UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YLR180W

Length:

382

Number of sequences:

5887

Description:

YLR180W SAM1 SGDID:S000004170, Chr XII from 515262-516410, Genome Release 64-1-1, Verified ORF, "S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	P10659	382	METK1_YEAST S-adenosylmethionine synthase 1 O...	382	0	786	100	100	GO:0005737; C:cytoplasm; IDA:SGD.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IGI:SGD.
									GO:0006555; P:methionine metabolic process; IMP:SGD.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IMP:SGD.
2	P19358	384	METK2_YEAST S-adenosylmethionine synthase 2 O...	379	0	710	93	97
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IDA:SGD.
									GO:0006555; P:methionine metabolic process; IMP:SGD.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IMP:SGD.
3	O60198	382	METK_SCHPO S-adenosylmethionine synthase OS=S...	382	0	612	76	88	GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IGI:PomBase.
									GO:0006555; P:methionine metabolic process; IGI:PomBase.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.
4	P48466	395	METK_NEUCR S-adenosylmethionine synthase OS=1...	381	0	595	77	86
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IEA:EC.
									GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.
5	Q00266	395	METK1_HUMAN S-adenosylmethionine synthase iso...	380	0	555	69	84	GO:0005829; C:cytosol; TAS:Reactome.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; TAS:ProtInc.
									GO:0032259; P:methylation; TAS:Reactome.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.::GO:0000096; P:sulfur amino acid metabolic process; TAS:Reactome.::GO:0006805; P:xenobiotic metabolic process; TAS:Reactome.
6	Q2KJC6	396	METK1_BOVIN S-adenosylmethionine synthase iso...	380	0	553	68	84
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IEA:EC.
									GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.
7	Q91X83	396	METK1_MOUSE S-adenosylmethionine synthase iso...	380	0	551	68	84
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; TAS:MGI.
									GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.
8	P13444	397	METK1_RAT S-adenosylmethionine synthase isofo...	381	0	549	69	84
									GO:0043531; F:ADP binding; IDA:RGD.::GO:0016597; F:amino acid binding; IDA:RGD.::GO:0005524; F:ATP binding; IDA:RGD.::GO:0000287; F:magnesium ion binding; IDA:RGD.::GO:0004478; F:methionine adenosyltransferase activity; IDA:RGD.::GO:0042803; F:protein homodimerization activity; IDA:RGD.
									GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0051289; P:protein homotetramerization; IDA:RGD.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IDA:RGD.
9	Q3THS6	395	METK2_MOUSE S-adenosylmethionine synthase iso...	380	0	548	68	84
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IDA:MGI.
									GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IDA:MGI.
10	Q5R5H1	395	METK2_PONAB S-adenosylmethionine synthase iso...	380	0	547	68	84
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IEA:EC.
									GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
11	Q4R924	395	METK2_MACFA S-adenosylmethionine synthase iso...	380	0	547	68	84
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IEA:EC.
									GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.
12	P31153	395	METK2_HUMAN S-adenosylmethionine synthase iso...	380	0	547	68	84	GO:0005829; C:cytosol; TAS:Reactome.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; TAS:ProtInc.
									GO:0032259; P:methylation; TAS:Reactome.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0000096; P:sulfur amino acid metabolic process; TAS:Reactome.::GO:0006805; P:xenobiotic metabolic process; TAS:Reactome.
13	P18298	395	METK2_RAT S-adenosylmethionine synthase isofo...	380	0	546	68	84
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; TAS:RGD.
									GO:0007623; P:circadian rhythm; IDA:RGD.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0051591; P:response to cAMP; IDA:RGD.::GO:0042493; P:response to drug; IDA:RGD.::GO:0009725; P:response to hormone stimulus; IDA:RGD.::GO:0009416; P:response to light stimulus; IEP:RGD.::GO:0006556; P:S-adenosylmethionine biosynthetic process; TAS:RGD.
14	P50304	393	METK_ASCIM S-adenosylmethionine synthase OS=A...	382	0	538	74	86
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IEA:EC.
									GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.
15	P50306	404	METK4_CAEEL Probable S-adenosylmethionine syn...	378	0	525	66	82
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IEA:EC.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0019915; P:lipid storage; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0040017; P:positive regulation of locomotion; IMP:WormBase.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.::GO:0032940; P:secretion by cell; IMP:WormBase.
