rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | Q8SSQ0 | 1721 | GEFR_DICDI Ras guanine nucleotide exchange fa... | 266 | 7e-30 | 133 | 33 | 58 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005488; F:binding; IEA:InterPro.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:dictyBase. | | | | | | | | | | GO:0007265; P:Ras protein signal transduction; IDA:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 32 | P27671 | 1262 | RGRF1_MOUSE Ras-specific guanine nucleotide-r... | 237 | 4e-29 | 130 | 34 | 57 | GO:0005829; C:cytosol; IDA:HGNC.::GO:0030426; C:growth cone; IDA:HGNC. | | | | | | | | | | GO:0035254; F:glutamate receptor binding; IPI:MGI.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0032863; P:activation of Rac GTPase activity; IDA:HGNC.::GO:0008283; P:cell proliferation; IMP:MGI.::GO:0031175; P:neuron projection development; IDA:HGNC.::GO:0046579; P:positive regulation of Ras protein signal transduction; ISS:UniProtKB.::GO:0048168; P:regulation of neuronal synaptic plasticity; IMP:MGI.::GO:0035020; P:regulation of Rac protein signal transduction; IDA:HGNC.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 33 | Q8SSQ3 | 929 | GEFM_DICDI Ras guanine nucleotide exchange fa... | 231 | 5e-29 | 130 | 29 | 54 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0043327; P:chemotaxis to cAMP; IMP:dictyBase.::GO:0045762; P:positive regulation of adenylate cyclase activity; IMP:dictyBase.::GO:0050850; P:positive regulation of calcium-mediated signaling; IMP:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 34 | Q13972 | 1275 | RGRF1_HUMAN Ras-specific guanine nucleotide-r... | 234 | 7e-29 | 130 | 33 | 57 | GO:0005829; C:cytosol; ISS:HGNC.::GO:0030426; C:growth cone; ISS:HGNC.::GO:0005886; C:plasma membrane; NAS:UniProtKB.::GO:0019717; C:synaptosome; NAS:UniProtKB. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0032863; P:activation of Rac GTPase activity; ISS:HGNC.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0007616; P:long-term memory; NAS:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0031175; P:neuron projection development; ISS:HGNC.::GO:0046579; P:positive regulation of Ras protein signal transduction; ISS:UniProtKB.::GO:0035020; P:regulation of Rac protein signal transduction; ISS:HGNC.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0007268; P:synaptic transmission; TAS:Reactome. | 35 | A2CEA7 | 1244 | RGRF2_DANRE Ras-specific guanine nucleotide-r... | 234 | 7e-29 | 130 | 34 | 56 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 36 | Q86G47 | 1298 | GEFQ_DICDI Ras guanine nucleotide exchange fa... | 247 | 3e-28 | 128 | 31 | 56 | GO:0005938; C:cell cortex; IDA:dictyBase.::GO:0005829; C:cytosol; IDA:dictyBase. | | | | | | | | | | GO:0051015; F:actin filament binding; IDA:dictyBase.::GO:0045159; F:myosin II binding; IPI:dictyBase.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:dictyBase. | | | | | | | | | | GO:0007265; P:Ras protein signal transduction; IDA:dictyBase.::GO:0043520; P:regulation of myosin II filament assembly; IDA:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0030587; P:sorocarp development; IMP:dictyBase. | 37 | P28818 | 1244 | RGRF1_RAT Ras-specific guanine nucleotide-rel... | 234 | 2e-27 | 125 | 33 | 56 | GO:0005829; C:cytosol; ISS:HGNC.::GO:0030426; C:growth cone; ISS:HGNC. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0005099; F:Ras GTPase activator activity; TAS:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0032863; P:activation of Rac GTPase activity; ISS:HGNC.::GO:0031175; P:neuron projection development; ISS:HGNC.::GO:0046579; P:positive regulation of Ras protein signal transduction; IDA:UniProtKB.::GO:0035020; P:regulation of Rac protein signal transduction; ISS:HGNC.::GO:0048167; P:regulation of synaptic plasticity; IDA:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 38 | Q3UYI5 | 709 | RGL3_MOUSE Ral guanine nucleotide dissociatio... | 272 | 2e-27 | 124 | 30 | 49 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0008321; F:Ral guanyl-nucleotide exchange factor activity; IDA:MGI.::GO:0017016; F:Ras GTPase binding; IDA:MGI. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:MGI. | 39 | B0UXH6 | 581 | RGPS1_DANRE Ras-specific guanine nucleotide-r... | 299 | 3e-26 | 119 | 30 | 50 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 40 | Q5ZJK0 | 584 | RGPS1_CHICK Ras-specific guanine nucleotide-r... | 259 | 3e-26 | 119 | 28 | 49 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 41 | Q3MIN7 | 710 | RGL3_HUMAN Ral guanine nucleotide dissociatio... | 275 | 9e-26 | 118 | 30 | 48 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 42 | Q86X27 | 583 | RGPS2_HUMAN Ras-specific guanine nucleotide-r... | 259 | 1e-25 | 117 | 27 | 49 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 43 | Q4R7W3 | 557 | RGPS2_MACFA Ras-specific guanine nucleotide-r... | 268 | 2e-25 | 117 | 26 | 49 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 44 | Q9ERD6 | 590 | RGPS2_MOUSE Ras-specific guanine nucleotide-r... | 275 | 2e-25 | 117 | 26 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 45 | Q8IS20 | 1457 | GEFC_DICDI Ras guanine nucleotide exchange fa... | 211 | 2e-25 | 119 | 34 | 50 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 46 | Q5JS13 | 557 | RGPS1_HUMAN Ras-specific guanine nucleotide-r... | 275 | 2e-25 | 116 | 28 | 52 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; NAS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 47 | A2AR50 | 585 | RGPS1_MOUSE Ras-specific guanine nucleotide-r... | 275 | 1e-24 | 114 | 28 | 52 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 48 | Q8IS21 | 1529 | GEFB_DICDI Ras guanine nucleotide exchange fa... | 87 | 0.075 | 41.6 | 31 | 49 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005488; F:binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IGI:dictyBase. | | | | | | | | | | GO:0007015; P:actin filament organization; IMP:dictyBase.::GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.::GO:0006928; P:cellular component movement; IMP:dictyBase.::GO:0030866; P:cortical actin cytoskeleton organization; IMP:dictyBase.::GO:0051271; P:negative regulation of cellular component movement; IMP:dictyBase.::GO:0006909; P:phagocytosis; IMP:dictyBase.::GO:0045762; P:positive regulation of adenylate cyclase activity; IMP:dictyBase.::GO:0050766; P:positive regulation of phagocytosis; IMP:dictyBase.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IMP:dictyBase.::GO:0007265; P:Ras protein signal transduction; ISS:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0019953; P:sexual reproduction; IEP:dictyBase. | 49 | Q6P112 | 804 | RGL1_DANRE Ral guanine nucleotide dissociatio... | 424 | 5e-24 | 113 | 25 | 44 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 50 | Q9NZL6 | 768 | RGL1_HUMAN Ral guanine nucleotide dissociatio... | 440 | 2e-23 | 111 | 27 | 44 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0008321; F:Ral guanyl-nucleotide exchange factor activity; NAS:UniProtKB. | | | | | | | | | | GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; NAS:UniProtKB.::GO:0044281; P:small molecule metabolic process; TAS:Reactome. | 51 | Q55FD8 | 1982 | GEFV_DICDI Ras guanine nucleotide exchange fa... | 453 | 2e-23 | 112 | 26 | 43 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0003779; F:actin binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0017048; F:Rho GTPase binding; IEA:InterPro. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0030587; P:sorocarp development; IMP:dictyBase. | 52 | Q6DCK3 | 594 | GRP2B_XENLA RAS guanyl-releasing protein 2-B ... | 260 | 4e-23 | 110 | 30 | 52 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 53 | Q32N25 | 594 | GRP2A_XENLA RAS guanyl-releasing protein 2-A ... | 255 | 4e-23 | 109 | 30 | 51 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 54 | Q61193 | 778 | RGL2_MOUSE Ral guanine nucleotide dissociatio... | 506 | 3e-22 | 107 | 23 | 40 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 55 | Q60695 | 768 | RGL1_MOUSE Ral guanine nucleotide dissociatio... | 436 | 3e-22 | 107 | 26 | 43 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 56 | Q03385 | 852 | GNDS_MOUSE Ral guanine nucleotide dissociatio... | 161 | 6.6 | 35 | 25 | 41 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 57 | Q8ST25 | 1556 | GEFG_DICDI Ras guanine nucleotide exchange fa... | 443 | 1e-21 | 106 | 23 | 44 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 58 | A6N9I4 | 608 | GRP2_BOVIN RAS guanyl-releasing protein 2 OS=... | 253 | 4e-21 | 103 | 30 | 51 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 59 | Q8IS11 | 944 | GEFO_DICDI Ras guanine nucleotide exchange fa... | 238 | 6e-21 | 103 | 32 | 53 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 60 | Q9Y4G8 | 1499 | RPGF2_HUMAN Rap guanine nucleotide exchange f... | 208 | 6e-21 | 104 | 30 | 51 | GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.::GO:0005622; C:intracellular; TAS:GOC. | | | | | | | | | | GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0019992; F:diacylglycerol binding; NAS:UniProtKB.::GO:0046582; F:Rap GTPase activator activity; IDA:UniProtKB.::GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; IDA:UniProtKB.::GO:0004871; F:signal transducer activity; TAS:UniProtKB. | | | | | | | | | | GO:0019933; P:cAMP-mediated signaling; NAS:UniProtKB.::GO:0000165; P:MAPK cascade; NAS:UniProtKB.::GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:UniProtKB. | 61 | F1M386 | 1496 | RPGF2_RAT Rap guanine nucleotide exchange fac... | 208 | 7e-21 | 103 | 30 | 50 | GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0019901; F:protein kinase binding; IPI:UniProtKB. | | | | | | | | | | GO:0048167; P:regulation of synaptic plasticity; IDA:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |