Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLR362W
Length:
717
Number of sequences:
5887
Description:
YLR362W STE11 SGDID:S000004354, Chr XII from 849866-852019, Genome Release 64-1-1, Verified ORF, "Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
991O60674    1132   JAK2_HUMAN Tyrosine-protein kinase JAK2 OS=Ho...2210.00007     50.1     24     43GO:0005901; C:caveola; ISS:BHF-UCL.::GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0031904; C:endosome lumen; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005131; F:growth hormone receptor binding; ISS:BHF-UCL.::GO:0020037; F:heme binding; IDA:UniProtKB.::GO:0042393; F:histone binding; IDA:UniProtKB.::GO:0035401; F:histone kinase activity (H3-Y41 specific); IDA:UniProtKB.::GO:0005143; F:interleukin-12 receptor binding; ISS:BHF-UCL.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0019901; F:protein kinase binding; IDA:BHF-UCL.::GO:0042169; F:SH2 domain binding; IPI:UniProtKB.
GO:0030041; P:actin filament polymerization; NAS:BHF-UCL.::GO:0008636; P:activation of caspase activity by protein phosphorylation; ISS:BHF-UCL.::GO:0042977; P:activation of JAK2 kinase activity; ISS:UniProtKB.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0006928; P:cellular component movement; TAS:ProtInc.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0035722; P:interleukin-12-mediated signaling pathway; IDA:BHF-UCL.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; ISS:UniProtKB.::GO:0061180; P:mammary gland epithelium development; ISS:BHF-UCL.::GO:0007498; P:mesoderm development; TAS:ProtInc.::GO:0008285; P:negative regulation of cell proliferation; ISS:BHF-UCL.::GO:0043392; P:negative regulation of DNA binding; ISS:BHF-UCL.::GO:0010811; P:positive regulation of cell-substrate adhesion; IDA:BHF-UCL.::GO:0060399; P:positive regulation of growth hormone receptor signaling pathway; ISS:BHF-UCL.::GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; ISS:BHF-UCL.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; ISS:BHF-UCL.::GO:0032760; P:positive regulation of tumor necrosis factor production; ISS:BHF-UCL.::GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; ISS:UniProtKB.::GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein; ISS:BHF-UCL.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0046677; P:response to antibiotic; IDA:MGI.::GO:0032496; P:response to lipopolysaccharide; ISS:BHF-UCL.::GO:0007262; P:STAT protein import into nucleus; ISS:BHF-UCL.::GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IDA:BHF-UCL.
992Q5RB23    1132   JAK2_PONAB Tyrosine-protein kinase JAK2 OS=Po...2210.00008     50.1     24     43GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0035401; F:histone kinase activity (H3-Y41 specific); ISS:UniProtKB.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
GO:0042977; P:activation of JAK2 kinase activity; ISS:UniProtKB.::GO:0019221; P:cytokine-mediated signaling pathway; ISS:UniProtKB.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; ISS:UniProtKB.::GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.
993Q62120    1129   JAK2_MOUSE Tyrosine-protein kinase JAK2 OS=Mu...2210.0001     49.7     23     43GO:0005901; C:caveola; IDA:MGI.::GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; ISS:BHF-UCL.::GO:0016363; C:nuclear matrix; ISS:BHF-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005131; F:growth hormone receptor binding; ISS:BHF-UCL.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0035401; F:histone kinase activity (H3-Y41 specific); ISS:UniProtKB.::GO:0005143; F:interleukin-12 receptor binding; IPI:MGI.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:Reactome.::GO:0019901; F:protein kinase binding; ISS:BHF-UCL.
