UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YKR019C

Length:

615

Number of sequences:

5887

Description:

YKR019C IRS4 SGDID:S000001727, Chr XI from 478063-476216, Genome Release 64-1-1, reverse complement, Verified ORF, "EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
31	P42566	896	EPS15_HUMAN Epidermal growth factor receptor ...	62	0.011	42.7	34	48	GO:0005829; C:cytosol; TAS:Reactome.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
									GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
									GO:0008283; P:cell proliferation; TAS:ProtInc.::GO:0048268; P:clathrin coat assembly; IDA:BHF-UCL.::GO:0032456; P:endocytic recycling; IC:BHF-UCL.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
32	Q1DQC1	1485	PAN1_COCIM Actin cytoskeleton-regulatory comp...	105	0.0002	48.5	29	48	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
33	A6R7X5	1481	PAN1_AJECN Actin cytoskeleton-regulatory comp...	116	0.0002	48.1	25	48	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
34	Q5B5B0	1484	PAN1_EMENI Actin cytoskeleton-regulatory comp...	116	0.0003	47.8	25	47	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
35	Q2UDY8	1473	PAN1_ASPOR Actin cytoskeleton-regulatory comp...	116	0.0005	47	25	47	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
36	O42287	1270	ITSN1_XENLA Intersectin-1 OS=Xenopus laevis (...	62	0.002	45.1	37	56	GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
									GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
37	Q9HGL2	1116	YHLA_SCHPO Uncharacterized calcium-binding pr...	70	0.002	45.1	30	51	GO:0030479; C:actin cortical patch; ISS:PomBase.
									GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0000147; P:actin cortical patch assembly; ISS:PomBase.::GO:0006886; P:intracellular protein transport; IC:PomBase.::GO:0006898; P:receptor-mediated endocytosis; ISS:PomBase.
38	Q6C908	1634	PAN1_YARLI Actin cytoskeleton-regulatory comp...	63	0.0006	46.6	35	52	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
39	Q9Z0R4	1714	ITSN1_MOUSE Intersectin-1 OS=Mus musculus (Mo...	62	0.002	45.1	37	56	GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0030139; C:endocytic vesicle; IDA:MGI.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
									GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0019209; F:kinase activator activity; IDA:MGI.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IDA:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IDA:MGI.
40	Q15811	1721	ITSN1_HUMAN Intersectin-1 OS=Homo sapiens (Hu...	62	0.002	45.1	37	56	GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005905; C:coated pit; IDA:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
									GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0070064; F:proline-rich region binding; IPI:UniProtKB.::GO:0032947; F:protein complex scaffold; IDA:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0048488; P:synaptic vesicle endocytosis; TAS:ProtInc.
41	A6S9N4	1444	PAN1_BOTFB Actin cytoskeleton-regulatory comp...	116	0.0008	46.2	24	47	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
42	Q9UBC2	864	EP15R_HUMAN Epidermal growth factor receptor ...	52	0.003	44.3	37	58	GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; TAS:Reactome.
									GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.
43	A1CD74	1485	PAN1_ASPCL Actin cytoskeleton-regulatory comp...	116	0.001	45.8	25	47	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
44	Q4WG58	1467	PAN1_ASPFU Actin cytoskeleton-regulatory comp...	116	0.002	45.4	24	47	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
45	B0YC95	1467	PAN1_ASPFC Actin cytoskeleton-regulatory comp...	116	0.002	45.4	24	47	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
46	P42567	897	EPS15_MOUSE Epidermal growth factor receptor ...	62	0.003	44.7	35	48	GO:0030122; C:AP-2 adaptor complex; IDA:UniProtKB.::GO:0060170; C:cilium membrane; IDA:MGI.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
									GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
									GO:0015031; P:protein transport; IEA:UniProtKB-KW.
47	P32521	1480	PAN1_YEAST Actin cytoskeleton-regulatory comp...	62	0.017	42	32	56	GO:0030479; C:actin cortical patch; IDA:SGD.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0043332; C:mating projection tip; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.::GO:0005886; C:plasma membrane; IDA:SGD.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0030674; F:protein binding, bridging; IPI:SGD.
									GO:0000147; P:actin cortical patch assembly; IMP:SGD.::GO:0007120; P:axial cellular bud site selection; IMP:SGD.::GO:0007121; P:bipolar cellular bud site selection; IMP:SGD.::GO:0006897; P:endocytosis; IMP:SGD.
48	Q60902	907	EP15R_MOUSE Epidermal growth factor receptor ...	57	0.003	44.3	40	54	GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
49	A6ZVS5	1460	PAN1_YEAS7 Actin cytoskeleton-regulatory comp...	51	0.3	38.1	33	59	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
50	Q9NZN3	535	EHD3_HUMAN EH domain-containing protein 3 OS=...	63	0.002	44.7	41	52	GO:0005634; C:nucleus; TAS:ProtInc.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0055038; C:recycling endosome membrane; IDA:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005525; F:GTP binding; IEA:InterPro.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; TAS:ProtInc.::GO:0005515; F:protein binding; IPI:UniProtKB.
									GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0032456; P:endocytic recycling; IDA:UniProtKB.::GO:0051260; P:protein homooligomerization; IPI:UniProtKB.
51	A7EKZ0	1373	PAN1_SCLS1 Actin cytoskeleton-regulatory comp...	116	0.003	44.7	24	47	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
52	A1DC51	1470	PAN1_NEOFI Actin cytoskeleton-regulatory comp...	116	0.003	44.7	24	46	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
53	A5DP36	1440	PAN1_PICGU Actin cytoskeleton-regulatory comp...	88	0.003	44.7	34	49	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
54	A4R8N4	1462	PAN1_MAGO7 Actin cytoskeleton-regulatory comp...	116	0.004	43.9	23	45	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
55	Q7SAT8	1533	PAN1_NEUCR Actin cytoskeleton-regulatory comp...	113	0.21	38.5	25	39	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
56	Q9QXY6	535	EHD3_MOUSE EH domain-containing protein 3 OS=...	63	0.007	43.1	40	54	GO:0030139; C:endocytic vesicle; IDA:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005525; F:GTP binding; IEA:InterPro.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MGI.
									GO:0032456; P:endocytic recycling; ISS:UniProtKB.::GO:0051260; P:protein homooligomerization; ISS:UniProtKB.
57	Q8R491	535	EHD3_RAT EH domain-containing protein 3 OS=Ra...	63	0.007	43.1	40	54	GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005525; F:GTP binding; IEA:InterPro.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0005515; F:protein binding; ISS:UniProtKB.
									GO:0032456; P:endocytic recycling; ISS:UniProtKB.::GO:0051260; P:protein homooligomerization; ISS:UniProtKB.
58	Q0CPW4	1469	PAN1_ASPTN Actin cytoskeleton-regulatory comp...	116	0.01	42.7	24	46	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
59	Q10172	1794	PAN1_SCHPO Actin cytoskeleton-regulatory comp...	65	0.011	42.7	31	54	GO:0030479; C:actin cortical patch; ISS:PomBase.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:PomBase.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0000147; P:actin cortical patch assembly; ISS:PomBase.::GO:0006897; P:endocytosis; ISS:PomBase.::GO:0006886; P:intracellular protein transport; IC:PomBase.
60	Q6CQX9	1324	PAN1_KLULA Actin cytoskeleton-regulatory comp...	53	0.032	41.2	38	58	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
61	Q75AA0	1203	PAN1_ASHGO Actin cytoskeleton-regulatory comp...	56	0.018	42	34	57	GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.
									GO:0006897; P:endocytosis; IEA:UniProtKB-KW.

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