Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLR362W
Length:
717
Number of sequences:
5887
Description:
YLR362W STE11 SGDID:S000004354, Chr XII from 849866-852019, Genome Release 64-1-1, Verified ORF, "Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
961Q5UQG7    1651   YR818_MIMIV Putative serine/threonine-protein...2341e-17     91.7     29     48GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0016849; F:phosphorus-oxygen lyase activity; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.
962P51812    740   KS6A3_HUMAN Ribosomal protein S6 kinase alpha...2602e-17     90.5     28     45GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0007417; P:central nervous system development; TAS:ProtInc.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0043066; P:negative regulation of apoptotic process; TAS:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0045597; P:positive regulation of cell differentiation; TAS:UniProtKB.::GO:0030307; P:positive regulation of cell growth; TAS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0043620; P:regulation of DNA-dependent transcription in response to stress; TAS:UniProtKB.::GO:0043555; P:regulation of translation in response to stress; TAS:UniProtKB.::GO:0032496; P:response to lipopolysaccharide; ISS:UniProtKB.::GO:0001501; P:skeletal system development; TAS:ProtInc.::GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.::GO:0007268; P:synaptic transmission; TAS:Reactome.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome.
963P18654    740   KS6A3_MOUSE Ribosomal protein S6 kinase alpha...2602e-17     90.5     28     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:MGI.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.::GO:0032496; P:response to lipopolysaccharide; IMP:UniProtKB.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0002224; P:toll-like receptor signaling pathway; IMP:UniProtKB.
964Q15418    735   KS6A1_HUMAN Ribosomal protein S6 kinase alpha...2453e-17     89.7     28     47GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0045597; P:positive regulation of cell differentiation; TAS:UniProtKB.::GO:0030307; P:positive regulation of cell growth; TAS:UniProtKB.::GO:2000491; P:positive regulation of hepatic stellate cell activation; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0043620; P:regulation of DNA-dependent transcription in response to stress; TAS:UniProtKB.::GO:0043555; P:regulation of translation in response to stress; TAS:UniProtKB.::GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.::GO:0007268; P:synaptic transmission; TAS:Reactome.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome.
965Q21734    784   KS6A1_CAEEL Putative ribosomal protein S6 kin...2396e-17     89     26     46
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.
966Q15349    733   KS6A2_HUMAN Ribosomal protein S6 kinase alpha...2668e-17     88.2     26     47GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0045786; P:negative regulation of cell cycle; IDA:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; IDA:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.::GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.::GO:0007268; P:synaptic transmission; TAS:Reactome.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome.
967Q7T6X2    1657   YR826_MIMIV Putative serine/threonine-protein...2366e-16     86.3     27     47GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0016849; F:phosphorus-oxygen lyase activity; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.
968P18652    752   KS6AA_CHICK Ribosomal protein S6 kinase 2 alp...2458e-16     85.1     27     46
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.
969Q63531    735   KS6A1_RAT Ribosomal protein S6 kinase alpha-1...2459e-16     85.1     27     46GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004711; F:ribosomal protein S6 kinase activity; TAS:RGD.::GO:0008134; F:transcription factor binding; IDA:RGD.
GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:2000491; P:positive regulation of hepatic stellate cell activation; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:RGD.
970Q6PFQ0    740   KS6A6_DANRE Ribosomal protein S6 kinase alpha...2600.000000000000003     83.2     26     46
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.
971Q63638    3259   SPEG_RAT Striated muscle-specific serine/thre...2180.000000000000004     84     29     48GO:0005634; C:nucleus; IDA:RGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0042692; P:muscle cell differentiation; IEP:RGD.
972Q62407    3262   SPEG_MOUSE Striated muscle-specific serine/th...2180.000000000000008     82.4     29     47GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
973Q15772    3267   SPEG_HUMAN Striated muscle preferentially exp...2180.00000000000001     82     28     47GO:0005634; C:nucleus; TAS:ProtInc.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007517; P:muscle organ development; TAS:ProtInc.::GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
974Q7TPS0    764   KS6A6_MOUSE Ribosomal protein S6 kinase alpha...2660.0000000000001     78.6     25     45GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; ISS:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.::GO:0045992; P:negative regulation of embryonic development; IDA:UniProtKB.::GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.::GO:2000381; P:negative regulation of mesoderm development; IDA:UniProtKB.
975P10665    733   KS6AA_XENLA Ribosomal protein S6 kinase 2 alp...2450.0000000000002     77.8     26     47
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.
976Q9UK32    745   KS6A6_HUMAN Ribosomal protein S6 kinase alpha...2740.0000000000002     77.4     26     45GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007417; P:central nervous system development; TAS:ProtInc.::GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IMP:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.::GO:0045992; P:negative regulation of embryonic development; ISS:UniProtKB.::GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:2000381; P:negative regulation of mesoderm development; ISS:UniProtKB.::GO:0007268; P:synaptic transmission; TAS:Reactome.
