Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLR032W
Length:
1169
Number of sequences:
5887
Description:
YLR032W RAD5 SGDID:S000004022, Chr XII from 204991-208500, Genome Release 64-1-1, Verified ORF, "DNA helicase proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
451Q8WVD5    230   RN141_HUMAN RING finger protein 141 OS=Homo s...520.78     36.6     37     50
GO:0008270; F:zinc ion binding; IEA:InterPro.
452Q6IV57    230   RN141_RAT RING finger protein 141 OS=Rattus n...520.8     36.6     37     50
GO:0008270; F:zinc ion binding; IEA:InterPro.
453Q28DS3    257   RN170_XENTR RING finger protein 170 OS=Xenopu...820.81     37     27     41GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
454Q9TST0    326   BMI1_FELCA Polycomb complex protein BMI-1 OS=...740.82     37     27     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0031519; C:PcG protein complex; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0051443; P:positive regulation of ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
455Q60YN5    828   BRE1_CAEBR E3 ubiquitin-protein ligase bre-1 ...920.82     37.7     27     43GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
456Q4KLN8    487   RNF8_RAT E3 ubiquitin-protein ligase RNF8 OS=...720.82     37.4     33     56GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0030496; C:midbody; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0003682; F:chromatin binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0006302; P:double-strand break repair; ISS:UniProtKB.::GO:0033522; P:histone H2A ubiquitination; ISS:UniProtKB.::GO:0033523; P:histone H2B ubiquitination; ISS:UniProtKB.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0045739; P:positive regulation of DNA repair; ISS:UniProtKB.::GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
457Q99MB7    230   RN141_MOUSE RING finger protein 141 OS=Mus mu...520.82     36.6     37     50
GO:0003677; F:DNA binding; IDA:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IDA:MGI.
458Q803C1    485   RNF8_DANRE E3 ubiquitin-protein ligase RNF8 O...530.85     37.4     36     53GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0003682; F:chromatin binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051301; P:cell division; IEA:InterPro.::GO:0006302; P:double-strand break repair; ISS:UniProtKB.::GO:0033522; P:histone H2A ubiquitination; ISS:UniProtKB.::GO:0033523; P:histone H2B ubiquitination; ISS:UniProtKB.::GO:0045739; P:positive regulation of DNA repair; ISS:UniProtKB.::GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
459Q9Y4K3    522   TRAF6_HUMAN TNF receptor-associated factor 6 ...460.85     37.4     41     57GO:0035631; C:CD40 receptor complex; ISS:BHF-UCL.::GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0010008; C:endosome membrane; TAS:Reactome.::GO:0009898; C:internal side of plasma membrane; ISS:BHF-UCL.::GO:0031965; C:nuclear membrane; IDA:HPA.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
GO:0042826; F:histone deacetylase binding; IPI:UniProtKB.::GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IPI:UniProtKB.::GO:0043422; F:protein kinase B binding; IPI:UniProtKB.::GO:0047485; F:protein N-terminus binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000187; P:activation of MAPK activity; TAS:Reactome.::GO:0007250; P:activation of NF-kappaB-inducing kinase activity; IMP:UniProtKB.::GO:0006916; P:anti-apoptosis; TAS:Reactome.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007249; P:I-kappaB kinase/NF-kappaB cascade; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0007254; P:JNK cascade; TAS:Reactome.::GO:0031293; P:membrane protein intracellular domain proteolysis; TAS:Reactome.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0070423; P:nucleotide-binding oligomerization domain containing signaling pathway; TAS:Reactome.::GO:0001503; P:ossification; IEA:UniProtKB-KW.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IDA:UniProtKB.::GO:0032743; P:positive regulation of interleukin-2 production; IMP:UniProtKB.::GO:0043507; P:positive regulation of JUN kinase activity; NAS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.::GO:0045672; P:positive regulation of osteoclast differentiation; IDA:UniProtKB.::GO:0050870; P:positive regulation of T cell activation; IC:UniProtKB.::GO:0002726; P:positive regulation of T cell cytokine production; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:2000679; P:positive regulation of transcription regulatory region DNA binding; IDA:BHF-UCL.::GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.::GO:0070555; P:response to interleukin-1; IDA:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; IMP:UniProtKB.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome.
460Q2XNS1    231   RN141_CANFA RING finger protein 141 OS=Canis ...520.85     36.6     37     50
GO:0008270; F:zinc ion binding; IEA:InterPro.
461Q1MTQ0    692   BRL1_SCHPO E3 ubiquitin-protein ligase brl1 O...610.86     37.4     28     43GO:0005721; C:centromeric heterochromatin; IDA:PomBase.::GO:0033503; C:HULC complex; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006342; P:chromatin silencing; IMP:PomBase.::GO:0006336; P:DNA replication-independent nucleosome assembly; TAS:PomBase.::GO:0071894; P:histone H2B conserved C-terminal lysine ubiquitination; IDA:PomBase.::GO:0051569; P:regulation of histone H3-K4 methylation; IMP:PomBase.::GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IEP:PomBase.
