UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YLR209C

Length:

311

Number of sequences:

5887

Description:

YLR209C PNP1 SGDID:S000004199, Chr XII from 561732-560797, Genome Release 64-1-1, reverse complement, Verified ORF, "Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	Q05788	311	PNPH_YEAST Purine nucleoside phosphorylase OS...	311	0	645	100	100	GO:0005622; C:intracellular; IC:SGD.
									GO:0047724; F:inosine nucleosidase activity; IDA:SGD.::GO:0070635; F:nicotinamide riboside hydrolase activity; IDA:SGD.::GO:0004731; F:purine-nucleoside phosphorylase activity; IMP:SGD.
									GO:0046115; P:guanosine catabolic process; IMP:SGD.::GO:0006148; P:inosine catabolic process; IMP:SGD.::GO:0019358; P:nicotinate nucleotide salvage; IGI:SGD.
2	P85973	289	PNPH_RAT Purine nucleoside phosphorylase OS=R...	271	2e-92	283	52	68	GO:0005737; C:cytoplasm; IDA:RGD.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005576; C:extracellular region; IDA:RGD.::GO:0005634; C:nucleus; IDA:RGD.
									GO:0004731; F:purine-nucleoside phosphorylase activity; IDA:RGD.
									GO:0042278; P:purine nucleoside metabolic process; IDA:RGD.::GO:0043101; P:purine-containing compound salvage; TAS:RGD.
3	Q9UTG1	315	PNPH_SCHPO Putative purine nucleoside phospho...	276	9e-92	282	53	67	GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
									GO:0004731; F:purine-nucleoside phosphorylase activity; ISS:PomBase.
									GO:0034356; P:NAD biosynthesis via nicotinamide riboside salvage pathway; ISS:PomBase.::GO:0006152; P:purine nucleoside catabolic process; ISS:PomBase.
4	P55859	289	PNPH_BOVIN Purine nucleoside phosphorylase OS...	276	1e-89	276	49	66	GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
									GO:0004731; F:purine-nucleoside phosphorylase activity; IDA:UniProtKB.
									GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
5	P00491	289	PNPH_HUMAN Purine nucleoside phosphorylase OS...	289	3e-89	275	48	65	GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.
									GO:0008144; F:drug binding; IDA:UniProtKB.::GO:0001882; F:nucleoside binding; IDA:UniProtKB.::GO:0042301; F:phosphate ion binding; IDA:UniProtKB.::GO:0002060; F:purine base binding; IDA:UniProtKB.::GO:0004731; F:purine-nucleoside phosphorylase activity; IDA:UniProtKB.
									GO:0006955; P:immune response; IMP:UniProtKB.::GO:0006148; P:inosine catabolic process; IDA:MGI.::GO:0070970; P:interleukin-2 secretion; IMP:UniProtKB.::GO:0034356; P:NAD biosynthesis via nicotinamide riboside salvage pathway; IGI:UniProtKB.::GO:0006738; P:nicotinamide riboside catabolic process; IDA:UniProtKB.::GO:0046638; P:positive regulation of alpha-beta T cell differentiation; IDA:MGI.::GO:0042102; P:positive regulation of T cell proliferation; IDA:MGI.::GO:0006144; P:purine base metabolic process; TAS:Reactome.::GO:0006195; P:purine nucleotide catabolic process; TAS:Reactome.::GO:0043101; P:purine-containing compound salvage; TAS:Reactome.::GO:0042493; P:response to drug; IDA:UniProtKB.::GO:0034418; P:urate biosynthetic process; IDA:MGI.
6	P23492	289	PNPH_MOUSE Purine nucleoside phosphorylase OS...	271	6e-88	271	50	66	GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IDA:MGI.
									GO:0004731; F:purine-nucleoside phosphorylase activity; IDA:MGI.
