| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | Q12198 | 575 | METW_YEAST Putative cystathionine gamma-synth... | 575 | 0 | 1181 | 100 | 100 | | | | | | | | | | | GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 2 | P47164 | 639 | MET7_YEAST Cystathionine gamma-synthase OS=Sa... | 641 | 4e-126 | 391 | 37 | 56 | GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD. | | | | | | | | | | GO:0003962; F:cystathionine gamma-synthase activity; IMP:SGD.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0019346; P:transsulfuration; IMP:SGD. | 3 | Q04533 | 649 | METX_YEAST Putative cystathionine gamma-synth... | 200 | 1e-22 | 105 | 34 | 50 | GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD. | | | | | | | | | | GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 4 | O74314 | 610 | MET7_SCHPO Probable cystathionine gamma-synth... | 626 | 8e-97 | 314 | 36 | 52 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0003962; F:cystathionine gamma-synthase activity; ISS:PomBase.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0006534; P:cysteine metabolic process; ISS:PomBase.::GO:0019281; P:L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine; ISS:PomBase. | 5 | P38675 | 621 | MET7_NEUCR Cystathionine gamma-synthase OS=12... | 162 | 8e-17 | 87.4 | 32 | 53 | | | | | | | | | | | GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 6 | P56069 | 380 | METB_HELPY Cystathionine gamma-synthase OS=py... | 363 | 2e-18 | 90.9 | 27 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 7 | O05394 | 379 | MCCB_BACSU Cystathionine gamma-lyase OS=Bacil... | 357 | 3e-18 | 90.5 | 27 | 44 | | | | | | | | | | | GO:0004123; F:cystathionine gamma-lyase activity; IEA:EC.::GO:0047982; F:homocysteine desulfhydrase activity; IEA:EC.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro. | 8 | Q1M0P5 | 380 | METB_HELPX Cystathionine gamma-synthase OS=He... | 363 | 2e-17 | 87.4 | 26 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 9 | Q9ZMW7 | 380 | METB_HELPJ Cystathionine gamma-synthase OS=He... | 365 | 6e-17 | 86.3 | 26 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 10 | A2RM21 | 380 | METC_LACLM Cystathionine beta-lyase OS=Lactoc... | 305 | 1e-16 | 85.5 | 28 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 11 | P0A4K2 | 380 | METC_LACLA Cystathionine beta-lyase OS=lactis... | 305 | 1e-16 | 85.5 | 28 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 12 | P0C2T9 | 380 | METC_LACLC Cystathionine beta-lyase OS=Lactoc... | 304 | 1e-16 | 85.5 | 27 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 13 | Q55DV9 | 387 | CGL_DICDI Cystathionine gamma-lyase OS=Dictyo... | 266 | 0.00000000000002 | 78.6 | 29 | 45 | GO:0005737; C:cytoplasm; ISS:dictyBase.::GO:0005615; C:extracellular space; IDA:dictyBase. | | | | | | | | | | GO:0004123; F:cystathionine gamma-lyase activity; ISS:dictyBase.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW. | 14 | P13254 | 398 | MEGL_PSEPU Methionine gamma-lyase OS=Pseudomo... | 372 | 0.0000000000002 | 75.5 | 24 | 41 | | | | | | | | | | | GO:0018826; F:methionine gamma-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro. | 15 | O31632 | 390 | METC_BACSU Cystathionine beta-lyase metC OS=B... | 343 | 0.000000000001 | 73.6 | 25 | 42 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 16 | Q19QT7 | 405 | CGL_PIG Cystathionine gamma-lyase OS=Sus scro... | 283 | 0.000000000005 | 71.6 | 25 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); ISS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB. | | | | | | | | | | GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0044524; P:protein sulfhydration; ISS:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB. | 17 | P00935 | 386 | METB_ECOLI Cystathionine gamma-synthase OS=Es... | 244 | 0.0000000008 | 64.3 | 27 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003962; F:cystathionine gamma-synthase activity; IDA:EcoCyc.::GO:0042802; F:identical protein binding; IPI:EcoCyc.::GO:0030170; F:pyridoxal phosphate binding; IDA:EcoCyc. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IMP:EcoCyc. | 18 | Q8VCN5 | 398 | CGL_MOUSE Cystathionine gamma-lyase OS=Mus mu... | 277 | 0.000000004 | 62.8 | 28 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IDA:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB. | | | | | | | | | | GO:0006916; P:anti-apoptosis; IMP:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB.::GO:0044524; P:protein sulfhydration; IDA:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB. | 19 | Q60HG7 | 405 | CGL_MACFA Cystathionine gamma-lyase OS=Macaca... | 287 | 0.000000006 | 62 | 25 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); ISS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB. | | | | | | | | | | GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0044524; P:protein sulfhydration; ISS:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB. | 20 | P38716 | 378 | YHR2_YEAST Uncharacterized trans-sulfuration ... | 259 | 0.00000002 | 60.5 | 25 | 43 | GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD. | | | | | | | | | | GO:0016829; F:lyase activity; IEA:UniProtKB-KW.