rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | P37370 | 817 | VRP1_YEAST Verprolin OS=Saccharomyces cerevis... | 817 | 0 | 1513 | 100 | 100 | GO:0030479; C:actin cortical patch; IDA:SGD.::GO:0005935; C:cellular bud neck; IDA:SGD.::GO:0000131; C:incipient cellular bud site; IDA:SGD.::GO:0043332; C:mating projection tip; IDA:SGD. | | | | | | | | | | GO:0003779; F:actin binding; IPI:SGD. | | | | | | | | | | GO:0051666; P:actin cortical patch localization; IMP:SGD.::GO:0007015; P:actin filament organization; IPI:SGD.::GO:0007121; P:bipolar cellular bud site selection; IMP:SGD.::GO:0006897; P:endocytosis; IMP:SGD. | 2 | P0C7L0 | 485 | WIPF3_MOUSE WAS/WASL-interacting protein fami... | 78 | 0.000005 | 53.5 | 38 | 58 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW. | 3 | Q9Z0G8 | 485 | WIPF3_RAT WAS/WASL-interacting protein family... | 86 | 0.000006 | 53.1 | 40 | 56 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IMP:RGD. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW. | 4 | Q9P6R1 | 309 | VRP1_SCHPO Verprolin OS=Schizosaccharomyces p... | 43 | 0.082 | 39.7 | 42 | 60 | GO:0030479; C:actin cortical patch; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0031097; C:medial cortex; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.::GO:0035840; C:old growing cell tip; IDA:PomBase. | | | | | | | | | | GO:0003779; F:actin binding; ISS:PomBase. | | | | | | | | | | GO:0000147; P:actin cortical patch assembly; IGI:PomBase.::GO:0045010; P:actin nucleation; IGI:PomBase.::GO:0006897; P:endocytosis; ISS:PomBase.::GO:0051127; P:positive regulation of actin nucleation; IDA:PomBase. | 5 | Q1LUA6 | 3028 | TRIO_DANRE Triple functional domain protein O... | 183 | 0.0002 | 48.5 | 26 | 38 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 6 | Q8K1I7 | 493 | WIPF1_MOUSE WAS/WASL-interacting protein fami... | 33 | 0.0007 | 46.6 | 67 | 76 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0030048; P:actin filament-based movement; IDA:MGI. | 7 | O75962 | 3097 | TRIO_HUMAN Triple functional domain protein O... | 174 | 2.2 | 35.8 | 28 | 38 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0007185; P:transmembrane receptor protein tyrosine phosphatase signaling pathway; TAS:ProtInc. | 8 | Q6IN36 | 487 | WIPF1_RAT WAS/WASL-interacting protein family... | 33 | 0.0008 | 46.6 | 67 | 76 | GO:0005884; C:actin filament; IDA:RGD.::GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IMP:RGD.::GO:0046827; P:positive regulation of protein export from nucleus; IDA:RGD. | 9 | Q55DU1 | 90 | ACTOB_DICDI Actobindin-B/C OS=Dictyostelium d... | 24 | 0.39 | 35.4 | 63 | 75 | | | | | | | | | | | GO:0003779; F:actin binding; ISS:dictyBase. | | | | | | | | | | | 10 | A6NGB9 | 483 | WIPF3_HUMAN WAS/WASL-interacting protein fami... | 119 | 0.004 | 43.9 | 32 | 48 | GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005730; C:nucleolus; IDA:HPA. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW. | 11 | O15602 | 85 | ACTO_ENTHI Actobindin homolog OS=Entamoeba hi... | 27 | 0.15 | 36.6 | 63 | 85 | | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW. | | | | | | | | | | | 12 | Q8R1S4 | 759 | MTSS1_MOUSE Metastasis suppressor protein 1 O... | 27 | 0.25 | 38.5 | 67 | 78 | GO:0015629; C:actin cytoskeleton; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IDA:MGI. | | | | | | | | | | GO:0003785; F:actin monomer binding; ISS:UniProtKB.::GO:0008093; F:cytoskeletal adaptor activity; IEA:InterPro.::GO:0005102; F:receptor binding; ISS:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:InterPro. | | | | | | | | | | GO:0030041; P:actin filament polymerization; IDA:MGI.::GO:0071498; P:cellular