Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLR274W
Length:
775
Number of sequences:
5887
Description:
YLR274W MCM5 SGDID:S000004264, Chr XII from 691555-693882, Genome Release 64-1-1, Verified ORF, "Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
61P34647    810   MCM6_CAEEL DNA replication licensing factor m...7091e-89     306     30     50GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0000910; P:cytokinesis; IMP:WormBase.::GO:0006270; P:DNA-dependent DNA replication initiation; IEA:InterPro.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0048477; P:oogenesis; IMP:WormBase.
62P24279    971   MCM3_YEAST DNA replication licensing factor M...5201e-89     308     36     57GO:0005737; C:cytoplasm; IDA:SGD.::GO:0031261; C:DNA replication preinitiation complex; IPI:SGD.::GO:0042555; C:MCM complex; IDA:SGD.::GO:0005656; C:pre-replicative complex; IDA:SGD.::GO:0031298; C:replication fork protection complex; IDA:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003682; F:chromatin binding; IDA:SGD.::GO:0003688; F:DNA replication origin binding; IDA:SGD.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0006200; P:ATP catabolic process; IDA:GOC.::GO:0030466; P:chromatin silencing at silent mating-type cassette; IMP:SGD.::GO:0006348; P:chromatin silencing at telomere; IMP:SGD.::GO:0032508; P:DNA duplex unwinding; IDA:GOC.::GO:0006271; P:DNA strand elongation involved in DNA replication; IMP:SGD.::GO:0006270; P:DNA-dependent DNA replication initiation; IMP:SGD.::GO:0000727; P:double-strand break repair via break-induced replication; IMP:SGD.::GO:0006267; P:pre-replicative complex assembly; IDA:SGD.::GO:0000084; P:S phase of mitotic cell cycle; IMP:SGD.
63Q3ZBH9    719   MCM7_BOVIN DNA replication licensing factor M...6792e-89     303     33     52GO:0042555; C:MCM complex; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003697; F:single-stranded DNA binding; ISS:AgBase.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0008283; P:cell proliferation; ISS:AgBase.::GO:0006268; P:DNA unwinding involved in replication; ISS:AgBase.::GO:0006270; P:DNA-dependent DNA replication initiation; IEA:InterPro.::GO:0042325; P:regulation of phosphorylation; ISS:AgBase.::GO:0006974; P:response to DNA damage stimulus; ISS:AgBase.
64Q62724    507   MCM6_RAT DNA replication licensing factor MCM...3562e-89     297     44     66
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
65P33993    719   MCM7_HUMAN DNA replication licensing factor M...6762e-89     303     33     52GO:0000785; C:chromatin; TAS:ProtInc.::GO:0042555; C:MCM complex; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0000075; P:cell cycle checkpoint; TAS:Reactome.::GO:0006271; P:DNA strand elongation involved in DNA replication; TAS:Reactome.::GO:0006270; P:DNA-dependent DNA replication initiation; IEA:InterPro.::GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome.::GO:0000216; P:M/G1 transition of mitotic cell cycle; TAS:Reactome.::GO:0042325; P:regulation of phosphorylation; IMP:UniProtKB.::GO:0006974; P:response to DNA damage stimulus; IMP:UniProtKB.::GO:0000084; P:S phase of mitotic cell cycle; TAS:Reactome.
66Q61881    719   MCM7_MOUSE DNA replication licensing factor M...5555e-89     301     35     55GO:0042555; C:MCM complex; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:MGI.::GO:0003697; F:single-stranded DNA binding; IPI:MGI.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0008283; P:cell proliferation; IDA:MGI.::GO:0006268; P:DNA unwinding involved in replication; IPI:MGI.::GO:0006270; P:DNA-dependent DNA replication initiation; IEA:InterPro.
67Q61J08    810   MCM6_CAEBR DNA replication licensing factor m...7097e-89     303     30     50GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006270; P:DNA-dependent DNA replication initiation; IEA:InterPro.