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro. | 21 | P55216 | 392 | CGL2_CAEEL Putative cystathionine gamma-lyase... | 272 | 0.00000004 | 59.3 | 26 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004123; F:cystathionine gamma-lyase activity; IEA:EC.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase. | 22 | Q83A83 | 387 | METC_COXBU Cystathionine beta-lyase OS=Coxiel... | 257 | 0.0000002 | 57.4 | 25 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 23 | P31373 | 394 | CYS3_YEAST Cystathionine gamma-lyase OS=Sacch... | 270 | 0.0000002 | 57.4 | 27 | 43 | GO:0005737; C:cytoplasm; IDA:SGD. | | | | | | | | | | GO:0004123; F:cystathionine gamma-lyase activity; IDA:SGD.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0019343; P:cysteine biosynthetic process via cystathionine; IMP:SGD.::GO:0019346; P:transsulfuration; IMP:SGD. | 24 | O42851 | 398 | YFHE_SCHPO Uncharacterized trans-sulfuration ... | 260 | 0.0000003 | 56.6 | 25 | 44 | | | | | | | | | | | GO:0016829; F:lyase activity; IEA:UniProtKB-KW.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro. | 25 | P46807 | 388 | METB_MYCLE Cystathionine gamma-synthase OS=My... | 257 | 0.0000004 | 56.2 | 26 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003962; F:cystathionine gamma-synthase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 26 | P18757 | 398 | CGL_RAT Cystathionine gamma-lyase OS=Rattus n... | 277 | 0.0000005 | 55.8 | 26 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004121; F:cystathionine beta-lyase activity; IDA:RGD.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); ISS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB. | | | | | | | | | | GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0006749; P:glutathione metabolic process; IMP:RGD.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0030308; P:negative regulation of cell growth; IMP:RGD.::GO:0008285; P:negative regulation of cell proliferation; IMP:RGD.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0044524; P:protein sulfhydration; ISS:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB.::GO:0019346; P:transsulfuration; TAS:RGD. | 27 | P55217 | 563 | METB_ARATH Cystathionine gamma-synthase, chlo... | 253 | 0.0000006 | 56.2 | 26 | 43 | GO:0009570; C:chloroplast stroma; IDA:TAIR. | | | | | | | | | | GO:0003962; F:cystathionine gamma-synthase activity; IDA:TAIR.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IMP:TAIR.::GO:0001887; P:selenium compound metabolic process; IDA:TAIR. | 28 | P55218 | 403 | METZ_PSEAE O-succinylhomoserine sulfhydrylase... | 242 | 0.000001 | 54.7 | 25 | 42 | | | | | | | | | | | GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0016740; F:transferase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0071268; P:homocysteine biosynthetic process; IEA:InterPro.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 29 | O31631 | 373 | METI_BACSU Cystathionine gamma-synthase/O-ace... | 256 | 0.000003 | 53.1 | 25 | 40 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0016740; F:transferase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 30 | Q58DW2 | 405 | CGL_BOVIN Cystathionine gamma-lyase OS=Bos ta... | 257 | 0.000006 | 52.4 | 25 | 42 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004123; F:cystathionine gamma-lyase activity; ISS:UniProtKB.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); ISS:UniProtKB.::GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB. | | | | | | | | | | GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0019344; P:cysteine biosynthetic process; ISS:UniProtKB.::GO:0070814; P:hydrogen sulfide biosynthetic process; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0044524; P:protein sulfhydration; ISS:UniProtKB.::GO:0018272; P:protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine; ISS:UniProtKB. | 31 | P66875 | 388 | METB_MYCTU Cystathionine gamma-synthase OS=My... | 256 | 0.00001 | 51.6 | 25 | 42 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:MTBBASE. | | | | | | | | | | GO:0004123; F:cystathionine gamma-lyase activity; IDA:MTBBASE.::GO:0003962; F:cystathionine gamma-synthase activity; IDA:MTBBASE.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0019343; P:cysteine biosynthetic process via cystathionine; IMP:MTBBASE.::GO:0019279; P:L-methionine biosynthetic process from L-homoserine via cystathionine; IMP:MTBBASE. |
