Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLR056W
Length:
365
Number of sequences:
5887
Description:
YLR056W ERG3 SGDID:S000004046, Chr XII from 253861-254958, Genome Release 64-1-1, Verified ORF, "C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P32353    365   ERG3_YEAST C-5 sterol desaturase OS=Saccharom...3650     758     100     100GO:0005788; C:endoplasmic reticulum lumen; IDA:SGD.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000248; F:C-5 sterol desaturase activity; IDA:SGD.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006696; P:ergosterol biosynthetic process; IMP:SGD.::GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
2P50860    364   ERG3_CANGA C-5 sterol desaturase OS=NRRL Y-65...3660     558     71     84GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
3Q754B9    351   ERG3_ASHGO C-5 sterol desaturase OS=Y-1056) (...3574e-159     457     59     75GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
4O93875    386   ERG3_CANAX C-5 sterol desaturase OS=Candida a...3832e-143     419     56     68GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
5Q8NJ57    386   ERG3_CANDC C-5 sterol desaturase OS=3949 / NR...3835e-138     405     55     68GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
6Q7SBB6    344   ERG3_NEUCR Probable C-5 sterol desaturase OS=...3666e-113     339     48     64GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
7Q8J207    356   ERG3_LEPMC C-5 sterol desaturase OS=Leptospha...3682e-111     336     46     65GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
8O94457    300   ERG31_SCHPO C-5 sterol desaturase erg31 OS=Sc...2823e-101     308     52     72GO:0005794; C:Golgi apparatus; IDA:PomBase.::GO:0030176; C:integral to endoplasmic reticulum membrane; ISS:PomBase.
GO:0000248; F:C-5 sterol desaturase activity; ISS:PomBase.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006696; P:ergosterol biosynthetic process; IGI:PomBase.::GO:0090002; P:establishment of protein localization in plasma membrane; IMP:PomBase.::GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0071210; P:protein insertion into membrane raft; IMP:PomBase.
9O75845    299   SC5D_HUMAN Lathosterol oxidase OS=Homo sapien...2773e-82     259     46     65GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000248; F:C-5 sterol desaturase activity; TAS:ProtInc.::GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0050046; F:lathosterol oxidase activity; IEA:EC.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
10O13666    329   ERG32_SCHPO C-5 sterol desaturase erg32 OS=Sc...3663e-81     258     41     59GO:0005794; C:Golgi apparatus; IDA:PomBase.::GO:0030176; C:integral to endoplasmic reticulum membrane; IC:PomBase.
GO:0000248; F:C-5 sterol desaturase activity; ISS:PomBase.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006696; P:ergosterol biosynthetic process; IMP:PomBase.::GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
11O88822    299   SC5D_MOUSE Lathosterol oxidase OS=Mus musculu...2374e-79     251     50     70GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0050046; F:lathosterol oxidase activity; IEA:EC.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
12Q39208    281   SC5D1_ARATH Delta(7)-sterol-C5(6)-desaturase ...2355e-21     94.7     31     49GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0050046; F:lathosterol oxidase activity; IEA:EC.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
13Q9ZT29    271   SC5D_TOBAC Delta(7)-sterol-C5(6)-desaturase O...2616e-21     94.4     29     48GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0050046; F:lathosterol oxidase activity; IEA:EC.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
14Q9M883    279   SC5D2_ARATH Putative Delta(7)-sterol-C5(6)-de...2352e-20     93.2     30     50GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0050046; F:lathosterol oxidase activity; IEA:EC.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
15Q8VYI1    260   SBH1_ARATH Sphingoid base hydroxylase 1 OS=Ar...1670.00000002     58.2     28     47GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IDA:TAIR.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0000170; F:sphingosine hydroxylase activity; IGI:TAIR.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0009640; P:photomorphogenesis; IMP:TAIR.::GO:0046520; P:sphingoid biosynthetic process; IMP:TAIR.