response to fluid shear stress; IDA:UniProtKB.::GO:2001013; P:epithelial cell proliferation involved in renal tubule morphogenesis; IMP:UniProtKB.::GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:0072102; P:glomerulus morphogenesis; IMP:UniProtKB.::GO:0007517; P:muscle organ development; NAS:UniProtKB.::GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:UniProtKB.::GO:0072160; P:nephron tubule epithelial cell differentiation; IMP:UniProtKB.::GO:0007399; P:nervous system development; NAS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 13 | O43312 | 755 | MTSS1_HUMAN Metastasis suppressor protein 1 O... | 27 | 0.26 | 38.5 | 67 | 78 | GO:0015629; C:actin cytoskeleton; IDA:UniProtKB.::GO:0030139; C:endocytic vesicle; TAS:UniProtKB.::GO:0001726; C:ruffle; NAS:UniProtKB. | | | | | | | | | | GO:0003785; F:actin monomer binding; IDA:UniProtKB.::GO:0008093; F:cytoskeletal adaptor activity; IEA:InterPro.::GO:0005102; F:receptor binding; IPI:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:InterPro. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; TAS:UniProtKB.::GO:0007155; P:cell adhesion; NAS:UniProtKB.::GO:0006928; P:cellular component movement; NAS:UniProtKB.::GO:0071498; P:cellular response to fluid shear stress; ISS:UniProtKB.::GO:2001013; P:epithelial cell proliferation involved in renal tubule morphogenesis; ISS:UniProtKB.::GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:0072102; P:glomerulus morphogenesis; ISS:UniProtKB.::GO:0030035; P:microspike assembly; NAS:UniProtKB.::GO:0050680; P:negative regulation of epithelial cell proliferation; ISS:UniProtKB.::GO:0072160; P:nephron tubule epithelial cell differentiation; ISS:UniProtKB.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; TAS:UniProtKB. | 14 | Q8TF74 | 440 | WIPF2_HUMAN WAS/WASL-interacting protein fami... | 154 | 0.36 | 37.7 | 31 | 42 | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW. | | | | | | | | | | | 15 | Q9QW30 | 2471 | NOTC2_RAT Neurogenic locus notch homolog prot... | 122 | 0.71 | 37.4 | 25 | 38 | GO:0009986; C:cell surface; ISS:UniProtKB.::GO:0005887; C:integral to plasma membrane; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004872; F:receptor activity; TAS:RGD. | | | | | | | | | | GO:0007050; P:cell cycle arrest; ISS:UniProtKB.::GO:0001709; P:cell fate determination; IDA:RGD.::GO:0016049; P:cell growth; ISS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.::GO:0009887; P:organ morphogenesis; ISS:UniProtKB.::GO:0046579; P:positive regulation of Ras protein signal transduction; ISS:UniProtKB.::GO:0050793; P:regulation of developmental process; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0042246; P:tissue regeneration; IEP:RGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 16 | A6R7X5 | 1481 | PAN1_AJECN Actin cytoskeleton-regulatory comp... | 33 | 0.76 | 37.4 | 55 | 64 | GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW. | 17 | Q4WG58 | 1467 | PAN1_ASPFU Actin cytoskeleton-regulatory comp... | 32 | 1.3 | 36.6 | 50 | 66 | GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW. | 18 | B0YC95 | 1467 | PAN1_ASPFC Actin cytoskeleton-regulatory comp... | 32 | 1.3 | 36.6 | 50 | 66 | GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW. | 19 | Q71LX6 | 3302 | XIRP2_RAT Xin actin-binding repeat-containing... | 154 | 1.3 | 36.6 | 22 | 43 | GO:0030054; C:cell junction; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IEA:InterPro. | 20 | Q10172 | 1794 | PAN1_SCHPO Actin cytoskeleton-regulatory comp... | 39 | 3.5 | 35 | 46 | 62 | GO:0030479; C:actin cortical patch; ISS:PomBase.