UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YKR072C

Length:

562

Number of sequences:

5887

Description:

YKR072C SIS2 SGDID:S000001780, Chr XI from 578123-576435, Genome Release 64-1-1, reverse complement, Verified ORF, "Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	P36024	562	SIS2_YEAST Phosphopantothenoylcysteine decarb...	562	0	1145	100	100	GO:0005634; C:nucleus; IDA:SGD.::GO:0071513; C:phosphopantothenoylcysteine decarboxylase complex; IDA:SGD.
									GO:0003824; F:catalytic activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004864; F:protein phosphatase inhibitor activity; IDA:SGD.
									GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-KW.::GO:0007346; P:regulation of mitotic cell cycle; IGI:SGD.::GO:0009651; P:response to salt stress; IGI:SGD.
2	Q08438	674	VHS3_YEAST Phosphopantothenoylcysteine decarb...	77	0.000000000007	72	58	70	GO:0071513; C:phosphopantothenoylcysteine decarboxylase complex; IDA:SGD.
									GO:0003824; F:catalytic activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004864; F:protein phosphatase inhibitor activity; IDA:SGD.
									GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0030004; P:cellular monovalent inorganic cation homeostasis; IPI:SGD.::GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-KW.
3	Q12600	531	SIS2_CANTR Protein SIS2 OS=Candida tropicalis...	312	3e-81	270	46	61	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0005488; F:binding; IEA:InterPro.::GO:0003824; F:catalytic activity; IEA:InterPro.
4	P36076	571	CAB3_YEAST Coenzyme A biosynthesis protein 3 ...	262	1e-46	177	36	57	GO:0071513; C:phosphopantothenoylcysteine decarboxylase complex; IDA:SGD.
									GO:0003824; F:catalytic activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0015937; P:coenzyme A biosynthetic process; IGI:SGD.::GO:0009651; P:response to salt stress; IGI:SGD.
5	Q96CD2	204	COAC_HUMAN Phosphopantothenoylcysteine decarb...	227	1e-36	139	37	55	GO:0005829; C:cytosol; TAS:Reactome.
									GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; TAS:Reactome.
									GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-KW.::GO:0015939; P:pantothenate metabolic process; TAS:Reactome.
6	Q9UTI7	625	TYSY_SCHPO Probable thymidylate synthase OS=S...	259	1e-36	147	35	50	GO:0005829; C:cytosol; IDA:PomBase.
									GO:0004799; F:thymidylate synthase activity; ISS:PomBase.
									GO:0006231; P:dTMP biosynthetic process; ISS:PomBase.
7	Q8BZB2	204	COAC_MOUSE Phosphopantothenoylcysteine decarb...	228	2e-36	138	36	55
									GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; IEA:EC.
									GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-KW.
8	Q9SWE5	209	HAL3A_ARATH Phosphopantothenoylcysteine decar...	126	1e-32	128	49	71	GO:0005829; C:cytosol; IDA:TAIR.
									GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; IDA:TAIR.
									GO:0015937; P:coenzyme A biosynthetic process; TAS:TAIR.::GO:0042538; P:hyperosmotic salinity response; IEP:TAIR.
9	P94063	201	HAL3B_ARATH Probable phosphopantothenoylcyste...	124	4e-32	127	48	72
									GO:0010181; F:FMN binding; ISS:TAIR.::GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; IGI:TAIR.
									GO:0015937; P:coenzyme A biosynthetic process; IMP:TAIR.::GO:0042538; P:hyperosmotic salinity response; IEP:TAIR.
10	Q54Y51	197	COAC_DICDI Putative phosphopantothenoylcystei...	118	1e-19	91.7	42	65
									GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; ISS:dictyBase.
									GO:0015937; P:coenzyme A biosynthetic process; ISS:dictyBase.
11	P73881	402	COABC_SYNY3 Coenzyme A biosynthesis bifunctio...	181	0.0000000002	66.2	29	45
									GO:0010181; F:FMN binding; IEA:InterPro.::GO:0004632; F:phosphopantothenate--cysteine ligase activity; IEA:EC.::GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; IEA:EC.
									GO:0015937; P:coenzyme A biosynthetic process; IEA:InterPro.::GO:0015941; P:pantothenate catabolic process; IEA:InterPro.
12	P44953	400	COABC_HAEIN Coenzyme A biosynthesis bifunctio...	224	0.0000000003	66.2	24	45
									GO:0010181; F:FMN binding; IEA:InterPro.::GO:0004632; F:phosphopantothenate--cysteine ligase activity; IEA:EC.::GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; IEA:EC.
									GO:0015937; P:coenzyme A biosynthetic process; IEA:InterPro.::GO:0015941; P:pantothenate catabolic process; IEA:InterPro.
13	Q9KVD1	399	COABC_VIBCH Coenzyme A biosynthesis bifunctio...	218	0.0000000009	64.3	25	47
									GO:0010181; F:FMN binding; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004632; F:phosphopantothenate--cysteine ligase activity; IEA:EC.::GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; IEA:EC.
									GO:0015937; P:coenzyme A biosynthetic process; IEA:InterPro.::GO:0015941; P:pantothenate catabolic process; IEA:InterPro.
