Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLR371W
Length:
1356
Number of sequences:
5887
Description:
YLR371W ROM2 SGDID:S000004363, Chr XII from 862714-866784, Genome Release 64-1-1, Verified ORF, "GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31Q8IW93    802   ARHGJ_HUMAN Rho guanine nucleotide exchange f...2390.000000003     65.1     25     49GO:0005622; C:intracellular; IEA:InterPro.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0032956; P:regulation of actin cytoskeleton organization; IGI:MGI.
32Q5RDX5    709   NGEF_PONAB Ephexin-1 OS=Pongo abelii (Sumatra...2070.00000001     63.2     27     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0061002; P:negative regulation of dendritic spine morphogenesis; ISS:UniProtKB.::GO:0043087; P:regulation of GTPase activity; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
33Q8N5V2    710   NGEF_HUMAN Ephexin-1 OS=Homo sapiens (Human)....2070.00000002     62.8     27     48GO:0005829; C:cytosol; TAS:Reactome.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:HPA.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0061002; P:negative regulation of dendritic spine morphogenesis; ISS:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0043087; P:regulation of GTPase activity; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
34Q3U5C8    713   ARHGG_MOUSE Rho guanine nucleotide exchange f...2710.00000002     62.4     23     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0032863; P:activation of Rac GTPase activity; ISS:UniProtKB.::GO:0060326; P:cell chemotaxis; ISS:UniProtKB.::GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; ISS:UniProtKB.
35Q70Z35    1606   PREX2_HUMAN Phosphatidylinositol 3,4,5-trisph...2770.00000003     62.4     22     47GO:0005622; C:intracellular; IEA:InterPro.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030675; F:Rac GTPase activator activity; IDA:MGI.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IDA:MGI.
GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.
36Q7Z6J4    655   FGD2_HUMAN FYVE, RhoGEF and PH domain-contain...2830.00000003     61.6     23     43GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0031267; F:small GTPase binding; ISS:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0046847; P:filopodium assembly; ISS:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0043088; P:regulation of Cdc42 GTPase activity; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
37Q8CHT1    710   NGEF_MOUSE Ephexin-1 OS=Mus musculus (Mouse)....2070.00000005     61.2     26     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0046875; F:ephrin receptor binding; IPI:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0048013; P:ephrin receptor signaling pathway; IDA:UniProtKB.::GO:0061002; P:negative regulation of dendritic spine morphogenesis; IDA:UniProtKB.::GO:0043087; P:regulation of GTPase activity; IDA:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
38Q9NZM3    1697   ITSN2_HUMAN Intersectin-2 OS=Homo sapiens (Hu...3020.00000005     61.6     22     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
39Q11100    665   TAG52_CAEEL Putative protein tag-52 OS=Caenor...2750.00000006     60.8     23     48GO:0005622; C:intracellular; IEA:InterPro.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
40B2DCZ9    961   ARHG2_PIG Rho guanine nucleotide exchange fac...3130.00000009     60.5     21     44GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005874; C:microtubule; ISS:UniProtKB.::GO:0032587; C:ruffle membrane; ISS:UniProtKB.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008017; F:microtubule binding; ISS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0048365; F:Rac GTPase binding; ISS:UniProtKB.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0007015; P:actin filament organization; ISS:UniProtKB.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0000902; P:cell morphogenesis; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007026; P:negative regulation of microtubule depolymerization; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
41Q5BKC9    701   NGEF_RAT Ephexin-1 OS=Rattus norvegicus (Rat)...1860.0000001     60.5     26     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0061002; P:negative regulation of dendritic spine morphogenesis; ISS:UniProtKB.::GO:0043087; P:regulation of GTPase activity; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
42Q45FX5    1007   VAV_CAEEL Protein vav-1 OS=Caenorhabditis ele...2880.0000003     58.9     23     45GO:0005622; C:intracellular; IEA:InterPro.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0045746; P:negative regulation of Notch signaling pathway; IGI:WormBase.::GO:0040027; P:negative regulation of vulval development; IMP:WormBase.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
43Q12774    1597   ARHG5_HUMAN Rho guanine nucleotide exchange f...2670.0000003     58.9     23     46GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005886; C:plasma membrane; IDA:HPA.
GO:0005525; F:GTP binding; TAS:ProtInc.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
44Q9NR80    690   ARHG4_HUMAN Rho guanine nucleotide exchange f...1920.0000004     58.5     23     47GO:0005829; C:cytosol; TAS:Reactome.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0019904; F:protein domain specific binding; IPI:UniProtKB.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IMP:UniProtKB.
GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0046847; P:filopodium assembly; IMP:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0030032; P:lamellipodium assembly; IMP:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
45Q008S8    904   ECT2L_HUMAN Epithelial cell-transforming sequ...1920.0000005     58.2     27     45GO:0005622; C:intracellular; IEA:InterPro.
GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
46Q5VV41    709   ARHGG_HUMAN Rho guanine nucleotide exchange f...2000.0000005     58.2     23     49GO:0005829; C:cytosol; TAS:Reactome.
GO:0030165; F:PDZ domain binding; IPI:BHF-UCL.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030971; F:receptor tyrosine kinase binding; IPI:UniProtKB.::GO:0017048; F:Rho GTPase binding; IPI:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:UniProtKB.
