Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLR291C
Length:
381
Number of sequences:
5887
Description:
YLR291C GCD7 SGDID:S000004282, Chr XII from 719462-718317, Genome Release 64-1-1, reverse complement, Verified ORF, "Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P32502    381   EI2BB_YEAST Translation initiation factor eIF...3810     790     100     100GO:0005851; C:eukaryotic translation initiation factor 2B complex; IDA:SGD.::GO:0032045; C:guanyl-nucleotide exchange factor complex; IDA:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.
GO:0030234; F:enzyme regulator activity; IMP:SGD.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0003743; F:translation initiation factor activity; IGI:SGD.
GO:0006446; P:regulation of translational initiation; IDA:SGD.
2Q9UT76    393   EI2BB_SCHPO Probable translation initiation f...3858e-82     261     40     59GO:0005829; C:cytosol; IDA:PomBase.::GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:PomBase.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:RefGenome.::GO:0003743; F:translation initiation factor activity; ISS:PomBase.
GO:0002183; P:cytoplasmic translational initiation; NAS:PomBase.::GO:0006446; P:regulation of translational initiation; ISS:RefGenome.
3Q90511    355   EI2BB_TAKRU Translation initiation factor eIF...3677e-52     182     33     51GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0005525; F:GTP binding; ISS:UniProtKB.::GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:RefGenome.::GO:0003743; F:translation initiation factor activity; ISS:RefGenome.
GO:0051716; P:cellular response to stimulus; ISS:UniProtKB.::GO:0042552; P:myelination; ISS:UniProtKB.::GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.::GO:0006446; P:regulation of translational initiation; ISS:RefGenome.
4Q5E9B4    351   EI2BB_BOVIN Translation initiation factor eIF...3712e-51     181     34     54GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0005525; F:GTP binding; ISS:UniProtKB.::GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:RefGenome.::GO:0003743; F:translation initiation factor activity; ISS:RefGenome.
GO:0051716; P:cellular response to stimulus; ISS:UniProtKB.::GO:0042552; P:myelination; ISS:UniProtKB.::GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.::GO:0001541; P:ovarian follicle development; ISS:UniProtKB.::GO:0006446; P:regulation of translational initiation; ISS:RefGenome.
5Q28690    351   EI2BB_RABIT Translation initiation factor eIF...3643e-50     177     34     53GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0005525; F:GTP binding; ISS:UniProtKB.::GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
GO:0051716; P:cellular response to stimulus; ISS:UniProtKB.::GO:0042552; P:myelination; ISS:UniProtKB.::GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.::GO:0001541; P:ovarian follicle development; ISS:UniProtKB.
6Q62818    351   EI2BB_RAT Translation initiation factor eIF-2...3799e-50     176     32     53GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0005525; F:GTP binding; ISS:UniProtKB.::GO:0003743; F:translation initiation factor activity; IBA:RefGenome.
GO:0051716; P:cellular response to stimulus; ISS:UniProtKB.::GO:0042552; P:myelination; ISS:UniProtKB.::GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.::GO:0001541; P:ovarian follicle development; ISS:UniProtKB.::GO:0006446; P:regulation of translational initiation; IBA:RefGenome.::GO:0009749; P:response to glucose stimulus; IDA:UniProtKB.::GO:0009408; P:response to heat; IDA:UniProtKB.::GO:0043434; P:response to peptide hormone stimulus; IDA:UniProtKB.
7Q99LD9    351   EI2BB_MOUSE Translation initiation factor eIF...3791e-49     176     32     52GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0005525; F:GTP binding; ISS:UniProtKB.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:RefGenome.::GO:0003743; F:translation initiation factor activity; IBA:RefGenome.
GO:0051716; P:cellular response to stimulus; ISS:UniProtKB.::GO:0042552; P:myelination; ISS:UniProtKB.::GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.::GO:0001541; P:ovarian follicle development; ISS:UniProtKB.::GO:0006446; P:regulation of translational initiation; IBA:RefGenome.
