Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLR034C
Length:
473
Number of sequences:
5887
Description:
YLR034C SMF3 SGDID:S000004024, Chr XII from 211933-210512, Genome Release 64-1-1, reverse complement, Verified ORF, "Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
121P51027    555   NRAM1_CHICK Natural resistance-associated mac...4274e-49     181     34     52GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IMP:BHF-UCL.
GO:0051139; F:metal ion:hydrogen antiporter activity; IGI:BHF-UCL.::GO:0046915; F:transition metal ion transmembrane transporter activity; IGI:BHF-UCL.
GO:0070574; P:cadmium ion transmembrane transport; IGI:BHF-UCL.::GO:0006876; P:cellular cadmium ion homeostasis; IGI:BHF-UCL.::GO:0070839; P:divalent metal ion export; ISS:BHF-UCL.::GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
122O69443    684   MNTH_MYCBO Probable manganese transport prote...3919e-49     182     34     52GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
123Q97TN5    431   MNTH_CLOAB Probable manganese transport prote...4063e-48     177     33     53GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
124P49282    568   NRAM2_MOUSE Natural resistance-associated mac...4131e-47     177     33     53GO:0005903; C:brush border; IDA:MGI.::GO:0009986; C:cell surface; IDA:MGI.::GO:0005769; C:early endosome; IDA:MGI.::GO:0012505; C:endomembrane system; IDA:MGI.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005887; C:integral to plasma membrane; IDA:MGI.::GO:0055037; C:recycling endosome; IDA:MGI.
GO:0015087; F:cobalt ion transmembrane transporter activity; IDA:MGI.::GO:0015093; F:ferrous iron transmembrane transporter activity; IDA:MGI.::GO:0015078; F:hydrogen ion transmembrane transporter activity; IDA:MGI.
GO:0048813; P:dendrite morphogenesis; IMP:MGI.::GO:0048821; P:erythrocyte development; IMP:MGI.::GO:0070627; P:ferrous iron import; IDA:MGI.::GO:0006783; P:heme biosynthetic process; IMP:MGI.::GO:0007611; P:learning or memory; IMP:MGI.::GO:0060586; P:multicellular organismal iron ion homeostasis; IMP:MGI.
125O54902    568   NRAM2_RAT Natural resistance-associated macro...4131e-47     177     33     53GO:0031902; C:late endosome membrane; IDA:RGD.::GO:0005765; C:lysosomal membrane; IDA:RGD.
GO:0046870; F:cadmium ion binding; IDA:RGD.::GO:0015086; F:cadmium ion transmembrane transporter activity; IDA:RGD.::GO:0050897; F:cobalt ion binding; IDA:RGD.::GO:0015087; F:cobalt ion transmembrane transporter activity; IDA:RGD.::GO:0005507; F:copper ion binding; IDA:RGD.::GO:0005375; F:copper ion transmembrane transporter activity; IDA:RGD.::GO:0015093; F:ferrous iron transmembrane transporter activity; IMP:RGD.::GO:0005506; F:iron ion binding; IDA:RGD.::GO:0015094; F:lead ion transmembrane transporter activity; IDA:RGD.::GO:0030145; F:manganese ion binding; IDA:RGD.::GO:0005384; F:manganese ion transmembrane transporter activity; IDA:RGD.::GO:0016151; F:nickel cation binding; IDA:RGD.::GO:0015099; F:nickel cation transmembrane transporter activity; IDA:RGD.::GO:0008270; F:zinc ion binding; IDA:RGD.
GO:0071456; P:cellular response to hypoxia; IEP:RGD.::GO:0071281; P:cellular response to iron ion; IEP:RGD.::GO:0071356; P:cellular response to tumor necrosis factor; IEP:RGD.::GO:0046686; P:response to cadmium ion; IEP:RGD.::GO:0010288; P:response to lead ion; IEP:RGD.::GO:0010042; P:response to manganese ion; IMP:RGD.
126P41251    548   NRAM1_MOUSE Natural resistance-associated mac...4808e-47     175     31     49GO:0009279; C:cell outer membrane; IDA:MGI.::GO:0010008; C:endosome membrane; IDA:MGI.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005770; C:late endosome; IDA:MGI.::GO:0005764; C:lysosome; IDA:MGI.::GO:0030670; C:phagocytic vesicle membrane; IDA:MGI.::GO:0005773; C:vacuole; IMP:GOC.
GO:0005384; F:manganese ion transmembrane transporter activity; IMP:MGI.
