UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YLR058C

Length:

469

Number of sequences:

5887

Description:

YLR058C SHM2 SGDID:S000004048, Chr XII from 259401-257992, Genome Release 64-1-1, reverse complement, Verified ORF, "Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
421	B9MAC8	414	GLYA_ACIET Serine hydroxymethyltransferase OS...	426	2e-105	326	42	58	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
422	Q2JT50	434	GLYA_SYNJA Serine hydroxymethyltransferase OS...	413	3e-105	327	44	61	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
423	Q6LU17	416	GLYA1_PHOPR Serine hydroxymethyltransferase 1...	402	3e-105	326	46	63	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
424	P59953	426	GLYA1_MYCBO Serine hydroxymethyltransferase 1...	432	3e-105	327	41	59	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
425	B1ZJN1	434	GLYA_METPB Serine hydroxymethyltransferase OS...	421	3e-105	327	44	59	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
426	O53441	426	GLYA1_MYCTU Serine hydroxymethyltransferase 1...	432	3e-105	326	41	59	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:MTBBASE.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IDA:MTBBASE.::GO:0042803; F:protein homodimerization activity; IPI:MTBBASE.::GO:0030170; F:pyridoxal phosphate binding; IDA:MTBBASE.
									GO:0042783; P:active evasion of host immune response; IMP:MTBBASE.::GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IDA:MTBBASE.::GO:0006563; P:L-serine metabolic process; IDA:MTBBASE.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
427	Q4A8E1	418	GLYA_MYCH7 Serine hydroxymethyltransferase OS...	399	3e-105	326	44	62	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
428	Q03QY0	413	GLYA_LACBA Serine hydroxymethyltransferase OS...	432	4e-105	325	42	59	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
429	Q7W400	415	GLYA2_BORPA Serine hydroxymethyltransferase 2...	431	4e-105	326	41	59	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
430	Q21V29	414	GLYA_RHOFD Serine hydroxymethyltransferase OS...	427	4e-105	325	42	58	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
431	A2C090	411	GLYA_PROM1 Serine hydroxymethyltransferase OS...	397	4e-105	325	43	63	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
432	P59432	417	GLYA_BUCBP Serine hydroxymethyltransferase OS...	426	5e-105	325	42	62	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
433	Q2KV15	416	GLYA_BORA1 Serine hydroxymethyltransferase OS...	431	5e-105	325	42	59	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
434	Q7ND67	426	GLYA_GLOVI Serine hydroxymethyltransferase OS...	426	6e-105	326	43	60	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
435	Q111H1	425	GLYA_TRIEI Serine hydroxymethyltransferase OS...	406	6e-105	325	43	62	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
436	Q47IH1	416	GLYA_DECAR Serine hydroxymethyltransferase OS...	407	6e-105	325	44	60	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
437	A8H1Q0	418	GLYA_SHEPA Serine hydroxymethyltransferase OS...	402	7e-105	325	45	64	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
438	Q2GLH3	425	GLYA_ANAPZ Serine hydroxymethyltransferase OS...	407	7e-105	325	43	61	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
439	A3PAX9	423	GLYA_PROM0 Serine hydroxymethyltransferase OS...	405	7e-105	325	43	62	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
440	B3ER62	422	GLYA_AMOA5 Serine hydroxymethyltransferase OS...	451	8e-105	325	41	59	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
441	Q7NYI8	415	GLYA_CHRVO Serine hydroxymethyltransferase OS...	389	9e-105	325	45	62	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
442	Q2NAR9	434	GLYA_ERYLH Serine hydroxymethyltransferase OS...	419	9e-105	325	42	59	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
443	B6J8Q9	419	GLYA_COXB1 Serine hydroxymethyltransferase OS...	397	1e-104	325	45	62	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
444	Q83BT3	419	GLYA_COXBU Serine hydroxymethyltransferase OS...	397	1e-104	325	45	62	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
445	A9KBN4	419	GLYA_COXBN Serine hydroxymethyltransferase OS...	397	1e-104	325	45	62	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
446	Q7VUW7	415	GLYA_BORPE Serine hydroxymethyltransferase OS...	431	1e-104	325	41	59	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
447	Q7WFD2	415	GLYA2_BORBR Serine hydroxymethyltransferase 2...	431	1e-104	325	41	59	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
448	B0TYH3	417	GLYA_FRAP2 Serine hydroxymethyltransferase OS...	405	1e-104	325	44	61	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
449	A9N8T8	419	GLYA_COXBR Serine hydroxymethyltransferase OS...	397	1e-104	325	45	62	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
450	B6JGH9	433	GLYA_OLICO Serine hydroxymethyltransferase OS...	450	1e-104	325	42	57	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
451	Q3AN03	431	GLYA_SYNSC Serine hydroxymethyltransferase OS...	413	1e-104	325	42	59	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
									GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.

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