GO:0032864; P:activation of Cdc42 GTPase activity; IDA:BHF-UCL.::GO:0032863; P:activation of Rac GTPase activity; IMP:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0060326; P:cell chemotaxis; IMP:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; IMP:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
47Q865S3    986   ARHG2_CANFA Rho guanine nucleotide exchange f...3240.0000006     57.8     21     43GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005874; C:microtubule; ISS:UniProtKB.::GO:0032587; C:ruffle membrane; ISS:UniProtKB.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008017; F:microtubule binding; ISS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0048365; F:Rac GTPase binding; ISS:UniProtKB.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0007015; P:actin filament organization; ISS:UniProtKB.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0000902; P:cell morphogenesis; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007026; P:negative regulation of microtubule depolymerization; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
48Q3LAC4    1598   PREX2_MOUSE Phosphatidylinositol 3,4,5-trisph...2800.0000007     57.8     21     46GO:0005622; C:intracellular; IEA:InterPro.
GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
49Q1ZXH8    1632   GXCDD_DICDI Guanine exchange factor for Rac 3...2690.0000008     57.8     23     48GO:0005938; C:cell cortex; IMP:dictyBase.::GO:0032009; C:early phagosome; IMP:dictyBase.::GO:0005626; C:insoluble fraction; IDA:dictyBase.::GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; IDA:dictyBase.
GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0048365; F:Rac GTPase binding; IDA:dictyBase.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IPI:dictyBase.
50Q8BY35    655   FGD2_MOUSE FYVE, RhoGEF and PH domain-contain...2850.0000009     57     23     41GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
51Q8C033    1345   ARHGA_MOUSE Rho guanine nucleotide exchange f...2890.000001     57.4     22     45GO:0005622; C:intracellular; IEA:InterPro.
GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
52Q91ZT5    766   FGD4_MOUSE FYVE, RhoGEF and PH domain-contain...1790.000001     57     25     46GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0030175; C:filopodium; IDA:MGI.::GO:0030027; C:lamellipodium; IDA:MGI.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0030032; P:lamellipodium assembly; IDA:MGI.::GO:0030035; P:microspike assembly; IDA:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
53Q6ZSZ5    1173   ARHGI_HUMAN Rho guanine nucleotide exchange f...2310.000001     56.6     23     47GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:HPA.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0030036; P:actin cytoskeleton organization; IDA:MGI.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0008360; P:regulation of cell shape; IDA:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IDA:MGI.
54Q8N1W1    1705   RGNEF_HUMAN Rho-guanine nucleotide exchange f...2250.000002     56.6     24     47GO:0005737; C:cytoplasm; IDA:HPA.::GO:0015630; C:microtubule cytoskeleton; IDA:HPA.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
55Q7TT49    1713   MRCKB_RAT Serine/threonine-protein kinase MRC...1470.000002     56.2     22     46GO:0042641; C:actomyosin; IDA:UniProtKB.::GO:0031252; C:cell leading edge; ISS:UniProtKB.::GO:0005911; C:cell-cell junction; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.::GO:0017048; F:Rho GTPase binding; IDA:RGD.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro.
GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0031032; P:actomyosin structure organization; IMP:UniProtKB.::GO:0016477; P:cell migration; IMP:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.
56O88842    733   FGD3_MOUSE FYVE, RhoGEF and PH domain-contain...2640.000003     55.8     23     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0046847; P:filopodium assembly; IDA:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
57P97433    1693   RGNEF_MOUSE Rho-guanine nucleotide exchange f...2890.000003     55.8     23     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MGI.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0021955; P:central nervous system neuron axonogenesis; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0060052; P:neurofilament cytoskeleton organization; IMP:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
58Q6P9R4    1021   ARHGI_MOUSE Rho guanine nucleotide exchange f...2320.000003     55.5     22     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
59Q06412    1307   TUS1_YEAST Rho1 guanine nucleotide exchange f...4260.000004     55.5     23     40GO:0005935; C:cellular bud neck; IDA:SGD.::GO:0000131; C:incipient cellular bud site; IDA:SGD.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:SGD.
GO:0031505; P:fungal-type cell wall organization; IGI:SGD.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007165; P:signal transduction; IGI:SGD.
60Q9Y5S2    1711   MRCKB_HUMAN Serine/threonine-protein kinase M...1580.000004     55.5     22     47GO:0042641; C:actomyosin; IDA:UniProtKB.::GO:0031252; C:cell leading edge; ISS:UniProtKB.::GO:0005911; C:cell-cell junction; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro.
GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0031032; P:actomyosin structure organization; IMP:UniProtKB.::GO:0016477; P:cell migration; IMP:UniProtKB.::GO:0007163; P:establishment or maintenance of cell polarity; TAS:ProtInc.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.
61Q92974    986   ARHG2_HUMAN Rho guanine nucleotide exchange f...3190.000004     55.1     21     45GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005874; C:microtubule; IDA:UniProtKB.::GO:0032587; C:ruffle membrane; IDA:UniProtKB.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
GO:0008017; F:microtubule binding; IDA:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0048365; F:Rac GTPase binding; IDA:UniProtKB.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; NAS:UniProtKB.
GO:0007015; P:actin filament organization; IMP:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0000902; P:cell morphogenesis; IMP:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0006886; P:intracellular protein transport; NAS:UniProtKB.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007026; P:negative regulation of microtubule depolymerization; IMP:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.::GO:0042127; P:regulation of cell proliferation; TAS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; NAS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
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