Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YLL050C
Length:
143
Number of sequences:
5887
Description:
YLL050C COF1 SGDID:S000003973, Chr XII from 40221-39804,40414-40401, Genome Release 64-1-1, reverse complement, Verified ORF, "Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31Q9FVI2    139   ADF1_PETHY Actin-depolymerizing factor 1 OS=P...1366e-31     114     40     64GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
32Q570Y6    140   ADF8_ARATH Actin-depolymerizing factor 8 OS=A...1379e-31     113     39     66GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
33Q9FVI1    143   ADF2_PETHY Actin-depolymerizing factor 2 OS=P...1341e-30     112     43     63GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
34Q9ZSK3    139   ADF4_ARATH Actin-depolymerizing factor 4 OS=A...1361e-29     110     39     64GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO:0009870; P:defense response signaling pathway, resistance gene-dependent; IMP:TAIR.::GO:0042742; P:defense response to bacterium; IMP:TAIR.
35Q39251    137   ADF2_ARATH Actin-depolymerizing factor 2 OS=A...1343e-29     109     42     60GO:0005737; C:cytoplasm; IDA:TAIR.::GO:0005634; C:nucleus; IDA:TAIR.::GO:0005886; C:plasma membrane; IDA:TAIR.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
36Q39250    139   ADF1_ARATH Actin-depolymerizing factor 1 OS=A...1286e-29     108     39     64GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; TAS:TAIR.
GO:0030042; P:actin filament depolymerization; IDA:TAIR.
37Q8SAG3    143   ADF_VITVI Actin-depolymerizing factor OS=Viti...1333e-28     107     42     68GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
38Q84TB6    150   ADF3_ORYSJ Actin-depolymerizing factor 3 OS=O...1457e-28     106     39     59GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO:0006950; P:response to stress; IEA:UniProtKB-KW.
39Q0DLA3    139   ADF7_ORYSJ Actin-depolymerizing factor 7 OS=O...1369e-28     105     44     65GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
40O49606    141   ADF9_ARATH Actin-depolymerizing factor 9 OS=A...1331e-27     105     37     64GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO:0030041; P:actin filament polymerization; IDA:TAIR.
41Q9ZNT3    143   ADF5_ARATH Actin-depolymerizing factor 5 OS=A...1361e-27     105     35     64GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
42Q9ZSK4    139   ADF3_ARATH Actin-depolymerizing factor 3 OS=A...1294e-27     103     39     65GO:0009507; C:chloroplast; IDA:TAIR.::GO:0005829; C:cytosol; IDA:TAIR.::GO:0005739; C:mitochondrion; IDA:TAIR.::GO:0005886; C:plasma membrane; IDA:TAIR.::GO:0009506; C:plasmodesma; IDA:TAIR.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO:0046686; P:response to cadmium ion; IEP:TAIR.::GO:0006979; P:response to oxidative stress; IDA:TAIR.
43P45592    166   COF1_RAT Cofilin-1 OS=Rattus norvegicus (Rat)...1436e-27     104     38     59GO:0005737; C:cytoplasm; IDA:RGD.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.::GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IMP:RGD.
GO:0030030; P:cell projection organization; IDA:MGI.::GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.::GO:0045792; P:negative regulation of cell size; IDA:MGI.::GO:0006606; P:protein import into nucleus; IMP:RGD.::GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB.
44P23528    166   COF1_HUMAN Cofilin-1 OS=Homo sapiens (Human)....1437e-27     103     38     59GO:0005737; C:cytoplasm; TAS:UniProtKB.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.::GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc.::GO:0006916; P:anti-apoptosis; TAS:UniProtKB.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0002576; P:platelet degranulation; TAS:Reactome.::GO:0022604; P:regulation of cell morphogenesis; IMP:UniProtKB.::GO:0009615; P:response to virus; IEP:UniProtKB.::GO:0007266; P:Rho protein signal transduction; TAS:ProtInc.
45Q6B7M7    166   COF1_SHEEP Cofilin-1 OS=Ovis aries (Sheep). G...1438e-27     103     38     59GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.::GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.::GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB.
46P10668    166   COF1_PIG Cofilin-1 OS=Sus scrofa (Pig). GN=CF...1438e-27     103     38     59GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.::GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.::GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB.
