UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YLR304C

Length:

778

Number of sequences:

5887

Description:

YLR304C ACO1 SGDID:S000004295, Chr XII from 737548-735212, Genome Release 64-1-1, reverse complement, Verified ORF, "Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
121	P0CM02	728	LYS4_CRYNJ Homoaconitase, mitochondrial OS=AT...	461	7e-37	152	26	48	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.::GO:0004409; F:homoaconitate hydratase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009085; P:lysine biosynthetic process; IEA:UniProtKB-KW.
122	P0CM03	728	LYS4_CRYNB Homoaconitase, mitochondrial OS=(F...	461	7e-37	151	26	48	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.::GO:0004409; F:homoaconitate hydratase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009085; P:lysine biosynthetic process; IEA:UniProtKB-KW.
123	A6LPX4	419	LEUC_CLOB8 3-isopropylmalate dehydratase larg...	423	1e-36	147	30	45
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
124	Q870W1	784	LYS4_NEUCR Homoaconitase, mitochondrial OS=12...	496	2e-36	151	28	49	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.::GO:0004409; F:homoaconitate hydratase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009085; P:lysine biosynthetic process; IEA:UniProtKB-KW.
125	Q7ZAG7	473	LEUC_HALVD 3-isopropylmalate dehydratase larg...	424	2e-36	147	29	45
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
126	Q74BX5	427	LEUC_GEOSL 3-isopropylmalate dehydratase larg...	452	2e-36	146	28	44
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
127	Q2U9G3	775	LYS4_ASPOR Homoaconitase, mitochondrial OS=As...	522	3e-36	150	28	46	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.::GO:0004409; F:homoaconitate hydratase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009085; P:lysine biosynthetic process; IEA:UniProtKB-KW.
128	Q4HVQ9	776	LYS4_GIBZE Homoaconitase, mitochondrial OS=(W...	529	3e-36	150	28	45	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.::GO:0004409; F:homoaconitate hydratase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009085; P:lysine biosynthetic process; IEA:UniProtKB-KW.
129	Q65V07	469	LEUC2_MANSM 3-isopropylmalate dehydratase lar...	452	4e-36	146	30	44
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
130	A7H0L8	421	LEUC_CAMC5 3-isopropylmalate dehydratase larg...	391	5e-36	145	30	48
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
131	Q974R0	415	LEUC_SULTO 3-isopropylmalate dehydratase larg...	426	7e-36	145	29	44
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
132	Q67MJ2	481	LEUC_SYMTH 3-isopropylmalate dehydratase larg...	351	9e-36	145	30	47
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
133	A7HZP6	419	LEUC_CAMHC 3-isopropylmalate dehydratase larg...	423	1e-35	144	29	45
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
134	B7GNM7	467	LEUC_BIFLS 3-isopropylmalate dehydratase larg...	363	1e-35	145	29	46
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
135	B0BS44	469	LEUC_ACTPJ 3-isopropylmalate dehydratase larg...	393	1e-35	145	31	46
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
136	Q8EN69	468	LEUC_OCEIH 3-isopropylmalate dehydratase larg...	388	2e-35	144	29	46
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
137	Q3IRQ4	474	LEUC_NATPD 3-isopropylmalate dehydratase larg...	366	2e-35	144	30	46
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
138	B1MVR0	455	LEUC_LEUCK 3-isopropylmalate dehydratase larg...	357	2e-35	144	31	48
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
139	B8FMM4	419	LEUC_DESAA 3-isopropylmalate dehydratase larg...	424	2e-35	143	30	43
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
140	Q47WG2	471	LEUC_COLP3 3-isopropylmalate dehydratase larg...	371	3e-35	144	29	46
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
141	P49367	693	LYS4_YEAST Homoaconitase, mitochondrial OS=Sa...	433	3e-35	146	29	47	GO:0005739; C:mitochondrion; IDA:SGD.
									GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.::GO:0004409; F:homoaconitate hydratase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0019878; P:lysine biosynthetic process via aminoadipic acid; NAS:SGD.
142	A9A043	431	LEUC_DESOH 3-isopropylmalate dehydratase larg...	433	3e-35	143	30	45
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
143	B3GZY1	469	LEUC_ACTP7 3-isopropylmalate dehydratase larg...	347	4e-35	143	32	47
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
144	P55251	755	LEUC_RHIPU 3-isopropylmalate dehydratase OS=R...	735	4e-35	146	27	40	GO:0009316; C:3-isopropylmalate dehydratase complex; IEA:InterPro.
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
145	A8MDY8	415	LEUC_CALMQ 3-isopropylmalate dehydratase larg...	351	4e-35	142	30	47
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
146	Q5E858	471	LEUC_VIBF1 3-isopropylmalate dehydratase larg...	456	5e-35	143	28	45
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
147	B5FGH2	471	LEUC_VIBFM 3-isopropylmalate dehydratase larg...	456	6e-35	143	28	45
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
148	Q9ZNE0	418	HACA_THET2 Homoaconitase large subunit OS=The...	402	9e-35	141	28	46
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:InterPro.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0004409; F:homoaconitate hydratase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:InterPro.::GO:0009085; P:lysine biosynthetic process; IEA:UniProtKB-KW.
149	Q92A26	462	LEUC_LISIN 3-isopropylmalate dehydratase larg...	358	1e-34	142	31	46
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
150	P44968	469	LEUC_HAEIN 3-isopropylmalate dehydratase larg...	406	1e-34	142	29	44
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
151	A6VQL0	469	LEUC_ACTSZ 3-isopropylmalate dehydratase larg...	346	2e-34	142	31	48
									GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:EC.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.

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