68P53091    1017   MCM6_YEAST DNA replication licensing factor M...5751e-85     298     33     51GO:0005737; C:cytoplasm; IDA:SGD.::GO:0031261; C:DNA replication preinitiation complex; IDA:SGD.::GO:0042555; C:MCM complex; IDA:SGD.::GO:0005656; C:pre-replicative complex; IDA:SGD.::GO:0031298; C:replication fork protection complex; IDA:SGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003688; F:DNA replication origin binding; IDA:SGD.::GO:0009378; F:four-way junction helicase activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0043142; F:single-stranded DNA-dependent ATPase activity; IDA:SGD.
GO:0006271; P:DNA strand elongation involved in DNA replication; IMP:SGD.::GO:0006268; P:DNA unwinding involved in replication; IDA:SGD.::GO:0006270; P:DNA-dependent DNA replication initiation; IPI:SGD.::GO:0000727; P:double-strand break repair via break-induced replication; IMP:SGD.::GO:0006267; P:pre-replicative complex assembly; IDA:SGD.::GO:0000084; P:S phase of mitotic cell cycle; IMP:SGD.
69Q9XYU0    720   MCM7_DROME DNA replication licensing factor M...6874e-85     291     32     52GO:0005875; C:microtubule associated complex; IDA:FlyBase.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
GO:0006270; P:DNA-dependent DNA replication initiation; IEA:InterPro.::GO:0007095; P:mitotic cell cycle G2/M transition DNA damage checkpoint; IGI:FlyBase.
70Q24849    597   MCM3_ENTHI DNA replication licensing factor M...4685e-79     271     36     54GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006270; P:DNA-dependent DNA replication initiation; IEA:InterPro.
71Q9UJA3    840   MCM8_HUMAN DNA replication licensing factor M...7553e-70     252     29     46GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
GO:0000075; P:cell cycle checkpoint; TAS:Reactome.::GO:0006271; P:DNA strand elongation involved in DNA replication; TAS:Reactome.::GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome.::GO:0000216; P:M/G1 transition of mitotic cell cycle; TAS:Reactome.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0000084; P:S phase of mitotic cell cycle; TAS:Reactome.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
72Q9CWV1    833   MCM8_MOUSE DNA replication licensing factor M...5111e-69     250     33     52GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
73Q6NRM6    1143   MCM9_XENLA DNA replication licensing factor M...7209e-67     244     29     49
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
GO:0006260; P:DNA replication; IEA:InterPro.
74Q9NXL9    1143   MCM9_HUMAN DNA replication licensing factor M...6622e-64     237     30     51
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
GO:0006260; P:DNA replication; IEA:InterPro.
75Q2KHI9    1134   MCM9_MOUSE DNA replication licensing factor M...7012e-63     234     30     50
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
GO:0006260; P:DNA replication; IEA:InterPro.
76Q58371    762   Y961_METJA Uncharacterized MCM-type protein M...6374e-45     176     28     45
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
77Q58884    682   Y1489_METJA Uncharacterized MCM-type protein ...6082e-39     159     27     45
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006270; P:DNA-dependent DNA replication initiation; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
78Q57809    759   Y363_METJA Uncharacterized MCM-type protein M...6151e-37     154     25     45
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
79Q9VF30    885   MCMR_DROME DNA replication licensing factor R...890.46     37.7     27     55GO:0005634; C:nucleus; TAS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004003; F:ATP-dependent DNA helicase activity; TAS:UniProtKB.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0006270; P:DNA-dependent DNA replication initiation; TAS:UniProtKB.::GO:0007131; P:reciprocal meiotic recombination; IMP:UniProtKB.
