Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLR371W
Length:
1356
Number of sequences:
5887
Description:
YLR371W ROM2 SGDID:S000004363, Chr XII from 862714-866784, Genome Release 64-1-1, Verified ORF, "GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
61Q92974    986   ARHG2_HUMAN Rho guanine nucleotide exchange f...3190.000004     55.1     21     45GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005874; C:microtubule; IDA:UniProtKB.::GO:0032587; C:ruffle membrane; IDA:UniProtKB.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
GO:0008017; F:microtubule binding; IDA:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0048365; F:Rac GTPase binding; IDA:UniProtKB.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; NAS:UniProtKB.
GO:0007015; P:actin filament organization; IMP:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0000902; P:cell morphogenesis; IMP:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0006886; P:intracellular protein transport; NAS:UniProtKB.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007026; P:negative regulation of microtubule depolymerization; IMP:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.::GO:0042127; P:regulation of cell proliferation; TAS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; NAS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
62P11433    854   CDC24_YEAST Cell division control protein 24 ...2200.000005     54.7     24     48GO:0005935; C:cellular bud neck; IDA:SGD.::GO:0005934; C:cellular bud tip; IDA:SGD.::GO:0005737; C:cytoplasm; IDA:SGD.::GO:0000131; C:incipient cellular bud site; IDA:SGD.::GO:0043332; C:mating projection tip; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; TAS:SGD.
GO:0030010; P:establishment of cell polarity; TAS:SGD.::GO:0007096; P:regulation of exit from mitosis; IMP:SGD.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:SGD.
63Q69ZK0    1650   PREX1_MOUSE Phosphatidylinositol 3,4,5-trisph...2650.000006     54.7     23     46GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
64Q9Z0R6    1659   ITSN2_MOUSE Intersectin-2 OS=Mus musculus (Mo...3040.000008     54.3     20     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
65O88387    766   FGD4_RAT FYVE, RhoGEF and PH domain-containin...1790.000009     53.9     24     45GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
GO:0051015; F:actin filament binding; IMP:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0007257; P:activation of JUN kinase activity; IDA:MGI.::GO:0008360; P:regulation of cell shape; IMP:RGD.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
66A1IGU5    675   ARH37_HUMAN Rho guanine nucleotide exchange f...1760.000009     53.9     28     48GO:0005737; C:cytoplasm; IEA:InterPro.
GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
67A2CG49    2964   KALRN_MOUSE Kalirin OS=Mus musculus (Mouse). ...1830.0005     48.5     26     48GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
68O15013    1369   ARHGA_HUMAN Rho guanine nucleotide exchange f...2200.000009     54.3     24     46GO:0005813; C:centrosome; IDA:BHF-UCL.::GO:0005829; C:cytosol; NAS:BHF-UCL.::GO:0005625; C:soluble fraction; IDA:BHF-UCL.
GO:0019894; F:kinesin binding; IPI:BHF-UCL.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:BHF-UCL.
GO:0051298; P:centrosome duplication; IMP:BHF-UCL.::GO:0022011; P:myelination in peripheral nervous system; IMP:BHF-UCL.::GO:0033126; P:positive regulation of GTP catabolic process; IDA:BHF-UCL.::GO:0051496; P:positive regulation of stress fiber assembly; IMP:BHF-UCL.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0090307; P:spindle assembly involved in mitosis; IMP:BHF-UCL.
69P97924    2959   KALRN_RAT Kalirin OS=Rattus norvegicus (Rat)....2290.0006     48.5     25     46GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0043005; C:neuron projection; IDA:RGD.::GO:0043025; C:neuronal cell body; IDA:RGD.::GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:RGD.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0007409; P:axonogenesis; IDA:RGD.::GO:0035556; P:intracellular signal transduction; IDA:HGNC.::GO:0050773; P:regulation of dendrite development; IDA:RGD.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
70O60229    2985   KALRN_HUMAN Kalirin OS=Homo sapiens (Human). ...2290.0007     48.1     25     46GO:0015629; C:actin cytoskeleton; TAS:ProtInc.::GO:0005829; C:cytosol; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007399; P:nervous system development; ISS:HGNC.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0016192; P:vesicle-mediated transport; TAS:ProtInc.