16Q9AST3    259   SBH2_ARATH Sphingoid base hydroxylase 2 OS=Ar...1450.00000004     57     30     48GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IDA:TAIR.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0000170; F:sphingosine hydroxylase activity; IGI:TAIR.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0009640; P:photomorphogenesis; IMP:TAIR.::GO:0046520; P:sphingoid biosynthetic process; IMP:TAIR.
17Q9GKT2    333   CE004_MACFA Uncharacterized protein C5orf4 ho...1320.000001     53.1     30     45GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0016491; F:oxidoreductase activity; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
18Q96IV6    333   CE004_HUMAN Uncharacterized protein C5orf4 OS...1320.000002     52.8     30     45GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0016491; F:oxidoreductase activity; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
19O35532    293   MSMO1_RAT Methylsterol monooxygenase 1 OS=Rat...1390.000002     52.4     28     42GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
20Q7ZW77    291   MSMO1_DANRE Methylsterol monooxygenase 1 OS=D...1340.000004     51.6     28     42GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
21Q5R574    293   MSMO1_PONAB Methylsterol monooxygenase 1 OS=P...1370.000009     50.4     27     42GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
22Q15800    293   MSMO1_HUMAN Methylsterol monooxygenase 1 OS=H...1370.000009     50.4     27     42GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0016021; C:integral to membrane; TAS:ProtInc.::GO:0005886; C:plasma membrane; TAS:ProtInc.
GO:0000254; F:C-4 methylsterol oxidase activity; TAS:ProtInc.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006695; P:cholesterol biosynthetic process; TAS:Reactome.::GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
23Q9CRA4    293   MSMO1_MOUSE Methylsterol monooxygenase 1 OS=M...1250.00001     50.4     28     43GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
24Q6UGB2    293   MSMO1_PIG Methylsterol monooxygenase 1 OS=Sus...1250.00001     50.1     28     44GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
25Q5ZLL6    296   MSMO1_CHICK Methylsterol monooxygenase 1 OS=G...1710.00002     49.7     25     40GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
26Q4R4Q4    293   MSMO1_MACFA Methylsterol monooxygenase 1 OS=M...1370.00002     49.7     27     42GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; IEA:EC.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW.
27P38992    349   SUR2_YEAST Sphingolipid C4-hydroxylase SUR2 O...1360.00005     48.5     31     44GO:0005789; C:endoplasmic reticulum membrane; IDA:SGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0000170; F:sphingosine hydroxylase activity; IMP:SGD.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0006665; P:sphingolipid metabolic process; IMP:SGD.
28O94298    293   YOOF_SCHPO Uncharacterized hydroxylase C887.1...1450.0001     47.4     28     41GO:0005789; C:endoplasmic reticulum membrane; ISS:PomBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0000170; F:sphingosine hydroxylase activity; ISS:PomBase.
GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.::GO:0006675; P:mannosyl-inositol phosphorylceramide metabolic process; IMP:PomBase.
29Q9UUH4    300   MSMO_SCHPO Methylsterol monooxygenase OS=Schi...1730.0002     46.2     26     39GO:0005789; C:endoplasmic reticulum membrane; ISS:PomBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; ISS:PomBase.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006696; P:ergosterol biosynthetic process; ISS:PomBase.::GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
30O59933    308   MSMO_CANAL Methylsterol monooxygenase OS=Cand...1800.009     41.2     26     39GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0000254; F:C-4 methylsterol oxidase activity; ISS:CGD.::GO:0005506; F:iron ion binding; IEA:InterPro.
GO:0006696; P:ergosterol biosynthetic process; ISS:CGD.::GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
31P53045    309   MSMO_YEAST Methylsterol monooxygenase OS=Sacc...1830.014     40.4     22     36GO:0005789; C:endoplasmic reticulum membrane; IDA:SGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:SGD.
GO:0000254; F:C-4 methylsterol oxidase activity; IDA:SGD.::GO:0005506; F:iron ion binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0006696; P:ergosterol biosynthetic process; IDA:SGD.::GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
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