80Q60275    602   Y3513_METJA Uncharacterized MCM-type protein ...2830.00000000000004     79.7     25     46
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
81Q660R1    430   CLPX_BORGA ATP-dependent Clp protease ATP-bin...1550.26     38.1     25     45GO:0005622; C:intracellular; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.::GO:0046983; F:protein dimerization activity; IEA:InterPro.::GO:0008134; F:transcription factor binding; IEA:InterPro.::GO:0051082; F:unfolded protein binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006457; P:protein folding; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
82O85057    543   LIHY_GEOSE Limonene hydroxylase OS=Geobacillu...1070.38     37.7     27     46GO:0005622; C:intracellular; IEA:InterPro.
GO:0018675; F:(S)-limonene 6-monooxygenase activity; IEA:EC.::GO:0018676; F:(S)-limonene 7-monooxygenase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0018459; F:carveol dehydrogenase activity; IEA:EC.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.::GO:0018457; F:perillyl-alcohol dehydrogenase activity; IEA:EC.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:InterPro.::GO:0008134; F:transcription factor binding; IEA:InterPro.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
83B5RPV8    429   CLPX_BORRA ATP-dependent Clp protease ATP-bin...1550.41     37.7     26     43
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.::GO:0046983; F:protein dimerization activity; IEA:InterPro.::GO:0051082; F:unfolded protein binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006457; P:protein folding; IEA:InterPro.
84B5RMG2    429   CLPX_BORDL ATP-dependent Clp protease ATP-bin...1550.41     37.7     26     43
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.::GO:0046983; F:protein dimerization activity; IEA:InterPro.::GO:0051082; F:unfolded protein binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006457; P:protein folding; IEA:InterPro.
85O51557    430   CLPX_BORBU ATP-dependent Clp protease ATP-bin...1470.62     37     25     45GO:0005622; C:intracellular; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.::GO:0046983; F:protein dimerization activity; IEA:InterPro.::GO:0008134; F:transcription factor binding; IEA:InterPro.::GO:0051082; F:unfolded protein binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006457; P:protein folding; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
86P22787    506   YIFB_ECOLI Uncharacterized protein YifB OS=Es...1391     36.6     27     42
GO:0016851; F:magnesium chelatase activity; IEA:InterPro.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.::GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0015995; P:chlorophyll biosynthetic process; IEA:InterPro.::GO:0015979; P:photosynthesis; IEA:InterPro.
87P57015    506   YIFB_SALTY Uncharacterized protein YifB OS=Sa...1392.3     35.4     26     42GO:0005622; C:intracellular; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:InterPro.::GO:0016851; F:magnesium chelatase activity; IEA:InterPro.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.::GO:0008134; F:transcription factor binding; IEA:InterPro.
GO:0015995; P:chlorophyll biosynthetic process; IEA:InterPro.::GO:0015979; P:photosynthesis; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
88P45049    509   COMM_HAEIN Competence protein ComM OS=Haemoph...1402.3     35.4     26     41
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0016851; F:magnesium chelatase activity; IEA:InterPro.::GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
GO:0015995; P:chlorophyll biosynthetic process; IEA:InterPro.::GO:0006260; P:DNA replication; IEA:InterPro.::GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.::GO:0015979; P:photosynthesis; IEA:InterPro.
89B1LJR7    336   PYRD_ECOSM Dihydroorotate dehydrogenase (quin...1682.9     34.7     24     42GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004158; F:dihydroorotate oxidase activity; IEA:InterPro.
GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0006222; P:UMP biosynthetic process; IEA:InterPro.
90B7N3A7    336   PYRD_ECOLU Dihydroorotate dehydrogenase (quin...1682.9     34.7     24     42GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004158; F:dihydroorotate oxidase activity; IEA:InterPro.
GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0006222; P:UMP biosynthetic process; IEA:InterPro.
91B7NM29    336   PYRD_ECO7I Dihydroorotate dehydrogenase (quin...1682.9     34.7     24     42GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004158; F:dihydroorotate oxidase activity; IEA:InterPro.
GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.::GO:0006222; P:UMP biosynthetic process; IEA:InterPro.
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