71Q5JSP0    725   FGD3_HUMAN FYVE, RhoGEF and PH domain-contain...2640.00002     53.1     22     45GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0031267; F:small GTPase binding; ISS:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0046847; P:filopodium assembly; ISS:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0043088; P:regulation of Cdc42 GTPase activity; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
72Q0KL02    3102   TRIO_MOUSE Triple functional domain protein O...1830.00002     52.8     26     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
73Q96M96    766   FGD4_HUMAN FYVE, RhoGEF and PH domain-contain...1790.00003     52.4     24     45GO:0015629; C:actin cytoskeleton; IDA:HPA.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0031267; F:small GTPase binding; ISS:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0046847; P:filopodium assembly; ISS:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0043088; P:regulation of Cdc42 GTPase activity; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
74O75962    3097   TRIO_HUMAN Triple functional domain protein O...1830.00003     52.8     26     48GO:0005829; C:cytosol; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0007185; P:transmembrane receptor protein tyrosine phosphatase signaling pathway; TAS:ProtInc.
75Q7TT50    1713   MRCKB_MOUSE Serine/threonine-protein kinase M...1470.00003     52.8     22     46GO:0031252; C:cell leading edge; ISS:UniProtKB.::GO:0005911; C:cell-cell junction; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro.
GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.
76Q6ZV73    1430   FGD6_HUMAN FYVE, RhoGEF and PH domain-contain...2530.00003     52.4     22     42GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0031267; F:small GTPase binding; ISS:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0046847; P:filopodium assembly; ISS:UniProtKB.::GO:0043088; P:regulation of Cdc42 GTPase activity; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
77O14578    2027   CTRO_HUMAN Citron Rho-interacting kinase OS=H...1330.00004     52.4     32     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro.
GO:0033205; P:cell cycle cytokinesis; IMP:UniProtKB.::GO:0048699; P:generation of neurons; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007067; P:mitosis; ISS:UniProtKB.
78Q5R5T1    737   FGD3_PONAB FYVE, RhoGEF and PH domain-contain...2640.00004     52     22     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
79Q07139    913   ECT2_MOUSE Protein ECT2 OS=Mus musculus (Mous...2010.00005     51.6     27     42GO:0097149; C:centralspindlin complex; ISS:UniProtKB.::GO:0032154; C:cleavage furrow; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0030496; C:midbody; ISS:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0005923; C:tight junction; ISS:UniProtKB.
GO:0005096; F:GTPase activator activity; ISS:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0017048; F:Rho GTPase binding; IPI:MGI.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0032147; P:activation of protein kinase activity; ISS:UniProtKB.::GO:0032863; P:activation of Rac GTPase activity; ISS:UniProtKB.::GO:0033205; P:cell cycle cytokinesis; ISS:UniProtKB.::GO:0000902; P:cell morphogenesis; IDA:MGI.::GO:0071277; P:cellular response to calcium ion; ISS:UniProtKB.::GO:0070301; P:cellular response to hydrogen peroxide; ISS:UniProtKB.::GO:0071479; P:cellular response to ionizing radiation; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.::GO:0043089; P:positive regulation of Cdc42 GTPase activity; ISS:UniProtKB.::GO:0071777; P:positive regulation of cell cycle cytokinesis; ISS:UniProtKB.::GO:0045666; P:positive regulation of neuron differentiation; IMP:UniProtKB.::GO:0042307; P:positive regulation of protein import into nucleus; IDA:UniProtKB.::GO:0051260; P:protein homooligomerization; ISS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0051988; P:regulation of attachment of spindle microtubules to kinetochore; ISS:UniProtKB.::GO:0070830; P:tight junction assembly; ISS:UniProtKB.