8P49770    351   EI2BB_HUMAN Translation initiation factor eIF...3673e-49     175     33     53GO:0005829; C:cytosol; TAS:Reactome.::GO:0005851; C:eukaryotic translation initiation factor 2B complex; IDA:UniProtKB.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0005525; F:GTP binding; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
GO:0051716; P:cellular response to stimulus; IDA:UniProtKB.::GO:0042552; P:myelination; IMP:UniProtKB.::GO:0014003; P:oligodendrocyte development; IMP:UniProtKB.::GO:0001541; P:ovarian follicle development; IMP:UniProtKB.::GO:0006446; P:regulation of translational initiation; TAS:UniProtKB.::GO:0009749; P:response to glucose stimulus; ISS:UniProtKB.::GO:0009408; P:response to heat; ISS:UniProtKB.::GO:0043434; P:response to peptide hormone stimulus; ISS:UniProtKB.
9Q9V281    324   EI2B2_PYRAB Putative translation initiation f...3340.000000000001     71.6     24     39
GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
10O28242    313   EI2B2_ARCFU Putative translation initiation f...3350.000000000002     71.2     23     37
GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
11Q54EY2    388   EI2BB_DICDI Translation initiation factor eIF...770.000000000007     69.7     35     65GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:dictyBase.
GO:0005525; F:GTP binding; IC:dictyBase.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:RefGenome.::GO:0003743; F:translation initiation factor activity; IBA:RefGenome.
GO:0006446; P:regulation of translational initiation; ISS:dictyBase.
12O57947    324   EI2B2_PYRHO Putative translation initiation f...2300.00000000001     68.9     28     43
GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
13Q54FM3    619   EI2BD_DICDI Translation initiation factor eIF...2240.00000000002     69.3     25     42GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:dictyBase.
GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:RefGenome.::GO:0003743; F:translation initiation factor activity; ISS:dictyBase.
GO:0045947; P:negative regulation of translational initiation; IBA:RefGenome.
14Q64270    305   EI2BA_RAT Translation initiation factor eIF-2...1700.0000000001     65.5     29     47GO:0005850; C:eukaryotic translation initiation factor 2 complex; IDA:RGD.::GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.::GO:0005625; C:soluble fraction; IDA:RGD.
GO:0019003; F:GDP binding; IDA:RGD.::GO:0005525; F:GTP binding; IMP:RGD.::GO:0003743; F:translation initiation factor activity; IDA:RGD.
GO:0032057; P:negative regulation of translational initiation in response to stress; IMP:RGD.::GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.::GO:0009749; P:response to glucose stimulus; IDA:UniProtKB.::GO:0009408; P:response to heat; IDA:UniProtKB.::GO:0043434; P:response to peptide hormone stimulus; IDA:UniProtKB.
15Q4R4V8    305   EI2BA_MACFA Translation initiation factor eIF...1840.0000000001     65.5     30     46GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.
GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
GO:0051716; P:cellular response to stimulus; ISS:UniProtKB.::GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.
16Q0IIF2    305   EI2BA_BOVIN Translation initiation factor eIF...1700.0000000001     65.5     29     47GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:RefGenome.
GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:RefGenome.::GO:0003743; F:translation initiation factor activity; ISS:RefGenome.
GO:0006446; P:regulation of translational initiation; ISS:RefGenome.
17Q99LC8    305   EI2BA_MOUSE Translation initiation factor eIF...1700.0000000002     64.7     29     47GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.
GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:RefGenome.::GO:0005515; F:protein binding; IPI:MGI.::GO:0003743; F:translation initiation factor activity; IBA:RefGenome.
GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.
18Q5RAR0    305   EI2BA_PONAB Translation initiation factor eIF...1840.0000000005     63.5     29     45
GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
19Q14232    305   EI2BA_HUMAN Translation initiation factor eIF...1840.0000000005     63.5     29     45GO:0005829; C:cytosol; TAS:Reactome.::GO:0005851; C:eukaryotic translation initiation factor 2B complex; IDA:UniProtKB.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0005886; C:plasma membrane; IDA:MGI.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
GO:0051716; P:cellular response to stimulus; IDA:UniProtKB.::GO:0014003; P:oligodendrocyte development; IMP:UniProtKB.::GO:0006446; P:regulation of translational initiation; IBA:RefGenome.::GO:0009749; P:response to glucose stimulus; ISS:UniProtKB.::GO:0009408; P:response to heat; ISS:UniProtKB.::GO:0043434; P:response to peptide hormone stimulus; ISS:UniProtKB.
