Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLR174W
Length:
412
Number of sequences:
5887
Description:
YLR174W IDP2 SGDID:S000004164, Chr XII from 504591-505829, Genome Release 64-1-1, Verified ORF, "Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P41939    412   IDHC_YEAST Isocitrate dehydrogenase [NADP] cy...4120     850     100     100GO:0005829; C:cytosol; IDA:SGD.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; TAS:SGD.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006537; P:glutamate biosynthetic process; TAS:SGD.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IMP:SGD.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
2P53982    420   IDHH_YEAST Isocitrate dehydrogenase [NADP] OS...4040     672     77     91GO:0005739; C:mitochondrion; IDA:SGD.::GO:0005777; C:peroxisome; IDA:SGD.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; TAS:SGD.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006635; P:fatty acid beta-oxidation; IMP:SGD.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; TAS:SGD.::GO:0006740; P:NADPH regeneration; TAS:SGD.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
3O13294    411   IDH2_CANTR Isocitrate dehydrogenase [NADP] pe...4070     642     74     86GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
4P21954    428   IDHP_YEAST Isocitrate dehydrogenase [NADP], m...4110     638     73     87GO:0042645; C:mitochondrial nucleoid; IDA:SGD.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; TAS:SGD.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0006537; P:glutamate biosynthetic process; IMP:SGD.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; TAS:SGD.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
5O13285    430   IDH1_CANTR Isocitrate dehydrogenase [NADP], m...4030     619     72     84GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
6P79089    498   IDHP_ASPNG Isocitrate dehydrogenase [NADP], m...4090     609     69     84GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
7Q40345    433   IDHP_MEDSA Isocitrate dehydrogenase [NADP], c...4090     565     66     80GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
8Q06197    413   IDHC_SOYBN Isocitrate dehydrogenase [NADP] OS...4090     563     65     79GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
9Q04467    452   IDHP_BOVIN Isocitrate dehydrogenase [NADP], m...4070     553     65     79GO:0005743; C:mitochondrial inner membrane; ISS:AgBase.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
10P33198    421   IDHP_PIG Isocitrate dehydrogenase [NADP], mit...4070     550     65     78GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
11P50215    406   IDH_SPHYA Isocitrate dehydrogenase [NADP] OS=...4060     548     65     79
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
12P54071    452   IDHP_MOUSE Isocitrate dehydrogenase [NADP], m...4070     548     64     78GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
13P50218    415   IDHC_TOBAC Isocitrate dehydrogenase [NADP] OS...4040     545     63     78GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
14P50217    416   IDHC_SOLTU Isocitrate dehydrogenase [NADP] OS...4050     545     63     78GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
15P56574    452   IDHP_RAT Isocitrate dehydrogenase [NADP], mit...4070     546     64     78
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
16P48735    452   IDHP_HUMAN Isocitrate dehydrogenase [NADP], m...4070     545     64     78GO:0005759; C:mitochondrial matrix; TAS:Reactome.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; TAS:Reactome.
17Q4R502    452   IDHP_MACFA Isocitrate dehydrogenase [NADP], m...4070     545     64     78GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
18O14254    439   IDHP_SCHPO Probable isocitrate dehydrogenase ...4060     538     64     78GO:0005739; C:mitochondrion; IDA:PomBase.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:PomBase.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006537; P:glutamate biosynthetic process; ISS:PomBase.::GO:0006102; P:isocitrate metabolic process; ISS:PomBase.::GO:0006740; P:NADPH regeneration; ISS:PomBase.::GO:0006099; P:tricarboxylic acid cycle; IC:PomBase.
19P65097    409   IDH_MYCTU Isocitrate dehydrogenase [NADP] OS=...4050     529     62     77GO:0005886; C:plasma membrane; IDA:MTBBASE.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IDA:MTBBASE.::GO:0000287; F:magnesium ion binding; IDA:MTBBASE.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; IPI:MTBBASE.::GO:0008270; F:zinc ion binding; IDA:MTBBASE.
GO:0006097; P:glyoxylate cycle; IDA:MTBBASE.::GO:0006102; P:isocitrate metabolic process; IDA:MTBBASE.::GO:0006099; P:tricarboxylic acid cycle; IDA:MTBBASE.
20P65098    409   IDH_MYCBO Isocitrate dehydrogenase [NADP] OS=...4050     529     62     77
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
21P41562    414   IDHC_RAT Isocitrate dehydrogenase [NADP] cyto...4060     526     63     75GO:0005777; C:peroxisome; IDA:HGNC.::GO:0005625; C:soluble fraction; IDA:RGD.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0050661; F:NADP binding; IDA:RGD.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0008585; P:female gonad development; IEP:RGD.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0014070; P:response to organic cyclic compound; IDA:RGD.::GO:0048545; P:response to steroid hormone stimulus; IDA:RGD.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
22Q9Z2K8    414   IDHC_MICOH Isocitrate dehydrogenase [NADP] cy...4150     525     61     74GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
23Q5R9C5    414   IDHC_PONAB Isocitrate dehydrogenase [NADP] cy...4150     524     61     74
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
24Q9Z2K9    414   IDHC_MICME Isocitrate dehydrogenase [NADP] cy...4150     524     61     74GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
25O88844    414   IDHC_MOUSE Isocitrate dehydrogenase [NADP] cy...4150     522     61     74GO:0005829; C:cytosol; IDA:MGI.::GO:0005739; C:mitochondrion; IDA:MGI.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006749; P:glutathione metabolic process; IMP:MGI.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006979; P:response to oxidative stress; IDA:MGI.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
26O75874    414   IDHC_HUMAN Isocitrate dehydrogenase [NADP] cy...4150     522     61     74GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005782; C:peroxisomal matrix; TAS:Reactome.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
GO:0006103; P:2-oxoglutarate metabolic process; IDA:UniProtKB.::GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IDA:UniProtKB.::GO:0006740; P:NADPH regeneration; TAS:Reactome.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
27Q6XUZ5    414   IDHC_SHEEP Isocitrate dehydrogenase [NADP] cy...4060     520     61     75GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
28Q75JR2    428   IDHP_DICDI Isocitrate dehydrogenase [NADP], m...3997e-180     515     62     77GO:0005739; C:mitochondrion; ISS:dictyBase.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
29Q75JR3    412   IDHC_DICDI Isocitrate dehydrogenase [NADP] cy...4117e-180     514     59     76GO:0005829; C:cytosol; ISS:dictyBase.::GO:0005615; C:extracellular space; IDA:dictyBase.::GO:0045335; C:phagocytic vesicle; IDA:dictyBase.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
30Q9XSG3    414   IDHC_BOVIN Isocitrate dehydrogenase [NADP] cy...4069e-180     514     61     75GO:0005829; C:cytosol; ISS:AgBase.
GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006749; P:glutathione metabolic process; ISS:AgBase.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006979; P:response to oxidative stress; ISS:AgBase.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
31Q4FP17    368   LEU3_PELUB 3-isopropylmalate dehydrogenase OS...2440.000000007     60.8     30     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
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