									GO:0006161; P:deoxyguanosine catabolic process; IMP:MGI.::GO:0006149; P:deoxyinosine catabolic process; IMP:MGI.::GO:0046070; P:dGTP metabolic process; IMP:MGI.::GO:0006183; P:GTP biosynthetic process; IMP:MGI.::GO:0046115; P:guanosine catabolic process; IMP:MGI.::GO:0006148; P:inosine catabolic process; IMP:MGI.::GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.::GO:0046638; P:positive regulation of alpha-beta T cell differentiation; IMP:MGI.::GO:0045579; P:positive regulation of B cell differentiation; IMP:MGI.::GO:0045739; P:positive regulation of DNA repair; IMP:MGI.::GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IMP:MGI.::GO:0042102; P:positive regulation of T cell proliferation; IMP:MGI.::GO:0010332; P:response to gamma radiation; IMP:MGI.::GO:0034418; P:urate biosynthetic process; IMP:MGI.
7	P46354	271	PUNA_BACSU Purine nucleoside phosphorylase 1 ...	276	7e-67	217	46	62
									GO:0004731; F:purine-nucleoside phosphorylase activity; IEA:EC.
									GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
8	P77834	274	PUNA_GEOSE Purine nucleoside phosphorylase 1 ...	298	2e-63	207	42	59
									GO:0004731; F:purine-nucleoside phosphorylase activity; IEA:EC.
									GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
9	P45563	277	XAPA_ECOLI Xanthosine phosphorylase OS=Escher...	272	1e-51	177	40	55	GO:0005737; C:cytoplasm; IDA:EcoliWiki.
									GO:0004731; F:purine-nucleoside phosphorylase activity; IDA:EcoliWiki.
									GO:0015949; P:nucleobase-containing small molecule interconversion; IMP:EcoliWiki.::GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
10	P46862	268	PUNA_MYCLE Purine nucleoside phosphorylase OS...	270	4e-35	133	34	50
									GO:0004731; F:purine-nucleoside phosphorylase activity; IEA:EC.
									GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
11	P0A538	268	PUNA_MYCTU Purine nucleoside phosphorylase OS...	251	5e-35	133	35	51
									GO:0004731; F:purine-nucleoside phosphorylase activity; IDA:MTBBASE.
									GO:0006161; P:deoxyguanosine catabolic process; IDA:MTBBASE.
12	P0A539	268	PUNA_MYCBO Purine nucleoside phosphorylase OS...	251	5e-35	133	35	51
									GO:0004731; F:purine-nucleoside phosphorylase activity; IEA:EC.
									GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
13	P81989	282	PUNA_CELSP Purine nucleoside phosphorylase OS...	285	1e-33	129	34	47
									GO:0004731; F:purine-nucleoside phosphorylase activity; IEA:EC.
									GO:0009116; P:nucleoside metabolic process; IEA:InterPro.
14	O57865	257	MTAP_PYRHO S-methyl-5'-thioadenosine phosphor...	196	0.000000000000002	77.8	30	49
									GO:0017061; F:S-methyl-5-thioadenosine phosphorylase activity; IEA:EC.
									GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
15	Q8U4Q8	257	MTAP_PYRFU S-methyl-5'-thioadenosine phosphor...	245	0.000000000000004	76.6	29	47
									GO:0017061; F:S-methyl-5-thioadenosine phosphorylase activity; IEA:EC.
									GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
16	Q9V2F1	257	MTAP_PYRAB S-methyl-5'-thioadenosine phosphor...	159	0.00000000000002	75.1	32	52
									GO:0017061; F:S-methyl-5-thioadenosine phosphorylase activity; IEA:EC.::GO:0016763; F:transferase activity, transferring pentosyl groups; IEA:InterPro.
									GO:0009116; P:nucleoside metabolic process; IEA:InterPro.::GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
17	A1RXU2	262	MTAP_THEPD S-methyl-5'-thioadenosine phosphor...	214	0.0000000000001	72.8	29	46
									GO:0017061; F:S-methyl-5-thioadenosine phosphorylase activity; IEA:EC.
									GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
18	Q5JJB8	267	PNPH_PYRKO Probable 6-oxopurine nucleoside ph...	277	0.0000000000007	70.5	28	43
									GO:0004731; F:purine-nucleoside phosphorylase activity; IEA:EC.
									GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