20Q8U4G6    324   EI2B2_PYRFU Putative translation initiation f...2340.0000000005     63.9     26     41
GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
21P14741    305   EI2BA_YEAST Translation initiation factor eIF...1930.0000000006     63.5     30     45GO:0005851; C:eukaryotic translation initiation factor 2B complex; IDA:SGD.::GO:0032045; C:guanyl-nucleotide exchange factor complex; IDA:SGD.
GO:0030234; F:enzyme regulator activity; IMP:SGD.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0003743; F:translation initiation factor activity; IDA:SGD.
GO:0006446; P:regulation of translational initiation; IDA:SGD.
22Q57586    308   EI2B2_METJA Putative translation initiation f...3510.0000000006     63.5     23     40
GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
23Q54I81    321   EI2BA_DICDI Translation initiation factor eIF...1980.0000000007     63.5     27     46GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.
GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:RefGenome.::GO:0003743; F:translation initiation factor activity; IBA:RefGenome.
GO:0006446; P:regulation of translational initiation; IBA:RefGenome.
24P34604    305   EI2BA_CAEEL Probable translation initiation f...2120.00000002     58.5     27     45GO:0005851; C:eukaryotic translation initiation factor 2B complex; IBA:RefGenome.
GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:RefGenome.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0003743; F:translation initiation factor activity; IBA:RefGenome.
GO:0006446; P:regulation of translational initiation; IBA:RefGenome.
25Q09924    467   EI2BD_SCHPO Probable translation initiation f...2180.00004     48.9     28     40GO:0005829; C:cytosol; IDA:PomBase.::GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:RefGenome.::GO:0003743; F:translation initiation factor activity; ISS:PomBase.
GO:0002183; P:cytoplasmic translational initiation; NAS:PomBase.::GO:0045947; P:negative regulation of translational initiation; ISS:RefGenome.
26D4GV73    323   EI2B2_HALVD Putative translation initiation f...2250.00005     48.5     24     40
GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
27Q9USP0    341   EI2BA_SCHPO Translation initiation factor eIF...1700.0001     47     29     45GO:0005829; C:cytosol; IDA:PomBase.::GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:RefGenome.::GO:0003743; F:translation initiation factor activity; ISS:PomBase.
GO:0002183; P:cytoplasmic translational initiation; NAS:PomBase.::GO:0006446; P:regulation of translational initiation; ISS:RefGenome.
28O58185    276   EI2BL_PYRHO Putative translation initiation f...1880.0006     44.7     24     43
GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
29Q61749    524   EI2BD_MOUSE Translation initiation factor eIF...2310.001     44.3     25     39GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.
GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:RefGenome.::GO:0003743; F:translation initiation factor activity; IBA:RefGenome.
GO:0042552; P:myelination; ISS:UniProtKB.::GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.::GO:0001541; P:ovarian follicle development; ISS:UniProtKB.
30Q3T058    524   EI2BD_BOVIN Translation initiation factor eIF...2570.003     43.1     23     39GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.
GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:RefGenome.::GO:0003743; F:translation initiation factor activity; ISS:RefGenome.
GO:0051716; P:cellular response to stimulus; ISS:UniProtKB.::GO:0042552; P:myelination; ISS:UniProtKB.::GO:0045947; P:negative regulation of translational initiation; ISS:RefGenome.::GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.::GO:0001541; P:ovarian follicle development; ISS:UniProtKB.
31Q63186    524   EI2BD_RAT Translation initiation factor eIF-2...2310.004     42.7     23     39GO:0005851; C:eukaryotic translation initiation factor 2B complex; ISS:UniProtKB.
GO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:RGD.::GO:0003743; F:translation initiation factor activity; NAS:UniProtKB.::GO:0031369; F:translation initiation factor binding; IDA:RGD.
GO:0042552; P:myelination; ISS:UniProtKB.::GO:0032057; P:negative regulation of translational initiation in response to stress; IMP:RGD.::GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.::GO:0001541; P:ovarian follicle development; ISS:UniProtKB.::GO:0009749; P:response to glucose stimulus; IDA:UniProtKB.::GO:0009408; P:response to heat; IDA:UniProtKB.::GO:0043434; P:response to peptide hormone stimulus; IDA:UniProtKB.
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