16	P50305	404	METK3_CAEEL Probable S-adenosylmethionine syn...	378	0	521	65	83
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IEA:EC.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0040007; P:growth; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0002009; P:morphogenesis of an epithelium; IMP:WormBase.::GO:0040027; P:negative regulation of vulval development; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0040017; P:positive regulation of locomotion; IMP:WormBase.::GO:0016246; P:RNA interference; IMP:WormBase.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.
17	Q27522	404	METK5_CAEEL Probable S-adenosylmethionine syn...	378	0	520	65	82
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IEA:EC.
									GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.::GO:0006898; P:receptor-mediated endocytosis; IMP:WormBase.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.::GO:0032940; P:secretion by cell; IMP:WormBase.
18	Q54F07	384	METK_DICDI S-adenosylmethionine synthase OS=D...	382	3e-178	508	66	80	GO:0005615; C:extracellular space; IDA:dictyBase.::GO:0048269; C:methionine adenosyltransferase complex; ISS:dictyBase.::GO:0045335; C:phagocytic vesicle; IDA:dictyBase.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; ISS:dictyBase.
									GO:0006555; P:methionine metabolic process; ISS:dictyBase.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.
19	O17680	403	METK1_CAEEL Probable S-adenosylmethionine syn...	382	1e-176	504	63	80
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IEA:EC.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0006629; P:lipid metabolic process; IMP:WormBase.::GO:0019915; P:lipid storage; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0040015; P:negative regulation of multicellular organism growth; IMP:WormBase.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0040017; P:positive regulation of locomotion; IMP:WormBase.::GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.::GO:0000003; P:reproduction; IMP:WormBase.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.::GO:0006412; P:translation; IMP:WormBase.
20	P40320	408	METK_DROME S-adenosylmethionine synthase OS=D...	379	2e-173	497	65	81
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; ISS:FlyBase.
									GO:0022416; P:chaeta development; IGI:FlyBase.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IMP:FlyBase.::GO:0035220; P:wing disc development; IGI:FlyBase.
21	Q95032	388	METK_ACACA S-adenosylmethionine synthase OS=A...	383	5e-172	492	62	79
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IEA:EC.
									GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.
22	Q837P9	394	METK_ENTFA S-adenosylmethionine synthase OS=E...	386	9e-163	469	59	77	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IEA:EC.
									GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.
23	Q6SYB9	390	METK2_TOBAC S-adenosylmethionine synthase 2 O...	385	1e-162	468	62	74	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IEA:EC.
									GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.
24	O43938	392	METK_LEIIN S-adenosylmethionine synthase OS=L...	387	3e-162	468	61	76
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IEA:EC.
									GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.
25	A8FGH7	400	METK_BACP2 S-adenosylmethionine synthase OS=B...	383	6e-162	467	59	77	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IEA:EC.
									GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.
26	Q9LGU6	396	METK3_ORYSJ S-adenosylmethionine synthase 3 O...	386	2e-161	466	62	75	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IEA:EC.
									GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.
27	B0LXM0	396	METK_WHEAT S-adenosylmethionine synthase OS=T...	386	2e-160	463	61	75	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IEA:EC.
									GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.
28	Q9CEE0	399	METK_LACLA S-adenosylmethionine synthase OS=l...	389	5e-160	462	59	76	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IEA:EC.
									GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.
29	Q96552	393	METK2_CATRO S-adenosylmethionine synthase 2 O...	386	6e-160	462	61	74	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IEA:EC.
									GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.
30	Q4LB21	396	METK4_HORVU S-adenosylmethionine synthase 4 O...	386	7e-160	462	61	75	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IEA:EC.
									GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.
31	Q02WN8	399	METK_LACLS S-adenosylmethionine synthase OS=L...	389	2e-159	461	58	76	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004478; F:methionine adenosyltransferase activity; IEA:EC.
									GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:InterPro.

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