14	Q54433	179	COAC_STRMU Probable phosphopantothenoylcystei...	145	0.000000001	61.2	29	52
									GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; IEA:EC.
15	Q5E8M6	409	COABC_VIBF1 Coenzyme A biosynthesis bifunctio...	105	0.00000001	60.8	29	66
									GO:0010181; F:FMN binding; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004632; F:phosphopantothenate--cysteine ligase activity; IEA:EC.::GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; IEA:EC.
									GO:0015937; P:coenzyme A biosynthetic process; IEA:InterPro.::GO:0015941; P:pantothenate catabolic process; IEA:InterPro.
16	Q7MPS9	401	COABC_VIBVY Coenzyme A biosynthesis bifunctio...	216	0.0000001	57.4	22	47
									GO:0010181; F:FMN binding; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004632; F:phosphopantothenate--cysteine ligase activity; IEA:EC.::GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; IEA:EC.
									GO:0015937; P:coenzyme A biosynthetic process; IEA:InterPro.::GO:0015941; P:pantothenate catabolic process; IEA:InterPro.
17	Q8DDX8	401	COABC_VIBVU Coenzyme A biosynthesis bifunctio...	216	0.0000002	57	22	47
									GO:0010181; F:FMN binding; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004632; F:phosphopantothenate--cysteine ligase activity; IEA:EC.::GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; IEA:EC.
									GO:0015937; P:coenzyme A biosynthetic process; IEA:InterPro.::GO:0015941; P:pantothenate catabolic process; IEA:InterPro.
18	P0ABQ0	406	COABC_ECOLI Coenzyme A biosynthesis bifunctio...	108	0.0000005	55.8	30	58
									GO:0010181; F:FMN binding; IDA:EcoCyc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004632; F:phosphopantothenate--cysteine ligase activity; IDA:EcoCyc.::GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; IDA:EcoCyc.
									GO:0015937; P:coenzyme A biosynthetic process; IDA:EcoCyc.::GO:0015941; P:pantothenate catabolic process; IEA:InterPro.
19	P0ABQ1	406	COABC_ECOL6 Coenzyme A biosynthesis bifunctio...	108	0.0000005	55.8	30	58
									GO:0010181; F:FMN binding; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004632; F:phosphopantothenate--cysteine ligase activity; IEA:EC.::GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; IEA:EC.
									GO:0015937; P:coenzyme A biosynthetic process; IEA:InterPro.::GO:0015941; P:pantothenate catabolic process; IEA:InterPro.
20	Q58323	403	COABC_METJA Coenzyme A biosynthesis bifunctio...	83	0.000001	54.3	31	59
									GO:0010181; F:FMN binding; IEA:InterPro.::GO:0004632; F:phosphopantothenate--cysteine ligase activity; IEA:EC.::GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; IEA:EC.
									GO:0015937; P:coenzyme A biosynthetic process; IEA:InterPro.::GO:0015941; P:pantothenate catabolic process; IEA:InterPro.
21	Q87T89	399	COABC_VIBPA Coenzyme A biosynthesis bifunctio...	105	0.000002	54.3	27	64
									GO:0010181; F:FMN binding; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004632; F:phosphopantothenate--cysteine ligase activity; IEA:EC.::GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; IEA:EC.
									GO:0015937; P:coenzyme A biosynthetic process; IEA:InterPro.::GO:0015941; P:pantothenate catabolic process; IEA:InterPro.
22	O51752	390	COABC_BORBU Coenzyme A biosynthesis bifunctio...	184	0.000006	52.4	24	46
									GO:0010181; F:FMN binding; IEA:InterPro.::GO:0004632; F:phosphopantothenate--cysteine ligase activity; IEA:EC.::GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; IEA:EC.
									GO:0015937; P:coenzyme A biosynthetic process; IEA:InterPro.::GO:0015941; P:pantothenate catabolic process; IEA:InterPro.
23	O35033	406	COABC_BACSU Probable coenzyme A biosynthesis ...	208	0.0002	47.8	24	45
									GO:0010181; F:FMN binding; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004632; F:phosphopantothenate--cysteine ligase activity; IEA:EC.::GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; IEA:EC.
									GO:0015937; P:coenzyme A biosynthetic process; IEA:InterPro.::GO:0015941; P:pantothenate catabolic process; IEA:InterPro.
24	P0C6U4	4441	R1A_CVHN2 Replicase polyprotein 1a OS=Human c...	59	6	33.5	34	56	GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.::GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0048471; C:perinuclear region of cytoplasm; IEA:InterPro.::GO:0019034; C:viral replication complex; IEA:InterPro.
									GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.::GO:0008242; F:omega peptidase activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0003968; F:RNA-directed RNA polymerase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
									GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0019079; P:viral genome replication; IEA:InterPro.::GO:0019082; P:viral protein processing; IEA:InterPro.
