Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLL050C
Length:
143
Number of sequences:
5887
Description:
YLL050C COF1 SGDID:S000003973, Chr XII from 40221-39804,40414-40401, Genome Release 64-1-1, reverse complement, Verified ORF, "Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
91Q91YR1    350   TWF1_MOUSE Twinfilin-1 OS=Mus musculus (Mouse...1350.0008     41.6     24     49GO:0015629; C:actin cytoskeleton; IDA:UniProtKB.::GO:0005911; C:cell-cell junction; IDA:BHF-UCL.::GO:0030175; C:filopodium; IDA:BHF-UCL.::GO:0030016; C:myofibril; IDA:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
GO:0003785; F:actin monomer binding; IDA:BHF-UCL.::GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:BHF-UCL.::GO:0004713; F:protein tyrosine kinase activity; IDA:UniProtKB.
GO:0051016; P:barbed-end actin filament capping; IDA:BHF-UCL.::GO:0042989; P:sequestering of actin monomers; IDA:BHF-UCL.
92Q17A58    343   TWF_AEDAE Twinfilin OS=Aedes aegypti (Yellowf...610.001     41.2     36     56GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
93Q5RFH1    341   TWF2_PONAB Twinfilin-2 OS=Pongo abelii (Sumat...870.001     41.2     26     51GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0032420; C:stereocilium; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
94Q56JV6    350   TWF1_BOVIN Twinfilin-1 OS=Bos taurus (Bovine)...1160.001     41.2     24     47
95Q6IBS0    349   TWF2_HUMAN Twinfilin-2 OS=Homo sapiens (Human...870.001     41.2     26     51GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030175; C:filopodium; ISS:BHF-UCL.::GO:0030426; C:growth cone; IDA:BHF-UCL.::GO:0030027; C:lamellipodium; ISS:BHF-UCL.::GO:0030016; C:myofibril; ISS:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; ISS:BHF-UCL.::GO:0032420; C:stereocilium; ISS:BHF-UCL.
GO:0003785; F:actin monomer binding; ISS:BHF-UCL.::GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISS:BHF-UCL.::GO:0005080; F:protein kinase C binding; IPI:BHF-UCL.
GO:0051016; P:barbed-end actin filament capping; ISS:BHF-UCL.::GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.::GO:0071363; P:cellular response to growth factor stimulus; IMP:BHF-UCL.::GO:0071300; P:cellular response to retinoic acid; IMP:BHF-UCL.::GO:0045773; P:positive regulation of axon extension; IMP:BHF-UCL.::GO:0010592; P:positive regulation of lamellipodium assembly; IMP:BHF-UCL.::GO:0010976; P:positive regulation of neuron projection development; IMP:BHF-UCL.::GO:0032532; P:regulation of microvillus length; IC:BHF-UCL.::GO:0042989; P:sequestering of actin monomers; ISS:BHF-UCL.
96Q5RJR2    350   TWF1_RAT Twinfilin-1 OS=Rattus norvegicus (Ra...1350.001     40.8     24     48
97Q9VFM9    343   TWF_DROME Twinfilin OS=Drosophila melanogaste...1340.002     40.4     25     44GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0003779; F:actin binding; IMP:UniProtKB.
GO:0030042; P:actin filament depolymerization; IDA:FlyBase.::GO:0007298; P:border follicle cell migration; IMP:FlyBase.::GO:0008407; P:chaeta morphogenesis; IMP:FlyBase.::GO:0016319; P:mushroom body development; IMP:FlyBase.::GO:0007274; P:neuromuscular synaptic transmission; IMP:FlyBase.::GO:0030833; P:regulation of actin filament polymerization; IMP:UniProtKB.::GO:0010591; P:regulation of lamellipodium assembly; IMP:FlyBase.::GO:0048488; P:synaptic vesicle endocytosis; IMP:FlyBase.
98Q9Z0P5    349   TWF2_MOUSE Twinfilin-2 OS=Mus musculus (Mouse...550.004     39.7     35     56GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030175; C:filopodium; IDA:BHF-UCL.::GO:0030027; C:lamellipodium; IDA:BHF-UCL.::GO:0030016; C:myofibril; IDA:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.::GO:0032420; C:stereocilium; IDA:BHF-UCL.
GO:0003785; F:actin monomer binding; IDA:BHF-UCL.::GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:BHF-UCL.
GO:0051016; P:barbed-end actin filament capping; IDA:BHF-UCL.::GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.::GO:0030837; P:negative regulation of actin filament polymerization; IDA:BHF-UCL.::GO:0032532; P:regulation of microvillus length; IC:BHF-UCL.::GO:0042989; P:sequestering of actin monomers; IDA:BHF-UCL.
99Q298X4    345   TWF_DROPS Twinfilin OS=Drosophila pseudoobscu...840.009     38.5     29     45GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0003779; F:actin binding; ISS:UniProtKB.
