Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLR136C
Length:
285
Number of sequences:
5887
Description:
YLR136C TIS11 SGDID:S000004126, Chr XII from 416658-415801, Genome Release 64-1-1, reverse complement, Verified ORF, "mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P47977    285   CTH2_YEAST mRNA decay factor CTH2 OS=Saccharo...2850     588     100     100GO:0000932; C:cytoplasmic mRNA processing body; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:SGD.
GO:0003729; F:mRNA binding; IDA:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006879; P:cellular iron ion homeostasis; IMP:SGD.::GO:0000956; P:nuclear-transcribed mRNA catabolic process; IMP:SGD.
2P47976    325   CTH1_YEAST mRNA decay factor CTH1 OS=Saccharo...2929e-60     199     42     58GO:0005634; C:nucleus; IC:SGD.
GO:0003729; F:mRNA binding; ISS:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006879; P:cellular iron ion homeostasis; IGI:SGD.::GO:0000956; P:nuclear-transcribed mRNA catabolic process; IGI:SGD.
3P47979    404   ZFS1_SCHPO Zinc finger protein zfs1 OS=Schizo...702e-16     82     49     67GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0035925; F:mRNA 3'-UTR AU-rich region binding; IDA:PomBase.::GO:0005515; F:protein binding; IPI:PomBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007094; P:mitotic cell cycle spindle assembly checkpoint; IGI:PomBase.::GO:0006402; P:mRNA catabolic process; IMP:PomBase.::GO:0031030; P:negative regulation of septation initiation signaling cascade; IGI:PomBase.::GO:0000750; P:pheromone-dependent signal transduction involved in conjugation with cellular fusion; IMP:PomBase.::GO:0031137; P:regulation of conjugation with cellular fusion; IGI:PomBase.
4Q6S9E0    325   TTP_SHEEP Tristetraprolin OS=Ovis aries (Shee...710.000000000000003     77.8     49     62GO:0010494; C:cytoplasmic stress granule; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0071889; F:14-3-3 protein binding; ISS:UniProtKB.::GO:0017091; F:AU-rich element binding; ISS:UniProtKB.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0070935; P:3'-UTR-mediated mRNA stabilization; ISS:UniProtKB.::GO:0006402; P:mRNA catabolic process; ISS:UniProtKB.::GO:0060213; P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; ISS:UniProtKB.::GO:0032680; P:regulation of tumor necrosis factor production; ISS:UniProtKB.::GO:0006950; P:response to stress; ISS:UniProtKB.
5P53781    324   TTP_BOVIN Tristetraprolin OS=Bos taurus (Bovi...710.000000000000005     77     49     62GO:0010494; C:cytoplasmic stress granule; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0071889; F:14-3-3 protein binding; ISS:UniProtKB.::GO:0017091; F:AU-rich element binding; ISS:UniProtKB.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0070935; P:3'-UTR-mediated mRNA stabilization; ISS:UniProtKB.::GO:0006402; P:mRNA catabolic process; ISS:UniProtKB.::GO:0060213; P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; ISS:UniProtKB.::GO:0032680; P:regulation of tumor necrosis factor production; ISS:UniProtKB.::GO:0006950; P:response to stress; ISS:UniProtKB.
6P26651    326   TTP_HUMAN Tristetraprolin OS=Homo sapiens (Hu...710.000000000000005     77     49     62GO:0010494; C:cytoplasmic stress granule; IDA:UniProtKB.::GO:0005829; C:cytosol; IDA:MGI.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0071889; F:14-3-3 protein binding; IDA:UniProtKB.::GO:0017091; F:AU-rich element binding; IDA:UniProtKB.::GO:0019957; F:C-C chemokine binding; IPI:UniProtKB.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003729; F:mRNA binding; IDA:MGI.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0003727; F:single-stranded RNA binding; TAS:ProtInc.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0070935; P:3'-UTR-mediated mRNA stabilization; IDA:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.::GO:0060213; P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; IDA:UniProtKB.::GO:0032680; P:regulation of tumor necrosis factor production; IDA:UniProtKB.::GO:0006950; P:response to stress; IDA:UniProtKB.