47Q4R5C0    166   COF1_MACFA Cofilin-1 OS=Macaca fascicularis (...1438e-27     103     38     59GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.::GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.::GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB.
48Q5E9F7    166   COF1_BOVIN Cofilin-1 OS=Bos taurus (Bovine). ...1438e-27     103     38     59GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.::GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.::GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB.
49P21566    166   COF2_CHICK Cofilin-2 OS=Gallus gallus (Chicke...1508e-27     103     39     57GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
50P18760    166   COF1_MOUSE Cofilin-1 OS=Mus musculus (Mouse)....1431e-26     103     38     59GO:0030864; C:cortical actin cytoskeleton; IDA:MGI.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005576; C:extracellular region; TAS:Reactome.::GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.::GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO:0007015; P:actin filament organization; IMP:MGI.::GO:0000910; P:cytokinesis; IMP:MGI.::GO:0030010; P:establishment of cell polarity; IMP:MGI.::GO:0001755; P:neural crest cell migration; IMP:MGI.::GO:0001842; P:neural fold formation; IMP:MGI.::GO:0030836; P:positive regulation of actin filament depolymerization; IMP:MGI.::GO:0006468; P:protein phosphorylation; IDA:MGI.::GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB.::GO:0043200; P:response to amino acid stimulus; IDA:MGI.
51Q5G6V9    166   COF2_PIG Cofilin-2 OS=Sus scrofa (Pig). GN=CF...1502e-26     102     39     57GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
52Q9Y281    166   COF2_HUMAN Cofilin-2 OS=Homo sapiens (Human)....1502e-26     102     39     57GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
53Q148F1    166   COF2_BOVIN Cofilin-2 OS=Bos taurus (Bovine). ...1502e-26     102     39     57GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
54P45591    166   COF2_MOUSE Cofilin-2 OS=Mus musculus (Mouse)....1502e-26     102     39     57GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
55P18359    165   DEST_CHICK Destrin OS=Gallus gallus (Chicken)...1538e-26     101     36     57GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
56Q10P87    143   ADF5_ORYSJ Actin-depolymerizing factor 5 OS=O...1363e-25     99.4     35     61GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
57Q337A5    151   ADF10_ORYSJ Actin-depolymerizing factor 10 OS...1383e-25     99.4     35     64GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
58P45594    148   CADF_DROME Cofilin/actin-depolymerizing facto...1403e-25     99.4     38     59GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005875; C:microtubule associated complex; IDA:FlyBase.::GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
GO:0003779; F:actin binding; IMP:FlyBase.
GO:0030041; P:actin filament polymerization; IMP:FlyBase.::GO:0007409; P:axonogenesis; IMP:FlyBase.::GO:0007298; P:border follicle cell migration; IMP:FlyBase.::GO:0000915; P:cytokinesis, actomyosin contractile ring assembly; TAS:FlyBase.::GO:0001737; P:establishment of imaginal disc-derived wing hair orientation; IMP:FlyBase.::GO:0042067; P:establishment of ommatidial planar polarity; IMP:FlyBase.::GO:0008585; P:female gonad development; IMP:FlyBase.::GO:0036011; P:imaginal disc-derived leg segmentation; IMP:FlyBase.::GO:0016319; P:mushroom body development; IMP:FlyBase.::GO:0010591; P:regulation of lamellipodium assembly; IMP:FlyBase.::GO:0042052; P:rhabdomere development; IMP:FlyBase.
59Q7M0E3    165   DEST_RAT Destrin OS=Rattus norvegicus (Rat). ...1533e-24     97.1     36     57GO:0005622; C:intracellular; IEA:InterPro.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
60P60982    165   DEST_PIG Destrin OS=Sus scrofa (Pig). GN=DSTN...1534e-24     96.7     35     56GO:0030864; C:cortical actin cytoskeleton; ISS:AgBase.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO:0006928; P:cellular component movement; ISS:AgBase.::GO:0000910; P:cytokinesis; ISS:AgBase.::GO:0030836; P:positive regulation of actin filament depolymerization; ISS:AgBase.
61P60981    165   DEST_HUMAN Destrin OS=Homo sapiens (Human). G...1534e-24     96.7     35     56
GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO:0051014; P:actin filament severing; TAS:ProtInc.::GO:0008154; P:actin polymerization or depolymerization; TAS:ProtInc.
records
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