GO:0030833; P:regulation of actin filament polymerization; ISS:UniProtKB.
100P53250    332   TWF1_YEAST Twinfilin-1 OS=Saccharomyces cerev...390.01     38.5     46     72GO:0030479; C:actin cortical patch; TAS:SGD.::GO:0043332; C:mating projection tip; IDA:SGD.
GO:0003785; F:actin monomer binding; IDA:SGD.
GO:0008154; P:actin polymerization or depolymerization; TAS:SGD.::GO:0007121; P:bipolar cellular bud site selection; TAS:SGD.::GO:0042989; P:sequestering of actin monomers; IDA:SGD.
101Q7QG28    343   TWF_ANOGA Twinfilin OS=Anopheles gambiae (Afr...1020.011     38.1     28     45GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
102O94399    328   TWF1_SCHPO Twinfilin OS=Schizosaccharomyces p...800.28     34.3     24     51GO:0030479; C:actin cortical patch; ISS:PomBase.::GO:0032153; C:cell division site; IDA:PomBase.::GO:0051286; C:cell tip; IDA:PomBase.
GO:0003785; F:actin monomer binding; ISS:PomBase.
GO:0042989; P:sequestering of actin monomers; ISS:PomBase.
103O36033    817   YLM1_SCHPO TPR repeat-containing protein C19B...720.36     33.9     32     54GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.::GO:0043234; C:protein complex; NAS:PomBase.
GO:0005488; F:binding; IEA:InterPro.
104Q869T1    335   TWF_DICDI Twinfilin OS=Dictyostelium discoide...1273.8     30.8     20     50GO:0015629; C:actin cytoskeleton; ISS:dictyBase.::GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; ISS:dictyBase.
105Q63228    142   GMFB_RAT Glia maturation factor beta OS=Rattu...821.1     32     27     50GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:InterPro.::GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
106Q5R6P6    142   GMFB_PONAB Glia maturation factor beta OS=Pon...821.1     32     27     50GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:InterPro.::GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
107P60983    142   GMFB_HUMAN Glia maturation factor beta OS=Hom...821.1     32     27     50GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:InterPro.::GO:0008047; F:enzyme activator activity; TAS:ProtInc.::GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.::GO:0004860; F:protein kinase inhibitor activity; TAS:ProtInc.::GO:0004871; F:signal transducer activity; TAS:ProtInc.
GO:0007399; P:nervous system development; TAS:ProtInc.::GO:0006468; P:protein phosphorylation; TAS:ProtInc.
108P60984    142   GMFB_BOVIN Glia maturation factor beta OS=Bos...821.1     32     27     50GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:InterPro.::GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
109P22105    4289   TENX_HUMAN Tenascin-X OS=Homo sapiens (Human)...281.8     32     46     64GO:0005615; C:extracellular space; IDA:BHF-UCL.::GO:0005622; C:intracellular; IDA:UniProtKB.::GO:0005578; C:proteinaceous extracellular matrix; NAS:UniProtKB.
GO:0008201; F:heparin binding; ISS:UniProtKB.::GO:0005178; F:integrin binding; ISS:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0007155; P:cell adhesion; ISS:UniProtKB.::GO:0032963; P:collagen metabolic process; IMP:UniProtKB.::GO:0048251; P:elastic fiber assembly; IMP:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
110P34212    178   ARL5_CAEEL ADP-ribosylation factor-like prote...711.8     31.6     31     51GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0051729; P:germline cell cycle switching, mitotic to meiotic cell cycle; IMP:WormBase.::GO:0008406; P:gonad development; IMP:WormBase.::GO:0000226; P:microtubule cytoskeleton organization; IMP:WormBase.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
111P34121    146   COAA_DICDI Coactosin OS=Dictyostelium discoid...672.9     30.8     21     54GO:0015629; C:actin cytoskeleton; IC:dictyBase.::GO:0005813; C:centrosome; IDA:dictyBase.::GO:0045335; C:phagocytic vesicle; IDA:dictyBase.
GO:0051015; F:actin filament binding; IDA:dictyBase.
GO:0030833; P:regulation of actin filament polymerization; IDA:dictyBase.::GO:0009617; P:response to bacterium; IEP:dictyBase.
112Q9CQI3    142   GMFB_MOUSE Glia maturation factor beta OS=Mus...823.5     30.4     26     50GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:InterPro.::GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
113P15891    592   ABP1_YEAST Actin-binding protein OS=Saccharom...637.4     30     27     54GO:0030479; C:actin cortical patch; IDA:SGD.::GO:0043332; C:mating projection tip; IDA:SGD.
GO:0051015; F:actin filament binding; IDA:SGD.
GO:0000147; P:actin cortical patch assembly; IMP:SGD.::GO:0008104; P:protein localization; IMP:SGD.
114P38479    617   ABP1_SACEX Actin-binding protein OS=Saccharom...929     30     23     50GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
records
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