7Q7ZXW9    363   TISDA_XENLA Zinc finger protein 36, C3H1 type...310.005     41.6     52     61GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000288; P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; ISS:UniProtKB.::GO:0048793; P:pronephros development; ISS:UniProtKB.::GO:0043488; P:regulation of mRNA stability; ISS:UniProtKB.
8P22893    319   TTP_MOUSE Tristetraprolin OS=Mus musculus (Mo...710.000000000000009     76.3     48     63GO:0010494; C:cytoplasmic stress granule; ISS:UniProtKB.::GO:0005829; C:cytosol; IDA:MGI.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0071889; F:14-3-3 protein binding; ISS:UniProtKB.::GO:0017091; F:AU-rich element binding; IDA:UniProtKB.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003729; F:mRNA binding; IDA:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0070935; P:3'-UTR-mediated mRNA stabilization; ISS:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; IDA:MGI.::GO:0050728; P:negative regulation of inflammatory response; IMP:UniProtKB.::GO:0045638; P:negative regulation of myeloid cell differentiation; IMP:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.::GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IDA:MGI.::GO:0060213; P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; ISS:UniProtKB.::GO:0032680; P:regulation of tumor necrosis factor production; ISS:UniProtKB.::GO:0006950; P:response to stress; ISS:UniProtKB.::GO:0050779; P:RNA destabilization; IMP:MGI.
9Q805B4    364   TISDB_XENLA Zinc finger protein 36, C3H1 type...310.004     41.6     52     61GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000288; P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; ISS:UniProtKB.::GO:0039020; P:pronephric nephron tubule development; IMP:UniProtKB.::GO:0043488; P:regulation of mRNA stability; ISS:UniProtKB.
10Q07352    338   TISB_HUMAN Zinc finger protein 36, C3H1 type-...390.003     42     41     54GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003729; F:mRNA binding; IDA:MGI.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:ProtInc.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0010467; P:gene expression; TAS:Reactome.::GO:0043488; P:regulation of mRNA stability; IDA:MGI.
11P23950    338   TISB_MOUSE Zinc finger protein 36, C3H1 type-...630.00000000000001     75.9     49     63GO:0005634; C:nucleus; IDA:MGI.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000288; P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; IDA:MGI.::GO:0006417; P:regulation of translation; IMP:MGI.::GO:0033077; P:T cell differentiation in thymus; IGI:BHF-UCL.::GO:0001570; P:vasculogenesis; IMP:MGI.
12P17431    338   TISB_RAT Zinc finger protein 36, C3H1 type-li...630.00000000000001     75.9     49     63GO:0005829; C:cytosol; IDA:MGI.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0017091; F:AU-rich element binding; IMP:RGD.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003729; F:mRNA binding; IDA:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
13A4IIN5    333   TISD_XENTR Zinc finger protein 36, C3H1 type-...310.027     39.3     48     58GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000288; P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; ISS:UniProtKB.::GO:0048793; P:pronephros development; ISS:UniProtKB.::GO:0043488; P:regulation of mRNA stability; ISS:UniProtKB.
14P47980    436   TIS1_DROME Protein TIS11 OS=Drosophila melano...660.00000000000006     74.7     48     59GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016246; P:RNA interference; IMP:FlyBase.
15P47974    494   TISD_HUMAN Zinc finger protein 36, C3H1 type-...660.0000000000001     73.9     48     61
16P47973    320   TTP_RAT Tristetraprolin OS=Rattus norvegicus ...710.0000000000001     73.2     46     62GO:0010494; C:cytoplasmic stress granule; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0071889; F:14-3-3 protein binding; ISS:UniProtKB.::GO:0017091; F:AU-rich element binding; ISS:UniProtKB.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0070935; P:3'-UTR-mediated mRNA stabilization; ISS:UniProtKB.::GO:0060213; P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; TAS:RGD.::GO:0032680; P:regulation of tumor necrosis factor production; ISS:UniProtKB.::GO:0006950; P:response to stress; ISS:UniProtKB.
