Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLR303W
Length:
444
Number of sequences:
5887
Description:
YLR303W MET17 SGDID:S000004294, Chr XII from 732542-733876, Genome Release 64-1-1, Verified ORF, "Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P06106    444   MET17_YEAST Protein MET17 OS=Saccharomyces ce...4440     914     100     100GO:0005737; C:cytoplasm; IDA:SGD.::GO:0001950; C:plasma membrane enriched fraction; IDA:SGD.
GO:0004124; F:cysteine synthase activity; IDA:SGD.::GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; IDA:SGD.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
2Q92441    444   MET17_KLULA Protein MET17 OS=1267 / NRRL Y-11...4440     763     84     92GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004124; F:cysteine synthase activity; IEA:EC.::GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
3P50125    437   CYSD_EMENI O-acetylhomoserine (thiol)-lyase O...4380     553     65     77
GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.
4O13326    429   CYSD_SCHPO O-acetylhomoserine (thiol)-lyase O...4330     543     64     77GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0004124; F:cysteine synthase activity; ISS:PomBase.::GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; TAS:PomBase.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
5P13254    398   MEGL_PSEPU Methionine gamma-lyase OS=Pseudomo...4102e-72     239     34     54
GO:0018826; F:methionine gamma-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
6O05394    379   MCCB_BACSU Cystathionine gamma-lyase OS=Bacil...4321e-71     237     36     52
GO:0004123; F:cystathionine gamma-lyase activity; IEA:EC.::GO:0047982; F:homocysteine desulfhydrase activity; IEA:EC.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro.
7P55218    403   METZ_PSEAE O-succinylhomoserine sulfhydrylase...4318e-69     230     35     52
GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
GO:0071268; P:homocysteine biosynthetic process; IEA:InterPro.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
8P95199    406   METZ_MYCTU O-succinylhomoserine sulfhydrylase...4078e-67     225     33     53
GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
GO:0071268; P:homocysteine biosynthetic process; IEA:InterPro.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
9Q1M0P5    380   METB_HELPX Cystathionine gamma-synthase OS=He...4361e-65     221     34     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
10A2RM21    380   METC_LACLM Cystathionine beta-lyase OS=Lactoc...4192e-64     218     36     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
11P0A4K2    380   METC_LACLA Cystathionine beta-lyase OS=lactis...4192e-64     218     36     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
12P56069    380   METB_HELPY Cystathionine gamma-synthase OS=py...4156e-63     214     34     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
13Q83A83    387   METC_COXBU Cystathionine beta-lyase OS=Coxiel...4342e-62     213     35     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
14P0C2T9    380   METC_LACLC Cystathionine beta-lyase OS=Lactoc...4191e-61     211     35     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
15P18757    398   CGL_RAT Cystathionine gamma-lyase OS=Rattus n...4406e-61     209     32     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004121; F:cystathionine beta-lyase activity; IDA:RGD.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); ISS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0006749; P:glutathione metabolic process; IMP:RGD.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0030308; P:negative regulation of cell growth; IMP:RGD.::GO:0008285; P:negative regulation of cell proliferation; IMP:RGD.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0044524; P:protein sulfhydration; ISS:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB.::GO:0019346; P:transsulfuration; TAS:RGD.
16Q8VCN5    398   CGL_MOUSE Cystathionine gamma-lyase OS=Mus mu...4416e-61     209     33     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IDA:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
GO:0006916; P:anti-apoptosis; IMP:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB.::GO:0044524; P:protein sulfhydration; IDA:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB.
17Q55DV9    387   CGL_DICDI Cystathionine gamma-lyase OS=Dictyo...4272e-60     207     32     49GO:0005737; C:cytoplasm; ISS:dictyBase.::GO:0005615; C:extracellular space; IDA:dictyBase.
GO:0004123; F:cystathionine gamma-lyase activity; ISS:dictyBase.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.
18Q19QT7    405   CGL_PIG Cystathionine gamma-lyase OS=Sus scro...4363e-59     205     33     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); ISS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0044524; P:protein sulfhydration; ISS:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB.
19Q60HG7    405   CGL_MACFA Cystathionine gamma-lyase OS=Macaca...4361e-57     201     33     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); ISS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0044524; P:protein sulfhydration; ISS:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB.
20Q9ZMW7    380   METB_HELPJ Cystathionine gamma-synthase OS=He...4153e-57     199     33     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
21Q58DW2    405   CGL_BOVIN Cystathionine gamma-lyase OS=Bos ta...4208e-56     196     33     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); ISS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0044524; P:protein sulfhydration; ISS:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB.
22P32929    405   CGL_HUMAN Cystathionine gamma-lyase OS=Homo s...4204e-54     191     33     50GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IDA:HPA.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; IDA:UniProtKB.::GO:0047982; F:homocysteine desulfhydrase activity; TAS:Reactome.::GO:0080146; F:L-cysteine desulfhydrase activity; TAS:Reactome.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IMP:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; IDA:UniProtKB.
GO:0019344; P:cysteine biosynthetic process; IDA:UniProtKB.::GO:0030968; P:endoplasmic reticulum unfolded protein response; TAS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; IDA:UniProtKB.::GO:0051289; P:protein homotetramerization; IPI:UniProtKB.::GO:0044524; P:protein sulfhydration; IMP:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; IDA:UniProtKB.::GO:0000098; P:sulfur amino acid catabolic process; TAS:Reactome.::GO:0019346; P:transsulfuration; TAS:Reactome.
23O31631    373   METI_BACSU Cystathionine gamma-synthase/O-ace...4431e-53     189     31     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
24P46807    388   METB_MYCLE Cystathionine gamma-synthase OS=My...4294e-53     188     30     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
25O31632    390   METC_BACSU Cystathionine beta-lyase metC OS=B...3896e-53     187     31     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
26P55217    563   METB_ARATH Cystathionine gamma-synthase, chlo...4337e-53     191     30     48GO:0009570; C:chloroplast stroma; IDA:TAIR.
GO:0003962; F:cystathionine gamma-synthase activity; IDA:TAIR.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0009086; P:methionine biosynthetic process; IMP:TAIR.::GO:0001887; P:selenium compound metabolic process; IDA:TAIR.
27P66875    388   METB_MYCTU Cystathionine gamma-synthase OS=My...4331e-51     184     31     48GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:MTBBASE.
GO:0004123; F:cystathionine gamma-lyase activity; IDA:MTBBASE.::GO:0003962; F:cystathionine gamma-synthase activity; IDA:MTBBASE.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0019343; P:cysteine biosynthetic process via cystathionine; IMP:MTBBASE.::GO:0019279; P:L-methionine biosynthetic process from L-homoserine via cystathionine; IMP:MTBBASE.
28P66876    388   METB_MYCBO Cystathionine gamma-synthase OS=My...4331e-51     184     31     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
29P44502    369   METB_HAEIN Cystathionine gamma-synthase OS=Ha...4324e-50     180     31     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
30P55216    392   CGL2_CAEEL Putative cystathionine gamma-lyase...4234e-50     180     34     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004123; F:cystathionine gamma-lyase activity; IEA:EC.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
31P53780    464   METC_ARATH Cystathionine beta-lyase, chloropl...4132e-48     177     31     47GO:0009570; C:chloroplast stroma; IDA:TAIR.
GO:0004121; F:cystathionine beta-lyase activity; IMP:TAIR.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0019279; P:L-methionine biosynthetic process from L-homoserine via cystathionine; TAS:TAIR.
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