GO:0008636; P:activation of caspase activity by protein phosphorylation; IDA:BHF-UCL.::GO:0042977; P:activation of JAK2 kinase activity; IDA:UniProtKB.::GO:0000186; P:activation of MAPKK activity; ISS:BHF-UCL.::GO:0031103; P:axon regeneration; ISS:BHF-UCL.::GO:0007204; P:elevation of cytosolic calcium ion concentration; ISS:BHF-UCL.::GO:0030218; P:erythrocyte differentiation; IMP:UniProtKB.::GO:0007186; P:G-protein coupled receptor signaling pathway; ISS:BHF-UCL.::GO:0009755; P:hormone-mediated signaling pathway; ISS:BHF-UCL.::GO:0008631; P:induction of apoptosis by oxidative stress; ISS:BHF-UCL.::GO:0060333; P:interferon-gamma-mediated signaling pathway; ISS:BHF-UCL.::GO:0035722; P:interleukin-12-mediated signaling pathway; ISS:BHF-UCL.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; IMP:UniProtKB.::GO:0061180; P:mammary gland epithelium development; IMP:MGI.::GO:0031959; P:mineralocorticoid receptor signaling pathway; ISS:BHF-UCL.::GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.::GO:0022408; P:negative regulation of cell-cell adhesion; ISS:BHF-UCL.::GO:0043392; P:negative regulation of DNA binding; IDA:MGI.::GO:0045822; P:negative regulation of heart contraction; ISS:BHF-UCL.::GO:0043526; P:neuroprotection; ISS:BHF-UCL.::GO:0048008; P:platelet-derived growth factor receptor signaling pathway; ISS:BHF-UCL.::GO:0050867; P:positive regulation of cell activation; ISS:BHF-UCL.::GO:0045597; P:positive regulation of cell differentiation; ISS:BHF-UCL.::GO:0030335; P:positive regulation of cell migration; ISS:BHF-UCL.::GO:0008284; P:positive regulation of cell proliferation; ISS:BHF-UCL.::GO:0010811; P:positive regulation of cell-substrate adhesion; ISS:BHF-UCL.::GO:0043388; P:positive regulation of DNA binding; ISS:BHF-UCL.::GO:0060399; P:positive regulation of growth hormone receptor signaling pathway; IMP:BHF-UCL.::GO:0050729; P:positive regulation of inflammatory response; ISS:BHF-UCL.::GO:0032024; P:positive regulation of insulin secretion; ISS:BHF-UCL.::GO:0032731; P:positive regulation of interleukin-1 beta production; ISS:BHF-UCL.::GO:0045429; P:positive regulation of nitric oxide biosynthetic process; ISS:BHF-UCL.::GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IDA:BHF-UCL.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IMP:BHF-UCL.::GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; ISS:BHF-UCL.::GO:0033160; P:positive regulation of protein import into nucleus, translocation; ISS:BHF-UCL.::GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; ISS:BHF-UCL.::GO:0032760; P:positive regulation of tumor necrosis factor production; IDA:BHF-UCL.::GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IDA:UniProtKB.::GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein; IDA:BHF-UCL.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0097012; P:response to granulocyte macrophage colony-stimulating factor stimulus; NAS:BHF-UCL.::GO:0033194; P:response to hydroperoxide; ISS:BHF-UCL.::GO:0032496; P:response to lipopolysaccharide; IDA:BHF-UCL.::GO:0007262; P:STAT protein import into nucleus; IDA:MGI.::GO:0033209; P:tumor necrosis factor-mediated signaling pathway; ISS:BHF-UCL.::GO:0042508; P:tyrosine phosphorylation of Stat1 protein; ISS:BHF-UCL.::GO:0042503; P:tyrosine phosphorylation of Stat3 protein; ISS:BHF-UCL.
994Q75R65    1129   JAK2_CHICK Tyrosine-protein kinase JAK2 OS=Ga...2270.0001     49.3     23     43GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0035401; F:histone kinase activity (H3-Y41 specific); ISS:UniProtKB.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
GO:0042977; P:activation of JAK2 kinase activity; ISS:UniProtKB.::GO:0019221; P:cytokine-mediated signaling pathway; ISS:UniProtKB.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.
995Q09178    1156   JAK1_CYPCA Tyrosine-protein kinase JAK1 OS=Cy...1780.0001     49.3     24     45GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.
996P29597    1187   TYK2_HUMAN Non-receptor tyrosine-protein kina...1770.0002     48.5     22     44GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0016020; C:membrane; IEA:InterPro.::GO:0005634; C:nucleus; IDA:BHF-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005131; F:growth hormone receptor binding; IPI:BHF-UCL.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:ProtInc.
GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.::GO:0060338; P:regulation of type I interferon-mediated signaling pathway; TAS:Reactome.::GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome.
997Q9R117    1180   TYK2_MOUSE Non-receptor tyrosine-protein kina...1750.001     46.2     21     43GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0016020; C:membrane; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.
998Q86HG9    1024   Y9871_DICDI Probable serine/threonine-protein...1220.039     41.2     26     48
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
999Q54I36    1338   PYK3_DICDI Dual specificity protein kinase py...1290.75     37     21     44
GO:0005524; F:ATP binding; IC:dictyBase.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IDA:dictyBase.
GO:0046777; P:protein autophosphorylation; IDA:dictyBase.::GO:0031156; P:regulation of sorocarp development; IMP:dictyBase.
1000Q55DD4    1678   PAKD_DICDI Serine/threonine-protein kinase pa...486     33.9     40     60GO:0016592; C:mediator complex; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0001104; F:RNA polymerase II transcription cofactor activity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
records
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