977Q696W0    2995   SPEG_DANRE Striated muscle preferentially exp...1670.000000000001     75.5     31     48GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0030018; C:Z disc; NAS:ZFIN.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
GO:0007517; P:muscle organ development; ISS:ZFIN.
978P10666    629   KS6AB_XENLA Ribosomal protein S6 kinase 2 bet...2010.00000000002     71.2     27     46
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
979Q5F3L1    789   KS6A5_CHICK Ribosomal protein S6 kinase alpha...1810.0000000001     68.6     25     48GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
980Q9Z2B9    773   KS6A4_MOUSE Ribosomal protein S6 kinase alpha...1130.000000004     63.9     33     53GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0048273; F:mitogen-activated protein kinase p38 binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
GO:0043987; P:histone H3-S10 phosphorylation; ISS:UniProtKB.::GO:0043988; P:histone H3-S28 phosphorylation; ISS:UniProtKB.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0007243; P:intracellular protein kinase cascade; ISS:UniProtKB.
981O75676    772   KS6A4_HUMAN Ribosomal protein S6 kinase alpha...1140.000000009     62.4     32     54GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0048273; F:mitogen-activated protein kinase p38 binding; IGI:UniProtKB.::GO:0004711; F:ribosomal protein S6 kinase activity; NAS:UniProtKB.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0043987; P:histone H3-S10 phosphorylation; IMP:UniProtKB.::GO:0043988; P:histone H3-S28 phosphorylation; IMP:UniProtKB.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0070498; P:interleukin-1-mediated signaling pathway; IMP:BHF-UCL.::GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:0001818; P:negative regulation of cytokine production; TAS:UniProtKB.::GO:0032793; P:positive regulation of CREB transcription factor activity; TAS:UniProtKB.::GO:0035066; P:positive regulation of histone acetylation; IMP:BHF-UCL.::GO:0033129; P:positive regulation of histone phosphorylation; IMP:BHF-UCL.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; TAS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
982Q9V3I5    1207   JIL1_DROME Chromosomal serine/threonine-prote...1550.0000006     56.6     24     48GO:0000228; C:nuclear chromosome; IDA:UniProtKB.::GO:0005705; C:polytene chromosome interband; IDA:UniProtKB.::GO:0016456; C:X chromosome located dosage compensation complex, transcription activating; IPI:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0035175; F:histone kinase activity (H3-S10 specific); IMP:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0016321; P:female meiosis chromosome segregation; IMP:FlyBase.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0031936; P:negative regulation of chromatin silencing; IMP:FlyBase.::GO:0048477; P:oogenesis; IMP:FlyBase.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
983P52332    1153   JAK1_MOUSE Tyrosine-protein kinase JAK1 OS=Mu...2210.000003     54.3     23     45GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005131; F:growth hormone receptor binding; IPI:BHF-UCL.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.
984Q62137    1100   JAK3_MOUSE Tyrosine-protein kinase JAK3 OS=Mu...1740.000006     53.5     21     46GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0005515; F:protein binding; IPI:MGI.
GO:0030183; P:B cell differentiation; IMP:BHF-UCL.::GO:0019221; P:cytokine-mediated signaling pathway; IDA:MGI.::GO:0007204; P:elevation of cytosolic calcium ion concentration; ISS:BHF-UCL.::GO:0007167; P:enzyme linked receptor protein signaling pathway; IDA:MGI.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0048535; P:lymph node development; TAS:MGI.::GO:0002731; P:negative regulation of dendritic cell cytokine production; IMP:BHF-UCL.::GO:0045221; P:negative regulation of FasL biosynthetic process; IMP:BHF-UCL.::GO:0032693; P:negative regulation of interleukin-10 production; IMP:BHF-UCL.::GO:0032695; P:negative regulation of interleukin-12 production; IMP:BHF-UCL.::GO:0045626; P:negative regulation of T-helper 1 cell differentiation; IMP:BHF-UCL.::GO:0070244; P:negative regulation of thymocyte apoptotic process; IMP:BHF-UCL.::GO:0042104; P:positive regulation of activated T cell proliferation; ISS:BHF-UCL.::GO:0045768; P:positive regulation of anti-apoptosis; IMP:BHF-UCL.::GO:0051928; P:positive regulation of calcium ion transport; ISS:BHF-UCL.::GO:0050778; P:positive regulation of immune response; ISS:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.::GO:0046777; P:protein autophosphorylation; ISS:BHF-UCL.::GO:0070672; P:response to interleukin-15; TAS:BHF-UCL.::GO:0070669; P:response to interleukin-2; TAS:BHF-UCL.::GO:0070670; P:response to interleukin-4; ISS:BHF-UCL.::GO:0071104; P:response to interleukin-9; TAS:BHF-UCL.::GO:0043029; P:T cell homeostasis; IMP:BHF-UCL.::GO:0042506; P:tyrosine phosphorylation of Stat5 protein; ISS:BHF-UCL.