462B6CJY5    522   TRAF6_MACMU TNF receptor-associated factor 6 ...460.87     37.4     41     57GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
463P25916    324   BMI1_MOUSE Polycomb complex protein BMI-1 OS=...740.87     37     27     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016604; C:nuclear body; IDA:MGI.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0003682; F:chromatin binding; IDA:MGI.::GO:0043565; F:sequence-specific DNA binding; IDA:MGI.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0007420; P:brain development; IMP:MGI.::GO:0048704; P:embryonic skeletal system morphogenesis; IGI:MGI.::GO:0016573; P:histone acetylation; IGI:MGI.::GO:0016574; P:histone ubiquitination; IDA:MGI.::GO:0006959; P:humoral immune response; IMP:MGI.::GO:0001701; P:in utero embryonic development; IGI:MGI.::GO:0043066; P:negative regulation of apoptotic process; IGI:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.::GO:0030890; P:positive regulation of B cell proliferation; IMP:HGNC.::GO:0033092; P:positive regulation of immature T cell proliferation in thymus; IMP:HGNC.::GO:0051443; P:positive regulation of ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0021903; P:rostrocaudal neural tube patterning; IMP:MGI.::GO:0048103; P:somatic stem cell division; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
464B6CJY4    522   TRAF6_CERAT TNF receptor-associated factor 6 ...460.88     37.4     41     57GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0042981; P:regulation of apoptotic process; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro.
465Q32KX7    326   BMI1_BOVIN Polycomb complex protein BMI-1 OS=...740.88     37     27     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0051443; P:positive regulation of ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
466Q5R8L2    326   BMI1_PONAB Polycomb complex protein BMI-1 OS=...740.91     37     27     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0051443; P:positive regulation of ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
467P35226    326   BMI1_HUMAN Polycomb complex protein BMI-1 OS=...740.91     37     27     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005730; C:nucleolus; IDA:HPA.::GO:0035102; C:PRC1 complex; IDA:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0071535; F:RING-like zinc finger domain binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0030097; P:hemopoiesis; IEP:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.::GO:0048146; P:positive regulation of fibroblast proliferation; IMP:BHF-UCL.::GO:0051443; P:positive regulation of ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0007379; P:segment specification; TAS:ProtInc.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
468Q5SDR3    326   BMI1_CHICK Polycomb complex protein BMI-1 OS=...740.91     37     27     46GO:0031519; C:PcG protein complex; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0051443; P:positive regulation of ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
469Q8N9V2    468   TRIML_HUMAN Probable E3 ubiquitin-protein lig...520.93     37.4     40     48
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
470Q2TBT8    240   RN151_BOVIN RING finger protein 151 OS=Bos ta...1030.93     36.6     25     45
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
471Q59NP8    631   SPB42_CANAL ATP-dependent rRNA helicase SPB42...1400.94     37.4     23     40GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
472Q1XHT8    229   TRI40_PANTR Tripartite motif-containing prote...480.95     36.6     38     54GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
473O54952    1817   BRCA1_RAT Breast cancer type 1 susceptibility...540.97     37.4     37     57GO:0031436; C:BRCA1-BARD1 complex; ISS:UniProtKB.::GO:0005759; C:mitochondrial matrix; IDA:RGD.
GO:0003684; F:damaged DNA binding; TAS:RGD.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007420; P:brain development; IEP:RGD.::GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.::GO:0045717; P:negative regulation of fatty acid biosynthetic process; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; ISS:UniProtKB.::GO:0032355; P:response to estradiol stimulus; IEP:RGD.::GO:0033993; P:response to lipid; IEP:RGD.::GO:0007584; P:response to nutrient; IEP:RGD.
474Q6LFN2    1103   ZNRF1_PLAF7 RING finger protein PFF0165c OS=P...480.98     37.4     29     50
GO:0008270; F:zinc ion binding; IEA:InterPro.
475Q6BWW6    691   BRE1_DEBHA E3 ubiquitin-protein ligase BRE1 O...2040.99     37.4     22     43GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
476Q59N29    631   SPB41_CANAL ATP-dependent rRNA helicase SPB41...1401     37.4     23     40GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
477Q9D9R0    233   RN125_MOUSE E3 ubiquitin-protein ligase RNF12...511     36.2     35     47GO:0005829; C:cytosol; TAS:Reactome.
GO:0004842; F:ubiquitin-protein ligase activity; EXP:Reactome.::GO:0008270; F:zinc ion binding; IEA:InterPro.
478Q6P9F5    258   TRI40_HUMAN Tripartite motif-containing prote...481.1     36.6     38     54GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
479Q8TEJ3    882   SH3R3_HUMAN SH3 domain-containing RING finger...501.1     37.4     36     54
GO:0008270; F:zinc ion binding; IEA:InterPro.
480Q7SZN2    266   RN170_DANRE RING finger protein 170 OS=Danio ...1101.1     36.6     25     43GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0009790; P:embryo development; IMP:ZFIN.
481Q9M9Y4    421   DRIP1_ARATH E3 ubiquitin protein ligase DRIP1...341.1     37     44     62GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
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