17P23949    367   TISD_MOUSE Zinc finger protein 36, C3H1 type-...760.0000000000001     73.6     46     58GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005634; C:nucleus; IDA:MGI.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000288; P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; IDA:MGI.::GO:0043488; P:regulation of mRNA stability; IDA:MGI.::GO:0033077; P:T cell differentiation in thymus; IGI:BHF-UCL.
18A2ZVY5    333   C3H9_ORYSJ Zinc finger CCCH domain-containing...270.92     34.3     44     52
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
19Q6L5G1    343   C3H39_ORYSJ Zinc finger CCCH domain-containin...270.24     36.2     44     59
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
20Q10MN8    457   C3H21_ORYSJ Putative zinc finger CCCH domain-...400.37     35.8     45     63
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
21Q9C9F5    308   C3H15_ARATH Zinc finger CCCH domain-containin...250.51     35     48     64
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; TAS:TAIR.
22Q9C9N3    310   C3H14_ARATH Zinc finger CCCH domain-containin...282.7     33.1     43     57
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
23Q09436    467   MEX6_CAEEL Zinc finger protein mex-6 OS=Caeno...1190.000000005     60.1     33     48GO:0043186; C:P granule; IDA:WormBase.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003730; F:mRNA 3'-UTR binding; IDA:WormBase.::GO:0019904; F:protein domain specific binding; IPI:WormBase.::GO:0019901; F:protein kinase binding; IPI:WormBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0010171; P:body morphogenesis; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0002009; P:morphogenesis of an epithelium; IMP:WormBase.::GO:0032880; P:regulation of protein localization; IGI:WormBase.
24Q9XUB2    468   MEX5_CAEEL Zinc finger protein mex-5 OS=Caeno...1180.00000002     58.5     33     49GO:0005813; C:centrosome; IDA:WormBase.::GO:0043186; C:P granule; IDA:WormBase.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003730; F:mRNA 3'-UTR binding; IDA:WormBase.::GO:0008187; F:poly-pyrimidine tract binding; IDA:WormBase.::GO:0019904; F:protein domain specific binding; IPI:WormBase.::GO:0019901; F:protein kinase binding; IPI:WormBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0032880; P:regulation of protein localization; IMP:WormBase.
25Q5PP65    252   C3H28_ARATH Zinc finger CCCH domain-containin...700.003     42     34     51
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; TAS:TAIR.
26A3BUD2    605   C3H57_ORYSJ Putative zinc finger CCCH domain-...960.000005     51.2     33     50
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
27Q8GVZ8    496   C3H48_ORYSJ Putative zinc finger CCCH domain-...890.12     37.4     25     44
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
28Q94131    335   PIE1_CAEEL Pharynx and intestine in excess pr...340.00007     47.4     50     68GO:0005813; C:centrosome; IDA:WormBase.::GO:0005829; C:cytosol; IDA:WormBase.::GO:0005634; C:nucleus; IDA:WormBase.::GO:0043186; C:P granule; IDA:WormBase.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0001709; P:cell fate determination; IMP:WormBase.::GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0009880; P:embryonic pattern specification; IMP:WormBase.::GO:0001704; P:formation of primary germ layer; IMP:WormBase.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:WormBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
29Q9LT81    386   C3H39_ARATH Zinc finger CCCH domain-containin...630.29     36.2     35     48
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; TAS:TAIR.
30Q84UQ3    367   C3H56_ORYSJ Zinc finger CCCH domain-containin...600.003     42.4     37     55
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
31Q6CWM0    665   DUS3_KLULA tRNA-dihydrouridine(47) synthase [...610.0003     45.8     34     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0017150; F:tRNA dihydrouridine synthase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
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