19	B8E181	263	PNPH_DICTD Probable 6-oxopurine nucleoside ph...	141	0.000000000001	69.7	39	51
									GO:0004731; F:purine-nucleoside phosphorylase activity; IEA:EC.
									GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
20	Q2RKL6	260	PNPH_MOOTA Probable 6-oxopurine nucleoside ph...	182	0.000000000002	69.3	30	46
									GO:0004731; F:purine-nucleoside phosphorylase activity; IEA:EC.
									GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
21	Q8U2I1	265	PNPH_PYRFU Probable 6-oxopurine nucleoside ph...	199	0.000000000002	69.3	32	46
									GO:0004731; F:purine-nucleoside phosphorylase activity; IEA:EC.
									GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
22	O66839	277	PNPH_AQUAE Probable 6-oxopurine nucleoside ph...	245	0.000000000004	68.6	27	46
									GO:0004731; F:purine-nucleoside phosphorylase activity; IEA:EC.
									GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
23	Q9CQ65	283	MTAP_MOUSE S-methyl-5'-thioadenosine phosphor...	189	0.00000000001	67.4	28	48	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0017061; F:S-methyl-5-thioadenosine phosphorylase activity; IEA:EC.
									GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
24	Q5JEQ6	257	MTAP_PYRKO S-methyl-5'-thioadenosine phosphor...	159	0.00000000002	66.6	30	49
									GO:0017061; F:S-methyl-5-thioadenosine phosphorylase activity; IEA:EC.
									GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
25	Q9V813	289	MTAP_DROME S-methyl-5'-thioadenosine phosphor...	184	0.00000000003	66.2	29	48	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0017061; F:S-methyl-5-thioadenosine phosphorylase activity; NAS:UniProtKB.
									GO:0016310; P:phosphorylation; NAS:UniProtKB.::GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
26	F6RQL9	283	MTAP_MACMU S-methyl-5'-thioadenosine phosphor...	189	0.00000000006	65.5	27	48	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0017061; F:S-methyl-5-thioadenosine phosphorylase activity; IEA:EC.
									GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
27	Q13126	283	MTAP_HUMAN S-methyl-5'-thioadenosine phosphor...	189	0.00000000006	65.5	27	48	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0004645; F:phosphorylase activity; TAS:ProtInc.::GO:0017061; F:S-methyl-5-thioadenosine phosphorylase activity; TAS:Reactome.
									GO:0019509; P:L-methionine salvage from methylthioadenosine; TAS:Reactome.::GO:0006595; P:polyamine metabolic process; TAS:Reactome.::GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
28	Q291H4	289	MTAP_DROPS S-methyl-5'-thioadenosine phosphor...	184	0.00000000008	65.1	29	48	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0017061; F:S-methyl-5-thioadenosine phosphorylase activity; IEA:EC.
									GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
29	Q8TZB4	256	MTIP_METKA Probable S-methyl-5'-thioinosine p...	170	0.0000000007	62	29	48
									GO:0016763; F:transferase activity, transferring pentosyl groups; IEA:InterPro.
									GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
30	Q9HL98	261	MTAP_THEAC S-methyl-5'-thioadenosine phosphor...	197	0.000000002	60.8	30	45
									GO:0017061; F:S-methyl-5-thioadenosine phosphorylase activity; IEA:EC.
									GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
31	Q7ZV22	280	MTAP_DANRE S-methyl-5'-thioadenosine phosphor...	190	0.00000001	58.5	26	45	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0017061; F:S-methyl-5-thioadenosine phosphorylase activity; IEA:EC.
									GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.

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