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:PomBase.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro. | | | | | | | | | | GO:0000147; P:actin cortical patch assembly; ISS:PomBase.::GO:0006897; P:endocytosis; ISS:PomBase.::GO:0006886; P:intracellular protein transport; IC:PomBase. | 21 | P50795 | 520 | VL2_HPV21 Minor capsid protein L2 OS=Human pa... | 120 | 3.6 | 34.7 | 31 | 45 | GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.::GO:0019028; C:viral capsid; IEA:UniProtKB-KW. | | | | | | | | | | GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0005198; F:structural molecule activity; IEA:InterPro. | | | | | | | | | | GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW. | 22 | Q07008 | 2531 | NOTC1_RAT Neurogenic locus notch homolog prot... | 308 | 4.5 | 34.7 | 20 | 34 | GO:0001669; C:acrosomal vesicle; IDA:RGD.::GO:0005794; C:Golgi apparatus; IDA:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; IDA:RGD.::GO:0005886; C:plasma membrane; IDA:RGD. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0001047; F:core promoter binding; ISS:UniProtKB.::GO:0019899; F:enzyme binding; ISS:UniProtKB.::GO:0004857; F:enzyme inhibitor activity; ISS:UniProtKB.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0048708; P:astrocyte differentiation; IDA:RGD.::GO:0021515; P:cell differentiation in spinal cord; IEP:RGD.::GO:0060253; P:negative regulation of glial cell proliferation; ISS:UniProtKB.::GO:0010832; P:negative regulation of myotube differentiation; ISS:UniProtKB.::GO:0048715; P:negative regulation of oligodendrocyte differentiation; ISS:UniProtKB.::GO:2000974; P:negative regulation of pro-B cell differentiation; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0048709; P:oligodendrocyte differentiation; IEP:RGD.::GO:0031100; P:organ regeneration; IEP:RGD.::GO:0048711; P:positive regulation of astrocyte differentiation; ISS:UniProtKB.::GO:0030513; P:positive regulation of BMP signaling pathway; ISS:UniProtKB.::GO:0045603; P:positive regulation of endothelial cell differentiation; IMP:RGD.::GO:0046427; P:positive regulation of JAK-STAT cascade; ISS:UniProtKB.::GO:0002052; P:positive regulation of neuroblast proliferation; IMP:RGD.::GO:0061419; P:positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; ISS:UniProtKB.::GO:0007221; P:positive regulation of transcription of Notch receptor target; IMP:RGD.::GO:0031960; P:response to corticosteroid stimulus; IEP:RGD.::GO:0032496; P:response to lipopolysaccharide; IEP:RGD.::GO:0007283; P:spermatogenesis; IMP:RGD.::GO:0042246; P:tissue regeneration; IEP:RGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 23 | Q6PEV3 | 440 | WIPF2_MOUSE WAS/WASL-interacting protein fami... | 215 | 6.7 | 33.9 | 28 | 35 | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW. | | | | | | | | | | | 24 | Q1DQC1 | 1485 | PAN1_COCIM Actin cytoskeleton-regulatory comp... | 33 | 6.8 | 33.9 | 48 | 58 | GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW. | 25 | A2AAJ9 | 8891 | OBSCN_MOUSE Obscurin OS=Mus musculus (Mouse).... | 183 | 9.9 | 33.5 | 27 | 37 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 26 | Q2UDY8 | 1473 | PAN1_ASPOR Actin cytoskeleton-regulatory comp... | 32 | 8.7 | 33.9 | 50 | 63 | GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW. | 27 | Q673G8 | 837 | DACT2_DANRE Dapper homolog 2 OS=Danio rerio (... | 203 | 9 | 33.5 | 27 | 35 | GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005515; F:protein binding; IPI:ZFIN. | | | | | | | | | | GO:0048332; P:mesoderm morphogenesis; IMP:ZFIN.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0016055; P:Wnt receptor signaling pathway; IMP:ZFIN. |