985P52333    1124   JAK3_HUMAN Tyrosine-protein kinase JAK3 OS=Ho...1680.000009     52.8     21     46GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0030183; P:B cell differentiation; ISS:BHF-UCL.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0035771; P:interleukin-4-mediated signaling pathway; IDA:BHF-UCL.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; TAS:UniProtKB.::GO:0002731; P:negative regulation of dendritic cell cytokine production; ISS:BHF-UCL.::GO:0045221; P:negative regulation of FasL biosynthetic process; ISS:BHF-UCL.::GO:0032693; P:negative regulation of interleukin-10 production; ISS:BHF-UCL.::GO:0032695; P:negative regulation of interleukin-12 production; ISS:BHF-UCL.::GO:0045626; P:negative regulation of T-helper 1 cell differentiation; ISS:BHF-UCL.::GO:0070244; P:negative regulation of thymocyte apoptotic process; ISS:BHF-UCL.::GO:0045768; P:positive regulation of anti-apoptosis; ISS:BHF-UCL.::GO:0070672; P:response to interleukin-15; TAS:BHF-UCL.::GO:0070669; P:response to interleukin-2; TAS:BHF-UCL.::GO:0071104; P:response to interleukin-9; TAS:BHF-UCL.::GO:0007262; P:STAT protein import into nucleus; TAS:UniProtKB.::GO:0043029; P:T cell homeostasis; TAS:UniProtKB.
986O12990    1153   JAK1_DANRE Tyrosine-protein kinase JAK1 OS=Da...1780.00001     52.4     25     44GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
987Q63272    1100   JAK3_RAT Tyrosine-protein kinase JAK3 OS=Ratt...1740.00001     52.8     21     47GO:0005737; C:cytoplasm; IDA:RGD.::GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0008134; F:transcription factor binding; IC:RGD.
GO:0030183; P:B cell differentiation; ISS:BHF-UCL.::GO:0019221; P:cytokine-mediated signaling pathway; IDA:RGD.::GO:0007204; P:elevation of cytosolic calcium ion concentration; IMP:RGD.::GO:0007167; P:enzyme linked receptor protein signaling pathway; ISS:BHF-UCL.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0002731; P:negative regulation of dendritic cell cytokine production; ISS:BHF-UCL.::GO:0045221; P:negative regulation of FasL biosynthetic process; ISS:BHF-UCL.::GO:0032693; P:negative regulation of interleukin-10 production; ISS:BHF-UCL.::GO:0032695; P:negative regulation of interleukin-12 production; ISS:BHF-UCL.::GO:0045626; P:negative regulation of T-helper 1 cell differentiation; ISS:BHF-UCL.::GO:0070244; P:negative regulation of thymocyte apoptotic process; ISS:BHF-UCL.::GO:0042104; P:positive regulation of activated T cell proliferation; IMP:RGD.::GO:0045768; P:positive regulation of anti-apoptosis; ISS:BHF-UCL.::GO:0051928; P:positive regulation of calcium ion transport; IMP:RGD.::GO:0050778; P:positive regulation of immune response; IMP:RGD.::GO:0046777; P:protein autophosphorylation; IMP:RGD.::GO:0043029; P:T cell homeostasis; ISS:BHF-UCL.::GO:0042506; P:tyrosine phosphorylation of Stat5 protein; IMP:RGD.
988P23458    1154   JAK1_HUMAN Tyrosine-protein kinase JAK1 OS=Ho...2480.00001     52.8     22     46GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; IDA:BHF-UCL.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005131; F:growth hormone receptor binding; ISS:BHF-UCL.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0060338; P:regulation of type I interferon-mediated signaling pathway; TAS:Reactome.::GO:0046677; P:response to antibiotic; IDA:MGI.::GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome.
989Q62689    1132   JAK2_RAT Tyrosine-protein kinase JAK2 OS=Ratt...2210.00002     52     24     43GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; IDA:RGD.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:RGD.::GO:0016363; C:nuclear matrix; IDA:RGD.
GO:0033130; F:acetylcholine receptor binding; IPI:RGD.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005131; F:growth hormone receptor binding; IPI:BHF-UCL.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0035401; F:histone kinase activity (H3-Y41 specific); ISS:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; IPI:RGD.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:Reactome.::GO:0051428; F:peptide hormone receptor binding; IPI:RGD.::GO:0043548; F:phosphatidylinositol 3-kinase binding; IPI:RGD.::GO:0008022; F:protein C-terminus binding; IPI:RGD.::GO:0031702; F:type 1 angiotensin receptor binding; IPI:RGD.