GO:0032147; P:activation of protein kinase activity; IMP:MGI.::GO:0048002; P:antigen processing and presentation of peptide antigen; IMP:MGI.::GO:0006879; P:cellular iron ion homeostasis; IMP:MGI.::GO:0050829; P:defense response to Gram-negative bacterium; IMP:MGI.::GO:0042832; P:defense response to protozoan; IMP:MGI.::GO:0070839; P:divalent metal ion export; IDA:BHF-UCL.::GO:0006954; P:inflammatory response; IMP:MGI.::GO:0032623; P:interleukin-2 production; IMP:MGI.::GO:0032632; P:interleukin-3 production; IMP:MGI.::GO:0006826; P:iron ion transport; IMP:MGI.::GO:0043091; P:L-arginine import; IDA:MGI.::GO:0042116; P:macrophage activation; IDA:MGI.::GO:0045342; P:MHC class II biosynthetic process; IMP:MGI.::GO:0048255; P:mRNA stabilization; IMP:MGI.::GO:0060586; P:multicellular organismal iron ion homeostasis; IMP:MGI.::GO:0001818; P:negative regulation of cytokine production; IMP:MGI.::GO:0015707; P:nitrite transport; IDA:MGI.::GO:0006909; P:phagocytosis; IMP:MGI.::GO:0002606; P:positive regulation of dendritic cell antigen processing and presentation; IMP:MGI.::GO:0010628; P:positive regulation of gene expression; IMP:MGI.::GO:0032729; P:positive regulation of interferon-gamma production; IMP:MGI.::GO:0050766; P:positive regulation of phagocytosis; IMP:MGI.::GO:0002827; P:positive regulation of T-helper 1 type immune response; IMP:MGI.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.::GO:0000060; P:protein import into nucleus, translocation; IMP:MGI.::GO:0045730; P:respiratory burst; IDA:MGI.::GO:0034341; P:response to interferon-gamma; IDA:MGI.::GO:0032496; P:response to lipopolysaccharide; IDA:MGI.::GO:0002369; P:T cell cytokine production; IMP:MGI.::GO:0002309; P:T cell proliferation involved in immune response; IMP:MGI.::GO:0007035; P:vacuolar acidification; IMP:MGI.::GO:0042060; P:wound healing; IMP:MGI.
127P49279    550   NRAM1_HUMAN Natural resistance-associated mac...4137e-46     172     33     53GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.::GO:0031902; C:late endosome membrane; TAS:Reactome.::GO:0005764; C:lysosome; ISS:BHF-UCL.::GO:0030670; C:phagocytic vesicle membrane; IDA:BHF-UCL.::GO:0070821; C:tertiary granule membrane; IDA:BHF-UCL.
GO:0005384; F:manganese ion transmembrane transporter activity; ISS:BHF-UCL.::GO:0051139; F:metal ion:hydrogen antiporter activity; IGI:BHF-UCL.::GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
GO:0032147; P:activation of protein kinase activity; ISS:BHF-UCL.::GO:0048002; P:antigen processing and presentation of peptide antigen; ISS:BHF-UCL.::GO:0070574; P:cadmium ion transmembrane transport; IGI:BHF-UCL.::GO:0006876; P:cellular cadmium ion homeostasis; IGI:BHF-UCL.::GO:0006879; P:cellular iron ion homeostasis; IMP:BHF-UCL.::GO:0050829; P:defense response to Gram-negative bacterium; ISS:BHF-UCL.::GO:0042832; P:defense response to protozoan; ISS:BHF-UCL.::GO:0070839; P:divalent metal ion export; ISS:BHF-UCL.::GO:0006954; P:inflammatory response; ISS:BHF-UCL.::GO:0032623; P:interleukin-2 production; ISS:BHF-UCL.::GO:0032632; P:interleukin-3 production; ISS:BHF-UCL.::GO:0006826; P:iron ion transport; IMP:BHF-UCL.::GO:0043091; P:L-arginine import; ISS:BHF-UCL.::GO:0042116; P:macrophage activation; ISS:BHF-UCL.::GO:0045342; P:MHC class II biosynthetic process; ISS:BHF-UCL.::GO:0048255; P:mRNA stabilization; ISS:BHF-UCL.::GO:0060586; P:multicellular organismal iron ion homeostasis; ISS:BHF-UCL.::GO:0001818; P:negative regulation of cytokine production; ISS:BHF-UCL.::GO:0015707; P:nitrite transport; ISS:BHF-UCL.::GO:0006909; P:phagocytosis; ISS:BHF-UCL.::GO:0002606; P:positive regulation of dendritic cell antigen processing and presentation; ISS:BHF-UCL.::GO:0032729; P:positive regulation of interferon-gamma production; ISS:BHF-UCL.::GO:0050766; P:positive regulation of phagocytosis; ISS:BHF-UCL.::GO:0002827; P:positive regulation of T-helper 1 type immune response; ISS:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.::GO:0045730; P:respiratory burst; ISS:BHF-UCL.::GO:0034341; P:response to interferon-gamma; ISS:BHF-UCL.::GO:0032496; P:response to lipopolysaccharide; ISS:BHF-UCL.::GO:0002369; P:T cell cytokine production; ISS:BHF-UCL.::GO:0002309; P:T cell proliferation involved in immune response; ISS:BHF-UCL.::GO:0007035; P:vacuolar acidification; ISS:BHF-UCL.::GO:0042060; P:wound healing; ISS:BHF-UCL.