25	P0C6U3	4471	R1A_CVHN1 Replicase polyprotein 1a OS=Human c...	59	6	33.5	34	56	GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.::GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0048471; C:perinuclear region of cytoplasm; IEA:InterPro.::GO:0019034; C:viral replication complex; IEA:InterPro.
									GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.::GO:0008242; F:omega peptidase activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0003968; F:RNA-directed RNA polymerase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
									GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0019079; P:viral genome replication; IEA:InterPro.::GO:0019082; P:viral protein processing; IEA:InterPro.
26	P0C6X3	7152	R1AB_CVHN2 Replicase polyprotein 1ab OS=Human...	59	6.1	33.5	34	56	GO:0044172; C:host cell endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.::GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.::GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0048471; C:perinuclear region of cytoplasm; IEA:InterPro.::GO:0019034; C:viral replication complex; IEA:InterPro.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0008168; F:methyltransferase activity; IEA:InterPro.::GO:0008242; F:omega peptidase activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0003968; F:RNA-directed RNA polymerase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
									GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:InterPro.::GO:0019079; P:viral genome replication; IEA:InterPro.::GO:0019082; P:viral protein processing; IEA:InterPro.
27	P0C6X2	7182	R1AB_CVHN1 Replicase polyprotein 1ab OS=Human...	59	6.1	33.5	34	56	GO:0044172; C:host cell endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.::GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.::GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0048471; C:perinuclear region of cytoplasm; IEA:InterPro.::GO:0019034; C:viral replication complex; IEA:InterPro.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0008168; F:methyltransferase activity; IEA:InterPro.::GO:0008242; F:omega peptidase activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0003968; F:RNA-directed RNA polymerase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
									GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:InterPro.::GO:0019079; P:viral genome replication; IEA:InterPro.::GO:0019082; P:viral protein processing; IEA:InterPro.
28	P0C6U5	4421	R1A_CVHN5 Replicase polyprotein 1a OS=Human c...	59	6	33.5	34	56	GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.::GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0048471; C:perinuclear region of cytoplasm; IEA:InterPro.::GO:0019034; C:viral replication complex; IEA:InterPro.
									GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.::GO:0008242; F:omega peptidase activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0003968; F:RNA-directed RNA polymerase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
									GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0019079; P:viral genome replication; IEA:InterPro.::GO:0019082; P:viral protein processing; IEA:InterPro.
29	P0C6X4	7132	R1AB_CVHN5 Replicase polyprotein 1ab OS=Human...	59	6.1	33.5	34	56	GO:0044172; C:host cell endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.::GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.::GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0048471; C:perinuclear region of cytoplasm; IEA:InterPro.::GO:0019034; C:viral replication complex; IEA:InterPro.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.::GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.::GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0008168; F:methyltransferase activity; IEA:InterPro.::GO:0008242; F:omega peptidase activity; IEA:InterPro.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0003968; F:RNA-directed RNA polymerase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
									GO:0030683; P:evasion by virus of host immune response; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:InterPro.::GO:0019079; P:viral genome replication; IEA:InterPro.::GO:0019082; P:viral protein processing; IEA:InterPro.
30	Q9RC23	194	MRSD_BACSY Mersacidin decarboxylase OS=Bacill...	72	0.006	41.6	31	57
									GO:0016829; F:lyase activity; IEA:UniProtKB-KW.::GO:0016491; F:oxidoreductase activity; IDA:UniProtKB.
									GO:0017000; P:antibiotic biosynthetic process; IDA:UniProtKB.
31	P30197	181	EPID_STAEP Epidermin decarboxylase OS=Staphyl...	41	0.006	41.6	51	76
									GO:0016829; F:lyase activity; IEA:UniProtKB-KW.

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