Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLR058C
Length:
469
Number of sequences:
5887
Description:
YLR058C SHM2 SGDID:S000004048, Chr XII from 259401-257992, Genome Release 64-1-1, reverse complement, Verified ORF, "Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P37291    469   GLYC_YEAST Serine hydroxymethyltransferase, c...4690     980     100     100GO:0005737; C:cytoplasm; IDA:SGD.::GO:0043332; C:mating projection tip; IDA:SGD.::GO:0001950; C:plasma membrane enriched fraction; IDA:SGD.
GO:0004372; F:glycine hydroxymethyltransferase activity; IMP:SGD.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IMP:SGD.
2Q6FUP6    469   GLYC_CANGA Serine hydroxymethyltransferase, c...4690     893     90     96GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
3Q75BQ6    469   GLYC_ASHGO Serine hydroxymethyltransferase, c...4690     850     85     93GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
4O13426    470   GLYC_CANAL Serine hydroxymethyltransferase, c...4670     815     83     90GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; IDA:CGD.
GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
5P34898    480   GLYC_NEUCR Serine hydroxymethyltransferase, c...4690     705     71     84GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
6O13972    467   GLYD_SCHPO Probable serine hydroxymethyltrans...4630     655     67     80GO:0005737; C:cytoplasm; ISS:PomBase.
GO:0004372; F:glycine hydroxymethyltransferase activity; ISS:PomBase.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; ISS:PomBase.::GO:0006563; P:L-serine metabolic process; ISS:PomBase.::GO:0006730; P:one-carbon metabolic process; ISS:PomBase.
7Q10104    488   GLYM_SCHPO Serine hydroxymethyltransferase, m...4700     622     64     77GO:0005739; C:mitochondrion; IDA:PomBase.
GO:0004372; F:glycine hydroxymethyltransferase activity; ISS:PomBase.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; ISS:PomBase.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IC:PomBase.::GO:0009070; P:serine family amino acid biosynthetic process; ISS:PomBase.
8Q6CLQ5    498   GLYM_KLULA Serine hydroxymethyltransferase, m...4670     586     60     75GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
9Q758F0    497   GLYM_ASHGO Serine hydroxymethyltransferase, m...4610     579     59     75GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
10O13425    493   GLYM_CANAX Serine hydroxymethyltransferase, m...4690     575     59     74GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
11P37292    490   GLYM_YEAST Serine hydroxymethyltransferase, m...4680     572     60     74GO:0005739; C:mitochondrion; IDA:SGD.
GO:0004372; F:glycine hydroxymethyltransferase activity; IMP:SGD.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IMP:SGD.::GO:0009070; P:serine family amino acid biosynthetic process; IGI:SGD.
12Q9SZJ5    517   GLYM_ARATH Serine hydroxymethyltransferase, m...4590     568     58     75GO:0048046; C:apoplast; IDA:TAIR.::GO:0009570; C:chloroplast stroma; IDA:TAIR.::GO:0009534; C:chloroplast thylakoid; IDA:TAIR.::GO:0022626; C:cytosolic ribosome; IDA:TAIR.::GO:0005739; C:mitochondrion; IDA:TAIR.::GO:0005634; C:nucleus; IDA:TAIR.::GO:0005886; C:plasma membrane; IDA:TAIR.::GO:0010319; C:stromule; IDA:TAIR.
GO:0004372; F:glycine hydroxymethyltransferase activity; TAS:TAIR.::GO:0008266; F:poly(U) RNA binding; IDA:TAIR.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0009853; P:photorespiration; IMP:TAIR.::GO:0009626; P:plant-type hypersensitive response; TAS:TAIR.::GO:0046686; P:response to cadmium ion; IEP:TAIR.::GO:0009409; P:response to cold; IEP:TAIR.