80Q13009    1591   TIAM1_HUMAN T-lymphoma invasion and metastasi...2350.00005     51.6     21     45GO:0005911; C:cell-cell junction; IDA:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome.
GO:0005057; F:receptor signaling protein activity; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; TAS:ProtInc.
GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
81Q1LUA6    3028   TRIO_DANRE Triple functional domain protein O...1830.0003     48.9     25     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
82Q91VS8    1065   FARP2_MOUSE FERM, RhoGEF and pleckstrin domai...2740.00006     51.2     22     43GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0019898; C:extrinsic to membrane; IEA:InterPro.
GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
83P0C6P5    1700   RGNEF_RAT Rho-guanine nucleotide exchange fac...2840.00007     51.2     22     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
84Q60610    1591   TIAM1_MOUSE T-lymphoma invasion and metastasi...2350.00007     51.2     21     45GO:0005911; C:cell-cell junction; ISS:UniProtKB.::GO:0005622; C:intracellular; IEA:InterPro.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro.::GO:0030971; F:receptor tyrosine kinase binding; IPI:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0031547; P:brain-derived neurotrophic factor receptor signaling pathway; IDA:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0010976; P:positive regulation of neuron projection development; IDA:UniProtKB.::GO:0032314; P:regulation of Rac GTPase activity; IDA:UniProtKB.
85Q21653    1182   YNG2_CAEEL Uncharacterized protein R02F2.2 OS...2410.00007     51.2     24     43GO:0005622; C:intracellular; IEA:InterPro.
GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
86P54100    843   VAV_RAT Proto-oncogene vav OS=Rattus norvegic...2780.00009     50.8     26     44GO:0005622; C:intracellular; IEA:InterPro.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0048468; P:cell development; TAS:RGD.::GO:0002768; P:immune response-regulating cell surface receptor signaling pathway; IEP:RGD.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
87P27870    845   VAV_MOUSE Proto-oncogene vav OS=Mus musculus ...2750.0001     50.4     25     44GO:0005829; C:cytosol; TAS:Reactome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MGI.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IGI:MGI.
GO:0006955; P:immune response; IMP:MGI.::GO:0007229; P:integrin-mediated signaling pathway; IGI:MGI.::GO:0035556; P:intracellular signal transduction; IMP:MGI.::GO:0006909; P:phagocytosis; IGI:MGI.::GO:0045785; P:positive regulation of cell adhesion; IGI:MGI.::GO:0043087; P:regulation of GTPase activity; IGI:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0030217; P:T cell differentiation; TAS:MGI.
88Q7TNR9    484   ARHG4_MOUSE Rho guanine nucleotide exchange f...1920.0001     49.7     21     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0046847; P:filopodium assembly; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0030032; P:lamellipodium assembly; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
89Q69ZL1    1399   FGD6_MOUSE FYVE, RhoGEF and PH domain-contain...2530.0002     50.1     21     42GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
90Q96N96    652   SPT13_HUMAN Spermatogenesis-associated protei...1920.0002     49.3     24     43GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0030175; C:filopodium; IDA:UniProtKB.::GO:0030027; C:lamellipodium; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA.::GO:0032587; C:ruffle membrane; IDA:UniProtKB.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IDA:UniProtKB.
GO:0016477; P:cell migration; IMP:UniProtKB.::GO:0046847; P:filopodium assembly; IMP:UniProtKB.::GO:0030032; P:lamellipodium assembly; IMP:UniProtKB.::GO:0030334; P:regulation of cell migration; IMP:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
91Q5DU57    656   SPT13_MOUSE Spermatogenesis-associated protei...2610.0004     48.5     22     41GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0030175; C:filopodium; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0032587; C:ruffle membrane; ISS:UniProtKB.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0046847; P:filopodium assembly; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0030032; P:lamellipodium assembly; ISS:UniProtKB.::GO:0030334; P:regulation of cell migration; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
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