::GO:0007528; P:neuromuscular junction development; TAS:ProtInc.::GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IDA:BHF-UCL.::GO:0006508; P:proteolysis; NAS:UniProtKB.::GO:0052548; P:regulation of endopeptidase activity; IDA:BHF-UCL. | 11 | Q8BHG1 | 1161 | NRDC_MOUSE Nardilysin OS=Mus musculus (Mouse)... | 882 | 5e-120 | 402 | 30 | 50 | GO:0005739; C:mitochondrion; IDA:MGI. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 12 | P47245 | 1161 | NRDC_RAT Nardilysin OS=Rattus norvegicus (Rat... | 878 | 1e-118 | 399 | 30 | 50 | | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 13 | Q8ZMB5 | 962 | PTRA_SALTY Protease 3 OS=Salmonella typhimuri... | 941 | 1e-100 | 344 | 27 | 47 | GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 14 | Q10040 | 856 | YQA4_CAEEL Putative zinc protease C28F5.4 OS=... | 440 | 2e-30 | 133 | 23 | 47 | | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 15 | Q8CVS2 | 962 | PTRA_ECOL6 Protease 3 OS=Escherichia coli O6:... | 940 | 3e-100 | 343 | 27 | 47 | GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 16 | P05458 | 962 | PTRA_ECOLI Protease 3 OS=Escherichia coli (st... | 940 | 1e-99 | 342 | 27 | 47 | GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IDA:EcoCyc. | 17 | Q83QC3 | 962 | PTRA_SHIFL Protease 3 OS=Shigella flexneri. G... | 940 | 3e-99 | 340 | 27 | 47 | GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 18 | Q8X6M8 | 962 | PTRA_ECO57 Protease 3 OS=Escherichia coli O15... | 940 | 6e-99 | 340 | 27 | 46 | GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 19 | Q8Z418 | 962 | PTRA_SALTI Protease 3 OS=Salmonella typhi. GN... | 941 | 5e-98 | 337 | 27 | 46 | GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 20 | Q54JQ2 | 962 | IDE_DICDI Insulin-degrading enzyme homolog OS... | 923 | 9e-85 | 300 | 26 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 21 | P42789 | 596 | SDP_EIMBO Sporozoite developmental protein OS... | 559 | 1e-61 | 225 | 28 | 48 | | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 22 | P40851 | 1208 | AXL1_YEAST Putative protease AXL1 OS=Saccharo... | 166 | 3.1 | 35.4 | 28 | 42 | GO:0005935; C:cellular bud neck; IDA:SGD.::GO:0043332; C:mating projection tip; IDA:SGD.::GO:0000300; C:peripheral to membrane of membrane fraction; IDA:SGD. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IMP:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007120; P:axial cellular bud site selection; IMP:SGD.::GO:0007323; P:peptide pheromone maturation; IMP:SGD.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 23 | Q9I2D2 | 775 | PQQF_PSEAE Coenzyme PQQ synthesis protein F O... | 202 | 2e-23 | 110 | 34 | 49 | | | | | | | | | | | GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.::GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0018189; P:pyrroloquinoline quinone biosynthetic process; IEA:UniProtKB-KW. | 24 | Q88A79 | 779 | PQQF_PSESM Coenzyme PQQ synthesis protein F O... | 259 | 3e-22 | 107 | 29 | 46 | | | | | | | | | | | GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.::GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0018189; P:pyrroloquinoline quinone biosynthetic process; IEA:UniProtKB-KW. | 25 | Q88QV3 | 766 | PQQF_PSEPK Coenzyme PQQ synthesis protein F O... | 46 | 0.08 | 40.4 | 41 | 52 | | | | | | | | | | | GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.::GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0018189; P:pyrroloquinoline quinone biosynthetic process; IEA:UniProtKB-KW. | 26 | P55174 | 829 | PQQF_PSEFL Coenzyme PQQ synthesis protein F O... | 71 | 0.47 | 38.1 | 30 | 44 | | | | | | | | | | | GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.::GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0018189; P:pyrroloquinoline quinone biosynthetic process; IEA:UniProtKB-KW. | 27 | P27508 | 761 | PQQF_KLEPN Coenzyme PQQ synthesis protein F O... | 207 | 4e-20 | 100 | 29 | 51 | | | | | | | | | | | GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.::GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0018189; P:pyrroloquinoline quinone biosynthetic process; IEA:UniProtKB-KW. | 28 | P55679 | 512 | Y4WA_RHISN Uncharacterized zinc protease y4wA... | 259 | 0.0000000000004 | 76.6 | 24 | 45 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 29 | P31828 | 931 | PQQL_ECOLI Probable zinc protease pqqL OS=Esc... | 222 | 0.00000004 | 61.2 | 26 | 45 | | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 30 | Q92IX7 | 412 | Y293_RICCN Uncharacterized zinc protease RC02... | 208 | 0.00000004 | 60.5 | 26 | 42 | | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 31 | O31766 | 428 | YMFH_BACSU Uncharacterized zinc protease ymfH... | 287 | 0.0000004 | 57.4 | 24 | 42 | | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. |