13Q6FQ44    485   GLYM_CANGA Serine hydroxymethyltransferase, m...4650     565     59     74GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
14P34899    518   GLYM_PEA Serine hydroxymethyltransferase, mit...4590     562     58     75GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
15P50433    518   GLYM_SOLTU Serine hydroxymethyltransferase, m...4590     561     58     75GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
16Q7S5N8    527   GLYM_NEUCR Putative serine hydroxymethyltrans...4450     561     62     75GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
17Q60V73    511   GLYC_CAEBR Serine hydroxymethyltransferase OS...4590     558     57     75
GO:0004372; F:glycine hydroxymethyltransferase activity; TAS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; TAS:UniProtKB.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
18P35623    484   GLYC_SHEEP Serine hydroxymethyltransferase, c...4660     556     56     74GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
19Q5E9P9    484   GLYC_BOVIN Serine hydroxymethyltransferase, c...4660     550     55     74GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
20P50432    507   GLYC_CAEEL Serine hydroxymethyltransferase OS...4540     550     57     75
GO:0004372; F:glycine hydroxymethyltransferase activity; TAS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; TAS:UniProtKB.
GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
21P50431    478   GLYC_MOUSE Serine hydroxymethyltransferase, c...4670     548     57     75GO:0005739; C:mitochondrion; IDA:MGI.
GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.
GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
22P34897    504   GLYM_HUMAN Serine hydroxymethyltransferase, m...4540     548     56     76GO:0015630; C:microtubule cytoskeleton; IDA:HPA.::GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.::GO:0042645; C:mitochondrial nucleoid; IDA:BHF-UCL.
GO:0003682; F:chromatin binding; IDA:UniProtKB.::GO:0004372; F:glycine hydroxymethyltransferase activity; IDA:UniProtKB.::GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
GO:0006730; P:one-carbon metabolic process; IDA:UniProtKB.
23P49357    517   GLYM_FLAPR Serine hydroxymethyltransferase 1,...4580     548     56     74GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
24P07511    484   GLYC_RABIT Serine hydroxymethyltransferase, c...4670     547     56     75
GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
25P49358    517   GLYN_FLAPR Serine hydroxymethyltransferase 2,...4480     548     58     75GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
26Q3SZ20    504   GLYM_BOVIN Serine hydroxymethyltransferase, m...4540     545     55     76GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.::GO:0042645; C:mitochondrial nucleoid; ISS:UniProtKB.
GO:0003682; F:chromatin binding; ISS:UniProtKB.::GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
27P14519    504   GLYM_RABIT Serine hydroxymethyltransferase, m...4540     545     55     76GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.::GO:0042645; C:mitochondrial nucleoid; ISS:UniProtKB.
GO:0003682; F:chromatin binding; ISS:UniProtKB.::GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
28P34896    483   GLYC_HUMAN Serine hydroxymethyltransferase, c...4650     536     55     75GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA.
GO:0004372; F:glycine hydroxymethyltransferase activity; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; IDA:UniProtKB.
GO:0045329; P:carnitine biosynthetic process; TAS:Reactome.::GO:0046655; P:folic acid metabolic process; IDA:UniProtKB.::GO:0006565; P:L-serine catabolic process; IDA:UniProtKB.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0009113; P:purine base biosynthetic process; IDA:UniProtKB.
29Q5RFK5    483   GLYC_PONAB Serine hydroxymethyltransferase, c...4650     533     55     74GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
30Q54Z26    457   GLYC1_DICDI Serine hydroxymethyltransferase 1...4526e-168     488     51     73GO:0005829; C:cytosol; ISS:dictyBase.::GO:0045335; C:phagocytic vesicle; IDA:dictyBase.
GO:0004372; F:glycine hydroxymethyltransferase activity; ISS:dictyBase.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; ISS:dictyBase.::GO:0006730; P:one-carbon metabolic process; ISS:dictyBase.
31Q54EW1    481   GLYC2_DICDI Serine hydroxymethyltransferase 2...4492e-165     483     49     73GO:0005759; C:mitochondrial matrix; ISS:dictyBase.
GO:0004372; F:glycine hydroxymethyltransferase activity; ISS:dictyBase.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
GO:0006544; P:glycine metabolic process; IEA:InterPro.::GO:0006563; P:L-serine metabolic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; ISS:dictyBase.
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