Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLR310C
Length:
1589
Number of sequences:
5887
Description:
YLR310C CDC25 SGDID:S000004301, Chr XII from 756993-752224, Genome Release 64-1-1, reverse complement, Verified ORF, "Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
61F1M386    1496   RPGF2_RAT Rap guanine nucleotide exchange fac...2087e-21     103     30     50GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO:0048167; P:regulation of synaptic plasticity; IDA:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
62Q8CHG7    1496   RPGF2_MOUSE Rap guanine nucleotide exchange f...2088e-21     103     30     50GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
63Q03386    895   GNDS_RAT Ral guanine nucleotide dissociation ...1530.54     38.5     27     44GO:0005829; C:cytosol; TAS:Reactome.
GO:0008321; F:Ral guanyl-nucleotide exchange factor activity; TAS:RGD.
GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:RGD.
64Q7LDG7    609   GRP2_HUMAN RAS guanyl-releasing protein 2 OS=...2521e-20     102     29     52GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0019992; F:diacylglycerol binding; NAS:UniProtKB.::GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:UniProtKB.
GO:0030168; P:platelet activation; TAS:Reactome.::GO:0007265; P:Ras protein signal transduction; NAS:UniProtKB.::GO:0001558; P:regulation of cell growth; NAS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
65Q8IZJ4    473   RGDSR_HUMAN Ral-GDS-related protein OS=Homo s...2611e-20     100     30     51GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
66Q54S40    1312   GBPD_DICDI Cyclic GMP-binding protein D OS=Di...843.9     35.8     30     50GO:0005622; C:intracellular; IEA:InterPro.
GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.::GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; IDA:dictyBase.
GO:0031589; P:cell-substrate adhesion; IMP:dictyBase.::GO:0007163; P:establishment or maintenance of cell polarity; IMP:dictyBase.::GO:0051272; P:positive regulation of cellular component movement; TAS:dictyBase.::GO:0050920; P:regulation of chemotaxis; IMP:dictyBase.::GO:0031275; P:regulation of lateral pseudopodium assembly; IMP:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
67Q8TEU7    1601   RPGF6_HUMAN Rap guanine nucleotide exchange f...2045e-20     101     29     54GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005634; C:nucleus; IDA:HPA.::GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0030742; F:GTP-dependent protein binding; IDA:UniProtKB.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:UniProtKB.::GO:0017016; F:Ras GTPase binding; IDA:UniProtKB.
GO:0007265; P:Ras protein signal transduction; NAS:UniProtKB.::GO:0043087; P:regulation of GTPase activity; NAS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
68P0C643    608   GRP2_RAT RAS guanyl-releasing protein 2 OS=Ra...2526e-20     99.8     29     51GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
69Q9QUG9    608   GRP2_MOUSE RAS guanyl-releasing protein 2 OS=...2528e-20     99.4     29     51GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
70Q12967    914   GNDS_HUMAN Ral guanine nucleotide dissociatio...1712.4     36.6     25     43GO:0005829; C:cytosol; TAS:Reactome.::GO:0005622; C:intracellular; IEA:InterPro.
GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005083; F:small GTPase regulator activity; IDA:UniProtKB.
GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
71Q8N431    466   RGF1C_HUMAN Ras-GEF domain-containing family ...2165e-19     95.9     31     48GO:0005622; C:intracellular; IEA:InterPro.
GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
72O15211    777   RGL2_HUMAN Ral guanine nucleotide dissociatio...2779e-19     96.3     27     44GO:0005622; C:intracellular; IEA:InterPro.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; NAS:UniProtKB.
GO:0007265; P:Ras protein signal transduction; NAS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
73A4IFE4    472   RGF1B_BOVIN Ras-GEF domain-containing family ...4141e-18     94.7     26     44GO:0005622; C:intracellular; IEA:InterPro.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
74Q6DBW1    475   RG1BB_DANRE Ras-GEF domain-containing family ...2261e-18     94.7     30     50GO:0005622; C:intracellular; IEA:InterPro.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
75Q95KH6    466   RGF1C_MACFA Ras-GEF domain-containing family ...2161e-18     94.4     31     48GO:0005622; C:intracellular; IEA:InterPro.
GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
76Q5TJE5    780   RGL2_CANFA Ral guanine nucleotide dissociatio...2772e-18     95.5     26     43GO:0005622; C:intracellular; IEA:InterPro.
GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
77Q9D300    466   RGF1C_MOUSE Ras-GEF domain-containing family ...2163e-18     93.6     31     48GO:0005622; C:intracellular; IEA:InterPro.
GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
78Q5RC04    472   RGF1B_PONAB Ras-GEF domain-containing family ...2268e-18     92     30     47GO:0005622; C:intracellular; IEA:InterPro.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
79Q0VAM2    473   RGF1B_HUMAN Ras-GEF domain-containing family ...2268e-18     92     30     47GO:0005622; C:intracellular; IEA:InterPro.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:UniProtKB.
GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
80Q8JZL7    473   RGF1B_MOUSE Ras-GEF domain-containing family ...2261e-17     91.7     30     47GO:0005622; C:intracellular; IEA:InterPro.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
81Q8IS16    604   GEFH_DICDI Ras guanine nucleotide exchange fa...2132e-17     91.7     27     49GO:0005622; C:intracellular; IEA:InterPro.
GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
82A4IJ06    791   GRP1_XENTR RAS guanyl-releasing protein 1 OS=...2484e-17     91.3     28     49GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
83Q6NTL4    791   GRP1_XENLA RAS guanyl-releasing protein 1 OS=...2481e-16     90.1     28     48GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
84Q6DHR3    514   RG1BA_DANRE Ras-GEF domain-containing family ...4391e-16     89     25     43GO:0005622; C:intracellular; IEA:InterPro.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
85A0JM95    475   RGF1A_XENTR Ras-GEF domain-containing family ...2382e-16     88.2     29     47GO:0005622; C:intracellular; IEA:InterPro.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
86Q8IS12    1138   GEFN_DICDI Ras guanine nucleotide exchange fa...2262e-16     89.4     28     48GO:0005622; C:intracellular; IEA:InterPro.
GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
87O95267    797   GRP1_HUMAN RAS guanyl-releasing protein 1 OS=...2484e-16     88.2     27     49GO:0005829; C:cytosol; TAS:Reactome.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; TAS:ProtInc.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005509; F:calcium ion binding; TAS:ProtInc.::GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:Reactome.::GO:0008289; F:lipid binding; TAS:ProtInc.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0007265; P:Ras protein signal transduction; TAS:ProtInc.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
88Q28EC1    472   RGF1B_XENTR Ras-GEF domain-containing family ...2219e-16     85.9     29     48GO:0005622; C:intracellular; IEA:InterPro.
GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
89Q8IV61    690   GRP3_HUMAN Ras guanyl-releasing protein 3 OS=...2440.000000000000001     86.3     26     50GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0019992; F:diacylglycerol binding; NAS:UniProtKB.::GO:0046582; F:Rap GTPase activator activity; IDA:UniProtKB.::GO:0004871; F:signal transducer activity; TAS:UniProtKB.
GO:0000165; P:MAPK cascade; NAS:UniProtKB.
90Q6CY10    1366   LTE1_KLULA Guanine nucleotide exchange factor...2190.000000000000001     86.7     29     48GO:0005933; C:cellular bud; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
91Q9Z1S3    795   GRP1_MOUSE RAS guanyl-releasing protein 1 OS=...2480.000000000000005     84.3     26     48GO:0005829; C:cytosol; TAS:Reactome.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
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