UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YLR304C

Length:

778

Number of sequences:

5887

Description:

YLR304C ACO1 SGDID:S000004295, Chr XII from 737548-735212, Genome Release 64-1-1, reverse complement, Verified ORF, "Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
61	Q2HZ33	688	LYS4_CANPA Homoaconitase, mitochondrial OS=Ca...	652	4e-47	182	28	44	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.::GO:0004409; F:homoaconitate hydratase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009085; P:lysine biosynthetic process; IEA:UniProtKB-KW.
62	Q6L0K5	413	LEUC_PICTO 3-isopropylmalate dehydratase larg...	446	2e-46	175	31	48
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
63	Q5ZLQ4	965	IREB2_CHICK Iron-responsive element-binding p...	752	4e-46	181	27	43	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
									GO:0008152; P:metabolic process; IEA:InterPro.
64	O27668	428	LEUC2_METTH 3-isopropylmalate dehydratase lar...	343	2e-45	172	33	52
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
65	O67078	432	LEUC_AQUAE 3-isopropylmalate dehydratase larg...	450	3e-45	172	30	47
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
66	Q8U2A1	424	LEUC1_PYRFU 3-isopropylmalate dehydratase lar...	449	7e-45	171	31	48
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
67	Q9WZ24	417	LEUC2_THEMA 3-isopropylmalate dehydratase lar...	434	2e-44	169	32	47
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
68	Q4WUL6	777	LYS4_ASPFU Homoaconitase, mitochondrial OS=A1...	464	2e-44	174	31	50	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.::GO:0004409; F:homoaconitate hydratase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009085; P:lysine biosynthetic process; IEA:UniProtKB-KW.
69	A4XJ48	429	LEUC_CALS8 3-isopropylmalate dehydratase larg...	440	3e-44	169	31	48
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
70	Q2RG98	421	LEUC_MOOTA 3-isopropylmalate dehydratase larg...	434	5e-44	168	31	47
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
71	Q8TVF2	418	LEUC1_METKA 3-isopropylmalate dehydratase lar...	449	6e-44	168	29	48
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
72	Q30WD3	418	LEUC_DESDG 3-isopropylmalate dehydratase larg...	448	4e-43	166	31	47
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
73	B9MLV4	429	LEUC_ANATD 3-isopropylmalate dehydratase larg...	440	5e-43	166	31	47
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
74	Q6C791	687	LYS4_YARLI Homoaconitase, mitochondrial OS=li...	475	6e-43	169	30	48	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.::GO:0004409; F:homoaconitate hydratase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009085; P:lysine biosynthetic process; IEA:UniProtKB-KW.
75	Q24XT4	421	LEUC_DESHY 3-isopropylmalate dehydratase larg...	448	2e-42	164	30	46
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
76	A5MZ75	420	LEUC_CLOK5 3-isopropylmalate dehydratase larg...	424	3e-42	163	32	47
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
77	Q0QLE2	420	DMDA_EUBBA 2,3-dimethylmalate dehydratase lar...	449	5e-42	162	32	47
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:InterPro.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0047868; F:dimethylmaleate hydratase activity; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0051187; P:cofactor catabolic process; IDA:UniProtKB.::GO:0009098; P:leucine biosynthetic process; IEA:InterPro.
78	B0TCR2	420	LEUC_HELMI 3-isopropylmalate dehydratase larg...	450	6e-42	162	30	46
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
79	B5YKE0	421	LEUC_THEYD 3-isopropylmalate dehydratase larg...	450	6e-42	162	29	47
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
80	Q9UZ07	423	LEUC1_PYRAB 3-isopropylmalate dehydratase lar...	449	7e-42	162	29	48
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:HAMAP.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:HAMAP.
81	A0JMA0	957	IREB2_XENTR Iron-responsive element-binding p...	756	1e-41	167	25	43	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
									GO:0008152; P:metabolic process; IEA:InterPro.
82	B8J4F9	420	LEUC_DESDA 3-isopropylmalate dehydratase larg...	446	2e-41	160	30	46
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
83	Q4JC09	414	LEUC_SULAC 3-isopropylmalate dehydratase larg...	451	3e-41	160	30	46
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
84	A6Q5L6	421	LEUC_NITSB 3-isopropylmalate dehydratase larg...	421	4e-41	160	31	46
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
85	Q9RTI6	431	LEUC2_DEIRA 3-isopropylmalate dehydratase lar...	448	4e-41	160	30	44
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
86	Q58409	420	HACA_METJA Homoaconitase large subunit OS=JCM...	364	7e-41	159	30	47
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:InterPro.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0004409; F:homoaconitate hydratase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:InterPro.
87	B8CX22	420	LEUC_HALOH 3-isopropylmalate dehydratase larg...	434	9e-41	159	29	47
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
88	B2UYH6	419	LEUC_CLOBA 3-isopropylmalate dehydratase larg...	424	1e-40	158	31	47
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
89	Q92412	776	LYS4_EMENI Homoaconitase, mitochondrial OS=19...	479	2e-40	163	30	49	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.::GO:0004409; F:homoaconitate hydratase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009085; P:lysine biosynthetic process; IEA:UniProtKB-KW.
90	Q6NTP2	955	IREB2_XENLA Iron-responsive element-binding p...	756	2e-40	163	25	43	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
									GO:0008152; P:metabolic process; IEA:InterPro.
91	B2TIQ9	419	LEUC_CLOBB 3-isopropylmalate dehydratase larg...	424	2e-40	157	30	46
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.

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