128Q9XT74    547   NRAM1_CANFA Natural resistance-associated mac...4761e-45     172     30     49GO:0016021; C:integral to membrane; NAS:UniProtKB.
GO:0005384; F:manganese ion transmembrane transporter activity; NAS:UniProtKB.
129P49281    568   NRAM2_HUMAN Natural resistance-associated mac...4133e-45     171     34     54GO:0016324; C:apical plasma membrane; IDA:UniProtKB.::GO:0045178; C:basal part of cell; IDA:UniProtKB.::GO:0009986; C:cell surface; IDA:UniProtKB.::GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB.::GO:0005769; C:early endosome; IDA:UniProtKB.::GO:0005770; C:late endosome; IDA:UniProtKB.::GO:0031902; C:late endosome membrane; IDA:BHF-UCL.::GO:0005765; C:lysosomal membrane; IDA:BHF-UCL.::GO:0005764; C:lysosome; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0070826; C:paraferritin complex; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0055037; C:recycling endosome; IDA:UniProtKB.::GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
GO:0015086; F:cadmium ion transmembrane transporter activity; IDA:BHF-UCL.::GO:0015087; F:cobalt ion transmembrane transporter activity; IDA:UniProtKB.::GO:0005375; F:copper ion transmembrane transporter activity; IDA:BHF-UCL.::GO:0015093; F:ferrous iron transmembrane transporter activity; IDA:BHF-UCL.::GO:0015094; F:lead ion transmembrane transporter activity; IDA:BHF-UCL.::GO:0005384; F:manganese ion transmembrane transporter activity; IDA:BHF-UCL.::GO:0015099; F:nickel cation transmembrane transporter activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0015295; F:solute:hydrogen symporter activity; IDA:UniProtKB.::GO:0015100; F:vanadium ion transmembrane transporter activity; IDA:UniProtKB.::GO:0005385; F:zinc ion transmembrane transporter activity; IDA:UniProtKB.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.::GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.::GO:0034599; P:cellular response to oxidative stress; IDA:UniProtKB.::GO:0003032; P:detection of oxygen; IEP:UniProtKB.::GO:0070627; P:ferrous iron import; IDA:UniProtKB.::GO:0060586; P:multicellular organismal iron ion homeostasis; IMP:BHF-UCL.::GO:0001666; P:response to hypoxia; IEP:UniProtKB.::GO:0010039; P:response to iron ion; IEP:UniProtKB.
130Q27946    548   NRAM1_BUBBU Natural resistance-associated mac...4131e-44     169     33     52GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005215; F:transporter activity; IEA:InterPro.
GO:0006811; P:ion transport; IEA:UniProtKB-KW.::GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
131P56436    548   NRAM1_CEREL Natural resistance-associated mac...4132e-44     168     33     52GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005215; F:transporter activity; IEA:InterPro.
GO:0006811; P:ion transport; IEA:UniProtKB-KW.::GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
132Q95102    548   NRAM1_BISBI Natural resistance-associated mac...4132e-44     168     33     52GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005215; F:transporter activity; IEA:InterPro.
GO:0006811; P:ion transport; IEA:UniProtKB-KW.::GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
133O77741    538   NRAM1_PIG Natural resistance-associated macro...4132e-44     168     33     52GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005215; F:transporter activity; IEA:InterPro.
GO:0006811; P:ion transport; IEA:UniProtKB-KW.::GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.::GO:0000165; P:MAPK cascade; IDA:MGI.::GO:0032496; P:response to lipopolysaccharide; IDA:MGI.
134Q21434    562   NRAML_CAEEL NRAMP-like transporter smf-1 OS=C...4193e-44     167     31     50GO:0016324; C:apical plasma membrane; IDA:WormBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0046915; F:transition metal ion transmembrane transporter activity; ISS:WormBase.
GO:0055072; P:iron ion homeostasis; IMP:WormBase.::GO:0055071; P:manganese ion homeostasis; IMP:WormBase.::GO:0010042; P:response to manganese ion; IMP:WormBase.
135P49280    548   NRAM1_SHEEP Natural resistance-associated mac...4138e-44     166     33     52GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005215; F:transporter activity; IEA:InterPro.
GO:0006811; P:ion transport; IEA:UniProtKB-KW.::GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
136Q27981    548   NRAM1_BOVIN Natural resistance-associated mac...4139e-44     166     33     52GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005215; F:transporter activity; IEA:InterPro.
GO:0006811; P:ion transport; IEA:UniProtKB-KW.::GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
137Q10Q65    524   NRAM2_ORYSJ Metal transporter Nramp2 OS=Oryza...4012e-43     165     31     49GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005215; F:transporter activity; IEA:InterPro.
GO:0006811; P:ion transport; IEA:UniProtKB-KW.
138Q9C6B2    530   NRAM2_ARATH Metal transporter Nramp2 OS=Arabi...4032e-43     165     31     49GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005215; F:transporter activity; IEA:InterPro.
GO:0006811; P:ion transport; IEA:UniProtKB-KW.::GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
139Q9SN36    530   NRAM5_ARATH Metal transporter Nramp5 OS=Arabi...4077e-43     163     30     50GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005215; F:transporter activity; IEA:InterPro.
GO:0006811; P:ion transport; IEA:UniProtKB-KW.::GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
140Q5QN13    550   NRAM4_ORYSJ Metal transporter Nramp4 OS=Oryza...3961e-42     163     31     49GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005215; F:transporter activity; IEA:InterPro.
GO:0006811; P:ion transport; IEA:UniProtKB-KW.::GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
141Q9SNV9    509   NRAM3_ARATH Metal transporter Nramp3 OS=Arabi...4054e-42     161     31     50GO:0005794; C:Golgi apparatus; IDA:TAIR.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0009506; C:plasmodesma; IDA:TAIR.::GO:0005774; C:vacuolar membrane; IDA:TAIR.
GO:0005215; F:transporter activity; IEA:InterPro.
GO:0042742; P:defense response to bacterium; IMP:TAIR.::GO:0055072; P:iron ion homeostasis; IMP:TAIR.::GO:0006828; P:manganese ion transport; IMP:TAIR.::GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IGI:TAIR.::GO:0010043; P:response to zinc ion; IEP:TAIR.
142Q9FN18    512   NRAM4_ARATH Metal transporter Nramp4 OS=Arabi...4055e-42     161     31     50GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005774; C:vacuolar membrane; IDA:TAIR.
GO:0005215; F:transporter activity; IEA:InterPro.
GO:0006879; P:cellular iron ion homeostasis; IGI:TAIR.::GO:0042742; P:defense response to bacterium; IMP:TAIR.::GO:0006828; P:manganese ion transport; IMP:TAIR.::GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IGI:TAIR.::GO:0010039; P:response to iron ion; IEP:TAIR.::GO:0009624; P:response to nematode; IEP:TAIR.
143Q2QN30    541   NRAM6_ORYSJ Metal transporter Nramp6 OS=Oryza...4089e-42     160     31     49GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005215; F:transporter activity; IEA:InterPro.
GO:0006811; P:ion transport; IEA:UniProtKB-KW.
144Q50103    426   MNTH_MYCLE Probable manganese transport prote...3891e-41     158     32     51GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
145P70553    507   NRAM1_RAT Natural resistance-associated macro...4445e-36     143     31     48GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005215; F:transporter activity; IEA:InterPro.
GO:0006811; P:ion transport; IEA:UniProtKB-KW.::GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
146Q9S814    1294   EIN2_ARATH Ethylene-insensitive protein 2 OS=...4162e-32     135     26     46GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0005215; F:transporter activity; IEA:InterPro.
GO:0009734; P:auxin mediated signaling pathway; IEA:UniProtKB-KW.::GO:0009926; P:auxin polar transport; IMP:TAIR.::GO:0071281; P:cellular response to iron ion; IEP:TAIR.::GO:0009736; P:cytokinin mediated signaling pathway; IEA:UniProtKB-KW.::GO:0052544; P:defense response by callose deposition in cell wall; IMP:TAIR.::GO:0042742; P:defense response to bacterium; IMP:TAIR.::GO:0050832; P:defense response to fungus; IMP:TAIR.::GO:0009871; P:jasmonic acid and ethylene-dependent systemic resistance, ethylene mediated signaling pathway; TAS:TAIR.::GO:0010150; P:leaf senescence; IMP:TAIR.::GO:0031348; P:negative regulation of defense response; IMP:TAIR.::GO:0009789; P:positive regulation of abscisic acid mediated signaling pathway; IMP:TAIR.::GO:0010119; P:regulation of stomatal movement; IMP:TAIR.::GO:0009408; P:response to heat; IMP:TAIR.::GO:0002237; P:response to molecule of bacterial origin; IMP:TAIR.::GO:0009651; P:response to salt stress; IMP:TAIR.::GO:0010182; P:sugar mediated signaling pathway; TAS:TAIR.
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