GO:0042977; P:activation of JAK2 kinase activity; ISS:UniProtKB.::GO:0000186; P:activation of MAPKK activity; IMP:RGD.::GO:0031103; P:axon regeneration; IMP:RGD.::GO:0007204; P:elevation of cytosolic calcium ion concentration; IMP:RGD.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0007186; P:G-protein coupled receptor signaling pathway; IMP:RGD.::GO:0009755; P:hormone-mediated signaling pathway; IDA:RGD.::GO:0008631; P:induction of apoptosis by oxidative stress; IMP:RGD.::GO:0060333; P:interferon-gamma-mediated signaling pathway; IDA:BHF-UCL.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; ISS:UniProtKB.::GO:0031959; P:mineralocorticoid receptor signaling pathway; IMP:RGD.::GO:0022408; P:negative regulation of cell-cell adhesion; IMP:RGD.::GO:0045822; P:negative regulation of heart contraction; IMP:RGD.::GO:0043526; P:neuroprotection; IMP:RGD.::GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IMP:RGD.::GO:0050867; P:positive regulation of cell activation; IMP:RGD.::GO:0045597; P:positive regulation of cell differentiation; IMP:RGD.::GO:0030335; P:positive regulation of cell migration; IMP:RGD.::GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.::GO:0043388; P:positive regulation of DNA binding; IMP:RGD.::GO:0050729; P:positive regulation of inflammatory response; IMP:RGD.::GO:0032024; P:positive regulation of insulin secretion; IMP:RGD.::GO:0032731; P:positive regulation of interleukin-1 beta production; IMP:RGD.::GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IMP:RGD.::GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IDA:BHF-UCL.::GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; IMP:RGD.::GO:0033160; P:positive regulation of protein import into nucleus, translocation; IMP:RGD.::GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IMP:RGD.::GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0033194; P:response to hydroperoxide; IMP:RGD.::GO:0042508; P:tyrosine phosphorylation of Stat1 protein; IMP:RGD.::GO:0042503; P:tyrosine phosphorylation of Stat3 protein; IMP:RGD.::GO:0042506; P:tyrosine phosphorylation of Stat5 protein; IMP:RGD.
990O19064    1131   JAK2_PIG Tyrosine-protein kinase JAK2 OS=Sus ...2210.00005     50.8     24     43GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0035401; F:histone kinase activity (H3-Y41 specific); ISS:UniProtKB.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
GO:0042977; P:activation of JAK2 kinase activity; ISS:UniProtKB.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; ISS:UniProtKB.::GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.
991O60674    1132   JAK2_HUMAN Tyrosine-protein kinase JAK2 OS=Ho...2210.00007     50.1     24     43GO:0005901; C:caveola; ISS:BHF-UCL.::GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0031904; C:endosome lumen; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005131; F:growth hormone receptor binding; ISS:BHF-UCL.::GO:0020037; F:heme binding; IDA:UniProtKB.::GO:0042393; F:histone binding; IDA:UniProtKB.::GO:0035401; F:histone kinase activity (H3-Y41 specific); IDA:UniProtKB.::GO:0005143; F:interleukin-12 receptor binding; ISS:BHF-UCL.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0019901; F:protein kinase binding; IDA:BHF-UCL.::GO:0042169; F:SH2 domain binding; IPI:UniProtKB.
GO:0030041; P:actin filament polymerization; NAS:BHF-UCL.::GO:0008636; P:activation of caspase activity by protein phosphorylation; ISS:BHF-UCL.::GO:0042977; P:activation of JAK2 kinase activity; ISS:UniProtKB.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0006928; P:cellular component movement; TAS:ProtInc.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0035722; P:interleukin-12-mediated signaling pathway; IDA:BHF-UCL.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; ISS:UniProtKB.::GO:0061180; P:mammary gland epithelium development; ISS:BHF-UCL.::GO:0007498; P:mesoderm development; TAS:ProtInc.::GO:0008285; P:negative regulation of cell proliferation; ISS:BHF-UCL.::GO:0043392; P:negative regulation of DNA binding; ISS:BHF-UCL.::GO:0010811; P:positive regulation of cell-substrate adhesion; IDA:BHF-UCL.::GO:0060399; P:positive regulation of growth hormone receptor signaling pathway; ISS:BHF-UCL.::GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; ISS:BHF-UCL.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; ISS:BHF-UCL.::GO:0032760; P:positive regulation of tumor necrosis factor production; ISS:BHF-UCL.::GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; ISS:UniProtKB.::GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein; ISS:BHF-UCL.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0046677; P:response to antibiotic; IDA:MGI.::GO:0032496; P:response to lipopolysaccharide; ISS:BHF-UCL.::GO:0007262; P:STAT protein import into nucleus; ISS:BHF-UCL.::GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IDA:BHF-UCL.
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